CA2506242C - 4-tetrazolyl-4phenylpiperidine derivatives for treating pain - Google Patents
4-tetrazolyl-4phenylpiperidine derivatives for treating pain Download PDFInfo
- Publication number
- CA2506242C CA2506242C CA2506242A CA2506242A CA2506242C CA 2506242 C CA2506242 C CA 2506242C CA 2506242 A CA2506242 A CA 2506242A CA 2506242 A CA2506242 A CA 2506242A CA 2506242 C CA2506242 C CA 2506242C
- Authority
- CA
- Canada
- Prior art keywords
- compound
- alkyl
- tetrazolyl
- pharmaceutically acceptable
- acceptable salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 208000002193 Pain Diseases 0.000 title claims abstract description 58
- OGPKTRWLBLRODW-UHFFFAOYSA-N 4-phenyl-4-(2h-tetrazol-5-yl)piperidine Chemical class C1CNCCC1(C=1C=CC=CC=1)C1=NNN=N1 OGPKTRWLBLRODW-UHFFFAOYSA-N 0.000 title abstract description 449
- 239000000203 mixture Substances 0.000 claims abstract description 91
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- 238000000034 method Methods 0.000 claims abstract description 37
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- 150000001875 compounds Chemical class 0.000 claims description 223
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- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims description 87
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 52
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims description 31
- 125000000217 alkyl group Chemical group 0.000 claims description 31
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- 125000001072 heteroaryl group Chemical group 0.000 claims description 29
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 28
- 125000005428 anthryl group Chemical group [H]C1=C([H])C([H])=C2C([H])=C3C(*)=C([H])C([H])=C([H])C3=C([H])C2=C1[H] 0.000 claims description 26
- 125000001624 naphthyl group Chemical group 0.000 claims description 26
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- -1 4-Tetrazolyl-4-phenylpiperidine Compound Chemical class 0.000 abstract description 111
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 191
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 description 169
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
- C07D211/64—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4 having an aryl radical as the second substituent in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
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Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
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| US10/000,000 | 2002-01-29 | ||
| US42738102P | 2002-11-18 | 2002-11-18 | |
| US60/427,381 | 2002-11-18 | ||
| US46027803P | 2003-04-03 | 2003-04-03 | |
| US60/460,278 | 2003-04-03 | ||
| US48848803P | 2003-07-17 | 2003-07-17 | |
| US60/488,488 | 2003-07-17 | ||
| US10/714,066 US7202259B2 (en) | 2002-11-18 | 2003-11-13 | Therapeutic agents useful for treating pain |
| PCT/US2003/036742 WO2004046132A1 (en) | 2002-11-18 | 2003-11-17 | 4-tetrazolyl-4phenylpiperidine derivatives for treating pain |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2506242A1 CA2506242A1 (en) | 2004-06-03 |
| CA2506242C true CA2506242C (en) | 2011-07-05 |
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|---|---|---|---|
| CA2506242A Expired - Fee Related CA2506242C (en) | 2002-11-18 | 2003-11-17 | 4-tetrazolyl-4phenylpiperidine derivatives for treating pain |
