ATE482206T1 - Heterozyklische substituierte piperidine als orl- 1-liganden - Google Patents
Heterozyklische substituierte piperidine als orl- 1-ligandenInfo
- Publication number
- ATE482206T1 ATE482206T1 AT08727696T AT08727696T ATE482206T1 AT E482206 T1 ATE482206 T1 AT E482206T1 AT 08727696 T AT08727696 T AT 08727696T AT 08727696 T AT08727696 T AT 08727696T AT E482206 T1 ATE482206 T1 AT E482206T1
- Authority
- AT
- Austria
- Prior art keywords
- orl
- ligands
- heterocyclic substituted
- heterocyclic
- substituted piperidines
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/14—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US88095507P | 2007-01-16 | 2007-01-16 | |
US93003507P | 2007-05-11 | 2007-05-11 | |
PCT/US2008/051096 WO2008089201A2 (en) | 2007-01-16 | 2008-01-15 | Heterocyclic-substituted piperidine as orl-1 ligands |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE482206T1 true ATE482206T1 (de) | 2010-10-15 |
Family
ID=39434287
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT08727696T ATE482206T1 (de) | 2007-01-16 | 2008-01-15 | Heterozyklische substituierte piperidine als orl- 1-liganden |
Country Status (23)
Country | Link |
---|---|
US (2) | US8110602B2 (de) |
EP (3) | EP2397477B1 (de) |
JP (2) | JP5462633B2 (de) |
KR (2) | KR101370434B1 (de) |
CN (1) | CN101595100B (de) |
AT (1) | ATE482206T1 (de) |
AU (2) | AU2008206317B2 (de) |
CA (1) | CA2675419C (de) |
CY (1) | CY1111085T1 (de) |
DE (1) | DE602008002690D1 (de) |
DK (1) | DK2076506T3 (de) |
ES (1) | ES2353448T3 (de) |
HK (1) | HK1152296A1 (de) |
HR (1) | HRP20100691T1 (de) |
IL (1) | IL199741A0 (de) |
MX (1) | MX2009007644A (de) |
NZ (2) | NZ601683A (de) |
PL (1) | PL2076506T3 (de) |
PT (1) | PT2076506E (de) |
RS (1) | RS51474B (de) |
SI (1) | SI2076506T1 (de) |
WO (1) | WO2008089201A2 (de) |
ZA (1) | ZA200903742B (de) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2353448T3 (es) | 2007-01-16 | 2011-03-02 | Purdue Pharma L.P. | Piperidinas heterocíclico-sustituidas como ligandos de orl-1. |
TWI448289B (zh) * | 2007-08-31 | 2014-08-11 | Purdue Pharma Lp | 經取代之喹啉型哌啶化合物及其用途 |
UA99540C2 (ru) * | 2008-07-21 | 2012-08-27 | Пердью Фарма Л.П. | Замещенные мостиковым хиноксалином пиперидиновые соединения и их применение |
JP5236019B2 (ja) * | 2009-02-03 | 2013-07-17 | 田辺三菱製薬株式会社 | 1−(4−ピペリジニル)ベンゾイミダゾロン誘導体の製造方法 |
KR20120069710A (ko) | 2009-09-08 | 2012-06-28 | 교린 세이야꾸 가부시키 가이샤 | 4?(5?메틸피리딘?2?일아미노)피페리딘?1?카복실산 유도체의 제조방법 |
US8673915B2 (en) * | 2010-07-29 | 2014-03-18 | Nippon Chemiphar Co., Ltd. | P 2×4 receptor antagonist |
AU2011346749A1 (en) | 2010-12-22 | 2013-05-02 | Purdue Pharma L.P. | Phosphorus-substituted quinoxaline-type piperidine compounds and uses thereof |
EP2567959B1 (de) | 2011-09-12 | 2014-04-16 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridin-4-carbonsäureamid-derivate als kinaseinhibitoren |
EP2797912B1 (de) | 2011-12-01 | 2016-05-25 | Purdue Pharma L.P. | Azetidin-substituierte quinoxalin-typ piperidin-verbindungen und ihre verwendungen |
US9085561B2 (en) | 2012-07-30 | 2015-07-21 | Purdue Pharma L.P. | Cyclic urea- or lactam-substituted quinoxaline-type piperidines as ORL-1 modulators |
WO2014102590A1 (en) | 2012-12-27 | 2014-07-03 | Purdue Pharma L.P. | Substituted piperidin-4-amino-type compounds and uses thereof |
US9090618B2 (en) | 2012-12-27 | 2015-07-28 | Purdue Pharma L.P. | Substituted benzimidazole-type piperidine compounds and uses thereof |
WO2014102588A2 (en) | 2012-12-27 | 2014-07-03 | Purdue Pharma L.P. | Indole and indoline-type piperidine compounds and uses thereof |
