JP2006525944A5 - - Google Patents
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- Publication number
- JP2006525944A5 JP2006525944A5 JP2004570427A JP2004570427A JP2006525944A5 JP 2006525944 A5 JP2006525944 A5 JP 2006525944A5 JP 2004570427 A JP2004570427 A JP 2004570427A JP 2004570427 A JP2004570427 A JP 2004570427A JP 2006525944 A5 JP2006525944 A5 JP 2006525944A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- pharmaceutically acceptable
- acceptable salt
- compound
- compound according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000003839 salts Chemical class 0.000 claims 25
- 150000001875 compounds Chemical class 0.000 claims 23
- 239000008194 pharmaceutical composition Substances 0.000 claims 10
- 239000000203 mixture Substances 0.000 claims 8
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 7
- 230000003474 anti-emetic effect Effects 0.000 claims 6
- 239000002111 antiemetic agent Substances 0.000 claims 6
- 229940121367 non-opioid analgesics Drugs 0.000 claims 6
- 239000000014 opioid analgesic Substances 0.000 claims 6
- 125000000217 alkyl group Chemical group 0.000 claims 5
- 125000005428 anthryl group Chemical group [H]C1=C([H])C([H])=C2C([H])=C3C(*)=C([H])C([H])=C([H])C3=C([H])C2=C1[H] 0.000 claims 5
- 125000001072 heteroaryl group Chemical group 0.000 claims 5
- 125000001624 naphthyl group Chemical group 0.000 claims 5
- 125000005561 phenanthryl group Chemical group 0.000 claims 5
- 239000003793 antidiarrheal agent Substances 0.000 claims 4
- 108090000137 Opioid Receptors Proteins 0.000 claims 3
- 102000003840 Opioid Receptors Human genes 0.000 claims 3
- 229940125714 antidiarrheal agent Drugs 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 206010012735 Diarrhoea Diseases 0.000 claims 2
- 229940125683 antiemetic agent Drugs 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- -1 non-opioid analgesic Substances 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 230000004936 stimulating effect Effects 0.000 claims 2
- 101100244562 Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) oprD gene Proteins 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 108700023159 delta Opioid Receptors Proteins 0.000 claims 1
- 102000048124 delta Opioid Receptors Human genes 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 102000048260 kappa Opioid Receptors Human genes 0.000 claims 1
- 102000051367 mu Opioid Receptors Human genes 0.000 claims 1
- 108010020615 nociceptin receptor Proteins 0.000 claims 1
- 108020003175 receptors Proteins 0.000 claims 1
- 102000005962 receptors Human genes 0.000 claims 1
- 108020001588 κ-opioid receptors Proteins 0.000 claims 1
- 108020001612 μ-opioid receptors Proteins 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US42738102P | 2002-11-18 | 2002-11-18 | |
| US46027803P | 2003-04-03 | 2003-04-03 | |
| US48848803P | 2003-07-17 | 2003-07-17 | |
| US10/714,066 US7202259B2 (en) | 2002-11-18 | 2003-11-13 | Therapeutic agents useful for treating pain |
| PCT/US2003/036742 WO2004046132A1 (en) | 2002-11-18 | 2003-11-17 | 4-tetrazolyl-4phenylpiperidine derivatives for treating pain |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010056560A Division JP2010163452A (ja) | 2002-11-18 | 2010-03-12 | 疼痛治療用４−テトラゾリル−４フェニルピペリジン誘導体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006525944A JP2006525944A (ja) | 2006-11-16 |
