JP2007503465A5 - - Google Patents
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- Publication number
- JP2007503465A5 JP2007503465A5 JP2006532992A JP2006532992A JP2007503465A5 JP 2007503465 A5 JP2007503465 A5 JP 2007503465A5 JP 2006532992 A JP2006532992 A JP 2006532992A JP 2006532992 A JP2006532992 A JP 2006532992A JP 2007503465 A5 JP2007503465 A5 JP 2007503465A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- antigen
- binding fragment
- seq
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 20
- 230000027455 binding Effects 0.000 claims 48
- 239000012634 fragment Substances 0.000 claims 46
- 239000000427 antigen Substances 0.000 claims 45
- 102000036639 antigens Human genes 0.000 claims 45
- 108091007433 antigens Proteins 0.000 claims 45
- 150000001875 compounds Chemical class 0.000 claims 11
- 239000000203 mixture Substances 0.000 claims 9
- 208000010626 plasma cell neoplasm Diseases 0.000 claims 4
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- 102000004169 proteins and genes Human genes 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 3
- 208000023275 Autoimmune disease Diseases 0.000 claims 2
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 2
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 2
- 208000033559 Waldenström macroglobulinemia Diseases 0.000 claims 2
- 238000012875 competitive assay Methods 0.000 claims 2
- 229940127089 cytotoxic agent Drugs 0.000 claims 2
- 239000012636 effector Substances 0.000 claims 2
- 210000004408 hybridoma Anatomy 0.000 claims 2
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims 2
- 208000023761 AL amyloidosis Diseases 0.000 claims 1
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 208000035186 Hemolytic Autoimmune Anemia Diseases 0.000 claims 1
- 108060003951 Immunoglobulin Proteins 0.000 claims 1
- 208000005531 Immunoglobulin Light-chain Amyloidosis Diseases 0.000 claims 1
- 102000004882 Lipase Human genes 0.000 claims 1
- 108090001060 Lipase Proteins 0.000 claims 1
- 239000004367 Lipase Substances 0.000 claims 1
- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 claims 1
- 208000034578 Multiple myelomas Diseases 0.000 claims 1
- 206010036673 Primary amyloidosis Diseases 0.000 claims 1
- 208000016025 Waldenstroem macroglobulinemia Diseases 0.000 claims 1
- 239000003242 anti bacterial agent Substances 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 201000000448 autoimmune hemolytic anemia Diseases 0.000 claims 1
- 230000003115 biocidal effect Effects 0.000 claims 1
- 210000000988 bone and bone Anatomy 0.000 claims 1
- 239000002975 chemoattractant Substances 0.000 claims 1
- 208000032852 chronic lymphocytic leukemia Diseases 0.000 claims 1
- 239000002254 cytotoxic agent Substances 0.000 claims 1
- 231100000599 cytotoxic agent Toxicity 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 239000007850 fluorescent dye Substances 0.000 claims 1
- 208000025750 heavy chain disease Diseases 0.000 claims 1
- 102000018358 immunoglobulin Human genes 0.000 claims 1
- 239000002955 immunomodulating agent Substances 0.000 claims 1
- 230000002584 immunomodulator Effects 0.000 claims 1
- 229940121354 immunomodulator Drugs 0.000 claims 1
- 235000019421 lipase Nutrition 0.000 claims 1
- 201000000564 macroglobulinemia Diseases 0.000 claims 1
- 206010028417 myasthenia gravis Diseases 0.000 claims 1
- 201000000050 myeloid neoplasm Diseases 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 210000004180 plasmocyte Anatomy 0.000 claims 1
- 230000002285 radioactive effect Effects 0.000 claims 1
- 230000028327 secretion Effects 0.000 claims 1
- 239000000758 substrate Substances 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 206010043554 thrombocytopenia Diseases 0.000 claims 1
- 239000003053 toxin Substances 0.000 claims 1
