JP2006515520A5 - - Google Patents
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- JP2006515520A5 JP2006515520A5 JP2006500508A JP2006500508A JP2006515520A5 JP 2006515520 A5 JP2006515520 A5 JP 2006515520A5 JP 2006500508 A JP2006500508 A JP 2006500508A JP 2006500508 A JP2006500508 A JP 2006500508A JP 2006515520 A5 JP2006515520 A5 JP 2006515520A5
- Authority
- JP
- Japan
- Prior art keywords
- cell
- nucleic acid
- collection
- library
- polyclonal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 210000004027 cell Anatomy 0.000 claims 74
- 238000000034 method Methods 0.000 claims 59
- 150000007523 nucleic acids Chemical group 0.000 claims 35
- 108090000623 proteins and genes Proteins 0.000 claims 31
- 102000004169 proteins and genes Human genes 0.000 claims 23
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 16
- 239000013598 vector Substances 0.000 claims 16
- 238000004519 manufacturing process Methods 0.000 claims 10
- 108091008874 T cell receptors Proteins 0.000 claims 9
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims 9
- 239000000427 antigen Substances 0.000 claims 7
- 108091007433 antigens Proteins 0.000 claims 7
- 102000036639 antigens Human genes 0.000 claims 7
- 108091026890 Coding region Proteins 0.000 claims 6
- 238000012216 screening Methods 0.000 claims 6
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 5
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 5
- 102000018120 Recombinases Human genes 0.000 claims 5
- 108010091086 Recombinases Proteins 0.000 claims 5
- 239000012634 fragment Substances 0.000 claims 5
- 108020004707 nucleic acids Proteins 0.000 claims 5
- 102000039446 nucleic acids Human genes 0.000 claims 5
- 210000004962 mammalian cell Anatomy 0.000 claims 4
- 108090000765 processed proteins & peptides Proteins 0.000 claims 3
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 2
- 241000699802 Cricetulus griseus Species 0.000 claims 2
- 108020004414 DNA Proteins 0.000 claims 2
- 238000002965 ELISA Methods 0.000 claims 2
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 2
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims 2
- 241000700605 Viruses Species 0.000 claims 2
- 102000006707 alpha-beta T-Cell Antigen Receptors Human genes 0.000 claims 2
- 108010087408 alpha-beta T-Cell Antigen Receptors Proteins 0.000 claims 2
- 238000003556 assay Methods 0.000 claims 2
- 230000001580 bacterial effect Effects 0.000 claims 2
- 238000004113 cell culture Methods 0.000 claims 2
- 238000012258 culturing Methods 0.000 claims 2
- 238000003114 enzyme-linked immunosorbent spot assay Methods 0.000 claims 2
- 210000002950 fibroblast Anatomy 0.000 claims 2
- 102000011778 gamma-delta T-Cell Antigen Receptors Human genes 0.000 claims 2
- 108010062214 gamma-delta T-Cell Antigen Receptors Proteins 0.000 claims 2
- 230000010354 integration Effects 0.000 claims 2
- 238000002955 isolation Methods 0.000 claims 2
- 201000000050 myeloid neoplasm Diseases 0.000 claims 2
- 210000001672 ovary Anatomy 0.000 claims 2
- 238000002823 phage display Methods 0.000 claims 2
- 238000002702 ribosome display Methods 0.000 claims 2
- 238000001890 transfection Methods 0.000 claims 2
- 101710098119 Chaperonin GroEL 2 Proteins 0.000 claims 1
- 239000012228 culture supernatant Substances 0.000 claims 1
- 108020004999 messenger RNA Proteins 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US43840303P | 2003-01-07 | 2003-01-07 | |
| DKPA200300008 | 2003-01-07 | ||
| US47601803P | 2003-06-05 | 2003-06-05 | |
| PCT/DK2004/000001 WO2004061104A2 (en) | 2003-01-07 | 2004-01-07 | Method for manufacturing recombinant polyclonal proteins |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010155716A Division JP2010268806A (ja) | 2003-01-07 | 2010-07-08 | 組換え型ポリクローナルタンパク質の製造方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006515520A JP2006515520A (ja) | 2006-06-01 |
| JP2006515520A5 true JP2006515520A5 (https=) | 2007-01-11 |
