BR112019012570A2 - anticorpos que se ligam especificamente à il-15 humana e seus usos - Google Patents
anticorpos que se ligam especificamente à il-15 humana e seus usosInfo
- Publication number
- BR112019012570A2 BR112019012570A2 BR112019012570A BR112019012570A BR112019012570A2 BR 112019012570 A2 BR112019012570 A2 BR 112019012570A2 BR 112019012570 A BR112019012570 A BR 112019012570A BR 112019012570 A BR112019012570 A BR 112019012570A BR 112019012570 A2 BR112019012570 A2 BR 112019012570A2
- Authority
- BR
- Brazil
- Prior art keywords
- antibodies
- specifically bind
- human
- unregulated
- autoimmune
- Prior art date
Links
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 208000015943 Coeliac disease Diseases 0.000 abstract 1
- 230000001363 autoimmune Effects 0.000 abstract 1
- 230000004663 cell proliferation Effects 0.000 abstract 1
- 210000002865 immune cell Anatomy 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
- G01N33/6869—Interleukin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/52—Assays involving cytokines
- G01N2333/54—Interleukins [IL]
- G01N2333/5443—IL-15
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Urology & Nephrology (AREA)
- Cell Biology (AREA)
- Biomedical Technology (AREA)
- Rheumatology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Obesity (AREA)
- Physics & Mathematics (AREA)
- Physical Education & Sports Medicine (AREA)
- Food Science & Technology (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Microbiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
Abstract
são fornecidos anticorpos recombinantes que se ligam especificamente à il-15, bem como um complexo de il-15 e o receptor de il-15-alfa. os anticorpos inibem a proliferação de células imunes, e podem ser usados no tratamento de qualquer doença ou condição autoimune ou inflamatória na qual il-15 está desregulada, incluindo doença celíaca.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662437143P | 2016-12-21 | 2016-12-21 | |
PCT/US2017/067917 WO2018119246A1 (en) | 2016-12-21 | 2017-12-21 | Antibodies that specifically bind to human il-15 and uses thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
BR112019012570A2 true BR112019012570A2 (pt) | 2019-11-26 |
BR112019012570A8 BR112019012570A8 (pt) | 2023-01-24 |
Family
ID=62627610
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112019012570A BR112019012570A8 (pt) | 2016-12-21 | 2017-12-21 | Anticorpos que se ligam especificamente à il-15 humana e seus usos, composição, método in vitro para detecção de il-15 ou um complexo de il-15 e receptor de il-15-alfa, polinucleotídeo, vetor e método de produção do dito anticorpo |
Country Status (19)
Country | Link |
---|---|
US (2) | US11267883B2 (pt) |
EP (1) | EP3558369A4 (pt) |
JP (2) | JP7155126B2 (pt) |
KR (2) | KR20190097094A (pt) |
CN (1) | CN110234349B (pt) |
AR (1) | AR110414A1 (pt) |
AU (1) | AU2017382850A1 (pt) |
BR (1) | BR112019012570A8 (pt) |
CA (1) | CA3046387A1 (pt) |
CL (1) | CL2019001729A1 (pt) |
EA (1) | EA201991514A1 (pt) |
IL (1) | IL267113B1 (pt) |
MA (1) | MA47130A (pt) |
MX (2) | MX2019007357A (pt) |
PE (1) | PE20191497A1 (pt) |
PH (1) | PH12019501453A1 (pt) |
UA (1) | UA126284C2 (pt) |
WO (1) | WO2018119246A1 (pt) |
ZA (1) | ZA201903848B (pt) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI646230B (zh) | 2013-08-05 | 2019-01-01 | 扭轉生物科技有限公司 | 重新合成之基因庫 |
CA2975852A1 (en) | 2015-02-04 | 2016-08-11 | Twist Bioscience Corporation | Methods and devices for de novo oligonucleic acid assembly |
US9981239B2 (en) | 2015-04-21 | 2018-05-29 | Twist Bioscience Corporation | Devices and methods for oligonucleic acid library synthesis |
