JP2008521884A5 - - Google Patents
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- Publication number
- JP2008521884A5 JP2008521884A5 JP2007544016A JP2007544016A JP2008521884A5 JP 2008521884 A5 JP2008521884 A5 JP 2008521884A5 JP 2007544016 A JP2007544016 A JP 2007544016A JP 2007544016 A JP2007544016 A JP 2007544016A JP 2008521884 A5 JP2008521884 A5 JP 2008521884A5
- Authority
- JP
- Japan
- Prior art keywords
- sodium
- composition
- ceftriaxone
- sulbactam
- present
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 23
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 12
- NKZMPZCWBSWAOX-IBTYICNHSA-M Sulbactam sodium Chemical compound [Na+].O=S1(=O)C(C)(C)[C@H](C([O-])=O)N2C(=O)C[C@H]21 NKZMPZCWBSWAOX-IBTYICNHSA-M 0.000 claims 12
- 229960000479 ceftriaxone sodium Drugs 0.000 claims 12
- FDRNWTJTHBSPMW-GNXCPKRQSA-L disodium;(6r,7r)-7-[[(2e)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-[(2-methyl-6-oxido-5-oxo-1,2,4-triazin-3-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate Chemical compound [Na+].[Na+].S([C@@H]1[C@@H](C(N1C=1C([O-])=O)=O)NC(=O)/C(=N/OC)C=2N=C(N)SC=2)CC=1CSC1=NC(=O)C([O-])=NN1C FDRNWTJTHBSPMW-GNXCPKRQSA-L 0.000 claims 12
- 229910052708 sodium Inorganic materials 0.000 claims 12
- 239000011734 sodium Substances 0.000 claims 12
- 229960000614 sulbactam sodium Drugs 0.000 claims 12
- 239000002253 acid Substances 0.000 claims 10
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims 7
- 229960004755 ceftriaxone Drugs 0.000 claims 6
- VAAUVRVFOQPIGI-SPQHTLEESA-N ceftriaxone Chemical compound S([C@@H]1[C@@H](C(N1C=1C(O)=O)=O)NC(=O)\C(=N/OC)C=2N=C(N)SC=2)CC=1CSC1=NC(=O)C(=O)NN1C VAAUVRVFOQPIGI-SPQHTLEESA-N 0.000 claims 6
- 229960005256 sulbactam Drugs 0.000 claims 6
- FKENQMMABCRJMK-RITPCOANSA-N sulbactam Chemical group O=S1(=O)C(C)(C)[C@H](C(O)=O)N2C(=O)C[C@H]21 FKENQMMABCRJMK-RITPCOANSA-N 0.000 claims 6
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 5
- 239000003125 aqueous solvent Substances 0.000 claims 5
- 239000003781 beta lactamase inhibitor Substances 0.000 claims 4
- 229940126813 beta-lactamase inhibitor Drugs 0.000 claims 4
- 239000011261 inert gas Substances 0.000 claims 4
- 229940126085 β‑Lactamase Inhibitor Drugs 0.000 claims 4
- 239000003782 beta lactam antibiotic agent Substances 0.000 claims 3
- 159000000000 sodium salts Chemical class 0.000 claims 3
- 239000002132 β-lactam antibiotic Substances 0.000 claims 3
- 229940124586 β-lactam antibiotics Drugs 0.000 claims 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 2
- 239000004480 active ingredient Substances 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 108090000204 Dipeptidase 1 Proteins 0.000 claims 1
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 claims 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims 1
- 102000006635 beta-lactamase Human genes 0.000 claims 1
- 230000003115 biocidal effect Effects 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 229940000425 combination drug Drugs 0.000 claims 1
- 229910001873 dinitrogen Inorganic materials 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- 239000008103 glucose Substances 0.000 claims 1
- 238000001802 infusion Methods 0.000 claims 1