| JP2006525944A5 true JP2006525944A5 (OSRAM) | 2007-01-11 |
| JP4601429B2 JP4601429B2 (ja) | 2010-12-22 |
Family
ID=32777221
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004570427A Expired - Fee Related JP4601429B2 (ja) | 2002-11-18 | 2003-11-17 | 疼痛治療用４−テトラゾリル−４フェニルピペリジン誘導体 |
| JP2010056560A Pending JP2010163452A (ja) | 2002-11-18 | 2010-03-12 | 疼痛治療用４−テトラゾリル−４フェニルピペリジン誘導体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010056560A Pending JP2010163452A (ja) | 2002-11-18 | 2010-03-12 | 疼痛治療用４−テトラゾリル−４フェニルピペリジン誘導体 |
Country Status (36)
| Country | Link |
|---|---|
| US (3) | US7202259B2 (OSRAM) |
| EP (2) | EP1562932B9 (OSRAM) |
| JP (2) | JP4601429B2 (OSRAM) |
| KR (1) | KR20050115221A (OSRAM) |
| CN (2) | CN101648941A (OSRAM) |
| AP (1) | AP2210A (OSRAM) |
| AR (1) | AR047008A1 (OSRAM) |
| AT (2) | ATE358674T1 (OSRAM) |
| AU (2) | AU2003294313B2 (OSRAM) |
| BR (1) | BR0316305A (OSRAM) |
| CA (1) | CA2506242C (OSRAM) |
| CO (1) | CO5690588A2 (OSRAM) |
| CR (2) | CR7877A (OSRAM) |
| CY (2) | CY1107682T1 (OSRAM) |
| DE (2) | DE60322451D1 (OSRAM) |
| DK (2) | DK1562932T3 (OSRAM) |
| EA (1) | EA008621B1 (OSRAM) |
| EC (1) | ECSP055840A (OSRAM) |
| ES (2) | ES2312150T3 (OSRAM) |
| GE (1) | GEP20084539B (OSRAM) |
| IL (1) | IL209352A0 (OSRAM) |
| IS (2) | IS2720B (OSRAM) |
| MA (1) | MA27565A1 (OSRAM) |
| ME (1) | MEP48108A (OSRAM) |
| MX (1) | MXPA05004669A (OSRAM) |
| MY (1) | MY135647A (OSRAM) |
| NI (1) | NI200500087A (OSRAM) |
| NO (1) | NO20052894D0 (OSRAM) |
| NZ (2) | NZ572685A (OSRAM) |
| OA (1) | OA13010A (OSRAM) |
| PT (2) | PT1562932E (OSRAM) |
| RS (1) | RS51047B (OSRAM) |
| SG (1) | SG165998A1 (OSRAM) |
| SI (2) | SI1562932T1 (OSRAM) |
| TW (2) | TWI343917B (OSRAM) |
| WO (1) | WO2004046132A1 (OSRAM) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7202259B2 (en) * | 2002-11-18 | 2007-04-10 | Euro-Celtique S.A. | Therapeutic agents useful for treating pain |
| NZ542969A (en) | 2003-04-30 | 2009-09-25 | Purdue Pharma Lp | Tamper resistant transdermal dosage form comprising an active agent component and an adverse agent component at the distal site of the active agent layer |
| US8790689B2 (en) * | 2003-04-30 | 2014-07-29 | Purdue Pharma L.P. | Tamper resistant transdermal dosage form |
| EP1709029A2 (en) * | 2004-01-30 | 2006-10-11 | Euro-Celtique S.A. | Methods for making 4-tetrazolyl-4-phenylpiperidine compounds |
| SE0401656D0 (sv) * | 2004-06-24 | 2004-06-24 | Astrazeneca Ab | Chemical compounds |
| WO2007057229A1 (en) * | 2005-11-21 | 2007-05-24 | Purdue Pharma L.P. | 4-oxadiazolyl-piperidine compounds and use thereof |
| US20080051380A1 (en) | 2006-08-25 | 2008-02-28 | Auerbach Alan H | Methods and compositions for treating cancer |
| US8771693B2 (en) | 2009-10-27 | 2014-07-08 | Beth Israel Deaconess Medical Center, Inc. | Methods and compositions for the generation and use of conformation-specific antibodies |
| JP5977240B2 (ja) | 2010-09-21 | 2016-08-24 | パーデュー、ファーマ、リミテッド、パートナーシップ | ブプレノルフィン類似体 |
| CN102648915B (zh) * | 2011-02-28 | 2015-04-15 | 鲁南制药集团股份有限公司 | 一种治疗或预防神经病理性疼痛的药物组合物 |
| WO2012149334A2 (en) | 2011-04-27 | 2012-11-01 | Beth Israel Deaconess Medical Center, Inc. | Methods and compositions for the generation and use of conformation-specific antibodies |
| TW201431842A (zh) | 2012-11-09 | 2014-08-16 | Purdue Pharma Lp | 苯並嗎啡烷類似物及其應用 |
| JP6317755B2 (ja) | 2012-12-07 | 2018-04-25 | パーデュー、ファーマ、リミテッド、パートナーシップ | オピオイド受容体モジュレーターとしてのブプレノルフィン類似体 |