CA2998169A1 (en) | 2015-09-18 | 2017-03-23 | Twist Bioscience Corporation | Oligonucleic acid variant libraries and synthesis thereof |
CN108698012A (zh) | 2015-09-22 | 2018-10-23 | 特韦斯特生物科学公司 | 用于核酸合成的柔性基底 |
US10417457B2 (en) | 2016-09-21 | 2019-09-17 | Twist Bioscience Corporation | Nucleic acid based data storage |
US11550939B2 (en) | 2017-02-22 | 2023-01-10 | Twist Bioscience Corporation | Nucleic acid based data storage using enzymatic bioencryption |
EP3638782A4 (en) | 2017-06-12 | 2021-03-17 | Twist Bioscience Corporation | SEALLESS NUCLEIC ACID ASSEMBLY METHODS |
WO2018231864A1 (en) | 2017-06-12 | 2018-12-20 | Twist Bioscience Corporation | Methods for seamless nucleic acid assembly |
CN111566125A (zh) | 2017-09-11 | 2020-08-21 | 特韦斯特生物科学公司 | Gpcr结合蛋白及其合成 |
KR20240024357A (ko) | 2017-10-20 | 2024-02-23 | 트위스트 바이오사이언스 코포레이션 | 폴리뉴클레오타이드 합성을 위한 가열된 나노웰 |
EP3814497A4 (en) | 2018-05-18 | 2022-03-02 | Twist Bioscience Corporation | POLYNUCLEOTIDES, REAGENTS, AND METHODS FOR NUCLEIC ACID HYBRIDIZATION |
US11828385B2 (en) | 2018-12-25 | 2023-11-28 | Ntn Corporation | Flow control valve seal and flow control valve device |
SG11202109283UA (en) | 2019-02-26 | 2021-09-29 | Twist Bioscience Corp | Variant nucleic acid libraries for antibody optimization |
KR20220020879A (ko) | 2019-06-12 | 2022-02-21 | 에스크진 파마, 아이엔씨. | 새로운 il-15 프로드럭 및 이를 사용하는 방법 |
EP3987019A4 (en) | 2019-06-21 | 2023-04-19 | Twist Bioscience Corporation | BARCODE-BASED NUCLEIC ACID SEQUENCE ARRANGEMENT |
AU2020400030A1 (en) * | 2019-12-09 | 2022-07-07 | Twist Bioscience Corporation | Variant nucleic acid libraries for adenosine receptors |
CN116655771A (zh) * | 2021-05-28 | 2023-08-29 | 苏州复融生物技术有限公司 | 一种新型白介素15突变体多肽的开发及其应用 |
WO2024028448A1 (en) | 2022-08-04 | 2024-02-08 | Calypso Biotech Sa | Il-15 inhibitors useful for the treatment of atopic dermatitis |
CN117209605B (zh) * | 2023-11-09 | 2024-01-30 | 北京百普赛斯生物科技股份有限公司 | 特异性结合il-15的抗体及其应用 |
Family Cites Families (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5795966A (en) * | 1995-02-22 | 1998-08-18 | Immunex Corp | Antagonists of interleukin-15 |
KR101077001B1 (ko) | 1999-01-15 | 2011-10-26 | 제넨테크, 인크. | 효과기 기능이 변화된 폴리펩티드 변이체 |
EP1355919B1 (en) | 2000-12-12 | 2010-11-24 | MedImmune, LLC | Molecules with extended half-lives, compositions and uses thereof |
US7132510B2 (en) | 2000-12-29 | 2006-11-07 | Bio-Technology General (Israel) Ltd. | Specific human antibodies for selective cancer therapy |
US7329405B2 (en) | 2001-08-23 | 2008-02-12 | Genmab A/S | Human antibodies specific for interleukin 15 (IL-15) |
US7153507B2 (en) * | 2001-08-23 | 2006-12-26 | Genmab A/S | Human antibodies specific for interleukin 15 (IL-15) |
US7247304B2 (en) * | 2001-08-23 | 2007-07-24 | Genmab A/S | Methods of treating using anti-IL-15 antibodies |
US20040132101A1 (en) | 2002-09-27 | 2004-07-08 | Xencor | Optimized Fc variants and methods for their generation |
US7317091B2 (en) | 2002-03-01 | 2008-01-08 | Xencor, Inc. | Optimized Fc variants |
US7217797B2 (en) | 2002-10-15 | 2007-05-15 | Pdl Biopharma, Inc. | Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis |
RU2377253C2 (ru) | 2002-12-02 | 2009-12-27 | Амген Фремонт,Инк. | Антитела, специфичные к фактору некроза опухолей, и их применение |
JP4892335B2 (ja) * | 2003-02-26 | 2012-03-07 | ゲンマブ エー/エス | インターロイキン15(il−15)に特異的なヒト抗体 |
US20060057102A1 (en) * | 2004-08-11 | 2006-03-16 | Zheng Xin X | Mutant interleukin-15-containing compositions and suppression of an immune response |
