JP2020501583A5 - - Google Patents
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- Publication number
- JP2020501583A5 JP2020501583A5 JP2019533652A JP2019533652A JP2020501583A5 JP 2020501583 A5 JP2020501583 A5 JP 2020501583A5 JP 2019533652 A JP2019533652 A JP 2019533652A JP 2019533652 A JP2019533652 A JP 2019533652A JP 2020501583 A5 JP2020501583 A5 JP 2020501583A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- acid sequence
- amino acid
- antibody
- variable region
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 125000003275 alpha amino acid group Chemical group 0.000 claims 90
- 238000004519 manufacturing process Methods 0.000 claims 19
- 239000003814 drug Substances 0.000 claims 18
- 102000003812 Interleukin-15 Human genes 0.000 claims 13
- 108090000172 Interleukin-15 Proteins 0.000 claims 13
- 210000004027 cell Anatomy 0.000 claims 13
- 108010068370 Glutens Proteins 0.000 claims 9
- 235000021312 gluten Nutrition 0.000 claims 9
- 150000007523 nucleic acids Chemical group 0.000 claims 9
- 208000015943 Coeliac disease Diseases 0.000 claims 8
- 101001055157 Homo sapiens Interleukin-15 Proteins 0.000 claims 8
- 102000004556 Interleukin-15 Receptors Human genes 0.000 claims 8
- 108010017535 Interleukin-15 Receptors Proteins 0.000 claims 8
- 102000056003 human IL15 Human genes 0.000 claims 8
- 206010020751 Hypersensitivity Diseases 0.000 claims 6
- 208000026935 allergic disease Diseases 0.000 claims 6
- 230000009610 hypersensitivity Effects 0.000 claims 6
- 210000000822 natural killer cell Anatomy 0.000 claims 6
- 108020004707 nucleic acids Proteins 0.000 claims 6
- 102000039446 nucleic acids Human genes 0.000 claims 6
- 108091033319 polynucleotide Proteins 0.000 claims 6
- 102000040430 polynucleotide Human genes 0.000 claims 6
- 239000002157 polynucleotide Substances 0.000 claims 6
- 208000023275 Autoimmune disease Diseases 0.000 claims 5
- 201000007235 gluten allergy Diseases 0.000 claims 5
- 208000027866 inflammatory disease Diseases 0.000 claims 4
- 239000013598 vector Substances 0.000 claims 4
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 3
- 238000001516 cell proliferation assay Methods 0.000 claims 3
- 238000010494 dissociation reaction Methods 0.000 claims 3
- 230000005593 dissociations Effects 0.000 claims 3
- 208000024891 symptom Diseases 0.000 claims 3
- 210000001519 tissue Anatomy 0.000 claims 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 2
- 201000004681 Psoriasis Diseases 0.000 claims 2
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 230000004968 inflammatory condition Effects 0.000 claims 2
- 210000004962 mammalian cell Anatomy 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 2
- 210000000813 small intestine Anatomy 0.000 claims 2
- 238000002198 surface plasmon resonance spectroscopy Methods 0.000 claims 2
- 201000004384 Alopecia Diseases 0.000 claims 1
- 208000019901 Anxiety disease Diseases 0.000 claims 1
- 208000006820 Arthralgia Diseases 0.000 claims 1
- 206010010774 Constipation Diseases 0.000 claims 1
