|
CN103265477B
(zh)
*
|
2003-02-26 |
2017-01-11 |
苏根公司 |
作为蛋白激酶抑制剂的氨基杂芳基化合物
|
|
US20060035907A1
(en)
*
|
2004-02-23 |
2006-02-16 |
Christensen James G |
Methods of treating abnormal cell growth using c-MET and m-TOR inhibitors
|
|
CN1906167A
(zh)
*
|
2004-02-27 |
2007-01-31 |
卫材株式会社 |
新型吡啶衍生物及嘧啶衍生物(2)
|
|
EP1732919A1
(en)
*
|
2004-03-30 |
2006-12-20 |
Chiron Corporation |
Substituted thiophene derivatives as anti-cancer agents
|
|
US8008301B2
(en)
|
2004-04-01 |
2011-08-30 |
Eli Lilly And Company |
Histamine H3 receptor agents, preparation and therapeutic uses
|
|
EP1735278B1
(en)
*
|
2004-04-01 |
2010-01-06 |
Eli Lilly And Company |
Histamine h3 receptor agents, preparation and therapeutic uses
|
|
AU2005277518B2
(en)
*
|
2004-08-23 |
2011-08-04 |
Eli Lilly And Company |
Histamine H3 receptor agents, preparation and therapeutic uses
|
|
ES2355923T3
(es)
*
|
2004-08-26 |
2011-04-01 |
Pfizer, Inc. |
Compuestos de aminoheteroarilo sustituidos con pirazol como inhibidores de proteina quinasa.
|
|
JP2008510792A
(ja)
*
|
2004-08-26 |
2008-04-10 |
ファイザー・インク |
タンパク質チロシンキナーゼ阻害剤としてのアミノヘテロアリール化合物
|
|
BRPI0514422A
(pt)
*
|
2004-08-26 |
2008-06-10 |
Pfizer |
biotransformação enantioseletiva para o preparo de intermediários do inibidor de proteìna tirosina quinase
|
|
KR100859891B1
(ko)
|
2004-08-26 |
2008-09-23 |
화이자 인코포레이티드 |
단백질 키나제 억제제로서 거울상이성질체적으로 순수한아미노헤테로아릴 화합물
|
|
GT200600042A
(es)
*
|
2005-02-10 |
2006-09-27 |
Aventis Pharma Inc |
Compuestos de bis arilo y heteroarilo sustituido como antagonistas selectivos de 5ht2a
|
|
EP1853610A1
(en)
*
|
2005-03-03 |
2007-11-14 |
Sirtris Pharmaceuticals, Inc. |
N-phenyl benzamide derivatives as sirtuin modulators
|
|
WO2006124748A2
(en)
*
|
2005-05-13 |
2006-11-23 |
Lexicon Genetics Incorporated |
Multicyclic compounds and methods of their use
|
|
US8088928B2
(en)
*
|
2005-08-04 |
2012-01-03 |
Sirtris Pharmaceuticals, Inc. |
Sirtuin modulating compounds
|
|
US8093401B2
(en)
*
|
2005-08-04 |
2012-01-10 |
Sirtris Pharmaceuticals, Inc. |
Sirtuin modulating compounds
|
|
US7855289B2
(en)
*
|
2005-08-04 |
2010-12-21 |
Sirtris Pharmaceuticals, Inc. |
Sirtuin modulating compounds
|
|
AU2006278397B2
(en)
*
|
2005-08-04 |
2013-01-17 |
Sirtris Pharmaceuticals, Inc. |
Oxazolopyridine derivatives as sirtuin modulators
|
|
TWI377198B
(en)
*
|
2005-08-24 |
2012-11-21 |
Eisai R&D Man Co Ltd |
Novel pyridine derivatives and pyrimidine derivatives (3)
|
|
US8217057B2
(en)
*
|
2005-12-05 |
2012-07-10 |
Pfizer Inc. |
Polymorphs of a c-MET/HGFR inhibitor
|
|
NZ568654A
(en)
*
|
2005-12-05 |
2012-02-24 |
Pfizer Prod Inc |
Method of treating abnormal cell growth
|
|
PE20070978A1
(es)
*
|
2006-02-14 |
2007-11-15 |
Novartis Ag |
COMPUESTOS HETEROCICLICOS COMO INHIBIDORES DE FOSFATIDILINOSITOL 3-QUINASAS (PI3Ks)
|
|
RU2008139599A
(ru)
|