EP1860119B1 (en) | 2005-02-28 | 2011-08-03 | Institute for Antibodies Co., Ltd. | ANTI-IgSF4 ANTIBODY AND UTILIZATION OF THE SAME |
ES2427646T5 (es) * | 2005-05-09 | 2017-08-22 | Ono Pharmaceutical Co., Ltd. | Anticuerpos monoclonales humanos contra muerte programada 1 (PD1) y métodos para el tratamiento del cáncer mediante el uso de anticuerpos anti-PD-1 solos o combinados con otros agentes inmunoterapéuticos |
DK2602323T3 (en) | 2007-06-01 | 2018-04-16 | Open Monoclonal Tech Inc | Compositions and Methods for Inhibiting Endogenous Immunoglobin Genes and Producing Transgenic Human Idiotypic Antibodies |
TWI489993B (zh) * | 2007-10-12 | 2015-07-01 | Novartis Ag | 骨硬化素(sclerostin)抗體組合物及使用方法 |
US20120204278A1 (en) | 2009-07-08 | 2012-08-09 | Kymab Limited | Animal models and therapeutic molecules |
JP2013507929A (ja) * | 2009-10-15 | 2013-03-07 | アボット・ラボラトリーズ | Il−1結合蛋白質 |
EP2550529B1 (en) | 2010-03-23 | 2021-11-17 | Iogenetics, LLC. | Bioinformatic processes for determination of peptide binding |
JP5972871B2 (ja) | 2010-07-20 | 2016-08-17 | テバ・ファーマシューティカルズ・オーストラリア・ピーティワイ・リミテッド | 抗il−23ヘテロ二量体特異的抗体 |
JP5820688B2 (ja) | 2011-03-23 | 2015-11-24 | 株式会社Kri | 多糖類の溶解に用いられる溶媒ならびに該溶媒を用いた成形体および多糖類誘導体の製造方法 |
US9309306B2 (en) | 2011-08-23 | 2016-04-12 | Roche Glycart Ag | Anti-MCSP antibodies |
EP3559049A4 (en) * | 2011-10-28 | 2019-12-04 | Teva Pharmaceuticals Australia Pty Ltd | POLYPEPTIDE CONSTRUCTS AND APPLICATIONS THEREOF |
EP2961773B1 (en) | 2013-02-26 | 2019-03-20 | Roche Glycart AG | Bispecific t cell activating antigen binding molecules |
UA118028C2 (uk) | 2013-04-03 | 2018-11-12 | Рош Глікарт Аг | Біспецифічне антитіло, специфічне щодо fap і dr5, антитіло, специфічне щодо dr5, і спосіб їх застосування |
EP2963057A1 (en) | 2014-07-02 | 2016-01-06 | Calypso Biotech SA | Antibodies to IL-15 |
ES2886114T3 (es) * | 2015-03-31 | 2021-12-16 | Medimmune Ltd | Una nueva forma de IL33, formas mutadas de IL33, anticuerpos, ensayos y métodos para usar los mismos |
JP2019521981A (ja) | 2016-06-15 | 2019-08-08 | アムジエン・インコーポレーテツド | セリアック病、非セリアックグルテン過敏症及び難治性セリアック病を治療するための方法及び組成物 |
KR102649972B1 (ko) | 2016-10-14 | 2024-03-22 | 젠코어 인코포레이티드 | IL15/IL15Rα 이종이량체 Fc-융합 단백질 |
-
2017
- 2017-12-21 CA CA3046387A patent/CA3046387A1/en active Pending
- 2017-12-21 CN CN201780079926.6A patent/CN110234349B/zh active Active
- 2017-12-21 AR ARP170103614A patent/AR110414A1/es unknown
- 2017-12-21 US US16/471,616 patent/US11267883B2/en active Active
- 2017-12-21 MA MA047130A patent/MA47130A/fr unknown
- 2017-12-21 WO PCT/US2017/067917 patent/WO2018119246A1/en unknown
- 2017-12-21 EP EP17883800.9A patent/EP3558369A4/en active Pending
- 2017-12-21 JP JP2019533652A patent/JP7155126B2/ja active Active
- 2017-12-21 MX MX2019007357A patent/MX2019007357A/es unknown
- 2017-12-21 IL IL267113A patent/IL267113B1/en unknown
- 2017-12-21 EA EA201991514A patent/EA201991514A1/ru unknown
- 2017-12-21 PE PE2019001283A patent/PE20191497A1/es unknown
- 2017-12-21 KR KR1020197019269A patent/KR20190097094A/ko not_active IP Right Cessation
- 2017-12-21 UA UAA201908753A patent/UA126284C2/uk unknown
- 2017-12-21 KR KR1020237031493A patent/KR20230135691A/ko not_active Application Discontinuation
- 2017-12-21 BR BR112019012570A patent/BR112019012570A8/pt unknown
- 2017-12-21 AU AU2017382850A patent/AU2017382850A1/en active Pending
-
2019
- 2019-06-13 ZA ZA2019/03848A patent/ZA201903848B/en unknown
- 2019-06-19 MX MX2023014081A patent/MX2023014081A/es unknown
- 2019-06-20 CL CL2019001729A patent/CL2019001729A1/es unknown
- 2019-06-21 PH PH12019501453A patent/PH12019501453A1/en unknown
-
2022
- 2022-01-05 US US17/647,082 patent/US20220127352A1/en active Pending