- 206010010904 Convulsion Diseases 0.000 claims 1
- 206010012735 Diarrhoea Diseases 0.000 claims 1
- 208000010201 Exanthema Diseases 0.000 claims 1
- 206010019233 Headaches Diseases 0.000 claims 1
- 208000006404 Large Granular Lymphocytic Leukemia Diseases 0.000 claims 1
- 206010023791 Large granular lymphocytosis Diseases 0.000 claims 1
- 208000028018 Lymphocytic leukaemia Diseases 0.000 claims 1
- 208000019695 Migraine disease Diseases 0.000 claims 1
- 208000000112 Myalgia Diseases 0.000 claims 1
- 206010028813 Nausea Diseases 0.000 claims 1
- 208000002193 Pain Diseases 0.000 claims 1
- 208000021329 Refractory celiac disease Diseases 0.000 claims 1
- 201000008717 T-cell large granular lymphocyte leukemia Diseases 0.000 claims 1
- 210000001744 T-lymphocyte Anatomy 0.000 claims 1
- 208000027418 Wounds and injury Diseases 0.000 claims 1
- 231100000360 alopecia Toxicity 0.000 claims 1
- 208000004631 alopecia areata Diseases 0.000 claims 1
- 230000036506 anxiety Effects 0.000 claims 1
- 210000004556 brain Anatomy 0.000 claims 1
- 210000004978 chinese hamster ovary cell Anatomy 0.000 claims 1
- 230000036461 convulsion Effects 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 230000006378 damage Effects 0.000 claims 1
- 230000037213 diet Effects 0.000 claims 1
- 235000005911 diet Nutrition 0.000 claims 1
- 230000008482 dysregulation Effects 0.000 claims 1
- 201000005884 exanthem Diseases 0.000 claims 1
- 206010016256 fatigue Diseases 0.000 claims 1
- 206010016766 flatulence Diseases 0.000 claims 1
- 239000008187 granular material Substances 0.000 claims 1
- 231100000869 headache Toxicity 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 208000014674 injury Diseases 0.000 claims 1
- 230000000968 intestinal effect Effects 0.000 claims 1
- 208000003747 lymphoid leukemia Diseases 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 206010027599 migraine Diseases 0.000 claims 1
- 210000004877 mucosa Anatomy 0.000 claims 1
- 208000013465 muscle pain Diseases 0.000 claims 1
- 230000008693 nausea Effects 0.000 claims 1
- 235000018102 proteins Nutrition 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 206010037844 rash Diseases 0.000 claims 1
- 231100000046 skin rash Toxicity 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022161059A JP2022176324A (ja) | 2016-12-21 | 2022-10-05 | ヒトｉｌ－１５に特異的に結合する抗体及びその使用 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662437143P | 2016-12-21 | 2016-12-21 | |
| US62/437,143 | 2016-12-21 | ||
| PCT/US2017/067917 WO2018119246A1 (en) | 2016-12-21 | 2017-12-21 | Antibodies that specifically bind to human il-15 and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022161059A Division JP2022176324A (ja) | 2016-12-21 | 2022-10-05 | ヒトｉｌ－１５に特異的に結合する抗体及びその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020501583A JP2020501583A (ja) | 2020-01-23 |
| JP2020501583A5 true JP2020501583A5 (enExample) | 2021-02-04 |
| JP7155126B2 JP7155126B2 (ja) | 2022-10-18 |
Family
ID=62627610
