MEP48108A - 4-tetrazolyl-4phenylpiperidine derivatives for treating pain - Google Patents
4-tetrazolyl-4phenylpiperidine derivatives for treating painInfo
- Publication number
- MEP48108A MEP48108A MEP-481/08A MEP48108A MEP48108A ME P48108 A MEP48108 A ME P48108A ME P48108 A MEP48108 A ME P48108A ME P48108 A MEP48108 A ME P48108A
- Authority
- ME
- Montenegro
- Prior art keywords
- tetrazolyl
- derivatives
- treating pain
- phenylpiperidine
- opioid receptor
- Prior art date
Links
- OGPKTRWLBLRODW-UHFFFAOYSA-N 4-phenyl-4-(2h-tetrazol-5-yl)piperidine Chemical class C1CNCCC1(C=1C=CC=CC=1)C1=NNN=N1 OGPKTRWLBLRODW-UHFFFAOYSA-N 0.000 title abstract 2
- -1 4-tetrazolyl-4-phenylpiperidine compound Chemical class 0.000 abstract 3
- 241001465754 Metazoa Species 0.000 abstract 2
- 102000003840 Opioid Receptors Human genes 0.000 abstract 2
- 108090000137 Opioid Receptors Proteins 0.000 abstract 2
- 206010012735 Diarrhoea Diseases 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000004936 stimulating effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
- C07D211/64—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4 having an aryl radical as the second substituent in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US42738102P | 2002-11-18 | 2002-11-18 | |
| US46027803P | 2003-04-03 | 2003-04-03 | |
| US48848803P | 2003-07-17 | 2003-07-17 | |
| US10/714,066 US7202259B2 (en) | 2002-11-18 | 2003-11-13 | Therapeutic agents useful for treating pain |
| PCT/US2003/036742 WO2004046132A1 (en) | 2002-11-18 | 2003-11-17 | 4-tetrazolyl-4phenylpiperidine derivatives for treating pain |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MEP48108A true MEP48108A (en) | 2011-02-10 |
Family
ID=32777221
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MEP-481/08A MEP48108A (en) | 2002-11-18 | 2003-11-17 | 4-tetrazolyl-4phenylpiperidine derivatives for treating pain |
Country Status (36)
| Country | Link |
|---|---|
| US (3) | US7202259B2 (OSRAM) |
| EP (2) | EP1562932B9 (OSRAM) |
| JP (2) | JP4601429B2 (OSRAM) |
| KR (1) | KR20050115221A (OSRAM) |
| CN (2) | CN100567288C (OSRAM) |
| AP (1) | AP2210A (OSRAM) |
| AR (1) | AR047008A1 (OSRAM) |
| AT (2) | ATE358674T1 (OSRAM) |
| AU (2) | AU2003294313B2 (OSRAM) |
| BR (1) | BR0316305A (OSRAM) |
| CA (1) | CA2506242C (OSRAM) |
| CO (1) | CO5690588A2 (OSRAM) |
| CR (2) | CR7877A (OSRAM) |
| CY (2) | CY1107682T1 (OSRAM) |
| DE (2) | DE60322451D1 (OSRAM) |
| DK (2) | DK1562932T3 (OSRAM) |
| EA (1) | EA008621B1 (OSRAM) |
| EC (1) | ECSP055840A (OSRAM) |
| ES (2) | ES2285235T3 (OSRAM) |
| GE (1) | GEP20084539B (OSRAM) |
| IL (1) | IL209352A0 (OSRAM) |
| IS (2) | IS2720B (OSRAM) |
| MA (1) | MA27565A1 (OSRAM) |
| ME (1) | MEP48108A (OSRAM) |
| MX (1) | MXPA05004669A (OSRAM) |
| MY (1) | MY135647A (OSRAM) |
| NI (1) | NI200500087A (OSRAM) |
| NO (1) | NO20052894D0 (OSRAM) |
| NZ (2) | NZ540068A (OSRAM) |
| OA (1) | OA13010A (OSRAM) |
| PT (2) | PT1803718E (OSRAM) |
| RS (1) | RS51047B (OSRAM) |
| SG (1) | SG165998A1 (OSRAM) |
| SI (2) | SI1562932T1 (OSRAM) |
| TW (2) | TW200819436A (OSRAM) |
| WO (1) | WO2004046132A1 (OSRAM) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7202259B2 (en) * | 2002-11-18 | 2007-04-10 | Euro-Celtique S.A. | Therapeutic agents useful for treating pain |
| US8790689B2 (en) * | 2003-04-30 | 2014-07-29 | Purdue Pharma L.P. | Tamper resistant transdermal dosage form |
