PT1841432E - Composições para combater a resistência aos antibióticos mediada pela beta-lactamase usando inibidores da betalactamase úteis para injecção - Google Patents
Composições para combater a resistência aos antibióticos mediada pela beta-lactamase usando inibidores da betalactamase úteis para injecção Download PDFInfo
- Publication number
- PT1841432E PT1841432E PT05817957T PT05817957T PT1841432E PT 1841432 E PT1841432 E PT 1841432E PT 05817957 T PT05817957 T PT 05817957T PT 05817957 T PT05817957 T PT 05817957T PT 1841432 E PT1841432 E PT 1841432E
- Authority
- PT
- Portugal
- Prior art keywords
- sodium
- ceftriaxone
- sulbactam
- composition
- amount
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 81
- 102000006635 beta-lactamase Human genes 0.000 title claims abstract description 15
- 108090000204 Dipeptidase 1 Proteins 0.000 title claims abstract description 13
- 230000003115 biocidal effect Effects 0.000 title claims abstract description 11
- 239000003781 beta lactamase inhibitor Substances 0.000 title claims abstract description 8
- 229940126813 beta-lactamase inhibitor Drugs 0.000 title claims abstract description 8
- 230000001404 mediated effect Effects 0.000 title claims abstract description 7
- 238000002347 injection Methods 0.000 title abstract description 5
- 239000007924 injection Substances 0.000 title abstract description 5
- VAAUVRVFOQPIGI-SPQHTLEESA-N ceftriaxone Chemical compound S([C@@H]1[C@@H](C(N1C=1C(O)=O)=O)NC(=O)\C(=N/OC)C=2N=C(N)SC=2)CC=1CSC1=NC(=O)C(=O)NN1C VAAUVRVFOQPIGI-SPQHTLEESA-N 0.000 claims abstract description 33
- 229960004755 ceftriaxone Drugs 0.000 claims abstract description 32
- NKZMPZCWBSWAOX-IBTYICNHSA-M Sulbactam sodium Chemical compound [Na+].O=S1(=O)C(C)(C)[C@H](C([O-])=O)N2C(=O)C[C@H]21 NKZMPZCWBSWAOX-IBTYICNHSA-M 0.000 claims abstract description 31
- 150000003839 salts Chemical class 0.000 claims abstract description 31
- 229960000479 ceftriaxone sodium Drugs 0.000 claims abstract description 27
- FDRNWTJTHBSPMW-GNXCPKRQSA-L disodium;(6r,7r)-7-[[(2e)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-[(2-methyl-6-oxido-5-oxo-1,2,4-triazin-3-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate Chemical compound [Na+].[Na+].S([C@@H]1[C@@H](C(N1C=1C([O-])=O)=O)NC(=O)/C(=N/OC)C=2N=C(N)SC=2)CC=1CSC1=NC(=O)C([O-])=NN1C FDRNWTJTHBSPMW-GNXCPKRQSA-L 0.000 claims abstract description 27
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims abstract description 25
- 229960000614 sulbactam sodium Drugs 0.000 claims abstract description 25
- FKENQMMABCRJMK-RITPCOANSA-N sulbactam Chemical compound O=S1(=O)C(C)(C)[C@H](C(O)=O)N2C(=O)C[C@H]21 FKENQMMABCRJMK-RITPCOANSA-N 0.000 claims abstract description 23
- 229960005256 sulbactam Drugs 0.000 claims abstract description 22
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 12
- 239000000243 solution Substances 0.000 claims abstract description 12
- 230000015572 biosynthetic process Effects 0.000 claims abstract description 11
- 238000000034 method Methods 0.000 claims abstract description 11
- 230000008569 process Effects 0.000 claims abstract description 6
- 239000002738 chelating agent Substances 0.000 claims abstract description 5
- 229940126085 β‑Lactamase Inhibitor Drugs 0.000 claims abstract description 5
- KXDHJXZQYSOELW-UHFFFAOYSA-N Carbamic acid Chemical compound NC(O)=O KXDHJXZQYSOELW-UHFFFAOYSA-N 0.000 claims abstract description 4
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 29
- 229910052708 sodium Inorganic materials 0.000 claims description 29
- 239000011734 sodium Substances 0.000 claims description 29