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019533652A Active JP7155126B2 (ja) | 2016-12-21 | 2017-12-21 | ヒトｉｌ－１５に特異的に結合する抗体及びその使用 |
| JP2022161059A Pending JP2022176324A (ja) | 2016-12-21 | 2022-10-05 | ヒトｉｌ－１５に特異的に結合する抗体及びその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022161059A Pending JP2022176324A (ja) | 2016-12-21 | 2022-10-05 | ヒトｉｌ－１５に特異的に結合する抗体及びその使用 |
Country Status (30)
| Country | Link |
|---|---|
| US (2) | US11267883B2 (enExample) |
| EP (2) | EP4585261A3 (enExample) |
| JP (2) | JP7155126B2 (enExample) |
| KR (2) | KR102706743B1 (enExample) |
| CN (1) | CN110234349B (enExample) |
| AR (1) | AR110414A1 (enExample) |
| AU (2) | AU2017382850B2 (enExample) |
| BR (1) | BR112019012570A8 (enExample) |
| CA (1) | CA3046387A1 (enExample) |
| CL (1) | CL2019001729A1 (enExample) |
| DK (1) | DK3558369T3 (enExample) |
| EA (1) | EA201991514A1 (enExample) |
| ES (1) | ES3026508T3 (enExample) |
| FI (1) | FI3558369T3 (enExample) |
| HR (1) | HRP20250482T1 (enExample) |
| HU (1) | HUE071878T2 (enExample) |
| IL (1) | IL267113B2 (enExample) |
| LT (1) | LT3558369T (enExample) |
| MA (1) | MA47130B1 (enExample) |
| MD (1) | MD3558369T2 (enExample) |
| MX (2) | MX2019007357A (enExample) |
| PE (1) | PE20191497A1 (enExample) |
| PH (1) | PH12019501453A1 (enExample) |
| PL (1) | PL3558369T3 (enExample) |
| PT (1) | PT3558369T (enExample) |
| RS (1) | RS66900B1 (enExample) |
| SI (1) | SI3558369T1 (enExample) |
| UA (1) | UA126284C2 (enExample) |
| WO (1) | WO2018119246A1 (enExample) |
| ZA (1) | ZA201903848B (enExample) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI707038B (zh) | 2013-08-05 | 2020-10-11 | 美商扭轉生物科技有限公司 | 重新合成之基因庫 |
| WO2016126882A1 (en) | 2015-02-04 | 2016-08-11 | Twist Bioscience Corporation | Methods and devices for de novo oligonucleic acid assembly |
| US9981239B2 (en) | 2015-04-21 | 2018-05-29 | Twist Bioscience Corporation | Devices and methods for oligonucleic acid library synthesis |
| KR20180050411A (ko) | 2015-09-18 | 2018-05-14 | 트위스트 바이오사이언스 코포레이션 | 올리고핵산 변이체 라이브러리 및 그의 합성 |
| CN108698012A (zh) | 2015-09-22 | 2018-10-23 | 特韦斯特生物科学公司 | 用于核酸合成的柔性基底 |
| WO2018057526A2 (en) | 2016-09-21 | 2018-03-29 | Twist Bioscience Corporation | Nucleic acid based data storage |
| RS66900B1 (sr) | 2016-12-21 | 2025-07-31 | Cephalon Llc | Antitela koja se specifično vezuju za humani il-15 i njihova upotreba |
| CN110892485B (zh) | 2017-02-22 | 2024-03-22 | 特韦斯特生物科学公司 | 基于核酸的数据存储 |
| JP7169999B2 (ja) | 2017-06-12 | 2022-11-11 | ツイスト バイオサイエンス コーポレーション | シームレス核酸アセンブリのための方法 |
| WO2018231864A1 (en) | 2017-06-12 | 2018-12-20 | Twist Bioscience Corporation | Methods for seamless nucleic acid assembly |
| AU2018328847A1 (en) | 2017-09-11 | 2020-04-23 | Twist Bioscience Corporation | GPCR binding proteins and synthesis thereof |
| WO2019079769A1 (en) | 2017-10-20 | 2019-04-25 | Twist Bioscience Corporation | HEATED NANOWELLS FOR THE SYNTHESIS OF POLYNUCLEOTIDES |
| EP4715681A2 (en) | 2018-01-04 | 2026-03-25 | Atlas Data Storage, Inc. | Dna-based digital information storage |
