JP2006516583A5 - - Google Patents
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- Publication number
- JP2006516583A5 JP2006516583A5 JP2006501686A JP2006501686A JP2006516583A5 JP 2006516583 A5 JP2006516583 A5 JP 2006516583A5 JP 2006501686 A JP2006501686 A JP 2006501686A JP 2006501686 A JP2006501686 A JP 2006501686A JP 2006516583 A5 JP2006516583 A5 JP 2006516583A5
- Authority
- JP
- Japan
- Prior art keywords
- solution
- pharmaceutically acceptable
- palonosetron
- acceptable salt
- pharmaceutically
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000243 solution Substances 0.000 claims 28
- 229960002131 palonosetron Drugs 0.000 claims 14
- CPZBLNMUGSZIPR-NVXWUHKLSA-N palonosetron Chemical compound C1N(CC2)CCC2[C@@H]1N1C(=O)C(C=CC=C2CCC3)=C2[C@H]3C1 CPZBLNMUGSZIPR-NVXWUHKLSA-N 0.000 claims 14
- 150000003839 salts Chemical class 0.000 claims 13
- 239000003937 drug carrier Substances 0.000 claims 7
- 206010047700 Vomiting Diseases 0.000 claims 5
- 239000007979 citrate buffer Substances 0.000 claims 5
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 4
- 229930195725 Mannitol Natural products 0.000 claims 4
- 235000010355 mannitol Nutrition 0.000 claims 4
- 239000000594 mannitol Substances 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims 3
- 239000002738 chelating agent Substances 0.000 claims 2
- 239000007972 injectable composition Substances 0.000 claims 2
- 229960003359 palonosetron hydrochloride Drugs 0.000 claims 2
- OLDRWYVIKMSFFB-SSPJITILSA-N palonosetron hydrochloride Chemical compound Cl.C1N(CC2)CCC2[C@@H]1N1C(=O)C(C=CC=C2CCC3)=C2[C@H]3C1 OLDRWYVIKMSFFB-SSPJITILSA-N 0.000 claims 2
- 238000007789 sealing Methods 0.000 claims 1
- 230000001954 sterilising effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US44435103P | 2003-01-30 | 2003-01-30 | |
| US60/444,351 | 2003-01-30 | ||
| PCT/EP2004/000888 WO2004067005A1 (en) | 2003-01-30 | 2004-01-30 | Liquid pharmaceutical formulations of palonosetron |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011165212A Division JP5551658B2 (ja) | 2003-01-30 | 2011-07-28 | パロノセトロン液状医薬製剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006516583A JP2006516583A (ja) | 2006-07-06 |
| JP2006516583A5 true JP2006516583A5 (cg-RX-API-DMAC7.html) | 2007-03-15 |
| JP5461763B2 JP5461763B2 (ja) | 2014-04-02 |
Family
ID=32825409
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006501686A Expired - Lifetime JP5461763B2 (ja) | 2003-01-30 | 2004-01-30 | パロノセトロン液状医薬製剤 |
| JP2011165212A Expired - Lifetime JP5551658B2 (ja) | 2003-01-30 | 2011-07-28 | パロノセトロン液状医薬製剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011165212A Expired - Lifetime JP5551658B2 (ja) | 2003-01-30 | 2011-07-28 | パロノセトロン液状医薬製剤 |
Country Status (40)
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004045615A1 (en) * | 2002-11-15 | 2004-06-03 | Helsinn Healthcare Sa | Palonosetron for the treatment of chemotherapy-induced emesis |
| JO2735B1 (en) | 2003-01-30 | 2013-09-15 | هيلسين هيلث كير أس ايه. | Liquid pharmaceutical formations of balloonosterone |