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 18
- 239000002253 acid Substances 0.000 claims description 16
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 13
- 239000002245 particle Substances 0.000 claims description 11
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 10
- 239000008215 water for injection Substances 0.000 claims description 10
- 239000011261 inert gas Substances 0.000 claims description 8
- 239000003795 chemical substances by application Substances 0.000 claims description 6
- 150000001875 compounds Chemical class 0.000 claims description 6
- 239000003112 inhibitor Substances 0.000 claims description 6
- 229910052757 nitrogen Inorganic materials 0.000 claims description 6
- 159000000000 sodium salts Chemical group 0.000 claims description 5
- 239000003782 beta lactam antibiotic agent Substances 0.000 claims description 4
- 239000011780 sodium chloride Substances 0.000 claims description 4
- 238000012859 sterile filling Methods 0.000 claims description 4
- 239000002132 β-lactam antibiotic Substances 0.000 claims description 4
- 229940124586 β-lactam antibiotics Drugs 0.000 claims description 4
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 3
- 239000003125 aqueous solvent Substances 0.000 claims description 3
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims description 3
- 229940000425 combination drug Drugs 0.000 claims description 3
- 239000008121 dextrose Substances 0.000 claims description 3
- 238000001802 infusion Methods 0.000 claims description 3
- 238000002360 preparation method Methods 0.000 claims description 3
- 239000008227 sterile water for injection Substances 0.000 claims description 3
- 239000003708 ampul Substances 0.000 claims description 2
- 229940090047 auto-injector Drugs 0.000 claims description 2
- 238000011049 filling Methods 0.000 claims description 2
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 claims 1
- 229910001873 dinitrogen Inorganic materials 0.000 claims 1
- 238000002309 gasification Methods 0.000 claims 1
- 229910052756 noble gas Inorganic materials 0.000 claims 1
- 150000002835 noble gases Chemical class 0.000 claims 1
- 238000004806 packaging method and process Methods 0.000 claims 1
- 239000003242 anti bacterial agent Substances 0.000 abstract description 7
- 208000015181 infectious disease Diseases 0.000 abstract description 7
- 238000011282 treatment Methods 0.000 abstract description 6
- 229940088710 antibiotic agent Drugs 0.000 abstract description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 4
- 238000007918 intramuscular administration Methods 0.000 abstract description 4
- 238000001990 intravenous administration Methods 0.000 abstract description 4
- 239000002552 dosage form Substances 0.000 abstract description 2
- 238000004519 manufacturing process Methods 0.000 abstract description 2
- 238000009472 formulation Methods 0.000 description 9
- 241000894006 Bacteria Species 0.000 description 6
- 239000000843 powder Substances 0.000 description 5
- 230000001580 bacterial effect Effects 0.000 description 4
- 208000035143 Bacterial infection Diseases 0.000 description 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 239000004480 active ingredient Substances 0.000 description 3
- 208000022362 bacterial infectious disease Diseases 0.000 description 3
- 239000007789 gas Substances 0.000 description 3
- 229940090044 injection Drugs 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- 108020004256 Beta-lactamase Proteins 0.000 description 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 239000008228 bacteriostatic water for injection Substances 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 229960001484 edetic acid Drugs 0.000 description 2
