UA126284C2 - Антитіла, які специфічно зв'язуються з людським il-15, та їхнє застосування - Google Patents

Антитіла, які специфічно зв'язуються з людським il-15, та їхнє застосування Download PDF

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Publication number
UA126284C2
UA126284C2 UAA201908753A UAA201908753A UA126284C2 UA 126284 C2 UA126284 C2 UA 126284C2 UA A201908753 A UAA201908753 A UA A201908753A UA A201908753 A UAA201908753 A UA A201908753A UA 126284 C2 UA126284 C2 UA 126284C2
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amino acid
acid sequence
shi
zeg
rgo
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UAA201908753A
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Ukrainian (uk)
Inventor
Девід Джозе Саймон Лейн
Дэвид Джозе Саймон Лейн
Метью Полард
Ентоні Джерард Дойл
Энтони Джерард Дойл
Лінн Дороті Поултон
Линн Дороти Поултон
Адам Уільям Кларк
Адам Уильям Кларк
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Сефалон, Інк.
Сефалон, Инк.
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Publication of UA126284C2 publication Critical patent/UA126284C2/uk

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244Interleukins [IL]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
    • G01N33/6869Interleukin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55Fab or Fab'
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567Framework region [FR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/52Assays involving cytokines
    • G01N2333/54Interleukins [IL]
    • G01N2333/5443IL-15

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Rheumatology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Obesity (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Emergency Medicine (AREA)
UAA201908753A 2016-12-21 2017-12-21 Антитіла, які специфічно зв'язуються з людським il-15, та їхнє застосування UA126284C2 (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662437143P 2016-12-21 2016-12-21
PCT/US2017/067917 WO2018119246A1 (en) 2016-12-21 2017-12-21 Antibodies that specifically bind to human il-15 and uses thereof

Publications (1)

Publication Number Publication Date
UA126284C2 true UA126284C2 (uk) 2022-09-14

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UAA201908753A UA126284C2 (uk) 2016-12-21 2017-12-21 Антитіла, які специфічно зв'язуються з людським il-15, та їхнє застосування

Country Status (30)

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US (2) US11267883B2 (enExample)
EP (2) EP4585261A3 (enExample)
JP (2) JP7155126B2 (enExample)
KR (2) KR102706743B1 (enExample)
CN (1) CN110234349B (enExample)
AR (1) AR110414A1 (enExample)
AU (2) AU2017382850B2 (enExample)
BR (1) BR112019012570A8 (enExample)
CA (1) CA3046387A1 (enExample)
CL (1) CL2019001729A1 (enExample)
DK (1) DK3558369T3 (enExample)
EA (1) EA201991514A1 (enExample)
ES (1) ES3026508T3 (enExample)
FI (1) FI3558369T3 (enExample)
HR (1) HRP20250482T1 (enExample)
HU (1) HUE071878T2 (enExample)
IL (1) IL267113B2 (enExample)
LT (1) LT3558369T (enExample)
MA (1) MA47130B1 (enExample)
MD (1) MD3558369T2 (enExample)
MX (2) MX2019007357A (enExample)
PE (1) PE20191497A1 (enExample)
PH (1) PH12019501453A1 (enExample)
PL (1) PL3558369T3 (enExample)
PT (1) PT3558369T (enExample)
RS (1) RS66900B1 (enExample)
SI (1) SI3558369T1 (enExample)
UA (1) UA126284C2 (enExample)
WO (1) WO2018119246A1 (enExample)
ZA (1) ZA201903848B (enExample)

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SI3558369T1 (sl) 2025-06-30
IL267113B2 (en) 2024-09-01
PE20191497A1 (es) 2019-10-21
AU2017382850A1 (en) 2019-07-04
CL2019001729A1 (es) 2019-09-13
LT3558369T (lt) 2025-07-25
IL267113B1 (en) 2024-05-01
EP3558369A1 (en) 2019-10-30
RS66900B1 (sr) 2025-07-31
US20200270339A1 (en) 2020-08-27
MX2019007357A (es) 2019-09-05
JP2020501583A (ja) 2020-01-23
EP3558369A4 (en) 2020-09-09
CN110234349B (zh) 2024-03-22
MX2023014081A (es) 2023-12-06
US20220127352A1 (en) 2022-04-28
PT3558369T (pt) 2025-05-06
AU2017382850B2 (en) 2024-11-21
EP3558369B1 (en) 2025-03-26
US12410247B2 (en) 2025-09-09
CA3046387A1 (en) 2018-06-28
PH12019501453A1 (en) 2020-06-15
BR112019012570A2 (pt) 2019-11-26
ES3026508T3 (en) 2025-06-11
ZA201903848B (en) 2023-02-22
MD3558369T2 (ro) 2025-08-31
JP2022176324A (ja) 2022-11-25
AR110414A1 (es) 2019-03-27
KR20230135691A (ko) 2023-09-25
HRP20250482T1 (hr) 2025-06-20
KR20190097094A (ko) 2019-08-20
EA201991514A1 (ru) 2019-12-30
FI3558369T3 (fi) 2025-05-02
DK3558369T3 (da) 2025-05-19
MA47130B1 (fr) 2025-05-30
IL267113A (en) 2019-08-29
JP7155126B2 (ja) 2022-10-18
PL3558369T3 (pl) 2025-06-23
KR102706743B1 (ko) 2024-09-19
EP4585261A3 (en) 2025-08-13
BR112019012570A8 (pt) 2023-01-24
EP4585261A2 (en) 2025-07-16
AU2025201185A1 (en) 2025-03-13
MA47130A (fr) 2019-10-30
HUE071878T2 (hu) 2025-09-28
US11267883B2 (en) 2022-03-08
WO2018119246A1 (en) 2018-06-28
CN110234349A (zh) 2019-09-13

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