JP2008530082A5 - - Google Patents

Info

Publication number

JP2008530082A5

JP2008530082A5 JP2007554741A JP2007554741A JP2008530082A5 JP 2008530082 A5 JP2008530082 A5 JP 2008530082A5 JP 2007554741 A JP2007554741 A JP 2007554741A JP 2007554741 A JP2007554741 A JP 2007554741A JP 2008530082 A5 JP2008530082 A5 JP 2008530082A5

Authority

JP

Japan

Prior art keywords

composition

present

weight ratio

filling

pharmaceutically acceptable

Prior art date

2006-02-08

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 239000000203 mixture Substances 0.000 claims 16
• 239000004599 antimicrobial Substances 0.000 claims 6
• 238000011049 filling Methods 0.000 claims 5
• 150000003839 salts Chemical class 0.000 claims 5
• 239000000126 substance Substances 0.000 claims 5
• 239000013598 vector Substances 0.000 claims 5
• IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 4
• 108010059993 Vancomycin Proteins 0.000 claims 4
• 239000003242 anti bacterial agent Substances 0.000 claims 4
• 230000001954 sterilising effect Effects 0.000 claims 4
• 238000004659 sterilization and disinfection Methods 0.000 claims 4
• 239000011261 inert gas Substances 0.000 claims 3
• 239000003112 inhibitor Substances 0.000 claims 3
• 239000002245 particle Substances 0.000 claims 3
• 238000001556 precipitation Methods 0.000 claims 3
• 229960003165 vancomycin Drugs 0.000 claims 3
• MYPYJXKWCTUITO-LYRMYLQWSA-N vancomycin Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)NC)[C@H]1C[C@](C)(N)[C@H](O)[C@H](C)O1 MYPYJXKWCTUITO-LYRMYLQWSA-N 0.000 claims 3
• MYPYJXKWCTUITO-UHFFFAOYSA-N vancomycin Natural products O1C(C(=C2)Cl)=CC=C2C(O)C(C(NC(C2=CC(O)=CC(O)=C2C=2C(O)=CC=C3C=2)C(O)=O)=O)NC(=O)C3NC(=O)C2NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(CC(C)C)NC)C(O)C(C=C3Cl)=CC=C3OC3=CC2=CC1=C3OC1OC(CO)C(O)C(O)C1OC1CC(C)(N)C(O)C(C)O1 MYPYJXKWCTUITO-UHFFFAOYSA-N 0.000 claims 3
• DQJCDTNMLBYVAY-ZXXIYAEKSA-N (2S,5R,10R,13R)-16-{[(2R,3S,4R,5R)-3-{[(2S,3R,4R,5S,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-5-(ethylamino)-6-hydroxy-2-(hydroxymethyl)oxan-4-yl]oxy}-5-(4-aminobutyl)-10-carbamoyl-2,13-dimethyl-4,7,12,15-tetraoxo-3,6,11,14-tetraazaheptadecan-1-oic acid Chemical group NCCCC[C@H](C(=O)N[C@@H](C)C(O)=O)NC(=O)CC[C@H](C(N)=O)NC(=O)[C@@H](C)NC(=O)C(C)O[C@@H]1[C@@H](NCC)C(O)O[C@H](CO)[C@H]1O[C@H]1[C@H](NC(C)=O)[C@@H](O)[C@H](O)[C@@H](CO)O1 DQJCDTNMLBYVAY-ZXXIYAEKSA-N 0.000 claims 2
• 229930186147 Cephalosporin Natural products 0.000 claims 2
• 239000003109 Disodium ethylene diamine tetraacetate Substances 0.000 claims 2
• ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 claims 2
• 108010015899 Glycopeptides Proteins 0.000 claims 2
• 102000002068 Glycopeptides Human genes 0.000 claims 2
• ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 claims 2
• 229930064664 L-arginine Natural products 0.000 claims 2
• 235000014852 L-arginine Nutrition 0.000 claims 2
• 230000003115 biocidal effect Effects 0.000 claims 2
• 230000015572 biosynthetic process Effects 0.000 claims 2
• 229960004755 ceftriaxone Drugs 0.000 claims 2
• VAAUVRVFOQPIGI-SPQHTLEESA-N ceftriaxone Chemical compound S([C@@H]1[C@@H](C(N1C=1C(O)=O)=O)NC(=O)\C(=N/OC)C=2N=C(N)SC=2)CC=1CSC1=NC(=O)C(=O)NN1C VAAUVRVFOQPIGI-SPQHTLEESA-N 0.000 claims 2
• 229960000479 ceftriaxone sodium Drugs 0.000 claims 2
• 229940124587 cephalosporin Drugs 0.000 claims 2
• 150000001780 cephalosporins Chemical group 0.000 claims 2
• 239000003795 chemical substances by application Substances 0.000 claims 2
• 229910001873 dinitrogen Inorganic materials 0.000 claims 2
• 235000019301 disodium ethylene diamine tetraacetate Nutrition 0.000 claims 2
• FDRNWTJTHBSPMW-GNXCPKRQSA-L disodium;(6r,7r)-7-[[(2e)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-[(2-methyl-6-oxido-5-oxo-1,2,4-triazin-3-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate Chemical compound [Na+].[Na+].S([C@@H]1[C@@H](C(N1C=1C([O-])=O)=O)NC(=O)/C(=N/OC)C=2N=C(N)SC=2)CC=1CSC1=NC(=O)C([O-])=NN1C FDRNWTJTHBSPMW-GNXCPKRQSA-L 0.000 claims 2
• 238000004519 manufacturing process Methods 0.000 claims 2
• 239000008194 pharmaceutical composition Substances 0.000 claims 2
• 239000000843 powder Substances 0.000 claims 2
• 239000003381 stabilizer Substances 0.000 claims 2
• 235000001014 amino acid Nutrition 0.000 claims 1
• 150000001413 amino acids Chemical class 0.000 claims 1
• 229940000425 combination drug Drugs 0.000 claims 1
• 229940079593 drug Drugs 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 239000007789 gas Substances 0.000 claims 1
• 239000008187 granular material Substances 0.000 claims 1
• 238000002347 injection Methods 0.000 claims 1
• 239000007924 injection Substances 0.000 claims 1
• 239000011859 microparticle Substances 0.000 claims 1
• 239000004005 microsphere Substances 0.000 claims 1
• 239000002105 nanoparticle Substances 0.000 claims 1
• 230000003472 neutralizing effect Effects 0.000 claims 1
• 229910052757 nitrogen Inorganic materials 0.000 claims 1
• 229910052756 noble gas Inorganic materials 0.000 claims 1
• 150000002835 noble gases Chemical class 0.000 claims 1
• 239000002904 solvent Substances 0.000 claims 1
• 238000012859 sterile filling Methods 0.000 claims 1
• 229960001572 vancomycin hydrochloride Drugs 0.000 claims 1
• LCTORFDMHNKUSG-XTTLPDOESA-N vancomycin monohydrochloride Chemical compound Cl.O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)NC)[C@H]1C[C@](C)(N)[C@H](O)[C@H](C)O1 LCTORFDMHNKUSG-XTTLPDOESA-N 0.000 claims 1