- 231100000765 toxin Toxicity 0.000 claims 1
- 108010047041 Complementarity Determining Regions Proteins 0.000 description 4
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US46921103P | 2003-05-08 | 2003-05-08 | |
| US60/469,211 | 2003-05-08 | ||
| US55762104P | 2004-03-29 | 2004-03-29 | |
| US55762004P | 2004-03-29 | 2004-03-29 | |
| US55762204P | 2004-03-29 | 2004-03-29 | |
| US60/557,622 | 2004-03-29 | ||
| US60/557,621 | 2004-03-29 | ||
| US60/557,620 | 2004-03-29 | ||
| PCT/US2004/014866 WO2004100898A2 (en) | 2003-05-08 | 2004-05-10 | Therapeutic use of anti-cs1 antibodies |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011207654A Division JP5976288B2 (ja) | 2003-05-08 | 2011-09-22 | 抗ｃｓ１抗体の治療的使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007503465A JP2007503465A (ja) | 2007-02-22 |
| JP2007503465A5 true JP2007503465A5 (enExample) | 2009-01-15 |
| JP4887152B2 JP4887152B2 (ja) | 2012-02-29 |
Family
ID=33459144
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006532992A Expired - Lifetime JP4887152B2 (ja) | 2003-05-08 | 2004-05-10 | 抗ｃｓ１抗体の治療的使用 |
| JP2011207654A Expired - Lifetime JP5976288B2 (ja) | 2003-05-08 | 2011-09-22 | 抗ｃｓ１抗体の治療的使用 |
| JP2014030549A Expired - Lifetime JP6042834B2 (ja) | 2003-05-08 | 2014-02-20 | 抗ｃｓ１抗体の治療的使用 |
| JP2016142300A Pending JP2017019795A (ja) | 2003-05-08 | 2016-07-20 | 抗ｃｓ１抗体の治療的使用 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011207654A Expired - Lifetime JP5976288B2 (ja) | 2003-05-08 | 2011-09-22 | 抗ｃｓ１抗体の治療的使用 |
| JP2014030549A Expired - Lifetime JP6042834B2 (ja) | 2003-05-08 | 2014-02-20 | 抗ｃｓ１抗体の治療的使用 |
| JP2016142300A Pending JP2017019795A (ja) | 2003-05-08 | 2016-07-20 | 抗ｃｓ１抗体の治療的使用 |
Country Status (25)
| Country | Link |
|---|---|
| US (8) | US20050025763A1 (enExample) |
| EP (4) | EP2371391B1 (enExample) |
| JP (4) | JP4887152B2 (enExample) |
| KR (1) | KR101268707B1 (enExample) |
| CN (1) | CN1805755B (enExample) |
| AT (1) | ATE506076T1 (enExample) |
| AU (2) | AU2004238363B2 (enExample) |
| BE (1) | BE2016C056I2 (enExample) |
| BR (1) | BRPI0410129B8 (enExample) |
| CA (1) | CA2523001C (enExample) |
| CY (4) | CY1111958T1 (enExample) |
| DE (1) | DE602004032328D1 (enExample) |
| DK (3) | DK2371391T3 (enExample) |
| ES (2) | ES2516840T3 (enExample) |
| FR (1) | FR16C1012I2 (enExample) |
| HK (1) | HK1208815A1 (enExample) |
| HU (2) | HUE034908T2 (enExample) |
| LT (1) | LT2853272T (enExample) |
| LU (1) | LU93274I2 (enExample) |
| MX (1) | MXPA05012011A (enExample) |
| NL (1) | NL300838I2 (enExample) |
| PL (3) | PL1624892T3 (enExample) |
| PT (3) | PT1624892E (enExample) |
| SI (3) | SI2371391T1 (enExample) |
| WO (1) | WO2004100898A2 (enExample) |
Families Citing this family (86)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050025763A1 (en) | 2003-05-08 | 2005-02-03 | Protein Design Laboratories, Inc. | Therapeutic use of anti-CS1 antibodies |
| US7709610B2 (en) | 2003-05-08 | 2010-05-04 | Facet Biotech Corporation | Therapeutic use of anti-CS1 antibodies |
| MX2009001440A (es) * | 2006-08-07 | 2009-04-15 | Pdl Biopharma Inc | Composiciones y metodos que utilizan anticuerpos anti-cs1 para tratar mieloma multiple. |
| WO2008019379A2 (en) * | 2006-08-07 | 2008-02-14 | Pdl Biopharma, Inc. | Use of allogeneic effector cells and anti-cs1 antibodies for selective killing of multiple myeloma cells |
| PT2641601T (pt) | 2006-08-07 | 2016-10-14 | Dana Farber Cancer Inst Inc | Métodos de tratamento de mieloma múltiplo utilizando terapias de combinação baseadas em huluc63 com bortezomib |
| US9096681B2 (en) * | 2008-06-02 | 2015-08-04 | Dana-Farber Cancer Institute, Inc. | XBP1, CD138, and CS1 peptides |
| EP2361263A1 (en) * | 2008-10-31 | 2011-08-31 | Abbott Biotherapeutics Corp. | Use of anti-cs1 antibodies for treatment of rare lymphomas |