| KR101159828B1 (ko) | 2003-04-30 | 2012-07-04 | 퍼듀 퍼머 엘피 | 활성제 구성요소 및 활성제 층의 원위부에 억제제 구성요소를 포함하는 내변조성 경피제형 |
| EP2277875A3 (en) * | 2004-01-30 | 2011-04-20 | Euro-Celtique S.A. | Methods for making 4-tetrazolyl-4-phenylpiperidine compounds |
| SE0401656D0 (sv) * | 2004-06-24 | 2004-06-24 | Astrazeneca Ab | Chemical compounds |
| NZ568430A (en) * | 2005-11-21 | 2011-02-25 | Purdue Pharma Lp | 4-oxadiazolyl-piperidine compounds and use thereof |
| US20080051380A1 (en) | 2006-08-25 | 2008-02-28 | Auerbach Alan H | Methods and compositions for treating cancer |
| US8771693B2 (en) | 2009-10-27 | 2014-07-08 | Beth Israel Deaconess Medical Center, Inc. | Methods and compositions for the generation and use of conformation-specific antibodies |
| EP2619212B1 (en) | 2010-09-21 | 2016-01-06 | Purdue Pharma L.P. | Buprenorphine analogs as opioid receptor agonists and/or antagonists |
| CN102648915B (zh) * | 2011-02-28 | 2015-04-15 | 鲁南制药集团股份有限公司 | 一种治疗或预防神经病理性疼痛的药物组合物 |
| US10487114B2 (en) | 2011-04-27 | 2019-11-26 | Beth Israel Deaconess Medical Center, Inc. | Methods for administering peptides for the generation of effective c/s conformation-specific antibodies to a human subject in need thereof |
| CA2890655A1 (en) | 2012-11-09 | 2014-05-15 | Purdue Pharma L.P. | Benzomorphan analogs and the use thereof |
| WO2014087226A1 (en) | 2012-12-07 | 2014-06-12 | Purdue Pharma L.P. | Buprenorphine analogs as opiod receptor modulators |
| ES2621305T3 (es) | 2012-12-14 | 2017-07-03 | Purdue Pharma Lp | Morfinanos espirocíclicos y su uso |
| ES2631197T3 (es) | 2012-12-14 | 2017-08-29 | Purdue Pharma Lp | Análogos de piridonamorfinano y actividad biológica sobre los receptores opiodes |
| WO2014118618A1 (en) | 2013-01-31 | 2014-08-07 | Purdue Pharma L.P. | Benzomorphan analogs and the use thereof |
| US8969358B2 (en) | 2013-03-15 | 2015-03-03 | Purdue Pharma L.P. | Buprenorphine analogs |
| US9862726B2 (en) | 2013-12-26 | 2018-01-09 | Purdue Pharma L.P. | Opioid receptor modulating oxabicyclo[2.2.2]octane morphinans |
| US9340542B2 (en) | 2013-12-26 | 2016-05-17 | Purdue Pharma L.P. | Propellane-based compounds and the use thereof |
| WO2015097547A1 (en) | 2013-12-26 | 2015-07-02 | Purdue Pharma L.P. | 10-substituted morphinan hydantoins |
| EP3087057A4 (en) | 2013-12-26 | 2017-06-28 | Purdue Pharma LP | Ring-contracted morphinans and the use thereof |
| US9988392B2 (en) | 2013-12-26 | 2018-06-05 | Purdue Pharma L.P. | 7-beta-alkyl analogs of orvinols |
| EP3086790A4 (en) | 2013-12-27 | 2017-07-19 | Purdue Pharma LP | 6-substituted and 7-substituted morphinan analogs and the use thereof |
| WO2015183780A1 (en) | 2014-05-27 | 2015-12-03 | Purdue Pharma L.P. | Spirocyclic morphinans and use thereof |
| JP6360915B2 (ja) | 2014-06-13 | 2018-07-18 | パーデュー、ファーマ、リミテッド、パートナーシップ | アザモルフィナン誘導体及びその使用 |
| MA41125A (fr) | 2014-12-05 | 2017-10-10 | Purdue Pharma Lp | Dérivés de 6.7-cyclomorphinane et leur utilisation |
| MA43834A (fr) | 2016-03-22 | 2018-11-28 | Univ Minnesota | Combinaison pour traiter la douleur |
| CN109640991A (zh) | 2016-07-29 | 2019-04-16 | 詹森药业有限公司 | 治疗前列腺癌的方法 |
| US10745402B2 (en) | 2017-01-02 | 2020-08-18 | Purdue Pharma L.P. | Morphinan derivatives and use thereof |
| WO2022246298A1 (en) * | 2021-05-21 | 2022-11-24 | Whiteside Garth | Methods of treating interstitial cystitis/bladder pain syndrome |