WO2022072783A1 (en) | 2020-10-02 | 2022-04-07 | Incyte Corporation | Bicyclic dione compounds as inhibitors of kras |
WO2023229380A1 (ko) * | 2022-05-25 | 2023-11-30 | 주식회사 엘지화학 | 다이아실글리세롤 키나아제 저해제로서 헤테로사이클 화합물 및 이의 용도 |
WO2023229378A1 (ko) * | 2022-05-25 | 2023-11-30 | 주식회사 엘지화학 | 다이아실글리세롤 키나아제 저해제로서 헤테로사이클 화합물 및 이의 용도 |
Family Cites Families (45)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3536809A (en) | 1969-02-17 | 1970-10-27 | Alza Corp | Medication method |
US3598123A (en) | 1969-04-01 | 1971-08-10 | Alza Corp | Bandage for administering drugs |
US3845770A (en) | 1972-06-05 | 1974-11-05 | Alza Corp | Osmatic dispensing device for releasing beneficial agent |
US3916899A (en) | 1973-04-25 | 1975-11-04 | Alza Corp | Osmotic dispensing device with maximum and minimum sizes for the passageway |
US4008719A (en) | 1976-02-02 | 1977-02-22 | Alza Corporation | Osmotic system having laminar arrangement for programming delivery of active agent |
IE58110B1 (en) | 1984-10-30 | 1993-07-14 | Elan Corp Plc | Controlled release powder and process for its preparation |
US5073543A (en) | 1988-07-21 | 1991-12-17 | G. D. Searle & Co. | Controlled release formulations of trophic factors in ganglioside-lipsome vehicle |
IT1229203B (it) | 1989-03-22 | 1991-07-25 | Bioresearch Spa | Impiego di acido 5 metiltetraidrofolico, di acido 5 formiltetraidrofolico e dei loro sali farmaceuticamente accettabili per la preparazione di composizioni farmaceutiche in forma a rilascio controllato attive nella terapia dei disturbi mentali organici e composizioni farmaceutiche relative. |
US5120548A (en) | 1989-11-07 | 1992-06-09 | Merck & Co., Inc. | Swelling modulated polymeric drug delivery device |
US5733566A (en) | 1990-05-15 | 1998-03-31 | Alkermes Controlled Therapeutics Inc. Ii | Controlled release of antiparasitic agents in animals |
AU656154B2 (en) | 1990-11-06 | 1995-01-27 | Astellas Pharma Inc. | Fused pyrazine derivative |
US5698155A (en) | 1991-05-31 | 1997-12-16 | Gs Technologies, Inc. | Method for the manufacture of pharmaceutical cellulose capsules |
US5580578A (en) | 1992-01-27 | 1996-12-03 | Euro-Celtique, S.A. | Controlled release formulations coated with aqueous dispersions of acrylic polymers |
US5591767A (en) | 1993-01-25 | 1997-01-07 | Pharmetrix Corporation | Liquid reservoir transdermal patch for the administration of ketorolac |
GB9314977D0 (en) | 1993-07-20 | 1993-09-01 | Glaxo Spa | Chemical compounds |
US5739129A (en) | 1994-04-14 | 1998-04-14 | Glaxo Wellcome Inc. | CCK or gastrin modulating 5-heterocyclic-1, 5 benzodiazepines |
PE27497A1 (es) | 1994-04-15 | 1997-08-07 | Glaxo Inc | Derivados de 1,5 benzodiazepina |
IT1270594B (it) | 1994-07-07 | 1997-05-07 | Recordati Chem Pharm | Composizione farmaceutica a rilascio controllato di moguisteina in sospensione liquida |
CZ189197A3 (cs) | 1994-12-23 | 1998-01-14 | Dr. Karl Thomae Gmbh | Piperazinové deriváty, způsob výroby a farmaceutický prostředek s jejich obsahem |
JP3845876B2 (ja) | 1995-04-20 | 2006-11-15 | アステラス製薬株式会社 | ピラジン誘導体又はその塩を含有する安定な注射用組成物及びその製造方法 |
ATE301457T1 (de) | 1995-06-12 | 2005-08-15 | Searle & Co | Mittel, enthaltend einen cyclooxygenase-2 inhibitor und einen 5-lipoxygenase inhibitor |
WO1998054168A1 (fr) * | 1997-05-30 | 1998-12-03 | Banyu Pharmaceutical Co., Ltd. | Derives de 2-0xoimidazole |
US6030130A (en) * | 1997-07-07 | 2000-02-29 | George Paddock Ii, Inc. | Body mounted camera support system |
AU1679099A (en) * | 1998-01-19 | 1999-08-02 | Pfizer Inc. | 4-(2-keto-1-benzimidazolinyl)piperidine compounds as orl1-receptor agonists |