2006-03-07 |
2010-04-20 |
Эррэй Биофарма Инк. (Us) |
Гетеробициклические производные пиразола и способы их применения
|
|
JP2009533327A
(ja)
*
|
2006-03-22 |
2009-09-17 |
バーテックス ファーマシューティカルズ インコーポレイテッド |
増殖性疾患を処置するためのc−METキナーゼ阻害剤
|
|
US8168383B2
(en)
|
2006-04-14 |
2012-05-01 |
Cell Signaling Technology, Inc. |
Gene defects and mutant ALK kinase in human solid tumors
|
|
EP2447360A1
(en)
|
2006-04-14 |
2012-05-02 |
Cell Signaling Technology, Inc. |
Gene defects and mutant ALK kinase in human solid tumors
|
|
US7601716B2
(en)
|
2006-05-01 |
2009-10-13 |
Cephalon, Inc. |
Pyridopyrazines and derivatives thereof as ALK and c-Met inhibitors
|
|
US20080045589A1
(en)
*
|
2006-05-26 |
2008-02-21 |
Susan Kelley |
Drug Combinations with Substituted Diaryl Ureas for the Treatment of Cancer
|
|
WO2007146824A2
(en)
*
|
2006-06-08 |
2007-12-21 |
Array Biopharma Inc. |
Quinoline compounds and methods of use
|
|
CA2660836A1
(en)
|
2006-08-07 |
2008-02-21 |
Incyte Corporation |
Triazolotriazines as kinase inhibitors
|
|
ATE535520T1
(de)
|
2006-08-23 |
2011-12-15 |
Eisai R&D Man Co Ltd |
Salz eines phenoxypyridinderivats oder kristall davon und verfahren zu dessen herstellung
|
|
US7790885B2
(en)
*
|
2006-08-31 |
2010-09-07 |
Eisai R&D Management Co., Ltd. |
Process for preparing phenoxypyridine derivatives
|
|
WO2008042867A2
(en)
*
|
2006-09-29 |
2008-04-10 |
Emiliem Inc. |
Modulators of multiple kinases
|
|
NZ576425A
(en)
|
2006-10-23 |
2012-04-27 |
Cephalon Inc |
Fused bicyclic derivatives of 2,4-diaminopyrimidine as alk and c-met inhibitors
|
|
GB0621607D0
(en)
*
|
2006-10-31 |
2006-12-06 |
Chroma Therapeutics Ltd |
Inhibitors of c-Met
|
|
AU2007323725B2
(en)
|
2006-11-22 |
2014-02-20 |
Incyte Holdings Corporation |
Imidazotriazines and imidazopyrimidines as kinase inhibitors
|
|
EP2121608B1
(en)
|
2006-12-14 |
2012-11-14 |
Bayer Intellectual Property GmbH |
Dihydropyridine derivatives useful as protein kinase inhibitors
|
|
ES2531002T3
(es)
*
|
2007-01-19 |
2015-03-09 |
Xcovery Inc |
Compuestos inhibidores de quinasa
|
|
JPWO2008087736A1
(ja)
*
|
2007-01-19 |
2010-05-06 |
宇部興産株式会社 |
アラルキルオキシ又はヘテロアラルキルオキシ基を有する芳香族アミンの製法
|
|
AU2008239594B2
(en)
|
2007-04-13 |
2013-10-24 |
Beth Israel Deaconess Medical Center |
Methods for treating cancer resistant to ErbB therapeutics
|
|
EP2134685B1
(en)
*
|
2007-04-16 |
2015-09-02 |
AbbVie Inc. |
7-nonsubstituted indole derivatives as mcl-1 inhibitors
|
|
US8263585B2
(en)
|
2007-05-04 |
2012-09-11 |
Novartis Ag |
Organic compounds
|
|
CL2008001822A1
(es)
*
|
2007-06-20 |
2009-03-13 |
Sirtris Pharmaceuticals Inc |
Compuestos derivados de tiazolo[5,4-b]piridina; composicion farmaceutica que comprende a dichos compuestos; y uso del compuesto en el tratamiento de la resistencia a la insulina, sindrome metabolico, diabetes, entre otras.