| AU2023287696A1 (en) * | 2022-06-24 | 2025-01-23 | Purdue Pharma L.P. | Methods of treating or preventing overactive bladder syndrome |
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-
2003
- 2003-11-13 US US10/714,066 patent/US7202259B2/en not_active Expired - Lifetime
- 2003-11-17 ES ES03789796T patent/ES2285235T3/es not_active Expired - Lifetime
- 2003-11-17 DK DK03789796T patent/DK1562932T3/da active
- 2003-11-17 CN CNB2003801035027A patent/CN100567288C/zh not_active Expired - Fee Related
- 2003-11-17 AP AP2005003297A patent/AP2210A/xx active
- 2003-11-17 DK DK07006697T patent/DK1803718T3/da active
- 2003-11-17 DE DE60322451T patent/DE60322451D1/de not_active Expired - Lifetime
- 2003-11-17 SI SI200330814T patent/SI1562932T1/sl unknown
- 2003-11-17 NZ NZ540068A patent/NZ540068A/en not_active IP Right Cessation
- 2003-11-17 AT AT03789796T patent/ATE358674T1/de active
- 2003-11-17 RS YUP-2005/0375A patent/RS51047B/sr unknown
- 2003-11-17 PT PT07006697T patent/PT1803718E/pt unknown
- 2003-11-17 JP JP2004570427A patent/JP4601429B2/ja not_active Expired - Fee Related
- 2003-11-17 WO PCT/US2003/036742 patent/WO2004046132A1/en not_active Ceased
- 2003-11-17 SI SI200331358T patent/SI1803718T1/sl unknown
- 2003-11-17 AT AT07006697T patent/ATE402167T1/de active
- 2003-11-17 ES ES07006697T patent/ES2312150T3/es not_active Expired - Lifetime
- 2003-11-17 EP EP03789796A patent/EP1562932B9/en not_active Expired - Lifetime
- 2003-11-17 BR BR0316305-9A patent/BR0316305A/pt not_active IP Right Cessation
- 2003-11-17 GE GEAP20038846A patent/GEP20084539B/en unknown
- 2003-11-17 KR KR1020057008903A patent/KR20050115221A/ko not_active Abandoned
- 2003-11-17 DE DE60313021T patent/DE60313021T2/de not_active Expired - Lifetime
- 2003-11-17 AU AU2003294313A patent/AU2003294313B2/en not_active Ceased
- 2003-11-17 ME MEP-481/08A patent/MEP48108A/xx unknown
- 2003-11-17 PT PT03789796T patent/PT1562932E/pt unknown
- 2003-11-17 CA CA2506242A patent/CA2506242C/en not_active Expired - Fee Related
- 2003-11-17 EA EA200500726A patent/EA008621B1/ru not_active IP Right Cessation
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- 2003-11-17 CN CN200910173679A patent/CN101648941A/zh active Pending
- 2003-11-17 EP EP07006697A patent/EP1803718B1/en not_active Expired - Lifetime
- 2003-11-17 SG SG200703631-2A patent/SG165998A1/en unknown
- 2003-11-17 MX MXPA05004669A patent/MXPA05004669A/es active IP Right Grant
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- 2003-11-18 TW TW092132303A patent/TWI343917B/zh not_active IP Right Cessation
- 2003-11-19 AR ARP030104269A patent/AR047008A1/es unknown
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2005
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- 2005-05-20 CO CO05048789A patent/CO5690588A2/es not_active Application Discontinuation
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- 2005-06-13 MA MA28335A patent/MA27565A1/fr unknown
- 2005-06-14 NO NO20052894A patent/NO20052894D0/no not_active Application Discontinuation
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2007
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2008
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2009
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2010
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