| US8598219B2 (en) | 2003-01-30 | 2013-12-03 | Helsinn Healthcare Sa | Liquid pharmaceutical formulations of palonosetron |
| MY143789A (en) * | 2003-02-18 | 2011-07-15 | Helsinn Healthcare Sa | Use of palonosetron treating post- operative nausea and vomiting |
| CN100336508C (zh) * | 2005-02-23 | 2007-09-12 | 重庆医药工业研究院有限责任公司 | 一种稳定的帕洛诺司琼注射液 |
| CN100455286C (zh) * | 2006-11-21 | 2009-01-28 | 深圳海创医药科技发展有限公司 | 帕洛诺司琼注射液及其制备方法 |
| US9061076B2 (en) | 2007-05-25 | 2015-06-23 | North Carolina State University | Viral nanoparticle cell-targeted delivery platform |
| US20100048607A1 (en) * | 2008-08-25 | 2010-02-25 | Chandrashekhar Kocherlakota | Formulations comprising palonosetron |
| US20100143461A1 (en) | 2008-12-08 | 2010-06-10 | Ben-Zion Solomon | Palonosetron formulation |
| US20130213393A1 (en) | 2009-12-22 | 2013-08-22 | Evoke Pharma, Inc. | Nasal formulations of metoclopramide |
| US20120253046A1 (en) | 2009-11-13 | 2012-10-04 | Helsinn Healthcare S.A. | Palonosetron metabolites |
| EP2722045B1 (en) | 2009-11-18 | 2016-07-06 | Helsinn Healthcare SA | Compositions for treating centrally mediated nausea and vomiting |
| ES2559475T3 (es) | 2009-11-18 | 2016-02-12 | Helsinn Healthcare Sa | Composiciones para tratar náuseas y vómitos de origen central |
| KR101368587B1 (ko) * | 2010-12-27 | 2014-03-05 | 주식회사 삼양바이오팜 | 오심 또는 구토 방지용 조성물 |
| HUE030811T2 (hu) | 2011-10-18 | 2017-05-29 | Helsinn Healthcare Sa | Netupitant és palonosetron terápiás kombinációi |
| KR20150073866A (ko) * | 2013-12-23 | 2015-07-01 | 주식회사 삼양바이오팜 | 팔로노세트론을 함유하는 약학 조성물 |
| CN104784107A (zh) * | 2014-01-17 | 2015-07-22 | 南京瑞尔医药有限公司 | 一种盐酸托烷司琼口服液的制备方法 |
| KR20160128573A (ko) * | 2015-04-29 | 2016-11-08 | 주식회사 삼양바이오팜 | 약제학적 패키지 |
| CN109310627B (zh) * | 2016-06-06 | 2021-12-14 | 赫尔森保健股份公司 | 福奈妥匹坦的生理平衡注射制剂 |
| JP6768404B2 (ja) * | 2016-08-12 | 2020-10-14 | 武田テバファーマ株式会社 | パロノセトロン又はその薬学的に許容される塩を含む医薬組成物 |
| JP6705348B2 (ja) * | 2016-09-23 | 2020-06-03 | ニプロ株式会社 | 液体製剤、及び、パロノセトロンの安定性を向上する方法 |
| JP6642377B2 (ja) * | 2016-10-25 | 2020-02-05 | ニプロ株式会社 | 液体製剤、及び、パロノセトロンの安定性を向上する方法 |
| KR101802183B1 (ko) * | 2016-11-16 | 2017-11-28 | 주식회사 유영제약 | 팔로노세트론을 활성성분으로 함유하는 약제학적 조성물 |
| US11517545B2 (en) | 2016-12-15 | 2022-12-06 | Evoke Pharma, Inc. | Treatment of moderate and severe gastroparesis |
| EP3672964A4 (en) | 2017-08-21 | 2021-05-26 | Leiutis Pharmaceuticals Pvt. Ltd. | Novel triple combination formulations for antiemetic therapy |
| US11433021B2 (en) * | 2018-01-12 | 2022-09-06 | Orion Corporation | Palonosetron for the treatment or prevention of nausea and vomiting |
| JP7090845B2 (ja) * | 2018-08-03 | 2022-06-27 | 高田製薬株式会社 | パロノセトロン含有液体組成物 |
| JP7438802B2 (ja) * | 2020-03-23 | 2024-02-27 | シオノギファーマ株式会社 | パロノセトロン含有組成物 |
| TW202428273A (zh) * | 2023-01-03 | 2024-07-16 | 瑞士商赫爾辛保健公司 | 奈妥吡坦(netupitant)及帕洛諾司瓊(palonosetron)的液態口服調配物 |
Family Cites Families (38)
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| JPS599539B2 (ja) * | 1979-11-13 | 1984-03-03 | 日本化薬株式会社 | ニトログリセリン水溶液及びその製造法 |