|
|
SG183036A1
(en)
|
2007-07-17 |
2012-08-30 |
Plexxikon Inc |
Compounds and methods for kinase modulation, and indications therefor
|
|
KR20100025006A
(ko)
*
|
2007-07-26 |
2010-03-08 |
노파르티스 아게 |
염증성 또는 알레르기성 질병의 치료에 유용한 피리미딘 유도체
|
|
CN101855342B
(zh)
|
2007-09-13 |
2013-07-10 |
科德克希思公司 |
用于还原苯乙酮的酮还原酶多肽
|
|
CN101868455B
(zh)
*
|
2007-10-23 |
2013-11-13 |
阿勒根公司 |
治疗性的取代的内酰胺
|
|
EA201070551A1
(ru)
*
|
2007-11-01 |
2010-12-30 |
Сертрис Фармасьютикалз, Инк. |
Сиртуинмодулирующие соединения
|
|
WO2009061453A1
(en)
*
|
2007-11-08 |
2009-05-14 |
Sirtris Pharmaceuticals, Inc. |
Solubilized thiazolopyridines
|
|
JP2009132660A
(ja)
*
|
2007-11-30 |
2009-06-18 |
Eisai R & D Management Co Ltd |
食道癌治療用組成物
|
|
WO2009073224A1
(en)
*
|
2007-12-07 |
2009-06-11 |
Ambit Biosciences Corp. |
Methods of treating certain diseases using pyrimidine derivatives
|
|
JP2009203226A
(ja)
*
|
2008-01-31 |
2009-09-10 |
Eisai R & D Management Co Ltd |
ピリジン誘導体およびピリミジン誘導体を含有するレセプターチロシンキナーゼ阻害剤
|
|
WO2009096198A1
(ja)
*
|
2008-02-01 |
2009-08-06 |
Pharma Ip Limited Liability Intermediary Corporations |
新規ビアリール誘導体
|
|
JP2011511005A
(ja)
*
|
2008-02-04 |
2011-04-07 |
オーエスアイ・フアーマスーテイカルズ・インコーポレーテツド |
2−アミノピリジン系キナーゼ阻害薬
|
|
AR070317A1
(es)
*
|
2008-02-06 |
2010-03-31 |
Osi Pharm Inc |
Furo (3,2-c) piridina y tieno (3,2-c) piridinas
|
|
EP2248810A4
(en)
*
|
2008-02-18 |
2011-05-25 |
Eisai R&D Man Co Ltd |
METHOD FOR PRODUCING A PHENOXYPYRIDINE DERIVATIVE
|
|
WO2009111644A2
(en)
*
|
2008-03-05 |
2009-09-11 |
The Regents Of The University Of Michigan |
Compositions and methods for diagnosing and treating pancreatic cancer
|
|
US8268834B2
(en)
|
2008-03-19 |
2012-09-18 |
Novartis Ag |
Pyrazine derivatives that inhibit phosphatidylinositol 3-kinase enzyme
|
|
FR2928924B1
(fr)
|
2008-03-21 |
2010-04-23 |
Sanofi Aventis |
Derives polysubstitues de 6-heteroaryle-imidazo°1,2-a! pyridines, leur preparation et leur application en therapeutique
|
|
FR2928922B1
(fr)
|
2008-03-21 |
2010-04-23 |
Sanofi Aventis |
Derives de 2-aryl-6-phenyl-imidazo°1,2-a!pyridines polysubstitues, leur preparation et leur application en therapeutique
|
|
FR2928923B1
(fr)
|
2008-03-21 |
2010-04-23 |
Sanofi Aventis |
Derives polysubstitues de 2-heteroaryl-6-phenyl-imidazo °1,2-a!pyridines, leur preparation et leur application en therapeutiques
|
|
US20110039860A1
(en)
*
|
2008-05-07 |
2011-02-17 |
Cangming Yang |
Soluble epoxide hydrolase inhibitors, compositions containing such compounds and methods of treatment
|
|
MX393622B
(es)
|
2008-05-21 |
2025-03-24 |
Incyte Corp |
Sales de 2-fluoro-n-metil-4-[7-(quinolin-6-il-metil)-imidazo[1,2-b][1,2,4]triazin-2-il]benzamida y procesos relacionados con la preparacion de las mismas.
|
|
MX2010014171A
(es)
|
2008-06-19 |
2011-07-04 |
Xcovery Holding Co Llc |
Compuestos de piridazin-carboxamida sustituida como compuestos inhibidores de cinasa.
|
|
EP2321433A2
(en)
*
|
2008-08-29 |
2011-05-18 |
F. Hoffmann-La Roche AG |
Diagnostics and treatments for vegf-independent tumors
|
|
WO2010046780A2
(en)
*
|
2008-10-22 |
2010-04-29 |
Institut Pasteur Korea |
Anti viral compounds
|
|
AT507187B1
(de)
|
2008-10-23 |
2010-03-15 |
Helmut Dr Buchberger |
Inhalator
|
|
JP2012509342A
(ja)
*
|
2008-11-20 |
2012-04-19 |
オーエスアイ・フアーマスーテイカルズ・インコーポレーテツド |
置換ピロロ[2,3−b]−ピリジンおよび−ピラジン
|
|
WO2010077624A1
(en)
*
|
2008-12-09 |
2010-07-08 |
Merck Sharp & Dohme Corp. |
Biaryl carboxamides
|
|
MX2011006555A
(es)
|
2008-12-19 |
2011-08-03 |
Sirtris Pharmaceuticals Inc |
Compuestos de tiazolopiridina moduladores de sirtuina.
