DK1330452T3 - Pyrazinderivater som modulatorer af tyrosinkinaser - Google Patents

Pyrazinderivater som modulatorer af tyrosinkinaser

Info

Publication number
DK1330452T3
DK1330452T3 DK01975243T DK01975243T DK1330452T3 DK 1330452 T3 DK1330452 T3 DK 1330452T3 DK 01975243 T DK01975243 T DK 01975243T DK 01975243 T DK01975243 T DK 01975243T DK 1330452 T3 DK1330452 T3 DK 1330452T3
Authority
DK
Denmark
Prior art keywords
modulators
tyrosine kinases
pyrazine derivatives
pyrazine
derivatives
Prior art date
Application number
DK01975243T
Other languages
English (en)
Inventor
Gee Hong Kuo
Peter Connolly
Catherine Prouty
Alan Deangelis
Aihua Wang
Linda Jolliffe
Steve Middleton
Stuart Emanuel
Original Assignee
Ortho Mcneil Janssen Pharm
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22879359&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1330452(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ortho Mcneil Janssen Pharm filed Critical Ortho Mcneil Janssen Pharm
Application granted granted Critical
Publication of DK1330452T3 publication Critical patent/DK1330452T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
DK01975243T 2000-09-20 2001-09-19 Pyrazinderivater som modulatorer af tyrosinkinaser DK1330452T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23396800P 2000-09-20 2000-09-20
PCT/US2001/029175 WO2002024681A2 (en) 2000-09-20 2001-09-19 Pyrazine derivatives as modulators of tyrosine kinases

Publications (1)

Publication Number Publication Date
DK1330452T3 true DK1330452T3 (da) 2009-03-16

Family

ID=22879359

Family Applications (1)

Application Number Title Priority Date Filing Date
DK01975243T DK1330452T3 (da) 2000-09-20 2001-09-19 Pyrazinderivater som modulatorer af tyrosinkinaser

Country Status (14)

Country Link
US (1) US6710048B2 (da)
EP (1) EP1330452B1 (da)
JP (1) JP2004523474A (da)
AR (1) AR035494A1 (da)
AT (1) ATE415396T1 (da)
AU (1) AU9458401A (da)
CA (1) CA2423050A1 (da)
DE (1) DE60136731D1 (da)
DK (1) DK1330452T3 (da)
ES (1) ES2315308T3 (da)
HK (1) HK1054393B (da)
PT (1) PT1330452E (da)
TW (1) TWI254711B (da)
WO (1) WO2002024681A2 (da)