| IL278771B2 (en) | 2018-05-18 | 2025-09-01 | Twist Bioscience Corp | Polynucleotides, reagents and methods for nucleic acid hybridization |
| CN112534052B (zh) | 2018-07-25 | 2024-09-20 | 奥美药业有限公司 | 全新il-21前药及使用方法 |
| US11828385B2 (en) | 2018-12-25 | 2023-11-28 | Ntn Corporation | Flow control valve seal and flow control valve device |
| WO2020139871A1 (en) | 2018-12-26 | 2020-07-02 | Twist Bioscience Corporation | Highly accurate de novo polynucleotide synthesis |
| AU2020227802A1 (en) | 2019-02-26 | 2021-10-14 | Twist Bioscience Corporation | Variant nucleic acid libraries for antibody optimization |
| WO2020176678A1 (en) | 2019-02-26 | 2020-09-03 | Twist Bioscience Corporation | Variant nucleic acid libraries for glp1 receptor |
| WO2020252264A1 (en) | 2019-06-12 | 2020-12-17 | AskGene Pharma, Inc. | Novel il-15 prodrugs and methods of use thereof |
| CA3144644A1 (en) | 2019-06-21 | 2020-12-24 | Twist Bioscience Corporation | Barcode-based nucleic acid sequence assembly |
| EP4034564A4 (en) | 2019-09-23 | 2023-12-13 | Twist Bioscience Corporation | VARIANT NUCLEIC ACID LIBRARIES FOR SINGLE-DOMAIN ANTIBODIES |
| US12091777B2 (en) | 2019-09-23 | 2024-09-17 | Twist Bioscience Corporation | Variant nucleic acid libraries for CRTH2 |
| BR112022011235A2 (pt) * | 2019-12-09 | 2022-12-13 | Twist Bioscience Corp | Bibliotecas de variantes de ácido nucleico para receptores de adenosina |
| JP7767290B2 (ja) | 2020-01-11 | 2025-11-11 | アスクジーン・ファーマ・インコーポレイテッド | 新規なマスクされたサイトカインおよびその使用方法 |
| TW202228775A (zh) * | 2020-10-14 | 2022-08-01 | 美商維里迪恩醫療股份有限公司 | 用於治療甲狀腺眼病之組合物及方法 |
| JP2023545821A (ja) * | 2020-10-16 | 2023-10-31 | ジェネンテック， インコーポレイテッド | 抗ｉＣａｓｐａｓｅ切断基質抗体および使用方法 |
| KR20230147617A (ko) | 2021-01-21 | 2023-10-23 | 트위스트 바이오사이언스 코포레이션 | 아데노신 수용체에 관한 방법 및 조성물 |
| CN116655771A (zh) * | 2021-05-28 | 2023-08-29 | 苏州复融生物技术有限公司 | 一种新型白介素15突变体多肽的开发及其应用 |
| CN119698301A (zh) | 2022-08-04 | 2025-03-25 | 诺华医药股份公司 | Il-15抑制剂用于治疗特应性皮炎 |
| CN118894934A (zh) * | 2023-05-05 | 2024-11-05 | 北京智仁美博生物科技有限公司 | 抗人il-15的抗体及其用途 |
| CN117209605B (zh) * | 2023-11-09 | 2024-01-30 | 北京百普赛斯生物科技股份有限公司 | 特异性结合il-15的抗体及其应用 |
| WO2025227052A1 (en) * | 2024-04-26 | 2025-10-30 | Cephalon Llc | Doses and formulations of anti-il-15 antibody for the treatment of immune diseases |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5795966A (en) | 1995-02-22 | 1998-08-18 | Immunex Corp | Antagonists of interleukin-15 |
| KR100940380B1 (ko) | 1999-01-15 | 2010-02-02 | 제넨테크, 인크. | 효과기 기능이 변화된 폴리펩티드 변이체 |
| JP4336498B2 (ja) | 2000-12-12 | 2009-09-30 | メディミューン，エルエルシー | 延長した半減期を有する分子ならびにその組成物および用途 |
| US7132510B2 (en) * | 2000-12-29 | 2006-11-07 | Bio-Technology General (Israel) Ltd. | Specific human antibodies for selective cancer therapy |
| US7247304B2 (en) * | 2001-08-23 | 2007-07-24 | Genmab A/S | Methods of treating using anti-IL-15 antibodies |
| US7329405B2 (en) * | 2001-08-23 | 2008-02-12 | Genmab A/S | Human antibodies specific for interleukin 15 (IL-15) |