- -1 (2S-5R) -3,3-dimethyl-7-oxo-4-thia-1-azabicyclo (3.2.0) heptane-2-carboxylate 4,4-dioxane sodium Chemical group 0.000 description 1
- FPUBTSUKWKXCPI-NXSYQRQQSA-N (6r,7r)-7-[[2-(2-amino-1,3-thiazol-4-yl)-2-oxoacetyl]amino]-3-[(2-methyl-5,6-dioxo-1h-1,2,4-triazin-3-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid Chemical group CN1NC(=O)C(=O)N=C1SCC1=C(C(O)=O)N2C(=O)[C@@H](NC(=O)C(=O)C=3N=C(N)SC=3)[C@H]2SC1 FPUBTSUKWKXCPI-NXSYQRQQSA-N 0.000 description 1
- WZPBZJONDBGPKJ-UHFFFAOYSA-N Antibiotic SQ 26917 Natural products O=C1N(S(O)(=O)=O)C(C)C1NC(=O)C(=NOC(C)(C)C(O)=O)C1=CSC(N)=N1 WZPBZJONDBGPKJ-UHFFFAOYSA-N 0.000 description 1
- 206010060968 Arthritis infective Diseases 0.000 description 1
- 229930186147 Cephalosporin Natural products 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 208000036209 Intraabdominal Infections Diseases 0.000 description 1
- 241000588747 Klebsiella pneumoniae Species 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 201000009906 Meningitis Diseases 0.000 description 1
- 206010033078 Otitis media Diseases 0.000 description 1
- 206010034133 Pathogen resistance Diseases 0.000 description 1
- 208000029082 Pelvic Inflammatory Disease Diseases 0.000 description 1
- 206010040047 Sepsis Diseases 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 229960003644 aztreonam Drugs 0.000 description 1
- WZPBZJONDBGPKJ-VEHQQRBSSA-N aztreonam Chemical compound O=C1N(S([O-])(=O)=O)[C@@H](C)[C@@H]1NC(=O)C(=N/OC(C)(C)C(O)=O)\C1=CSC([NH3+])=N1 WZPBZJONDBGPKJ-VEHQQRBSSA-N 0.000 description 1
- 229960004261 cefotaxime Drugs 0.000 description 1
- AZZMGZXNTDTSME-JUZDKLSSSA-M cefotaxime sodium Chemical compound [Na+].N([C@@H]1C(N2C(=C(COC(C)=O)CS[C@@H]21)C([O-])=O)=O)C(=O)\C(=N/OC)C1=CSC(N)=N1 AZZMGZXNTDTSME-JUZDKLSSSA-M 0.000 description 1
- 229960000484 ceftazidime Drugs 0.000 description 1
- ORFOPKXBNMVMKC-DWVKKRMSSA-N ceftazidime Chemical compound S([C@@H]1[C@@H](C(N1C=1C([O-])=O)=O)NC(=O)\C(=N/OC(C)(C)C(O)=O)C=2N=C(N)SC=2)CC=1C[N+]1=CC=CC=C1 ORFOPKXBNMVMKC-DWVKKRMSSA-N 0.000 description 1
- 229940000163 ceftriaxone injection Drugs 0.000 description 1
- 229940124587 cephalosporin Drugs 0.000 description 1
- 150000001780 cephalosporins Chemical class 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- VAYGXNSJCAHWJZ-UHFFFAOYSA-N dimethyl sulfate Chemical compound COS(=O)(=O)OC VAYGXNSJCAHWJZ-UHFFFAOYSA-N 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 229940041009 monobactams Drugs 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 239000013612 plasmid Substances 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- 208000013223 septicemia Diseases 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 239000012929 tonicity agent Substances 0.000 description 1
- 208000019206 urinary tract infection Diseases 0.000 description 1
- 150000003952 β-lactams Chemical class 0.000 description 1
Classifications
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
- A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
- A61K31/546—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine containing further heterocyclic rings, e.g. cephalothin
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
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- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
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- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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- Medicinal Chemistry (AREA)