Country Status (36)
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|---|---|
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| JP (2) | JP4601429B2 (OSRAM) |
| KR (1) | KR20050115221A (OSRAM) |
| CN (2) | CN101648941A (OSRAM) |
| AP (1) | AP2210A (OSRAM) |
| AR (1) | AR047008A1 (OSRAM) |
| AT (2) | ATE402167T1 (OSRAM) |
| AU (2) | AU2003294313B2 (OSRAM) |
| BR (1) | BR0316305A (OSRAM) |
| CA (1) | CA2506242C (OSRAM) |
| CO (1) | CO5690588A2 (OSRAM) |
| CR (2) | CR7877A (OSRAM) |
| CY (2) | CY1107682T1 (OSRAM) |
| DE (2) | DE60322451D1 (OSRAM) |
| DK (2) | DK1562932T3 (OSRAM) |
| EA (1) | EA008621B1 (OSRAM) |
| EC (1) | ECSP055840A (OSRAM) |
| ES (2) | ES2285235T3 (OSRAM) |
| GE (1) | GEP20084539B (OSRAM) |
| IL (1) | IL209352A0 (OSRAM) |
| IS (2) | IS2720B (OSRAM) |
| MA (1) | MA27565A1 (OSRAM) |
| ME (1) | MEP48108A (OSRAM) |
| MX (1) | MXPA05004669A (OSRAM) |
| MY (1) | MY135647A (OSRAM) |
| NI (1) | NI200500087A (OSRAM) |
| NO (1) | NO20052894D0 (OSRAM) |
| NZ (2) | NZ572685A (OSRAM) |
| OA (1) | OA13010A (OSRAM) |
| PT (2) | PT1803718E (OSRAM) |
| RS (1) | RS51047B (OSRAM) |
| SG (1) | SG165998A1 (OSRAM) |
| SI (2) | SI1562932T1 (OSRAM) |
| TW (2) | TW200819436A (OSRAM) |
| WO (1) | WO2004046132A1 (OSRAM) |
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| CA2720312A1 (en) * | 2004-01-30 | 2005-08-18 | Euro-Celtique S.A. | Methods for making 4-tetrazolyl-4-phenylpiperidine compounds |
| SE0401656D0 (sv) * | 2004-06-24 | 2004-06-24 | Astrazeneca Ab | Chemical compounds |
| SI1951718T1 (sl) * | 2005-11-21 | 2012-06-29 | Purdue Pharma Lp | 4-oksadiazolil-piperidinske spojine in njihova uporaba |
| US20080051380A1 (en) | 2006-08-25 | 2008-02-28 | Auerbach Alan H | Methods and compositions for treating cancer |
| WO2011056561A1 (en) | 2009-10-27 | 2011-05-12 | Beth Israel Deaconess Medical Center | Methods and compositions for the generation and use of conformation-specific antibodies |
| UY33618A (es) | 2010-09-21 | 2012-03-30 | Purdue Pharma Lp | Analogos de buprenorfina |
| CN102648915B (zh) * | 2011-02-28 | 2015-04-15 | 鲁南制药集团股份有限公司 | 一种治疗或预防神经病理性疼痛的药物组合物 |
| US10487114B2 (en) | 2011-04-27 | 2019-11-26 | Beth Israel Deaconess Medical Center, Inc. | Methods for administering peptides for the generation of effective c/s conformation-specific antibodies to a human subject in need thereof |
| TW201431842A (zh) | 2012-11-09 | 2014-08-16 | Purdue Pharma Lp | 苯並嗎啡烷類似物及其應用 |
| US9175000B2 (en) | 2012-12-07 | 2015-11-03 | Purdue Pharma L.P. | Buprenorphine analogs |
| ES2631197T3 (es) | 2012-12-14 | 2017-08-29 | Purdue Pharma Lp | Análogos de piridonamorfinano y actividad biológica sobre los receptores opiodes |
| US8987287B2 (en) | 2012-12-14 | 2015-03-24 | Purdue Pharma L.P. | Spirocyclic morphinans and their use |
| CA2900023A1 (en) | 2013-01-31 | 2014-08-07 | Purdue Pharma L.P. | Benzomorphan analogs and the use thereof |
| US8969358B2 (en) | 2013-03-15 | 2015-03-03 | Purdue Pharma L.P. | Buprenorphine analogs |
| EP3087073B1 (en) | 2013-12-26 | 2018-07-04 | Purdue Pharma LP | 10-substituted morphinan hydantoins |
| US9862726B2 (en) | 2013-12-26 | 2018-01-09 | Purdue Pharma L.P. | Opioid receptor modulating oxabicyclo[2.2.2]octane morphinans |
| WO2015097548A1 (en) | 2013-12-26 | 2015-07-02 | Purdue Pharma L.P. | 7-beta-alkyl analogs of orvinols |
