DE60303149D1 - Salz von morphin-6-glucuronid - Google Patents

Salz von morphin-6-glucuronid

Info

Publication number
DE60303149D1
DE60303149D1 DE60303149T DE60303149T DE60303149D1 DE 60303149 D1 DE60303149 D1 DE 60303149D1 DE 60303149 T DE60303149 T DE 60303149T DE 60303149 T DE60303149 T DE 60303149T DE 60303149 D1 DE60303149 D1 DE 60303149D1
Authority
DE
Germany
Prior art keywords
hbr
glucuronide
morphine
salt
medicament
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60303149T
Other languages
English (en)
Other versions
DE60303149T2 (de
Inventor
C O Cenes Limited Graham
Rudolf Franzmair
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Paion UK Ltd
Original Assignee
Cenes Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cenes Ltd filed Critical Cenes Ltd
Publication of DE60303149D1 publication Critical patent/DE60303149D1/de
Application granted granted Critical
Publication of DE60303149T2 publication Critical patent/DE60303149T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE60303149T 2002-08-14 2003-08-14 Salz von morphin-6-glucuronid Expired - Lifetime DE60303149T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0218811 2002-08-14
GBGB0218811.8A GB0218811D0 (en) 2002-08-14 2002-08-14 Salts of morphine-6-glucuronide
PCT/GB2003/003562 WO2004016633A1 (en) 2002-08-14 2003-08-14 Salt of morphine-6-glucuronide

Publications (2)

Publication Number Publication Date
DE60303149D1 true DE60303149D1 (de) 2006-03-30
DE60303149T2 DE60303149T2 (de) 2006-09-28

Family

ID=9942230

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60303149T Expired - Lifetime DE60303149T2 (de) 2002-08-14 2003-08-14 Salz von morphin-6-glucuronid

Country Status (17)

Country Link
US (1) US20060166900A1 (de)
EP (1) EP1537132B1 (de)
JP (1) JP4727990B2 (de)
KR (1) KR101077501B1 (de)
AT (1) ATE315041T1 (de)
AU (1) AU2003255790B2 (de)
CA (1) CA2494812C (de)
DE (1) DE60303149T2 (de)
DK (1) DK1537132T3 (de)
EA (1) EA008212B1 (de)
ES (1) ES2256790T3 (de)
GB (1) GB0218811D0 (de)
IL (1) IL166596A0 (de)
NO (1) NO20051261L (de)
PL (1) PL211031B1 (de)
WO (1) WO2004016633A1 (de)
ZA (1) ZA200501053B (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ561375A (en) 2005-06-27 2011-06-30 Biovail Lab Int Srl Bupropion hydrobromide, and crystalline forms, compositions, and uses of this compound
FR2939437B1 (fr) * 2008-12-10 2010-12-17 Sanofi Aventis Derives de morphine-6-glucuronide, leur preparation et leur application en therapeutique
FR2939796B1 (fr) * 2008-12-11 2010-12-17 Sanofi Aventis Derives bicycliques de morphine-6-glucuronide, leur preparation et leur application en therapeutique
CN107028968B (zh) * 2016-02-03 2020-12-04 江苏恒瑞医药股份有限公司 一种含有葡萄糖醛酸吗啡或其可药用盐的药物组合物
AU2017345765A1 (en) 2016-10-21 2019-06-06 Somniferum Labs LLC Compositions, methods and kits for the safe inhaled delivery of targeted opioids for the treatment of pain and addiction
CN110054656B (zh) * 2019-05-28 2021-02-02 宜昌人福药业有限责任公司 一种10-羰基/羟基吗啡-6-葡萄糖苷酸的合成方法
CN113831373B (zh) * 2020-06-23 2023-05-16 宜昌人福药业有限责任公司 一种吗啡-6-葡萄糖苷酸脱水物杂质的合成方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4908389A (en) * 1986-08-27 1990-03-13 Warner-Lambert Company Penetration enhancement system
FR2680786B1 (fr) * 1991-09-04 1995-03-10 Irepa Procede de synthese de glucuronides d'epoxy-4,5 morphinanes.
DE4403709A1 (de) * 1994-02-07 1995-08-10 Lohmann Therapie Syst Lts Pharmazeutische Zusammensetzung zur systemischen transdermalen Verabreichung mit dem Wirkstoff Morphin-6-glucuronid
US5460826A (en) * 1994-06-27 1995-10-24 Alza Corporation Morphine therapy
CA2211596A1 (en) * 1995-11-29 1997-06-19 Gregori Valencia Parera Glycoconjugates of opiated substances
JP2001517669A (ja) * 1997-09-25 2001-10-09 エルティエス ローマン テラピー−ズュステーメ アーゲー モルヒネアルカロイド類の酸添加塩類およびその応用
US6740641B2 (en) * 2001-07-27 2004-05-25 Euro-Celtique, S.A. Sugar derivatives of hydromorphone, dihydromorphine and dihydromorphine, compositions thereof and uses for treating or preventing pain

Also Published As

Publication number Publication date
JP2006500360A (ja) 2006-01-05
GB0218811D0 (en) 2002-09-18
NO20051261L (no) 2005-03-11
IL166596A0 (en) 2006-01-15
EP1537132A1 (de) 2005-06-08
US20060166900A1 (en) 2006-07-27
ATE315041T1 (de) 2006-02-15
DE60303149T2 (de) 2006-09-28
JP4727990B2 (ja) 2011-07-20
EA200500175A1 (ru) 2005-08-25
PL373553A1 (en) 2005-09-05
KR20050055710A (ko) 2005-06-13
CA2494812A1 (en) 2004-02-26
CA2494812C (en) 2011-03-08
AU2003255790A1 (en) 2004-03-03
EA008212B1 (ru) 2007-04-27
WO2004016633A1 (en) 2004-02-26
EP1537132B1 (de) 2006-01-04
KR101077501B1 (ko) 2011-10-28
ZA200501053B (en) 2005-10-26
AU2003255790B2 (en) 2010-05-27
ES2256790T3 (es) 2006-07-16
DK1537132T3 (da) 2006-05-08
PL211031B1 (pl) 2012-04-30

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Legal Events

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