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- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
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- Molecular Biology (AREA)
- Physical Education & Sports Medicine (AREA)
- Tropical Medicine & Parasitology (AREA)
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- Pain & Pain Management (AREA)
- AIDS & HIV (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN2411DE2004 | 2004-12-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1841432E true PT1841432E (pt) | 2010-10-25 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT05817957T PT1841432E (pt) | 2004-12-02 | 2005-11-28 | Composições para combater a resistência aos antibióticos mediada pela beta-lactamase usando inibidores da betalactamase úteis para injecção |
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Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20030010176A (ko) * | 2001-07-25 | 2003-02-05 | 이병두 | 은행 열매 추출물과 호도 열매 추출물을 이용한 천식 치료제 |
| CN101129382B (zh) * | 2006-08-25 | 2013-12-25 | 天津和美生物技术有限公司 | 含β-内酰胺类抗生素和缓冲组分的抗生素复方 |
| CN101129381B (zh) * | 2006-08-25 | 2012-02-01 | 天津和美生物技术有限公司 | 含β-内酰胺类抗生素和离子螯合剂的抗生素复方 |
| JP5639471B2 (ja) * | 2008-07-28 | 2014-12-10 | 惠三 山口 | 感染症治療効果増強剤 |
| CN101537009B (zh) * | 2009-04-30 | 2010-09-15 | 海口奇力制药股份有限公司 | 注射用头孢曲松钠他唑巴坦钠复方制剂的生产工艺 |
| JP2012176899A (ja) * | 2009-05-19 | 2012-09-13 | Mitsubishi Tanabe Pharma Corp | ２−（１−ピペラジニル）−５−メチルベンゼンスルホン酸誘導体を含む注射用水溶液 |
| AU2011369802B2 (en) * | 2011-05-28 | 2016-09-08 | Wockhardt Limited | Compositions comprising antibacterial agent and tazobactam |
| WO2013014497A1 (en) * | 2011-07-26 | 2013-01-31 | Wockhardt Limited | Pharmaceutical compositions comprising beta-lactam antibiotic, sulbactam and beta-lactamase inhibitor |
| WO2013042140A2 (en) * | 2011-09-23 | 2013-03-28 | Manu Chaudhary | Non antibiotic,non peptide compounds for antibiotic efficacy & safety enhancement |
| SG11201405799TA (en) | 2012-03-26 | 2014-11-27 | Santen Pharmaceutical Co Ltd | Ophthalmic solution comprising diquafosol |
| US11116738B2 (en) | 2012-06-07 | 2021-09-14 | Children's Hospital Los Angeles | Methods for treating neutropenia using retinoid agonists |
| CN105025901B (zh) * | 2012-09-27 | 2019-04-19 | 默沙东公司 | 他唑巴坦精氨酸抗生素组合物 |
| WO2015126989A1 (en) | 2014-02-18 | 2015-08-27 | Children's Hospital Los Angeles | Compositions and methods for treating neutropenia |
| CN106900171A (zh) * | 2014-03-29 | 2017-06-27 | 沃克哈特有限公司 | 包含头孢吡肟或舒巴坦的药物组合物 |
| BR112016021720B1 (pt) * | 2014-04-03 | 2021-09-28 | Baxter International Incorporated | Bolsa de injeção e conjunto de preparação de injeção |
| US10201518B2 (en) | 2016-09-28 | 2019-02-12 | The University Of Hong Kong | Bismuth(III) compounds and methods thereof |
| EP3429592A4 (en) * | 2016-11-02 | 2019-10-30 | Xiangbei Welman Pharmaceutical Co., Ltd | COMPOSITION OF CEFTRIAXONNATRIUM AND SULBACTUMNATRIUM |
| CN106822147B (zh) * | 2016-11-03 | 2021-07-20 | 湘北威尔曼制药股份有限公司 | 一种头孢曲松钠和舒巴坦钠组合物、包含该组合物的药物制剂及其应用 |
| RU2665006C1 (ru) * | 2017-02-28 | 2018-08-24 | Общество с ограниченной ответственностью "Супербаг Солюшенс" | Композиция антимикробных препаратов для лечения инфекционных заболеваний людей и животных и способ её применения |
| US11905286B2 (en) | 2018-08-09 | 2024-02-20 | Antabio Sas | Diazabicyclooctanones as inhibitors of serine beta-lactamases |
| PL3833665T3 (pl) | 2018-08-09 | 2023-12-27 | Antabio Sas | Diazabicykloktanony jako inhibitory beta-laktamaz serynowych |
| US12228578B2 (en) | 2020-12-17 | 2025-02-18 | Idexx Laboratories, Inc. | Rocky mountain spotted fever detection and treatment |