| JP6100917B2 (ja) | 2012-12-14 | 2017-03-22 | パーデュー、ファーマ、リミテッド、パートナーシップ | ピリドンモルフィナン類似体およびオピオイド受容体に対する生物活性 |
| TW201434837A (zh) | 2012-12-14 | 2014-09-16 | Purdue Pharma Lp | 螺環嗎啡喃及其用途 |
| JP6182620B2 (ja) | 2013-01-31 | 2017-08-16 | パーデュー、ファーマ、リミテッド、パートナーシップ | ベンゾモルファン類似体およびその使用 |
| US8969358B2 (en) | 2013-03-15 | 2015-03-03 | Purdue Pharma L.P. | Buprenorphine analogs |
| WO2015097546A1 (en) | 2013-12-26 | 2015-07-02 | Purdue Pharma L.P. | Propellane-based compounds and their use as opioid receptor modulators |
| CN106414408A (zh) | 2013-12-26 | 2017-02-15 | 普渡制药公司 | 缩合环吗啡喃和其用途 |
| EP3087078B1 (en) | 2013-12-26 | 2019-05-15 | Purdue Pharma LP | 7-beta-alkyl analogs of orvinols |
| WO2015097547A1 (en) | 2013-12-26 | 2015-07-02 | Purdue Pharma L.P. | 10-substituted morphinan hydantoins |
| EP3087079B1 (en) | 2013-12-26 | 2019-04-03 | Purdue Pharma LP | Opioid receptor modulating oxabicyclo[2.2.2]octane morphinans |
| WO2015099863A1 (en) | 2013-12-27 | 2015-07-02 | Purdue Pharma L.P. | 6-substituted and 7-substituted morphinan analogs and the use thereof |
| WO2015183780A1 (en) | 2014-05-27 | 2015-12-03 | Purdue Pharma L.P. | Spirocyclic morphinans and use thereof |
| JP6360915B2 (ja) | 2014-06-13 | 2018-07-18 | パーデュー、ファーマ、リミテッド、パートナーシップ | アザモルフィナン誘導体及びその使用 |
| MA41125A (fr) | 2014-12-05 | 2017-10-10 | Purdue Pharma Lp | Dérivés de 6.7-cyclomorphinane et leur utilisation |
| AU2017238208B2 (en) | 2016-03-22 | 2022-01-06 | Regents Of The University Of Minnesota | Combination for treating pain |
| RS66574B1 (sr) | 2016-07-29 | 2025-03-31 | Janssen Pharmaceutica Nv | Niraparib za upotrebu u postupku lečenja raka prostate |
| WO2018125716A1 (en) | 2017-01-02 | 2018-07-05 | Purdue Pharma L.P. | Morphinan derivatives and use thereof |
| MX2023013514A (es) * | 2021-05-21 | 2024-04-02 | Purdue Pharma Lp | Metodos para tratar la cistitis intersticial/sindrome de dolor en la vejiga. |
| WO2023250190A1 (en) * | 2022-06-24 | 2023-12-28 | Purdue Pharma L.P. | Methods of treating or preventing overactive bladder syndrome |
Family Cites Families (47)
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|---|---|---|---|---|
| US3536809A (en) | 1969-02-17 | 1970-10-27 | Alza Corp | Medication method |
| US3598123A (en) | 1969-04-01 | 1971-08-10 | Alza Corp | Bandage for administering drugs |
| US3598122A (en) | 1969-04-01 | 1971-08-10 | Alza Corp | Bandage for administering drugs |
| BE775611A (fr) | 1970-11-24 | 1972-03-16 | Synthelabo | Derives de la (diphenyl-3,3 propyl-1)-1 piperidine, leur preparation etles medicaments qui en contiennent |
| US4076717A (en) * | 1971-12-15 | 1978-02-28 | G. D. Searle & Co. | Derivatives of 1-(3-cyano-3,3-diphenylpropyl)-4-phenylpiperidine-4-carboxylic acid |
| US3845770A (en) | 1972-06-05 | 1974-11-05 | Alza Corp | Osmatic dispensing device for releasing beneficial agent |
| US3916899A (en) | 1973-04-25 | 1975-11-04 | Alza Corp | Osmotic dispensing device with maximum and minimum sizes for the passageway |
| US4008719A (en) | 1976-02-02 | 1977-02-22 | Alza Corporation | Osmotic system having laminar arrangement for programming delivery of active agent |
| IE58110B1 (en) | 1984-10-30 | 1993-07-14 | Elan Corp Plc | Controlled release powder and process for its preparation |
| DK162087D0 (da) * | 1987-03-31 | 1987-03-31 | Ferrosan As | Piperidinforbindelser, deres fremstilling og anvendelse |