| IL160358A0 (en) * | 2001-08-23 | 2004-07-25 | Genmab As | Human antibodies specific for interleukin 15 (il-15) |
| US7317091B2 (en) | 2002-03-01 | 2008-01-08 | Xencor, Inc. | Optimized Fc variants |
| US20040132101A1 (en) | 2002-09-27 | 2004-07-08 | Xencor | Optimized Fc variants and methods for their generation |
| US7217797B2 (en) | 2002-10-15 | 2007-05-15 | Pdl Biopharma, Inc. | Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis |
| ATE472556T1 (de) | 2002-12-02 | 2010-07-15 | Amgen Fremont Inc | Gegen den tumor nekrose faktor gerichtete antikörper und deren verwendungen |
| JP4892335B2 (ja) * | 2003-02-26 | 2012-03-07 | ゲンマブ エー／エス | インターロイキン１５（ｉｌ−１５）に特異的なヒト抗体 |
| WO2006017853A2 (en) * | 2004-08-11 | 2006-02-16 | Beth Israel Deaconess Medical Center, Inc. | Mutant interleukin-15-containing compositions and suppression of an immune response |
| AU2006216291B2 (en) | 2005-02-27 | 2011-01-27 | Institute For Antibodies Co., Ltd. | Anti-IgSF4 antibody and utilization of the same |
| PL2161336T5 (pl) * | 2005-05-09 | 2017-10-31 | Ono Pharmaceutical Co | Ludzkie przeciwciała monoklonalne przeciwko białku Programmed Death 1 (PD-1) oraz sposoby leczenia raka z zastosowaniem samych przeciwciał anty-PD-1 lub w połączeniu z innymi środkami immunoterapeutycznymi |
| CA2688834C (en) | 2007-06-01 | 2020-01-07 | Ronald Buelow | Compositions and methods for inhibiting endogenous immunoglobulin genes and producing transgenic human idiotype antibodies |
| TWI489993B (zh) * | 2007-10-12 | 2015-07-01 | Novartis Ag | 骨硬化素（ｓｃｌｅｒｏｓｔｉｎ）抗體組合物及使用方法 |
| CN102638971B (zh) | 2009-07-08 | 2015-10-07 | 科马布有限公司 | 动物模型及治疗分子 |
| TW201124427A (en) * | 2009-10-15 | 2011-07-16 | Abbott Lab | IL-1 binding proteins |
| WO2011119484A1 (en) * | 2010-03-23 | 2011-09-29 | Iogenetics, Llc | Bioinformatic processes for determination of peptide binding |
| CA2805653A1 (en) | 2010-07-20 | 2012-01-26 | Cephalon Australia Pty Ltd | Anti-il-23 heterodimer specific antibodies |
| JP5820688B2 (ja) | 2011-03-23 | 2015-11-24 | 株式会社Kri | 多糖類の溶解に用いられる溶媒ならびに該溶媒を用いた成形体および多糖類誘導体の製造方法 |
| BR112014003999A2 (pt) | 2011-08-23 | 2017-06-13 | Roche Glycart Ag | anticorpo isolado que se liga a um epítopo próximo da membrana de mcsp humano, ácido nucleico isolado, célula hospedeira, método de produção de um anticorpo, imunoconjugado, formulação farmacêutica, uso do anticorpo, método de tratamento de indivíduos portadores de câncer, método de undução da lise celular em indivíduos e teste imuno-histoquímico de mcsp |
| WO2013059885A2 (en) * | 2011-10-28 | 2013-05-02 | Cephalon Australia Pty Ltd | Polypeptide constructs and uses thereof |
| JP6499087B2 (ja) | 2013-02-26 | 2019-04-10 | ロシュ グリクアート アーゲー | 二重特異性ｔ細胞活性化抗原結合分子 |
| UA118028C2 (uk) * | 2013-04-03 | 2018-11-12 | Рош Глікарт Аг | Біспецифічне антитіло, специфічне щодо fap і dr5, антитіло, специфічне щодо dr5, і спосіб їх застосування |
| EP2963057A1 (en) | 2014-07-02 | 2016-01-06 | Calypso Biotech SA | Antibodies to IL-15 |