|
|
SI3354650T1
(sl)
|
2008-12-19 |
2022-06-30 |
Vertex Pharmaceuticals Incorporated |
Spojine, uporabne kot zaviralci ATR kinaze
|
|
JP2012102018A
(ja)
*
|
2009-03-03 |
2012-05-31 |
Astellas Pharma Inc |
アミド化合物
|
|
TW201100441A
(en)
*
|
2009-06-01 |
2011-01-01 |
Osi Pharm Inc |
Amino pyrimidine anticancer compounds
|
|
DE102009056886A1
(de)
|
2009-12-03 |
2011-06-09 |
Bayer Schering Pharma Aktiengesellschaft |
cMet-Inhibitoren zur Behandlung der Endometriose
|
|
EP2531509B1
(en)
|
2010-02-03 |
2016-10-05 |
Incyte Holdings Corporation |
Imidazo[1,2-b][1,2,4]triazines as c-met inhibitors
|
|
CA2796967C
(en)
*
|
2010-05-04 |
2015-12-01 |
Pfizer Inc. |
Heterocyclic derivatives as alk inhibitors
|
|
AU2011253025A1
(en)
|
2010-05-12 |
2012-11-29 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of ATR kinase
|
|
EP2569287B1
(en)
|
2010-05-12 |
2014-07-09 |
Vertex Pharmaceuticals Inc. |
Compounds useful as inhibitors of atr kinase
|
|
JP2013529200A
(ja)
*
|
2010-05-12 |
2013-07-18 |
バーテックス ファーマシューティカルズ インコーポレイテッド |
Atrキナーゼ阻害剤として有用な化合物
|
|
US20130072495A1
(en)
|
2010-05-14 |
2013-03-21 |
OSI Pharmaceuticals, LLC |
Fused bicyclic kinase inhibitors
|
|
AR081039A1
(es)
|
2010-05-14 |
2012-05-30 |
Osi Pharmaceuticals Llc |
Inhibidores biciclicos fusionados de quinasa
|
|
US10420665B2
(en)
|
2010-06-13 |
2019-09-24 |
W. L. Gore & Associates, Inc. |
Intragastric device for treating obesity
|
|
US9526648B2
(en)
|
2010-06-13 |
2016-12-27 |
Synerz Medical, Inc. |
Intragastric device for treating obesity
|
|
US8628554B2
(en)
|
2010-06-13 |
2014-01-14 |
Virender K. Sharma |
Intragastric device for treating obesity
|
|
US10010439B2
(en)
|
2010-06-13 |
2018-07-03 |
Synerz Medical, Inc. |
Intragastric device for treating obesity
|
|
AU2011270165B2
(en)
|
2010-06-25 |
2015-12-24 |
Eisai R&D Management Co., Ltd. |
Antitumor agent using compounds having kinase inhibitory effect in combination
|
|
US9120752B2
(en)
|
2010-07-16 |
2015-09-01 |
Purdue Pharma, L.P. |
Pyridine compounds as sodium channel blockers
|
|
WO2012042421A1
(en)
|
2010-09-29 |
2012-04-05 |
Pfizer Inc. |
Method of treating abnormal cell growth
|
|
AU2011311814B2
(en)
|
2010-10-08 |
2016-12-22 |
Xcovery Holdings, Inc. |
Substituted pyridazine carboxamide compounds
|
|
JP6000273B2
(ja)
|
2010-11-29 |
2016-09-28 |
オーエスアイ・ファーマシューティカルズ,エルエルシー |
大環状キナーゼ阻害剤
|
|
GB201021103D0
(en)
|
2010-12-13 |
2011-01-26 |
Univ Leuven Kath |
New compounds for the treatment of neurodegenerative diseases
|
|
PL2672847T3
(pl)
|
2011-02-11 |
2015-10-30 |
Batmark Ltd |
Część składowa inhalatora
|
|
MX2013009551A
(es)
*
|
2011-02-24 |
2013-09-06 |
Jiangsu Hanson Pharmaceutical Co Ltd |
Compuestos que contienen fosforo como inhibidores de proteina cinasa.