| US4831192A (en) * | 1987-12-31 | 1989-05-16 | Boc, Inc. | Methods of preparing 4-heteropentacyclic-4-(N-phenyl)amido) piperidine derivatives and intermediate compounds |
| US5073543A (en) | 1988-07-21 | 1991-12-17 | G. D. Searle & Co. | Controlled release formulations of trophic factors in ganglioside-lipsome vehicle |
| IT1229203B (it) | 1989-03-22 | 1991-07-25 | Bioresearch Spa | Impiego di acido 5 metiltetraidrofolico, di acido 5 formiltetraidrofolico e dei loro sali farmaceuticamente accettabili per la preparazione di composizioni farmaceutiche in forma a rilascio controllato attive nella terapia dei disturbi mentali organici e composizioni farmaceutiche relative. |
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| US5733566A (en) | 1990-05-15 | 1998-03-31 | Alkermes Controlled Therapeutics Inc. Ii | Controlled release of antiparasitic agents in animals |
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| US5591767A (en) | 1993-01-25 | 1997-01-07 | Pharmetrix Corporation | Liquid reservoir transdermal patch for the administration of ketorolac |
| IT1270594B (it) | 1994-07-07 | 1997-05-07 | Recordati Chem Pharm | Composizione farmaceutica a rilascio controllato di moguisteina in sospensione liquida |
| US5849737A (en) | 1995-04-14 | 1998-12-15 | The Regents Of The University Of California | Compositions and methods for treating pain |
| US6166085A (en) | 1995-04-14 | 2000-12-26 | The Regents Of The University Of California | Method of producing analgesia |
| AU6111796A (en) | 1995-06-12 | 1997-01-09 | G.D. Searle & Co. | Compositions comprising a cyclooxygenase-2 inhibitor and a 5 -lipoxygenase inhibitor |
| US5849761A (en) | 1995-09-12 | 1998-12-15 | Regents Of The University Of California | Peripherally active anti-hyperalgesic opiates |
| US6573282B1 (en) | 1995-09-12 | 2003-06-03 | Adolor Corporation | Peripherally active anti-hyperalgesic opiates |
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| EE04799B1 (et) | 1999-03-12 | 2007-04-16 | Boehringer Ingelheim Pharmaceuticals, Inc. | Ühendid, mis on kasulikud põletikuvastaste vahenditena, nende ühendite valmistamise meetodid ja neid sisaldavad farmatseutilised kompositsioonid |
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| CA2324330A1 (en) | 1999-11-08 | 2001-05-08 | Ssp Co., Ltd. | 4-hydroxy-4-phenylpiperidine derivatives and pharmaceuticals containing the same |
| ATE302770T1 (de) | 1999-12-06 | 2005-09-15 | Euro Celtique Sa | Benzimidazolverbindungen die nociceptinrezeptoraffinität haben |
| US6486142B2 (en) | 1999-12-22 | 2002-11-26 | Merck Frosst Canada & Co. | Phosphonic acid derivatives as inhibitors of protein tyrosine phosphatase 1B (PTP-1B) |
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| US7202259B2 (en) * | 2002-11-18 | 2007-04-10 | Euro-Celtique S.A. | Therapeutic agents useful for treating pain |
| EP1709029A2 (en) | 2004-01-30 | 2006-10-11 | Euro-Celtique S.A. | Methods for making 4-tetrazolyl-4-phenylpiperidine compounds |
-
2003
- 2003-11-13 US US10/714,066 patent/US7202259B2/en not_active Expired - Lifetime
- 2003-11-17 DE DE60322451T patent/DE60322451D1/de not_active Expired - Lifetime
- 2003-11-17 RS YUP-2005/0375A patent/RS51047B/sr unknown
- 2003-11-17 EP EP03789796A patent/EP1562932B9/en not_active Expired - Lifetime
- 2003-11-17 EP EP07006697A patent/EP1803718B1/en not_active Expired - Lifetime