| CN108064236B (zh) | 2015-03-31 | 2021-12-10 | 免疫医疗有限公司 | 新颖的il33形式、il33的突变形式、抗体、测定及其使用方法 |
| CN109311972A (zh) * | 2016-06-15 | 2019-02-05 | 美国安进公司 | 用于治疗乳糜泻、非乳糜泻麸质敏感和难治性乳糜泻的方法和组合物 |
| BR112019007281A2 (pt) | 2016-10-14 | 2019-07-09 | Xencor Inc | proteína heterodimérica, composições de ácido nucleico e de vetor de expressão, vetor de expressão, célula hospedeira, e, métodos para produzir proteína heterodimérica e para tratar câncer em um paciente |
| RS66900B1 (sr) | 2016-12-21 | 2025-07-31 | Cephalon Llc | Antitela koja se specifično vezuju za humani il-15 i njihova upotreba |
-
2017
- 2017-12-21 RS RS20250577A patent/RS66900B1/sr unknown
- 2017-12-21 EA EA201991514A patent/EA201991514A1/ru unknown
- 2017-12-21 PL PL17883800.9T patent/PL3558369T3/pl unknown
- 2017-12-21 SI SI201731602T patent/SI3558369T1/sl unknown
- 2017-12-21 LT LTEPPCT/US2017/067917T patent/LT3558369T/lt unknown
- 2017-12-21 EP EP25165676.5A patent/EP4585261A3/en active Pending
- 2017-12-21 DK DK17883800.9T patent/DK3558369T3/da active
- 2017-12-21 CN CN201780079926.6A patent/CN110234349B/zh active Active
- 2017-12-21 US US16/471,616 patent/US11267883B2/en active Active
- 2017-12-21 MA MA47130A patent/MA47130B1/fr unknown
- 2017-12-21 IL IL267113A patent/IL267113B2/en unknown
- 2017-12-21 MX MX2019007357A patent/MX2019007357A/es unknown
- 2017-12-21 JP JP2019533652A patent/JP7155126B2/ja active Active
- 2017-12-21 CA CA3046387A patent/CA3046387A1/en active Pending
- 2017-12-21 KR KR1020237031493A patent/KR102706743B1/ko active Active
- 2017-12-21 AR ARP170103614A patent/AR110414A1/es unknown
- 2017-12-21 PT PT178838009T patent/PT3558369T/pt unknown
- 2017-12-21 ES ES17883800T patent/ES3026508T3/es active Active
- 2017-12-21 KR KR1020197019269A patent/KR20190097094A/ko not_active Abandoned
- 2017-12-21 UA UAA201908753A patent/UA126284C2/uk unknown
- 2017-12-21 FI FIEP17883800.9T patent/FI3558369T3/fi active
- 2017-12-21 PE PE2019001283A patent/PE20191497A1/es unknown
- 2017-12-21 WO PCT/US2017/067917 patent/WO2018119246A1/en not_active Ceased
- 2017-12-21 AU AU2017382850A patent/AU2017382850B2/en active Active
- 2017-12-21 EP EP17883800.9A patent/EP3558369B1/en active Active
- 2017-12-21 HU HUE17883800A patent/HUE071878T2/hu unknown
- 2017-12-21 MD MDE20191253T patent/MD3558369T2/ro unknown
- 2017-12-21 BR BR112019012570A patent/BR112019012570A8/pt active IP Right Grant
- 2017-12-21 HR HRP20250482TT patent/HRP20250482T1/hr unknown
-
2019
- 2019-06-13 ZA ZA2019/03848A patent/ZA201903848B/en unknown
- 2019-06-19 MX MX2023014081A patent/MX2023014081A/es unknown
- 2019-06-20 CL CL2019001729A patent/CL2019001729A1/es unknown
- 2019-06-21 PH PH12019501453A patent/PH12019501453A1/en unknown
-
2022
- 2022-01-05 US US17/647,082 patent/US12410247B2/en active Active
- 2022-10-05 JP JP2022161059A patent/JP2022176324A/ja active Pending
-
2025
- 2025-02-20 AU AU2025201185A patent/AU2025201185A1/en not_active Abandoned
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