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US20040087548A1 (en) 2001-02-27 2004-05-06 Salvati Mark E. Fused cyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
PL206962B1 (pl) * 2001-12-19 2010-10-29 Bristol Myers Squibb Co Związek heterocykliczny o budowie skondensowanej
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AUPS251402A0 (en) * 2002-05-23 2002-06-13 Cytopia Pty Ltd Kinase inhibitors
WO2004000318A2 (en) * 2002-06-21 2003-12-31 Cellular Genomics, Inc. Certain amino-substituted monocycles as kinase modulators
GB0215775D0 (en) * 2002-07-06 2002-08-14 Astex Technology Ltd Pharmaceutical compounds
ES2378987T3 (es) * 2002-08-06 2012-04-19 Toray Industries, Inc. Remedio o agente preventivo para una enfermedad renal y procedimiento para diagnosticar una enfermedad renal
US8030336B2 (en) * 2002-12-13 2011-10-04 Ym Biosciences Australia Pty Ltd Nicotinamide-based kinase inhibitors
US20040121968A1 (en) * 2002-12-23 2004-06-24 Alexander Ljubimov Antiangiogenesis by inhibiting protein kinase CK2 activity
ES2401330T3 (es) * 2003-02-26 2013-04-18 Sugen, Inc. Compuesto de heteroarilamino inhibidores de proteín quinasas
GB2400101A (en) * 2003-03-28 2004-10-06 Biofocus Discovery Ltd Compounds capable of binding to the active site of protein kinases
CA2530389A1 (en) * 2003-07-02 2005-01-13 Biofocus Discovery Limited Pyrazine and pyridine derivatives as rho kinase inhibitors
US7390907B2 (en) 2003-09-30 2008-06-24 Amgen Inc. Vanilloid receptor ligands and their use in treatments
CA2545992A1 (en) * 2003-11-24 2005-06-16 F. Hoffmann-La Roche Ag Pyrazolyl and imidazolyl pyrimidines
EP1694670A1 (en) * 2003-12-16 2006-08-30 GPC Biotech AG Pyrazine derivatives as effective compounds against infectious diseases
WO2005072826A2 (en) 2004-01-21 2005-08-11 Emory University Compositions and use of tyrosine kinase inhibitors to treat pathogenic infection
WO2006051311A1 (en) * 2004-11-12 2006-05-18 Galapagos Nv Nitrogen heteroaromatic compounds which bind to the active site of protein kinase enzymes
GB0428082D0 (en) 2004-12-22 2005-01-26 Welcome Trust The Ltd Therapeutic compounds
GB0500226D0 (en) * 2005-01-07 2005-02-16 Biofocus Discovery Ltd Compounds which bind to the active site of protein kinase enzymes
KR100674813B1 (ko) * 2005-08-05 2007-01-29 일양약품주식회사 Ｎ-페닐-2-피리미딘-아민 유도체 및 그의 제조방법
US9296697B2 (en) 2005-08-24 2016-03-29 Abbott Laboratories Hetaryl-substituted guanidine compounds and use thereof as binding partners for 5-HT5-receptors
GT200600411A (es) * 2005-09-13 2007-05-21 Novartis Ag Combinaciones que comprenden un inhibidor del receptor del factor de crecimiento endotelial vascular
WO2008070350A2 (en) * 2006-10-27 2008-06-12 The Board Of Regents Of The University Of Texas System Methods and compositions related to wrapping of dehydrons
JP2010526856A (ja) * 2007-05-16 2010-08-05 バイエル・クロツプサイエンス・エス・アー 殺菌剤フェニル−ピリミジニル−アミノ誘導体
WO2009037247A1 (en) * 2007-09-17 2009-03-26 Neurosearch A/S Pyrazine derivatives and their use as potassium channel modulators
KR100898037B1 (ko) * 2007-10-05 2009-06-01 한국화학연구원 금속촉매의 커플링반응에 의한 트리알킬피라진 유도체의제조방법
EP2288607B1 (en) 2008-06-09 2014-09-24 Sanofi Sulfonamides with heterocycle and oxadiazolone headgroup, processes for their preparation and their use as pharmaceuticals
US20110112121A1 (en) * 2009-07-06 2011-05-12 Joerg Berghausen Pharmaceutical Compositions and Solid Forms
US8415381B2 (en) 2009-07-30 2013-04-09 Novartis Ag Heteroaryl compounds and their uses
ES2608670T3 (es) * 2009-08-17 2017-04-12 Memorial Sloan-Kettering Cancer Center Derivados de 2-(pirimidin-5-il)-tiopirimidina como moduladores de Hsp70 y Hsc70 para el tratamiento de trastornos proliferativos
BR112012004836A2 (pt) * 2009-09-04 2019-09-24 Novartis Ag pirazinilpiridinas úteis para o tratamento de doenças proliferativas
US20110185353A1 (en) * 2010-01-27 2011-07-28 Jack Matthew Mitigating Problems Arising From Incompatible Software
JP2013542967A (ja) * 2010-11-17 2013-11-28 ノバルティス アーゲー ３−（アミノアリール）−ピリジン化合物
CN103339110A (zh) * 2011-01-28 2013-10-02 诺瓦提斯公司 作为cdk9抑制剂的取代的杂-联芳基化合物及其用途
CA2840883C (en) * 2011-07-07 2019-07-16 Merck Patent Gmbh Substituted azaheterocycles
EP2922828B1 (en) 2012-11-21 2020-07-08 PTC Therapeutics, Inc. 4,6-diamino-pyrimidine derivatives as bmi-1 inhibitors for treating cancer
EA034866B1 (ru) 2013-08-30 2020-03-31 ПиТиСи ТЕРАПЬЮТИКС, ИНК. Замещенные пиримидиновые ингибиторы bmi-1
EP3071553A4 (en) * 2013-11-21 2017-08-02 PTC Therapeutics, Inc. Substituted pyridine and pyrazine bmi-1 inhibitors
TWI699204B (zh) 2014-05-13 2020-07-21 美國紀念斯隆 凱特琳癌症中心 Ｈｓｐ７０調節子及其製造及使用方法
KR102638678B1 (ko) 2017-03-27 2024-02-19 카듀리온 파마슈티칼스, 인크. 헤테로시클릭 화합물
GB201715318D0 (en) 2017-09-22 2017-11-08 Syngenta Participations Ag Improvements in or relating to organic compounds
GB201715414D0 (en) * 2017-09-22 2017-11-08 Syngenta Participations Ag Improvements in or relating to organic compounds
CA3114198A1 (en) 2018-09-25 2020-04-02 Cardurion Pharmaceuticals, Llc Aminopyrimidine compound
KR20230051500A (ko) 2020-07-15 2023-04-18 키에시 파르마슈티시 엣스. 피. 에이. Alk5 억제제로서 피리다진일 아미노 유도체
EP4216948A1 (en) 2020-09-28 2023-08-02 Cardurion Pharmaceuticals, Inc. Fused heteroaryl compounds and their use as camkii inhibitors
WO2023046698A1 (en) 2021-09-21 2023-03-30 Chiesi Farmaceutici S.P.A. Pyridazinyl amino derivatives as alk5 inhibitors
WO2023135107A1 (en) 2022-01-11 2023-07-20 Chiesi Farmaceutici S.P.A. Pyridazinyl amino derivatives as alk5 inhibitors

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HUP0301573A3 (en) * 2000-02-16 2004-03-29 Neurogen Corp Branford Substituted arylpyrazines, pharmaceutical compositions containing them and their use

Also Published As

Publication number Publication date
WO2002024681A3 (en) 2002-06-20
US20030060629A1 (en) 2003-03-27
AU9458401A (en) 2002-04-02
CA2423050A1 (en) 2002-03-28
EP1330452B1 (en) 2008-11-26
EP1330452A2 (en) 2003-07-30
ATE415396T1 (de) 2008-12-15
PT1330452E (pt) 2009-01-22
HK1054393B (zh) 2009-08-28
WO2002024681A2 (en) 2002-03-28
TWI254711B (en) 2006-05-11
AR035494A1 (es) 2004-06-02
HK1054393A1 (da) 2003-11-28
DE60136731D1 (de) 2009-01-08
ES2315308T3 (es) 2009-04-01
JP2004523474A (ja) 2004-08-05
US6710048B2 (en) 2004-03-23

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