|
|
US9145390B2
(en)
|
2011-03-03 |
2015-09-29 |
Concert Pharmaceuticals, Inc. |
Derivatives of pyrazole-substituted amino-heteroaryl compounds
|
|
JO3438B1
(ar)
*
|
2011-04-13 |
2019-10-20 |
Epizyme Inc |
مركبات بنزين مستبدلة بأريل أو أريل غير متجانس
|
|
US20140113824A1
(en)
|
2011-05-10 |
2014-04-24 |
Bayer Intellectual Property Gmbh |
Bicyclic (thio)carbonylamidines
|
|
JP2014513724A
(ja)
|
2011-05-16 |
2014-06-05 |
オーエスアイ・ファーマシューティカルズ,エルエルシー |
融合二環キナーゼ阻害剤
|
|
JP2014517079A
(ja)
|
2011-06-22 |
2014-07-17 |
バーテックス ファーマシューティカルズ インコーポレイテッド |
Atrキナーゼ阻害剤として有用な化合物
|
|
JP6062432B2
(ja)
*
|
2011-07-27 |
2017-01-18 |
ナンジン アルゲン ファルマ カンパニー リミテッドNanjing Allgen Pharma Co. Ltd. |
プロテインキナーゼ阻害薬用スピロ環状分子
|
|
RU2014102935A
(ru)
|
2011-08-02 |
2015-09-10 |
Пфайзер Инк. |
Кризотиниб для применения в лечении рака
|
|
BR112014007690B1
(pt)
|
2011-09-30 |
2022-10-04 |
Vertex Pharmaceuticals Incorporated |
Usos de inibidores de atr no tratamento de câncer pancreático e câncer de pulmão de células não pequenas
|
|
JP6212045B2
(ja)
|
2011-09-30 |
2017-10-11 |
バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated |
Atrキナーゼの阻害剤として有用な化合物を作製するためのプロセス
|
|
AP2014007881A0
(en)
|
2012-03-06 |
2014-08-31 |
Pfizer |
Macrocyclic derivatives for the treatment of proliferative diseases
|
|
WO2013136170A1
(en)
|
2012-03-16 |
2013-09-19 |
Purdue Pharma L.P. |
Substituted pyridines as sodium channel blockers
|
|
DK2833973T3
(en)
|
2012-04-05 |
2018-01-02 |
Vertex Pharma |
Compounds useful as ATR kinase inhibitors and combination therapies thereof
|
|
WO2013152252A1
(en)
|
2012-04-06 |
2013-10-10 |
OSI Pharmaceuticals, LLC |
Combination anti-cancer therapy
|
|
RU2699546C2
(ru)
*
|
2012-04-13 |
2019-09-06 |
Эпизайм, Инк. |
Комбинированная терапия для лечения рака
|
|
CN103387535B
(zh)
*
|
2012-05-10 |
2016-06-01 |
广东东阳光药业有限公司 |
取代的炔基吡啶化合物及其使用方法和用途
|
|
WO2013177092A1
(en)
*
|
2012-05-23 |
2013-11-28 |
Sunshine Lake Pharma Co., Ltd. |
Substituted alkynyl pyridine compounds and methods of use
|
|
MX367055B
(es)
|
2012-06-26 |
2019-08-02 |
Del Mar Pharmaceuticals |
El uso de una composición que comprende dianhidrogalactitol, diacetildianhidrogalactitol, y dibromodulcitol, y análogos o derivados de cada uno para el tratamiento de malignidades resistentes a inhibidores de tirosina cinasa.
|
|
GB201211310D0
(en)
*
|
2012-06-26 |
2012-08-08 |
Chroma Therapeutics Ltd |
CSF-1R kinase inhibitors
|
|
CN104603620B
(zh)
|
2012-09-24 |
2018-02-23 |
文塔纳医疗系统公司 |
使用间变性淋巴瘤激酶(alk)作为标志物鉴定治疗响应性非小细胞肺癌的方法
|
|
US8999632B2
(en)
|
2012-10-04 |
2015-04-07 |
Vertex Pharmaceuticals Incorporated |
Method for measuring ATR inhibition mediated increases in DNA damage
|
|
WO2014081816A1
(en)
*
|
2012-11-21 |
2014-05-30 |
Concert Pharmaceuticals, Inc. |
Fluoro-derivatives of pyrazole-substituted amino-heteroaryl compounds
|
|
EP3418281B1
(en)
|
2012-12-07 |
2020-09-30 |
Vertex Pharmaceuticals Inc. |
Pyrazolo[1,5-a]pyrimidines useful as inhibitors of atr kinase for the treatment of cancer diseases
|
|
US9714252B2
(en)
|
2012-12-20 |
2017-07-25 |
Purdue Pharma L.P. |
Cyclic sulfonamides as sodium channel blockers
|
|
JPWO2014098176A1
(ja)
|
2012-12-21 |
2017-01-12 |
エーザイ・アール・アンド・ディー・マネジメント株式会社 |
キノリン誘導体のアモルファス及びその製造方法
|
|
EP2952510B1
(en)
*
|
2013-02-02 |
2018-12-26 |
Chia Tai Tianqing Pharmaceutical Group Co.,Ltd |