| US4695578A (en) | 1984-01-25 | 1987-09-22 | Glaxo Group Limited | 1,2,3,9-tetrahydro-3-imidazol-1-ylmethyl-4H-carbazol-4-ones, composition containing them, and method of using them to treat neuronal 5HT function disturbances |
| EP0498466B1 (en) | 1985-04-27 | 2002-07-24 | F. Hoffmann-La Roche Ag | Indazole-3-carboxamide and -3-carboxylic acid derivatives |
| US4937247A (en) | 1985-04-27 | 1990-06-26 | Beecham Group P.L.C. | 1-acyl indazoles |
| US5240954A (en) | 1985-06-25 | 1993-08-31 | Glaxo Group Limited | Medicaments |
| US5578628A (en) | 1985-06-25 | 1996-11-26 | Glaxo Group Limited | Medicaments for the treatment of nausea and vomiting |
| GB8516083D0 (en) | 1985-06-25 | 1985-07-31 | Glaxo Group Ltd | Heterocyclic compounds |
| US4906755A (en) | 1986-11-03 | 1990-03-06 | Merrell Dow Pharmaceuticals Inc. | Esters of hexahydro-8-hydroxy-2,6-methano-2H-quinolizin-3-(4H)-one and related compounds |
| US5360800A (en) | 1987-09-03 | 1994-11-01 | Glaxo Group Limited | Tetrahydro-1H-pyrido[4,3-b]indol-1-one derivatives |
| US5011846A (en) | 1988-02-23 | 1991-04-30 | Merrell Dow Pharmaceuticals Inc. | Medicament compositions derived from quinolizine and quinolizinone and methods of use thereof |
| GB8914804D0 (en) | 1989-06-28 | 1989-08-16 | Glaxo Group Ltd | Process |
| US5344658A (en) | 1989-06-28 | 1994-09-06 | Glaxo Group Limited | Process and composition using ondansetron |
| PL166272B1 (pl) * | 1989-11-28 | 1995-04-28 | Syntex Inc | Sposób wytwarzania nowych addycyjnych soli z kwasami zwiazków trójpierscieniowych PL PL PL PL |
| ES2149305T3 (es) | 1991-05-03 | 2000-11-01 | Searle & Co | Compuestos de dibenzoxazepina sustituidos, composiciones farmaceuticas y procedimientos de uso. |
| US5272137A (en) | 1992-02-14 | 1993-12-21 | Mcneil-Pfc, Inc. | Aqueous pharmaceutical suspension for pharmaceutical actives |
| GB9305593D0 (en) * | 1993-03-18 | 1993-05-05 | Smithkline Beecham Plc | Pharmaceuticals |
| US5567818A (en) * | 1994-07-08 | 1996-10-22 | Syntex (U.S.A.) Inc. | Processes for preparing 2-(1-azabicyclo[2.2.2]oct-3-yl)-1H-benz[de] isoquinolin-1-one derivatives and intermediates useful therein |
| GB9423511D0 (en) | 1994-11-22 | 1995-01-11 | Glaxo Wellcome Inc | Compositions |
| GB9423588D0 (en) | 1994-11-22 | 1995-01-11 | Glaxo Wellcome Inc | Compositions |
| US5576317A (en) * | 1994-12-09 | 1996-11-19 | Pfizer Inc. | NK-1 receptor antagonists and 5HT3 receptor antagonists for the treatment of emesis |
| JP3845902B2 (ja) * | 1996-07-09 | 2006-11-15 | ソニー株式会社 | 磁気記録再生装置 |
| ATA156496A (de) | 1996-09-03 | 1997-10-15 | Nycomed Austria Gmbh | Pharmazeutische zusammensetzung |
| GB9625589D0 (en) * | 1996-12-10 | 1997-01-29 | Boots Co Plc | Therapeutic agents |
| US20030095926A1 (en) | 1997-10-01 | 2003-05-22 | Dugger Harry A. | Buccal, polar and non-polar spray or capsule containing drugs for treating disorders of the gastrointestinal tract or urinary tract |
| GB9721139D0 (en) | 1997-10-07 | 1997-12-03 | Glaxo Group Ltd | Medicaments |