DE69943144D1 (de) | 1998-03-31 | 2011-03-03 | Kyowa Hakko Kirin Co Ltd | Stickstoffenthaltende heterocyclische verbindungen |
US6262066B1 (en) | 1998-07-27 | 2001-07-17 | Schering Corporation | High affinity ligands for nociceptin receptor ORL-1 |
ID29137A (id) * | 1998-07-27 | 2001-08-02 | Schering Corp | Ligan-ligan afinitas tinggi untuk reseptor nosiseptin orl-1 |
MA26659A1 (fr) | 1998-08-06 | 2004-12-20 | Pfizer | Dérivés de benzimidazole nouveaux, compositions pharmaceutiques les contenant et procédé pour leur préparation. |
EP1123928A4 (de) | 1998-10-20 | 2005-02-16 | Takeda Pharmaceutical | 1,5-benzodiazepin-verbindungen, verfahren zu ihrer herstellung und eine medizin |
EP1230220A1 (de) | 1999-11-09 | 2002-08-14 | Eli Lilly And Company | Beta-aminosäure-verbindungen zur hemmung der freisetzung von beta-amyloid-peptid und/oder seiner synthese |
AU1816901A (en) * | 1999-12-06 | 2001-06-12 | Euro-Celtique S.A. | Benzimidazole compounds having nociceptin receptor affinity |
DE10013318A1 (de) | 2000-03-17 | 2001-09-20 | Merck Patent Gmbh | Formulierung enthaltend Chinoxalinderivate |
US6576644B2 (en) | 2000-09-06 | 2003-06-10 | Bristol-Myers Squibb Co. | Quinoline inhibitors of cGMP phosphodiesterase |
AU2002257114A1 (en) | 2001-04-06 | 2002-10-21 | Schering Corporation | Treatment of malaria with farsenyl protein transferase inhibitors |
KR100729242B1 (ko) * | 2001-04-18 | 2007-06-15 | 유로-셀티크 소시에떼 아노뉨 | 노시셉틴 유사체 |
HUP0401109A3 (en) * | 2001-04-18 | 2007-12-28 | Euro Celtique Sa | Nociceptin analogs, their use and pharmaceutical compositions containing them |
CA2444634C (en) | 2001-04-18 | 2011-06-07 | R. Richard Goehring | Spiropyrazole compounds |
DK1975164T3 (da) * | 2001-04-18 | 2010-05-25 | Euro Celtique Sa | Octahydrobenzimidazolon-forbindelser som analgetika |
US20030134846A1 (en) | 2001-10-09 | 2003-07-17 | Schering Corporation | Treatment of trypanosoma brucei with farnesyl protein transferase inhibitors |
US7001901B2 (en) | 2002-08-27 | 2006-02-21 | Bristol-Myers Squibb Company | Tetrazolylpropionamides as inhibitors of Aβ protein production |
US7067658B2 (en) | 2002-09-30 | 2006-06-27 | Bristol-Myers Squibb Company | Pyridino and pyrimidino pyrazinones |
UA80767C2 (en) | 2002-12-20 | 2007-10-25 | Pfizer Prod Inc | Pyrimidine derivatives for the treatment of abnormal cell growth |
EP1711484A4 (de) | 2004-02-03 | 2007-06-20 | Euro Celtique Sa | Synthese von cyanoiminobenzimidazolen |
US7459556B2 (en) | 2004-09-15 | 2008-12-02 | Schering-Plough Ltd. | Process for preparing substituted 8-azabicyclo[3.2.1]octan-3-ols |
ES2353448T3 (es) | 2007-01-16 | 2011-03-02 | Purdue Pharma L.P. | Piperidinas heterocíclico-sustituidas como ligandos de orl-1. |
-
2008
- 2008-01-15 ES ES08727696T patent/ES2353448T3/es active Active
- 2008-01-15 KR KR1020127008578A patent/KR101370434B1/ko not_active IP Right Cessation
- 2008-01-15 DE DE602008002690T patent/DE602008002690D1/de active Active
- 2008-01-15 JP JP2009546482A patent/JP5462633B2/ja not_active Expired - Fee Related
- 2008-01-15 AT AT08727696T patent/ATE482206T1/de active
- 2008-01-15 WO PCT/US2008/051096 patent/WO2008089201A2/en active Application Filing
- 2008-01-15 PL PL08727696T patent/PL2076506T3/pl unknown
- 2008-01-15 PT PT08727696T patent/PT2076506E/pt unknown
- 2008-01-15 SI SI200830118T patent/SI2076506T1/sl unknown
- 2008-01-15 MX MX2009007644A patent/MX2009007644A/es active IP Right Grant
- 2008-01-15 KR KR1020097017069A patent/KR101227072B1/ko not_active IP Right Cessation
- 2008-01-15 DK DK08727696.0T patent/DK2076506T3/da active