Substituted 2-aminopyridine protein kinase inhibitor
|
|
EP2970286A1
(en)
|
2013-03-15 |
2016-01-20 |
Vertex Pharmaceuticals Inc. |
Fused pyrazolopyrimidine derivatives useful as inhibitors of atr kinase
|
|
CN105492011A
(zh)
|
2013-04-08 |
2016-04-13 |
丹尼斯·M·布朗 |
不理想给药化学化合物的治疗增效
|
|
CN105264380B
(zh)
|
2013-05-14 |
2017-09-05 |
卫材R&D管理有限公司 |
用于预测和评价子宫内膜癌受试者对乐伐替尼化合物响应性的生物标志
|
|
WO2015034729A1
(en)
*
|
2013-09-05 |
2015-03-12 |
Calitor Sciences, Llc |
Substituted pyridine compounds and methods of use
|
|
WO2015036898A2
(en)
*
|
2013-09-10 |
2015-03-19 |
Shilpa Medicare Limited |
Novel salts of crizotinib and their preparation
|
|
RU2550346C2
(ru)
|
2013-09-26 |
2015-05-10 |
Общество с ограниченной ответственностью "Отечественные Фармацевтические Технологии" ООО"ФармТех" |
Новые химические соединения (варианты) и их применение для лечения онкологических заболеваний
|
|
RU2643361C2
(ru)
|
2013-09-30 |
2018-02-01 |
Кореа Рисёч Инститьют Оф Кемикал Текнолоджи |
Новые производные триазолопиразина и их применение
|
|
WO2015069922A2
(en)
|
2013-11-06 |
2015-05-14 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Alk antibodies, conjugates, and chimeric antigen receptors, and their use
|
|
EP3077397B1
(en)
|
2013-12-06 |
2019-09-18 |
Vertex Pharmaceuticals Inc. |
2-amino-6-fluoro-n-[5-fluoro-pyridin-3-yl]pyrazolo[1,5-a]pyrimidin-3-carboxamide compound useful as atr kinase inhibitor, its preparation, different solid forms and radiolabelled derivatives thereof
|
|
CA2934251C
(en)
|
2013-12-20 |
2024-01-02 |
3-V Biosciences, Inc. |
A combination of heterocyclic modulators of lipid synthesis and chemotherapeutic drugs in treatment of cancer
|
|
CN103755627B
(zh)
*
|
2014-01-09 |
2016-02-17 |
定陶县友帮化工有限公司 |
2-氨基-3-羟基-5-氯吡啶的合成方法
|
|
TWI672141B
(zh)
|
2014-02-20 |
2019-09-21 |
美商醫科泰生技 |
投予ros1突變癌細胞之分子
|
|
CA2943329A1
(en)
|
2014-03-24 |
2015-10-01 |
Genentech, Inc. |
Cancer treatment with c-met antagonists and correlation of the latter with hgf expression
|
|
US10730866B2
(en)
|
2014-04-07 |
2020-08-04 |
Purdue Pharma L.P. |
Indole derivatives and use thereof
|
|
US10052332B2
(en)
|
2014-04-29 |
2018-08-21 |
Emory University |
Prostaglandin receptor EP2 antagonists, derivatives, compositions, and uses related thereto
|
|
WO2015172747A1
(en)
*
|
2014-05-16 |
2015-11-19 |
Zhaoyin Wang |
Spirocyclic molecules as mth1 inhibitors
|
|
ES2777608T3
(es)
|
2014-06-05 |
2020-08-05 |
Vertex Pharma |
Derivados radiomarcados de un compuesto de 2-amino-6-fluoro-N-[5-fluoro-piridin-3-il]-pirazolo[1,5-a]pirimidin-3-carboxamida útiles como inhibidores de ATR cinasa, la preparación de dicho compuesto y diferentes formas sólidas del mismo
|
|
CA2950780C
(en)
|
2014-06-17 |
2023-05-16 |
Vertex Pharmaceuticals Incorporated |
Method for treating cancer using a combination of chk1 and atr inhibitors
|
|
WO2016019909A1
(zh)
*
|
2014-08-07 |
2016-02-11 |
江苏豪森药业股份有限公司 |
一种抗癌化合物的新晶型及其制备方法和用途
|
|
CN107108581B
(zh)
|
2014-08-21 |
2020-06-23 |
百时美施贵宝公司 |
作为强效rock抑制剂的回接苯甲酰胺衍生物
|
|
SMT202200367T1
(it)
|
2014-08-28 |
2022-11-18 |
Eisai R&D Man Co Ltd |
Derivato di chinolina a elevata purezza e metodo per la produzione dello stesso
|
|
MX389198B
(es)
*
|
2014-10-13 |
2025-03-20 |
Atrin Pharmaceuticals LLC |
Inhibidores de proteína-cinasas relacionados a ataxia-telengiectasia y rad3 (atr).