- 239000004615 ingredient Substances 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 239000000644 isotonic solution Substances 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 229910052756 noble gas Inorganic materials 0.000 claims 1
- 150000002835 noble gases Chemical class 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- 230000001954 sterilising effect Effects 0.000 claims 1
- 238000004659 sterilization and disinfection Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN2411/DEL/2004 | 2004-12-02 | ||
| IN2411DE2004 | 2004-12-02 | ||
| PCT/IN2005/000382 WO2006059344A1 (en) | 2004-12-02 | 2005-11-28 | Compositions for combating beta-lactamase-mediated antibiotic resistance using beta-lactamase inhibitors useful for injection |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008521884A JP2008521884A (ja) | 2008-06-26 |
| JP2008521884A5 true JP2008521884A5 (cg-RX-API-DMAC7.html) | 2008-12-18 |
| JP5269415B2 JP5269415B2 (ja) | 2013-08-21 |
Family
ID=35789266
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007544016A Expired - Fee Related JP5269415B2 (ja) | 2004-12-02 | 2005-11-28 | 注射に有用なβ−ラクタマーゼ阻害剤を使用したβ−ラクタマーゼ媒介性の抗生物質耐性を抑制する組成物 |
Country Status (23)
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20030010176A (ko) * | 2001-07-25 | 2003-02-05 | 이병두 | 은행 열매 추출물과 호도 열매 추출물을 이용한 천식 치료제 |
| CN101129382B (zh) * | 2006-08-25 | 2013-12-25 | 天津和美生物技术有限公司 | 含β-内酰胺类抗生素和缓冲组分的抗生素复方 |
| CN101129381B (zh) * | 2006-08-25 | 2012-02-01 | 天津和美生物技术有限公司 | 含β-内酰胺类抗生素和离子螯合剂的抗生素复方 |
| JP5639471B2 (ja) * | 2008-07-28 | 2014-12-10 | 惠三 山口 | 感染症治療効果増強剤 |
| CN101537009B (zh) * | 2009-04-30 | 2010-09-15 | 海口奇力制药股份有限公司 | 注射用头孢曲松钠他唑巴坦钠复方制剂的生产工艺 |
| JP2012176899A (ja) * | 2009-05-19 | 2012-09-13 | Mitsubishi Tanabe Pharma Corp | ２−（１−ピペラジニル）−５−メチルベンゼンスルホン酸誘導体を含む注射用水溶液 |
| AU2011369802B2 (en) * | 2011-05-28 | 2016-09-08 | Wockhardt Limited | Compositions comprising antibacterial agent and tazobactam |
| WO2013014497A1 (en) * | 2011-07-26 | 2013-01-31 | Wockhardt Limited | Pharmaceutical compositions comprising beta-lactam antibiotic, sulbactam and beta-lactamase inhibitor |
| WO2013042140A2 (en) * | 2011-09-23 | 2013-03-28 | Manu Chaudhary | Non antibiotic,non peptide compounds for antibiotic efficacy & safety enhancement |
| SG11201405799TA (en) | 2012-03-26 | 2014-11-27 | Santen Pharmaceutical Co Ltd | Ophthalmic solution comprising diquafosol |
| US11116738B2 (en) | 2012-06-07 | 2021-09-14 | Children's Hospital Los Angeles | Methods for treating neutropenia using retinoid agonists |
| CN105025901B (zh) * | 2012-09-27 | 2019-04-19 | 默沙东公司 | 他唑巴坦精氨酸抗生素组合物 |
| WO2015126989A1 (en) | 2014-02-18 | 2015-08-27 | Children's Hospital Los Angeles | Compositions and methods for treating neutropenia |
| CN106900171A (zh) * | 2014-03-29 | 2017-06-27 | 沃克哈特有限公司 | 包含头孢吡肟或舒巴坦的药物组合物 |
| BR112016021720B1 (pt) * | 2014-04-03 | 2021-09-28 | Baxter International Incorporated | Bolsa de injeção e conjunto de preparação de injeção |
| US10201518B2 (en) | 2016-09-28 | 2019-02-12 | The University Of Hong Kong | Bismuth(III) compounds and methods thereof |
| EP3429592A4 (en) * | 2016-11-02 | 2019-10-30 | Xiangbei Welman Pharmaceutical Co., Ltd | COMPOSITION OF CEFTRIAXONNATRIUM AND SULBACTUMNATRIUM |