| US6294548B1 (en) * | 1998-05-04 | 2001-09-25 | Hoffmann-La Roche Inc. | Multidose vial formulations for administering endo-N-(9-methyl-9-azabicyclo[3.3.1]non-3-yl)-1-methyl-1H-indazole-3-carboxamide hydrochloride |
| US6132758A (en) * | 1998-06-01 | 2000-10-17 | Schering Corporation | Stabilized antihistamine syrup |
| DE19833119A1 (de) | 1998-07-23 | 2000-01-27 | Roche Diagnostics Gmbh | Spritzfertige Injektionslösungen enthaltend Carvedilol |
| WO2000024375A1 (en) * | 1998-10-27 | 2000-05-04 | Alcon Laboratories, Inc. | Preservative system for topically administrable pharmaceutical compositions containing a fatty acid/amino acid soap |
| US6699852B2 (en) * | 2000-12-20 | 2004-03-02 | Bristol-Myers Squibb Pharma Company | Substituted pyridoindoles as serotonin agonists and antagonists |
| US7211596B2 (en) | 2001-05-11 | 2007-05-01 | Mitsubishi Pharma Corporation | Stable high-concentration injection containing pyrazolone derivative |
| AU2003237657A1 (en) | 2002-05-24 | 2003-12-12 | Epidauros Biotechnologie Ag | Means and methods for improved treatment using "setrones" |
| WO2004045615A1 (en) | 2002-11-15 | 2004-06-03 | Helsinn Healthcare Sa | Palonosetron for the treatment of chemotherapy-induced emesis |
| US7109339B2 (en) * | 2002-12-19 | 2006-09-19 | Bristol-Myers Squibb Company | Substituted tricyclic gamma-carbolines as serotonin receptor agonists and antagonists |
| DE602004005814T2 (de) | 2003-01-13 | 2008-01-10 | Dynogen Pharmaceuticals Inc., Waltham | Verfahren zur behandlung von übelkeit, erbrechen, würgereiz oder jede kombination daraus |
| JO2735B1 (en) | 2003-01-30 | 2013-09-15 | هيلسين هيلث كير أس ايه. | Liquid pharmaceutical formations of balloonosterone |
| US8598219B2 (en) | 2003-01-30 | 2013-12-03 | Helsinn Healthcare Sa | Liquid pharmaceutical formulations of palonosetron |
| MY143789A (en) * | 2003-02-18 | 2011-07-15 | Helsinn Healthcare Sa | Use of palonosetron treating post- operative nausea and vomiting |
-
2004
- 2004-01-27 JO JO20042A patent/JO2735B1/en active
- 2004-01-28 TW TW093101810A patent/TWI342212B/zh not_active IP Right Cessation
- 2004-01-29 AR ARP040100279A patent/AR042977A1/es not_active Application Discontinuation
- 2004-01-29 MY MYPI20040261A patent/MY144036A/en unknown
- 2004-01-30 CA CA002573241A patent/CA2573241A1/en not_active Abandoned
- 2004-01-30 NZ NZ541533A patent/NZ541533A/en not_active IP Right Cessation
- 2004-01-30 AP AP2005003382A patent/AP2110A/xx active
- 2004-01-30 BR BRPI0407121A patent/BRPI0407121B8/pt not_active IP Right Cessation
- 2004-01-30 WO PCT/EP2004/000888 patent/WO2004067005A1/en not_active Ceased
- 2004-01-30 CA CA002514224A patent/CA2514224C/en not_active Expired - Lifetime
- 2004-01-30 PL PL378398A patent/PL378398A1/pl not_active Application Discontinuation
- 2004-01-30 AT AT04706657T patent/ATE410167T1/de active
- 2004-01-30 DE DE602004016967T patent/DE602004016967D1/de not_active Expired - Lifetime
- 2004-01-30 JP JP2006501686A patent/JP5461763B2/ja not_active Expired - Lifetime