| JP6353543B2 (ja) | 2013-12-26 | 2018-07-04 | パーデュー、ファーマ、リミテッド、パートナーシップ | 環縮小モルフィナン及びその使用 |
| WO2015097546A1 (en) | 2013-12-26 | 2015-07-02 | Purdue Pharma L.P. | Propellane-based compounds and their use as opioid receptor modulators |
| WO2015099863A1 (en) | 2013-12-27 | 2015-07-02 | Purdue Pharma L.P. | 6-substituted and 7-substituted morphinan analogs and the use thereof |
| WO2015183780A1 (en) | 2014-05-27 | 2015-12-03 | Purdue Pharma L.P. | Spirocyclic morphinans and use thereof |
| EP3154972A4 (en) | 2014-06-13 | 2017-11-22 | Purdue Pharma L.P. | Azamophinan derivatives and use thereof |
| MA41125A (fr) | 2014-12-05 | 2017-10-10 | Purdue Pharma Lp | Dérivés de 6.7-cyclomorphinane et leur utilisation |
| US11529340B2 (en) | 2016-03-22 | 2022-12-20 | Regents Of The University Of Minnesota | Combination for treating pain |
| PE20190403A1 (es) | 2016-07-29 | 2019-03-13 | Janssen Pharmaceutica Nv | Metodos para tratar el cancer de prostata |
| WO2018125716A1 (en) | 2017-01-02 | 2018-07-05 | Purdue Pharma L.P. | Morphinan derivatives and use thereof |
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2003
- 2003-11-13 US US10/714,066 patent/US7202259B2/en not_active Expired - Lifetime
- 2003-11-17 AT AT07006697T patent/ATE402167T1/de active
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- 2003-11-17 NZ NZ572685A patent/NZ572685A/en not_active IP Right Cessation
- 2003-11-17 PT PT07006697T patent/PT1803718E/pt unknown
- 2003-11-17 EP EP07006697A patent/EP1803718B1/en not_active Expired - Lifetime
- 2003-11-17 EP EP03789796A patent/EP1562932B9/en not_active Expired - Lifetime
- 2003-11-17 EA EA200500726A patent/EA008621B1/ru not_active IP Right Cessation
- 2003-11-17 CN CN200910173679A patent/CN101648941A/zh active Pending
- 2003-11-17 MX MXPA05004669A patent/MXPA05004669A/es active IP Right Grant
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- 2003-11-17 JP JP2004570427A patent/JP4601429B2/ja not_active Expired - Fee Related
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- 2003-11-17 PT PT03789796T patent/PT1562932E/pt unknown
- 2003-11-17 DK DK03789796T patent/DK1562932T3/da active
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- 2003-11-17 NZ NZ540068A patent/NZ540068A/en not_active IP Right Cessation
- 2003-11-17 RS YUP-2005/0375A patent/RS51047B/sr unknown
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- 2003-11-17 AP AP2005003297A patent/AP2210A/xx active
- 2003-11-17 WO PCT/US2003/036742 patent/WO2004046132A1/en not_active Ceased
- 2003-11-17 AU AU2003294313A patent/AU2003294313B2/en not_active Ceased
- 2003-11-17 AT AT03789796T patent/ATE358674T1/de active
- 2003-11-17 KR KR1020057008903A patent/KR20050115221A/ko not_active Abandoned
- 2003-11-18 TW TW096151468A patent/TW200819436A/zh unknown
- 2003-11-18 TW TW092132303A patent/TWI343917B/zh not_active IP Right Cessation
- 2003-11-18 MY MYPI20034402A patent/MY135647A/en unknown
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- 2005-06-07 EC EC2005005840A patent/ECSP055840A/es unknown
- 2005-06-13 MA MA28335A patent/MA27565A1/fr unknown
- 2005-06-14 NO NO20052894A patent/NO20052894D0/no not_active Application Discontinuation
- 2005-06-16 CR CR7877A patent/CR7877A/es unknown
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2007
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2008
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