|
|
GB2535427A
(en)
|
2014-11-07 |
2016-08-24 |
Nicoventures Holdings Ltd |
Solution
|
|
AR102537A1
(es)
*
|
2014-11-05 |
2017-03-08 |
Flexus Biosciences Inc |
Agentes inmunomoduladores
|
|
ES2928502T3
(es)
|
2014-11-07 |
2022-11-18 |
Univ Michigan Regents |
Inhibidores de la transcripción génica mediada por el factor de transcripción relacionado con la miocardina y el factor de respuesta sérica (MRTF/SRF) y métodos para el uso de los mismos
|
|
EP3227276B1
(en)
|
2014-12-02 |
2021-09-01 |
Ignyta, Inc. |
Combinations for the treatment of neuroblastoma
|
|
CN107530430A
(zh)
|
2015-01-13 |
2018-01-02 |
国立大学法人京都大学 |
用于预防和/或治疗肌萎缩性侧索硬化症的药剂
|
|
MA41598A
(fr)
*
|
2015-02-25 |
2018-01-02 |
Constellation Pharmaceuticals Inc |
Composés thérapeutiques de pyridazine et leurs utilisations
|
|
CA2976325C
(en)
|
2015-02-25 |
2023-07-04 |
Eisai R&D Management Co., Ltd. |
Method for suppressing bitterness of quinoline derivative
|
|
KR102662228B1
(ko)
|
2015-03-04 |
2024-05-02 |
머크 샤프 앤드 돔 코포레이션 |
암을 치료하기 위한 pd-1 길항제 및 vegfr/fgfr/ret 티로신 키나제 억제제의 조합
|
|
KR20180011843A
(ko)
|
2015-06-11 |
2018-02-02 |
바실리어 파마슈티카 인터내셔널 리미티드 |
유출-펌프 억제제 및 이의 치료적 용도
|
|
CN107801379B
(zh)
|
2015-06-16 |
2021-05-25 |
卫材R&D管理有限公司 |
抗癌剂
|
|
US10405627B2
(en)
*
|
2015-07-14 |
2019-09-10 |
Michael Charles Boland, III |
Luggage with fold out table
|
|
AU2016309356B2
(en)
|
2015-08-20 |
2021-06-24 |
Eisai R&D Management Co., Ltd. |
Tumor therapeutic agent
|
|
WO2017059357A1
(en)
|
2015-09-30 |
2017-04-06 |
Vertex Pharmaceuticals Incorporated |
Method for treating cancer using a combination of dna damaging agents and atr inhibitors
|
|
GB2542838B
(en)
|
2015-10-01 |
2022-01-12 |
Nicoventures Trading Ltd |
Aerosol provision system
|
|
CA3008663A1
(en)
|
2015-12-18 |
2017-06-22 |
Ignyta, Inc. |
Combinations of a selective tyrosine kinase inhibitor (tki) with a mek or erk inhibitor for the treatment of cancer
|
|
WO2017161004A1
(en)
*
|
2016-03-15 |
2017-09-21 |
University Of South Florida |
PKCδ INHIBITOR FORMULATIONS AND USES THEREOF CROSS-REFERENCE TO RELATED APPLICATIONS
|
|
WO2017180723A1
(en)
|
2016-04-12 |
2017-10-19 |
Atrin Pharmaceuticals LLC |
Ataxia telengiectasia and rad3-related (atr) inhibitors and methods of their use
|
|
US10779980B2
(en)
|
2016-04-27 |
2020-09-22 |
Synerz Medical, Inc. |
Intragastric device for treating obesity
|
|
US10933068B2
(en)
*
|
2016-05-26 |
2021-03-02 |
Sonic Master Limited |
Modulators of DUX4 for regulation of muscle function
|
|
TWI646094B
(zh)
*
|
2016-06-01 |
2019-01-01 |
大陸商貝達藥業股份有限公司 |
Crystal form of inhibitory protein kinase active compound and application thereof
|
|
WO2018110669A1
(en)
|
2016-12-15 |
2018-06-21 |
Ono Pharmaceutical Co., Ltd. |
Activator of trek (twik related k+ channels) channels
|
|
CN106866627B
(zh)
*
|
2017-01-24 |
2021-09-14 |
南方医科大学 |