| CN106822147B (zh) * | 2016-11-03 | 2021-07-20 | 湘北威尔曼制药股份有限公司 | 一种头孢曲松钠和舒巴坦钠组合物、包含该组合物的药物制剂及其应用 |
| RU2665006C1 (ru) * | 2017-02-28 | 2018-08-24 | Общество с ограниченной ответственностью "Супербаг Солюшенс" | Композиция антимикробных препаратов для лечения инфекционных заболеваний людей и животных и способ её применения |
| US11905286B2 (en) | 2018-08-09 | 2024-02-20 | Antabio Sas | Diazabicyclooctanones as inhibitors of serine beta-lactamases |
| PL3833665T3 (pl) | 2018-08-09 | 2023-12-27 | Antabio Sas | Diazabicykloktanony jako inhibitory beta-laktamaz serynowych |
| US12228578B2 (en) | 2020-12-17 | 2025-02-18 | Idexx Laboratories, Inc. | Rocky mountain spotted fever detection and treatment |
| WO2025165952A1 (en) * | 2024-01-31 | 2025-08-07 | The Penn State Research Foundation | Process for reduction of drug-resistant bacteria |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6630510B1 (en) * | 1999-10-28 | 2003-10-07 | Merck & Co., Inc. | Substituted succinic acid metallo-β-lactamase inhibitors and their use in treating bacterial infections |
| US6677320B2 (en) * | 2000-01-20 | 2004-01-13 | Hoffmann-La Roches Inc. | Parenteral bisphosphonate composition with improved local tolerance |
| EP1468697B1 (en) * | 2003-04-14 | 2007-12-26 | Wyeth Holdings Corporation | Compositions containing piperacillin and tazobactam useful for injection |
-
2005
- 2005-11-28 DK DK05817957.3T patent/DK1841432T3/da active
- 2005-11-28 EP EP05817957A patent/EP1841432B1/en not_active Expired - Lifetime
- 2005-11-28 RU RU2007124325/15A patent/RU2397768C2/ru not_active IP Right Cessation
- 2005-11-28 KR KR1020077010375A patent/KR20070067189A/ko not_active Ceased
- 2005-11-28 UA UAA200707280A patent/UA91204C2/ru unknown
- 2005-11-28 CN CNA2005800395645A patent/CN101060846A/zh active Pending
- 2005-11-28 BR BRPI0517128-8A patent/BRPI0517128A/pt not_active IP Right Cessation
- 2005-11-28 PL PL05817957T patent/PL1841432T3/pl unknown
- 2005-11-28 DE DE602005022939T patent/DE602005022939D1/de not_active Expired - Lifetime
- 2005-11-28 SI SI200531130T patent/SI1841432T1/sl unknown
- 2005-11-28 AT AT05817957T patent/ATE476981T1/de active
- 2005-11-28 PT PT05817957T patent/PT1841432E/pt unknown
- 2005-11-28 JP JP2007544016A patent/JP5269415B2/ja not_active Expired - Fee Related
- 2005-11-28 MX MX2007006540A patent/MX2007006540A/es active IP Right Grant
- 2005-11-28 ES ES05817957T patent/ES2349301T3/es not_active Expired - Lifetime
- 2005-11-28 KR KR1020097018388A patent/KR101244362B1/ko not_active Expired - Fee Related
- 2005-11-28 NZ NZ555075A patent/NZ555075A/en not_active IP Right Cessation
- 2005-11-28 WO PCT/IN2005/000382 patent/WO2006059344A1/en not_active Ceased
- 2005-11-28 US US11/720,710 patent/US8273732B2/en not_active Expired - Fee Related
- 2005-11-28 AU AU2005310888A patent/AU2005310888B2/en not_active Ceased
- 2005-11-28 RS RSP-2010/0465A patent/RS51506B/sr unknown
- 2005-11-28 HR HR20100591T patent/HRP20100591T1/hr unknown
-
2007
- 2007-05-29 ZA ZA200704394A patent/ZA200704394B/xx unknown
-
2010
- 2010-11-10 CY CY20101101012T patent/CY1110886T1/el unknown
-
2012
- 2012-09-25 US US13/626,236 patent/US9012442B2/en not_active Expired - Fee Related
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