| WO2010080910A1 (en) * | 2009-01-08 | 2010-07-15 | Bio-Rad Laboratories, Inc. | Methods and compositions for improving efficiency of nucleic acids amplification reactions |
| US20120269814A1 (en) * | 2009-11-10 | 2012-10-25 | Amgen Inc. | Anti-c mpl antibodies |
| BR112012018914A2 (pt) | 2010-01-28 | 2017-07-25 | Glaxo Group Ltd | "anticorpo humanizado, proteína de ligação de antígeno, molécula de ácido nucleico, vetor de expressão, célula hospedeira recombinante, proteína de ligação de anticorpo ou de antígeno, métodos para a produção de uma proteína de ligação de antígeno e para tratar um sujeito afetado por uma doença autoimune ou inflamatória, e, composição farmacêutica." |
| EP3196212B1 (en) | 2010-02-24 | 2020-06-03 | ImmunoGen, Inc. | Immunoconjugates comprising a folate receptor 1 antibody |
| UA113403C2 (xx) | 2011-04-01 | 2017-01-25 | Спосіб підвищення ефективності folr1 терапії раку | |
| SMT202000158T1 (it) | 2012-08-31 | 2020-05-08 | Immunogen Inc | Saggi e kit diagnostici per il rilevamento del recettore dei folati 1 |
| JP6374392B2 (ja) | 2012-11-05 | 2018-08-15 | デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド | Ｘｂｐ１、ｃｄ１３８およびｃｓ１ペプチド、該ペプチドを含有する薬学的組成物、ならびにかかるペプチドおよび組成物を使用する方法 |
| AU2014233528B2 (en) * | 2013-03-15 | 2019-02-28 | Abbvie Biotherapeutics Inc. | Fc variants |
| CA2904532A1 (en) * | 2013-03-15 | 2014-09-18 | Abbvie Biotechnology Ltd. | Anti-cd25 antibodies and their uses |
| US10358494B2 (en) * | 2013-05-03 | 2019-07-23 | Ohio State Innovation Foundation | CS1-specific chimeric antigen receptor engineered immune effector cells |
| WO2015013508A2 (en) * | 2013-07-24 | 2015-01-29 | The General Hospital Corporation | Methods for diagnosing and treating immune disease |
| CA2921975C (en) | 2013-08-30 | 2024-02-13 | Immunogen, Inc. | Antibodies and assays for detection of folate receptor 1 |
| US9482289B2 (en) | 2013-10-14 | 2016-11-01 | Club Car, Llc | Self-preloading shift lever |
| EP3066127A1 (en) | 2013-11-06 | 2016-09-14 | Bristol-Myers Squibb Company | Immunotherapeutic dosing regimens and combinations thereof |
| WO2015069785A1 (en) | 2013-11-06 | 2015-05-14 | Bristol-Myers Squibb Company | Combination of anti-kir and anti-cs1 antibodies to treat multiple myeloma |
| JP2017518071A (ja) * | 2014-05-02 | 2017-07-06 | セレクティスＣｅｌｌｅｃｔｉｓ | Ｃｓ１特異的多重鎖キメラ抗原受容体 |
| RS60061B1 (sr) * | 2014-06-17 | 2020-04-30 | Medimmune Ltd | Unapređena alfa-v beta-8 antitela |
| KR20170032406A (ko) | 2014-07-15 | 2017-03-22 | 주노 쎄러퓨티크스 인코퍼레이티드 | 입양 세포 치료를 위한 조작된 세포 |
| WO2016049022A1 (en) * | 2014-09-23 | 2016-03-31 | Board Of Trustees Of Michigan State University | Compositions and methods for modulating an immune response |
| AU2015339012B2 (en) * | 2014-10-31 | 2020-11-05 | Abbvie Biotherapeutics Inc. | Anti-CS1 antibodies and antibody drug conjugates |
| EA201791049A1 (ru) | 2014-12-04 | 2017-10-31 | Бристол-Майерс Сквибб Компани | Комбинация анти-cs1 и анти-pd1 антител для лечения рака (миеломы) |
| DE102015102183B4 (de) * | 2015-02-16 | 2018-03-01 | Robert Bosch Automotive Steering Gmbh | Lenkzwischenwelle für ein Kraftfahrzeug und Verfahren zum Betreiben einer Lenkzwischenwelle für ein Kraftfahrzeug |
| JP2018510623A (ja) | 2015-02-20 | 2018-04-19 | オハイオ・ステイト・イノベーション・ファウンデーション | Ｎｋｇ２ｄ及び腫瘍関連抗原に対する二価抗体 |
| WO2016168766A1 (en) * | 2015-04-15 | 2016-10-20 | The California Institute For Biomedical Research | Optimized chimeric receptor t cell switches and uses thereof |
| CN107949425A (zh) | 2015-06-29 | 2018-04-20 | 百时美施贵宝公司 | 用于治疗癌症的包含泊马度胺和抗cs1抗体的免疫治疗给药方案 |
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| HUE057837T2 (hu) | 2015-11-03 | 2022-06-28 | Janssen Biotech Inc | PD-1-et specifikusan kötõ ellenanyagok és alkalmazásaik |
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