- 2003-11-17 MX MXPA05004669A patent/MXPA05004669A/es active IP Right Grant
- 2003-11-17 GE GEAP20038846A patent/GEP20084539B/en unknown
- 2003-11-17 AU AU2003294313A patent/AU2003294313B2/en not_active Ceased
- 2003-11-17 AT AT03789796T patent/ATE358674T1/de active
- 2003-11-17 DK DK03789796T patent/DK1562932T3/da active
- 2003-11-17 JP JP2004570427A patent/JP4601429B2/ja not_active Expired - Fee Related
- 2003-11-17 ES ES07006697T patent/ES2312150T3/es not_active Expired - Lifetime
- 2003-11-17 KR KR1020057008903A patent/KR20050115221A/ko not_active Abandoned
- 2003-11-17 SI SI200330814T patent/SI1562932T1/sl unknown
- 2003-11-17 CN CN200910173679A patent/CN101648941A/zh active Pending
- 2003-11-17 PT PT03789796T patent/PT1562932E/pt unknown
- 2003-11-17 CA CA2506242A patent/CA2506242C/en not_active Expired - Fee Related
- 2003-11-17 DE DE60313021T patent/DE60313021T2/de not_active Expired - Lifetime
- 2003-11-17 AP AP2005003297A patent/AP2210A/xx active
- 2003-11-17 ES ES03789796T patent/ES2285235T3/es not_active Expired - Lifetime
- 2003-11-17 CN CNB2003801035027A patent/CN100567288C/zh not_active Expired - Fee Related
- 2003-11-17 ME MEP-481/08A patent/MEP48108A/xx unknown
- 2003-11-17 WO PCT/US2003/036742 patent/WO2004046132A1/en not_active Ceased
- 2003-11-17 NZ NZ572685A patent/NZ572685A/en not_active IP Right Cessation
- 2003-11-17 PT PT07006697T patent/PT1803718E/pt unknown
- 2003-11-17 AT AT07006697T patent/ATE402167T1/de active
- 2003-11-17 SI SI200331358T patent/SI1803718T1/sl unknown
- 2003-11-17 SG SG200703631-2A patent/SG165998A1/en unknown
- 2003-11-17 NZ NZ540068A patent/NZ540068A/en not_active IP Right Cessation
- 2003-11-17 BR BR0316305-9A patent/BR0316305A/pt not_active IP Right Cessation
- 2003-11-17 DK DK07006697T patent/DK1803718T3/da active
- 2003-11-17 EA EA200500726A patent/EA008621B1/ru not_active IP Right Cessation
- 2003-11-17 OA OA1200500145A patent/OA13010A/en unknown
- 2003-11-18 TW TW092132303A patent/TWI343917B/zh not_active IP Right Cessation
- 2003-11-18 MY MYPI20034402A patent/MY135647A/en unknown
- 2003-11-18 TW TW096151468A patent/TW200819436A/zh unknown
- 2003-11-19 AR ARP030104269A patent/AR047008A1/es unknown
-
2005
- 2005-04-19 IS IS7812A patent/IS2720B/is unknown
- 2005-04-22 NI NI200500087A patent/NI200500087A/es unknown
- 2005-05-20 CO CO05048789A patent/CO5690588A2/es not_active Application Discontinuation
- 2005-06-07 EC EC2005005840A patent/ECSP055840A/es unknown
- 2005-06-13 MA MA28335A patent/MA27565A1/fr unknown
- 2005-06-14 NO NO20052894A patent/NO20052894D0/no not_active Application Discontinuation
- 2005-06-16 CR CR7877A patent/CR7877A/es unknown
-
2007
- 2007-03-28 US US11/729,660 patent/US7687518B2/en not_active Expired - Lifetime
- 2007-06-21 CY CY20071100825T patent/CY1107682T1/el unknown
-
2008
- 2008-10-16 CY CY20081101151T patent/CY1108422T1/el unknown
-
2009
- 2009-09-21 CR CR11037A patent/CR11037A/es not_active Application Discontinuation
- 2009-11-10 US US12/615,510 patent/US8026254B2/en not_active Expired - Lifetime
-
2010
- 2010-03-12 JP JP2010056560A patent/JP2010163452A/ja active Pending
- 2010-07-21 IS IS8913A patent/IS8913A/is unknown
- 2010-11-16 IL IL209352A patent/IL209352A0/en unknown
- 2010-11-25 AU AU2010246411A patent/AU2010246411A1/en not_active Abandoned
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