- 2022-10-05 JP JP2022161059A patent/JP2022176324A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
EP3558369A4 (en) | 2020-09-09 |
WO2018119246A1 (en) | 2018-06-28 |
BR112019012570A8 (pt) | 2023-01-24 |
AR110414A1 (es) | 2019-03-27 |
KR20190097094A (ko) | 2019-08-20 |
US20200270339A1 (en) | 2020-08-27 |
KR20230135691A (ko) | 2023-09-25 |
JP7155126B2 (ja) | 2022-10-18 |
MX2023014081A (es) | 2023-12-06 |
EP3558369A1 (en) | 2019-10-30 |
CN110234349A (zh) | 2019-09-13 |
PE20191497A1 (es) | 2019-10-21 |
CN110234349B (zh) | 2024-03-22 |
US11267883B2 (en) | 2022-03-08 |
US20220127352A1 (en) | 2022-04-28 |
PH12019501453A1 (en) | 2020-06-15 |
EA201991514A1 (ru) | 2019-12-30 |
JP2020501583A (ja) | 2020-01-23 |
ZA201903848B (en) | 2023-02-22 |
MX2019007357A (es) | 2019-09-05 |
CA3046387A1 (en) | 2018-06-28 |
IL267113A (en) | 2019-08-29 |
IL267113B1 (en) | 2024-05-01 |
MA47130A (fr) | 2019-10-30 |
AU2017382850A1 (en) | 2019-07-04 |
CL2019001729A1 (es) | 2019-09-13 |
UA126284C2 (uk) | 2022-09-14 |
JP2022176324A (ja) | 2022-11-25 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR112019012570A2 (pt) | anticorpos que se ligam especificamente à il-15 humana e seus usos | |
CO2018009995A2 (es) | Proteínas de unión y métodos de uso de las mismas | |
CO2017005650A2 (es) | Anticuerpos anti-interleucina-33 | |
CO2019003809A2 (es) | Anticuerpos contra proteína alfa reguladora de señal y métodos de uso | |
NI201500103A (es) | Anticuerpos cd47 que no agotan plaquetas ni glóbulos rojos y métodos de uso de los mismos. | |
CL2017000651A1 (es) | Anticuerpos anti-glucagón y sus usos | |
CO2017005842A2 (es) | Anticuerpos heterodiméricos que se unen a cd3 y cd38 | |
GEP20227419B (en) | Pd-1-binding molecules and methods of use thereof | |
BR112015018104A2 (pt) | polipeptídeos de gdf15 modificados, seu uso, composições compreendendo os mesmos e recipiente estéril compreendendo as referidas composições | |
CL2020003026A1 (es) | Anticuerpos anti-sirpa y métodos de utilización de los mismos | |
EA201890337A1 (ru) | Конструкции антитела к flt3 и cd3 | |
CR20150618A (es) | Anticuerpos receptores de antitransferina y métodos de uso | |
BR112017003104A2 (pt) | tratamento de câncer usando um receptor antigênico quimérico anti-cd123 | |
BR112019011065A2 (pt) | métodos para determinação da dosagem de células t car | |
PE20151871A1 (es) | Anticuerpos de receptor anti-glucagon y metodos de uso de los mismos | |
TWD173639S (zh) | 針盤 | |
AR104309A1 (es) | Construcciones de anticuerpos biespecíficos para cdh3 y cd3 | |
BR112017005517A2 (pt) | anticorpos antiage para o tratamento de inflama-ção e de transtornos autoimunes | |
CO7111273A2 (es) | Anticuerpos cd47 y métodos de uso de los mismos | |
EA201691438A1 (ru) | Антитело, которое связывается с erbb-2 и erbb-3 | |
AR103726A1 (es) | Cristales de anticuerpos monoclonales anti-pd-1 humanos | |
BR112014026740A8 (pt) | anticorpo, composição, método para fornecer um anticorpo com adcc realçada, e, uso de um anticorpo | |
BR112017013111A2 (pt) | métodos de tratamento de um distúrbio e de tratamento da sinovite, uso de um anticorpo e anticorpo | |
EA201500744A1 (ru) | Комбинированная терапия с использованием антител к her3 и к her2 | |
PE20170519A1 (es) | Anticuerpos antagonistas del interferon alfa y omega |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B350 | Update of information on the portal [chapter 15.35 patent gazette] | ||
B25D | Requested change of name of applicant approved |
Owner name: CEPHALON LLC (US) |
|
B25G | Requested change of headquarter approved |
Owner name: CEPHALON LLC (US) |