EP1711484A4 - Synthese von cyanoiminobenzimidazolen - Google Patents

Synthese von cyanoiminobenzimidazolen

Info

Publication number
EP1711484A4
EP1711484A4 EP05726385A EP05726385A EP1711484A4 EP 1711484 A4 EP1711484 A4 EP 1711484A4 EP 05726385 A EP05726385 A EP 05726385A EP 05726385 A EP05726385 A EP 05726385A EP 1711484 A4 EP1711484 A4 EP 1711484A4
Authority
EP
European Patent Office
Prior art keywords
benzoimidazoles
cyanoimino
synthesis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP05726385A
Other languages
English (en)
French (fr)
Other versions
EP1711484A1 (de
Inventor
R Richard Goehring
John Whitehead
Bin Shao
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Euro Celtique SA
Original Assignee
Euro Celtique SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Euro Celtique SA filed Critical Euro Celtique SA
Publication of EP1711484A1 publication Critical patent/EP1711484A1/de
Publication of EP1711484A4 publication Critical patent/EP1711484A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
EP05726385A 2004-02-03 2005-02-02 Synthese von cyanoiminobenzimidazolen Withdrawn EP1711484A4 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US54139304P 2004-02-03 2004-02-03
PCT/US2005/002824 WO2005075459A1 (en) 2004-02-03 2005-02-02 Synthesis of cyanoimino-benzoimidazoles

Publications (2)

Publication Number Publication Date
EP1711484A1 EP1711484A1 (de) 2006-10-18
EP1711484A4 true EP1711484A4 (de) 2007-06-20

Family

ID=34837485

Family Applications (1)

Application Number Title Priority Date Filing Date
EP05726385A Withdrawn EP1711484A4 (de) 2004-02-03 2005-02-02 Synthese von cyanoiminobenzimidazolen

Country Status (5)

Country Link
US (1) US20080214827A1 (de)
EP (1) EP1711484A4 (de)
JP (1) JP2007520493A (de)
CA (1) CA2555219A1 (de)
WO (1) WO2005075459A1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1983992A4 (de) * 2006-01-19 2010-08-18 Abbott Lab 2-imino-benzimidazole
KR101227072B1 (ko) * 2007-01-16 2013-01-29 시오노기세이야쿠가부시키가이샤 Ｏｒｌ-1 리간드로서의 헤테로시클릭-치환 피페리딘
MX2010002449A (es) 2007-08-31 2010-09-07 Purdue Pharma Lp Compuestos de piperidina tipo quinoxalina sustituida y uso de los mismsos.
WO2010010458A1 (en) 2008-07-21 2010-01-28 Purdue Pharma L.P. Substituted-quinoxaline-type bridged-piperidine compounds and the uses thereof
EP2654751B1 (de) 2010-12-22 2016-11-23 Purdue Pharma L.P. Phosphorsubstituierte quinoxalin-piperidinverbindungen und verwendungen davon
AU2012324015A1 (en) 2011-12-01 2013-06-20 Purdue Pharma L.P. Azetidine-substituted quinoxaline-type piperidine compounds and uses thererof
US9085561B2 (en) 2012-07-30 2015-07-21 Purdue Pharma L.P. Cyclic urea- or lactam-substituted quinoxaline-type piperidines as ORL-1 modulators
US9963458B2 (en) 2012-12-27 2018-05-08 Purdue Pharma L.P. Indole and indoline-type piperidine compounds and uses thereof
US9951038B2 (en) 2012-12-27 2018-04-24 Purdue Pharma L.P. Quinazolin-4(3H)-one-type piperidine compounds and uses thereof
WO2014102592A2 (en) 2012-12-27 2014-07-03 Purdue Pharma L.P. Oxime/substituted quinoxaline-type piperidine compounds and uses thereof
US9090618B2 (en) 2012-12-27 2015-07-28 Purdue Pharma L.P. Substituted benzimidazole-type piperidine compounds and uses thereof
US10118927B2 (en) 2012-12-27 2018-11-06 Purdue Pharma L.P. Substituted piperidin-4-amino-type compounds and uses thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002085357A1 (en) * 2001-04-18 2002-10-31 Euro-Celtique, S.A. Nociceptin analogs

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1130386A (en) * 1965-11-26 1968-10-16 Sankyo Co Novel polyolefin stabilizers
US3737464A (en) * 1968-03-16 1973-06-05 Frosst & Co Charles E Deuterated paraformaldehyde process
JPS56164184A (en) * 1980-05-21 1981-12-17 Kyowa Hakko Kogyo Co Ltd Novel piperidine derivative
EP0029707B1 (de) * 1979-11-21 1984-02-01 Kyowa Hakko Kogyo Co., Ltd Piperidinderivate, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Zusammensetzungen
US4285878A (en) * 1980-01-31 1981-08-25 Smithkline Corporation N-Phenyl-N'-cyano-O-phenylisoureas
US4410528A (en) * 1980-05-16 1983-10-18 Kyowa Hakko Kogyo Co., Ltd. Hypotensive piperidine derivatives
JP3101770B2 (ja) * 1991-02-06 2000-10-23 日本化学工業株式会社 シアノイミノ置換複素環化合物の製造方法

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002085357A1 (en) * 2001-04-18 2002-10-31 Euro-Celtique, S.A. Nociceptin analogs

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
OBASE ET AL: "Synthesis of (1-substituted piperidin-4-yl)-1H-benzimidazoles and (1-substituted piperidin-4-yl)-3,4-dihydroquinazolines as possible antihypertensive agents", JOURNAL OF HETEROCYCLIC CHEMISTRY, HETEROCORPORATION. PROVO, US, vol. 20, no. 3, May 1983 (1983-05-01), pages 565 - 573, XP002333375, ISSN: 0022-152X *
See also references of WO2005075459A1 *

Also Published As

Publication number Publication date
JP2007520493A (ja) 2007-07-26
CA2555219A1 (en) 2005-08-18
US20080214827A1 (en) 2008-09-04
WO2005075459A1 (en) 2005-08-18
EP1711484A1 (de) 2006-10-18

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20060725

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU MC NL PL PT RO SE SI SK TR

DAX Request for extension of the european patent (deleted)
A4 Supplementary search report drawn up and despatched

Effective date: 20070518

RIC1 Information provided on ipc code assigned before grant

Ipc: C07D 401/04 20060101AFI20050824BHEP

Ipc: A61K 31/454 20060101ALI20070511BHEP

Ipc: A61K 31/4184 20060101ALI20070511BHEP

Ipc: A61P 29/00 20060101ALI20070511BHEP

Ipc: C07D 471/10 20060101ALI20070511BHEP

17Q First examination report despatched

Effective date: 20071116

R17C First examination report despatched (corrected)

Effective date: 20080218

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: EURO-CELTIQUE S.A.

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20090811