| WO2025165952A1 (en) * | 2024-01-31 | 2025-08-07 | The Penn State Research Foundation | Process for reduction of drug-resistant bacteria |
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| US6630510B1 (en) * | 1999-10-28 | 2003-10-07 | Merck & Co., Inc. | Substituted succinic acid metallo-β-lactamase inhibitors and their use in treating bacterial infections |
| US6677320B2 (en) * | 2000-01-20 | 2004-01-13 | Hoffmann-La Roches Inc. | Parenteral bisphosphonate composition with improved local tolerance |
| EP1468697B1 (en) * | 2003-04-14 | 2007-12-26 | Wyeth Holdings Corporation | Compositions containing piperacillin and tazobactam useful for injection |
-
2005
- 2005-11-28 DK DK05817957.3T patent/DK1841432T3/da active
- 2005-11-28 EP EP05817957A patent/EP1841432B1/en not_active Expired - Lifetime
- 2005-11-28 RU RU2007124325/15A patent/RU2397768C2/ru not_active IP Right Cessation
- 2005-11-28 KR KR1020077010375A patent/KR20070067189A/ko not_active Ceased
- 2005-11-28 UA UAA200707280A patent/UA91204C2/ru unknown
- 2005-11-28 CN CNA2005800395645A patent/CN101060846A/zh active Pending
- 2005-11-28 BR BRPI0517128-8A patent/BRPI0517128A/pt not_active IP Right Cessation
- 2005-11-28 PL PL05817957T patent/PL1841432T3/pl unknown
- 2005-11-28 DE DE602005022939T patent/DE602005022939D1/de not_active Expired - Lifetime
- 2005-11-28 SI SI200531130T patent/SI1841432T1/sl unknown
- 2005-11-28 AT AT05817957T patent/ATE476981T1/de active
- 2005-11-28 PT PT05817957T patent/PT1841432E/pt unknown
- 2005-11-28 JP JP2007544016A patent/JP5269415B2/ja not_active Expired - Fee Related
- 2005-11-28 MX MX2007006540A patent/MX2007006540A/es active IP Right Grant
- 2005-11-28 ES ES05817957T patent/ES2349301T3/es not_active Expired - Lifetime
- 2005-11-28 KR KR1020097018388A patent/KR101244362B1/ko not_active Expired - Fee Related
- 2005-11-28 NZ NZ555075A patent/NZ555075A/en not_active IP Right Cessation
- 2005-11-28 WO PCT/IN2005/000382 patent/WO2006059344A1/en not_active Ceased
- 2005-11-28 US US11/720,710 patent/US8273732B2/en not_active Expired - Fee Related
- 2005-11-28 AU AU2005310888A patent/AU2005310888B2/en not_active Ceased
- 2005-11-28 RS RSP-2010/0465A patent/RS51506B/sr unknown
- 2005-11-28 HR HR20100591T patent/HRP20100591T1/hr unknown
-
2007
- 2007-05-29 ZA ZA200704394A patent/ZA200704394B/xx unknown
-
2010
- 2010-11-10 CY CY20101101012T patent/CY1110886T1/el unknown
-
2012
- 2012-09-25 US US13/626,236 patent/US9012442B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| RU2007124325A (ru) | 2009-01-10 |
| RS51506B (sr) | 2011-06-30 |
| EP1841432B1 (en) | 2010-08-11 |
| JP2008521884A (ja) | 2008-06-26 |
| PL1841432T3 (pl) | 2011-01-31 |
| BRPI0517128A (pt) | 2008-09-30 |
| KR101244362B1 (ko) | 2013-03-18 |
| HRP20100591T1 (hr) | 2010-12-31 |
| US20130023512A1 (en) | 2013-01-24 |
| NZ555075A (en) | 2011-02-25 |
| ATE476981T1 (de) | 2010-08-15 |
| EP1841432A1 (en) | 2007-10-10 |
| MX2007006540A (es) | 2008-01-31 |
| US20100160277A1 (en) | 2010-06-24 |
| UA91204C2 (ru) | 2010-07-12 |
| US8273732B2 (en) | 2012-09-25 |
| ZA200704394B (en) | 2008-09-25 |
| AU2005310888B2 (en) | 2011-01-06 |
| RU2397768C2 (ru) | 2010-08-27 |
| DE602005022939D1 (de) | 2010-09-23 |
| WO2006059344B1 (en) | 2006-11-02 |
| KR20070067189A (ko) | 2007-06-27 |
| DK1841432T3 (da) | 2010-12-06 |
| AU2005310888A1 (en) | 2006-06-08 |
| SI1841432T1 (sl) | 2011-02-28 |
| CN101060846A (zh) | 2007-10-24 |
| KR20090101514A (ko) | 2009-09-28 |
| ES2349301T3 (es) | 2010-12-29 |
| US9012442B2 (en) | 2015-04-21 |
| JP5269415B2 (ja) | 2013-08-21 |
| WO2006059344A1 (en) | 2006-06-08 |
| CY1110886T1 (el) | 2015-06-10 |
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