- 2008-01-15 EP EP11178018.5A patent/EP2397477B1/de active Active
- 2008-01-15 EP EP10177612.8A patent/EP2280008B1/de active Active
- 2008-01-15 RS RSP-2010/0489A patent/RS51474B/en unknown
- 2008-01-15 CN CN200880002219.8A patent/CN101595100B/zh not_active Expired - Fee Related
- 2008-01-15 NZ NZ601683A patent/NZ601683A/xx not_active IP Right Cessation
- 2008-01-15 NZ NZ578078A patent/NZ578078A/en not_active IP Right Cessation
- 2008-01-15 AU AU2008206317A patent/AU2008206317B2/en not_active Ceased
- 2008-01-15 EP EP08727696A patent/EP2076506B1/de active Active
- 2008-01-15 CA CA2675419A patent/CA2675419C/en not_active Expired - Fee Related
-
2009
- 2009-06-08 ZA ZA2009/03742A patent/ZA200903742B/en unknown
- 2009-07-07 IL IL199741A patent/IL199741A0/en unknown
- 2009-07-15 US US12/503,598 patent/US8110602B2/en active Active
-
2010
- 2010-12-14 HR HR20100691T patent/HRP20100691T1/hr unknown
- 2010-12-17 CY CY20101101169T patent/CY1111085T1/el unknown
-
2011
- 2011-02-17 AU AU2011200692A patent/AU2011200692B2/en not_active Ceased
- 2011-06-21 HK HK11106303.6A patent/HK1152296A1/xx not_active IP Right Cessation
-
2012
- 2012-01-12 US US13/349,522 patent/US8637502B2/en active Active
-
2013
- 2013-10-17 JP JP2013216047A patent/JP2014040467A/ja active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE482206T1 (de) | Heterozyklische substituierte piperidine als orl- 1-liganden | |
PH12013500913A1 (en) | Substituted-quinoxaline-type-piperidine compounds and the uses thereof | |
MY148657A (en) | Trpv1 antagonists and uses thereof | |
MY153948A (en) | Substituted-quinoxaline-type bridged-piperidine compounds and the uses thereof | |
PH12016501057A1 (en) | Pyrrolidinones as herbicides | |
ATE536349T1 (de) | In der 2-stellung durch phenyl substituierte 1h- benzimidazol-4-carbonsäureamide sind wirksame parp-inhibitoren | |
EA201001230A1 (ru) | Пестицидные смеси | |
BR112015002153A2 (pt) | composto heterocíclico parcialmente saturado contendo nitrogênio | |
EA201001234A1 (ru) | Пестицидные смеси | |
EA201000895A1 (ru) | Композиции и способы для лечения лизосомных болезней | |
SV2010003723A (es) | Derivados de piperidina 3,4-sustituida como inhibidores de renina | |
WO2008112647A3 (en) | Nitroxide radical as a treatment for neurodegeneration | |
WO2014102594A3 (en) | Substituted benzimidazole-type piperidine compounds and uses thereof | |
WO2014102592A3 (en) | Oxime/substituted quinoxaline-type piperidine compounds and uses thereof | |
DE602005010744D1 (de) | Piperazinylpyridinderivate als mittel gegen adipositas | |
WO2014020405A8 (en) | Cyclic urea- or lactam-substituted quinoxaline-type piperidine compounds and the uses thereof | |
ATE466841T1 (de) | 1-phenethylpiperidinderivate und ihre verwendung als opioidrezeptor-liganden | |
EA201170447A1 (ru) | Производные изохинолинона в качестве антагонистов nk3 | |
BRPI0916347A2 (pt) | compostos inseticidas de fenil ou piridil piperidina | |
ATE441647T1 (de) | N-amidderivate von 8-azabicycloä3.2.1üoct-3-yl als ccr1-antagonisten | |
EA200701813A1 (ru) | Новые амидозамещенные 6-фенилфенантридины | |
UA101954C2 (ru) | Замещенные ароматические гетероциклические соединения как фунгициды | |
MX2011003306A (es) | Ligandos nicotinicos de receptor de acetilcolina y los usos de los mismos. | |
WO2006138589A3 (en) | Opioid receptor ligands | |
UA97540C2 (ru) | Замещенные хиноксалином пиперидиновые соединения и их применение |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification |
Ref document number: 2076506 Country of ref document: EP |