- 2004-01-30 MX MXPA05008028A patent/MXPA05008028A/es active IP Right Grant
- 2004-01-30 PE PE2004000115A patent/PE20050066A1/es not_active Application Discontinuation
- 2004-01-30 RS YUP-2005/0578A patent/RS20050578A/sr unknown
- 2004-01-30 UA UAA200508414A patent/UA90449C2/ru unknown
- 2004-01-30 KR KR1020057014093A patent/KR101113084B1/ko not_active Ceased
- 2004-01-30 CN CNA2004800063221A patent/CN1758911A/zh active Pending
- 2004-01-30 GE GEAP20048958A patent/GEP20084445B/en unknown
- 2004-01-30 PA PA20048594801A patent/PA8594801A1/es unknown
- 2004-01-30 ES ES04706657T patent/ES2315635T3/es not_active Expired - Lifetime
- 2004-01-30 PT PT04706657T patent/PT1601359E/pt unknown
- 2004-01-30 SI SI200430976T patent/SI1601359T1/sl unknown
- 2004-01-30 CA CA002573228A patent/CA2573228A1/en not_active Abandoned
- 2004-01-30 HR HRP20050676AA patent/HRP20050676B1/hr active IP Right Review Request
- 2004-01-30 CA CA002573363A patent/CA2573363A1/en not_active Abandoned
- 2004-01-30 EP EP04706657A patent/EP1601359B1/en not_active Revoked
- 2004-01-30 AU AU2004208505A patent/AU2004208505C1/en not_active Expired
- 2004-01-30 UY UY28175A patent/UY28175A1/es not_active IP Right Cessation
- 2004-01-30 DK DK04706657T patent/DK1601359T3/da active
- 2004-01-30 EA EA200501203A patent/EA014066B1/ru unknown
- 2004-01-30 CN CN2012102874523A patent/CN102813621A/zh active Pending
- 2004-01-30 EP EP08015410A patent/EP2008659A1/en not_active Withdrawn
- 2004-01-30 CA CA002573194A patent/CA2573194A1/en not_active Abandoned
-
2005
- 2005-07-21 US US11/186,311 patent/US7947724B2/en not_active Expired - Lifetime
- 2005-07-22 CR CR7921A patent/CR7921A/es unknown
- 2005-07-25 IL IL169859A patent/IL169859A/en active IP Right Grant
- 2005-07-27 TN TNP2005000180A patent/TNSN05180A1/en unknown
- 2005-07-29 EC EC2005005938A patent/ECSP055938A/es unknown
- 2005-08-12 MA MA28440A patent/MA27710A1/fr unknown
- 2005-08-15 IS IS7984A patent/IS7984A/is unknown
- 2005-08-26 NO NO20053987A patent/NO329500B1/no not_active IP Right Cessation
- 2005-08-29 ZA ZA200506917A patent/ZA200506917B/xx unknown
-
2006
- 2006-03-24 US US11/388,270 patent/US7960424B2/en not_active Expired - Lifetime
- 2006-03-24 US US11/388,268 patent/US7947725B2/en not_active Expired - Lifetime
-
2008
- 2008-12-22 CY CY20081101485T patent/CY1108660T1/el unknown
-
2011
- 2011-04-14 US US13/087,012 patent/US8518981B2/en not_active Expired - Fee Related
- 2011-07-28 JP JP2011165212A patent/JP5551658B2/ja not_active Expired - Lifetime
-
2013
- 2013-05-23 US US13/901,288 patent/US8598218B2/en not_active Expired - Fee Related
- 2013-10-14 US US14/052,925 patent/US20140039000A1/en not_active Abandoned
- 2013-11-04 US US14/070,981 patent/US9308266B2/en not_active Expired - Fee Related
-
2015
- 2015-09-16 US US14/855,564 patent/US9457020B2/en not_active Expired - Fee Related
-
2016
- 2016-07-14 US US15/209,995 patent/US20160317440A1/en not_active Abandoned
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