3-(1-(氨基吡啶氧基)乙基)苯甲酰胺衍生物及其合成方法和应用
|
|
ES2971448T3
(es)
|
2017-02-08 |
2024-06-05 |
Eisai R&D Man Co Ltd |
Composición farmacéutica para el tratamiento de tumores
|
|
CA3061888A1
(en)
|
2017-05-16 |
2018-11-22 |
Eisai R&D Management Co., Ltd. |
Treatment of hepatocellular carcinoma
|
|
JP2020527588A
(ja)
|
2017-07-18 |
2020-09-10 |
ニューベイション・バイオ・インコーポレイテッドNuvation Bio Inc. |
アデノシンアンタゴニストとしてのヘテロ環式化合物
|
|
KR20200040764A
(ko)
|
2017-07-18 |
2020-04-20 |
누베이션 바이오 인크. |
1,8-나프티리디논 화합물 및 그의 용도
|
|
WO2019018570A1
(en)
|
2017-07-19 |
2019-01-24 |
Ignyta, Inc. |
PHARMACEUTICAL COMPOSITIONS CONTAINING ENTRECTINIB
|
|
JP7311498B2
(ja)
|
2017-10-17 |
2023-07-19 |
イグナイタ インコーポレイテッド |
薬学的組成物および剤形
|
|
CN107794282B
(zh)
*
|
2017-11-20 |
2020-12-25 |
浙江工业大学 |
一种克唑替尼手性中间体的制备方法及菌株
|
|
WO2019154665A1
(en)
*
|
2018-02-07 |
2019-08-15 |
Basf Se |
New pyridine carboxamides
|
|
AU2019233207B2
(en)
*
|
2018-03-15 |
2021-05-27 |
Fujian Haixi Pharmaceuticals Co., Ltd |
Heteroaryl compounds as kinase inhibitor
|
|
CN110372664A
(zh)
*
|
2018-04-13 |
2019-10-25 |
华东理工大学 |
选择性jak2抑制剂及其应用
|
|
WO2019206049A1
(en)
*
|
2018-04-25 |
2019-10-31 |
Zhuhai Yufan Biotechnologies Co., Ltd |
Hpk1 inhibitors, preparation method and application thereof
|
|
CN110396088B
(zh)
*
|
2018-04-25 |
2024-03-12 |
珠海宇繁生物科技有限责任公司 |
Hpk1激酶抑制剂、制备方法及其应用
|
|
CN108947895B
(zh)
*
|
2018-08-22 |
2021-09-24 |
肇庆中彩机电技术研发有限公司 |
一种抗癌活性的化合物
|
|
JP2022517418A
(ja)
*
|
2019-01-18 |
2022-03-08 |
ニューベイション・バイオ・インコーポレイテッド |
アデノシンアンタゴニストとしてのヘテロ環式化合物
|
|
EP3911324A4
(en)
|
2019-01-18 |
2022-08-17 |
Nuvation Bio Inc. |
1,8-NAPHTHYRIDINONE COMPOUNDS AND THEIR USES
|
|
KR20210116550A
(ko)
|
2019-01-18 |
2021-09-27 |
누베이션 바이오 인크. |
아데노신 길항제로서의 헤테로시클릭 화합물
|
|
WO2020191208A1
(en)
|
2019-03-20 |
2020-09-24 |
Emory University |
Prostaglandin receptor ep2 antagonists, derivatives, and uses related thereto
|
|
EP3844166B1
(en)
|
2019-05-14 |
2023-07-12 |
Teligene Ltd |
Substituted macrocycles useful as kinase inhibitors
|
|
KR102426921B1
(ko)
*
|
2019-09-24 |
2022-07-29 |
주식회사 이노보테라퓨틱스 |
헤테로아릴아미도피리딘올 유도체 및 이를 유효성분으로 포함하는 자가면역질환의 예방 또는 치료용 약학적 조성물
|
|
CN112552293A
(zh)
*
|
2019-09-25 |
2021-03-26 |
珠海宇繁生物科技有限责任公司 |
一种protac小分子化合物及其应用
|
|
KR102344185B1
(ko)
*
|
2020-02-26 |
2021-12-27 |
계명대학교 산학협력단 |
신규한 Pim 키나아제 억제제 및 이의 용도
|
|
WO2021196655A1
(zh)
*
|
2020-04-03 |
2021-10-07 |
中国药科大学 |
含苯并咪唑结构的化合物及其制备方法与用途
|
|
CN113493437B
(zh)
*
|
2020-04-03 |
2022-07-26 |
中国药科大学 |
含苯并咪唑结构的化合物及其制备方法和用途
|
|
EP4433445A1
(en)
*
|
2021-11-15 |
2024-09-25 |
The Broad Institute, Inc. |
Compounds, compositions, and methods for inducing antimicrobial intracellular activity and for preventing and treating microbial infections
|
|
IL317839A
(en)
|
2022-07-04 |
2025-02-01 |
Chugai Pharmaceutical Co Ltd |
Combination drug
|
|
CN119789871A
(zh)
|
2022-08-30 |
2025-04-08 |
中外制药株式会社 |
并用药物
|