| JP4589914B2 JP4589914B2 (ja) | 2010-12-01 |
Family
ID=32718469
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006500508A Expired - Fee Related JP4589914B2 (ja) | 2003-01-07 | 2004-01-07 | 組換え型ポリクローナルタンパク質の製造方法 |
| JP2010155716A Pending JP2010268806A (ja) | 2003-01-07 | 2010-07-08 | 組換え型ポリクローナルタンパク質の製造方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010155716A Pending JP2010268806A (ja) | 2003-01-07 | 2010-07-08 | 組換え型ポリクローナルタンパク質の製造方法 |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US9163232B2 (https=) |
| EP (2) | EP1583830B1 (https=) |
| JP (2) | JP4589914B2 (https=) |
| KR (1) | KR101024443B1 (https=) |
| AT (1) | ATE338816T1 (https=) |
| AU (1) | AU2004203727C1 (https=) |
| BR (1) | BRPI0406678A (https=) |
| CA (1) | CA2512647C (https=) |
| DE (1) | DE602004002275T2 (https=) |
| DK (1) | DK1583830T3 (https=) |
| EA (1) | EA013225B1 (https=) |
| ES (1) | ES2273202T3 (https=) |
| IL (1) | IL169101A (https=) |
| MX (1) | MXPA05006724A (https=) |
| NZ (1) | NZ541458A (https=) |
| PT (1) | PT1583830E (https=) |
| SI (1) | SI1583830T1 (https=) |
| WO (1) | WO2004061104A2 (https=) |
Families Citing this family (81)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| USRE47770E1 (en) | 2002-07-18 | 2019-12-17 | Merus N.V. | Recombinant production of mixtures of antibodies |
| NZ537277A (en) | 2002-07-18 | 2008-04-30 | Crucell Holland Bv | Recombinant production of mixtures of antibodies |
| ES2273202T3 (es) | 2003-01-07 | 2007-05-01 | Symphogen A/S | Procedimiento para producir proteinas policlonales recombinantes. |
| TWI333977B (en) | 2003-09-18 | 2010-12-01 | Symphogen As | Method for linking sequences of interest |
| KR20070038556A (ko) * | 2004-07-20 | 2007-04-10 | 심포젠 에이/에스 | 항-ｒｈｅｓｕｓ ｄ 재조합 폴리클로날 항체 및 이의 제조방법 |
| ES2332524T3 (es) * | 2004-07-20 | 2010-02-08 | Symphogen A/S | Un procedimiento para la caracterizacion de una linea celular policlonal. |
| JP4856177B2 (ja) | 2005-06-24 | 2012-01-18 | ユニジーン・ラボラトリーズ・インコーポレーテッド | アミド化生成物の調製に有用な酵素を発現させるための細胞株 |
| EP2314619A1 (en) | 2005-12-05 | 2011-04-27 | Symphogen A/S | Anti-orthopoxvirus recombinant polyclonal antibody |
| JP2009528828A (ja) * | 2006-03-06 | 2009-08-13 | シムフォゲン・アクティーゼルスカブ | 消化器多核体ウイルス感染症の治療のための組み換えポリクローナル抗体 |
| US7504106B2 (en) | 2006-03-14 | 2009-03-17 | Boris Skurkovich | Method and composition for treatment of renal failure with antibodies and their equivalents as partial or complete replacement for dialysis |
| FR2910490B1 (fr) * | 2006-12-20 | 2012-10-26 | Lab Francais Du Fractionnement | Lignee cellulaire a forte activite transcriptionnelle pour la production de proteines, notamment therapeutiques |
| US9249423B2 (en) | 2007-02-02 | 2016-02-02 | Yale University | Method of de-differentiating and re-differentiating somatic cells using RNA |
| US10155038B2 (en) | 2007-02-02 | 2018-12-18 | Yale University | Cells prepared by transient transfection and methods of use thereof |
| US8859229B2 (en) * | 2007-02-02 | 2014-10-14 | Yale University | Transient transfection with RNA |
| TW200846362A (en) * | 2007-02-09 | 2008-12-01 | Symphogen As | A polyclonal antibody product |
| PT2121920E (pt) | 2007-03-01 | 2011-10-03 | Symphogen As | Método de clonagem de anticorpos cognatos |
| CN101675075B (zh) | 2007-03-01 | 2014-06-18 | 西福根有限公司 | 重组抗表皮生长因子受体抗体组合物 |
| WO2008106980A2 (en) | 2007-03-06 | 2008-09-12 | Symphogen A/S | Recombinant antibodies for treatment of respiratory syncytial virus infections |
| HRP20100640T1 (hr) | 2007-05-25 | 2010-12-31 | Symphogen A/S | Postupak proizvodnje rekombinantnog poliklonskog proteina |
| HRP20170407T1 (hr) | 2007-08-30 | 2017-05-05 | Daiichi Sankyo Company, Limited | Anti-epha2 anitijelo |
| EP2725035A1 (en) | 2007-10-02 | 2014-04-30 | Avaxia Biologics, Inc. | Antibody therapy for use in the digestive tract |
| JPWO2009048072A1 (ja) | 2007-10-11 | 2011-02-17 | 第一三共株式会社 | 破骨細胞関連蛋白質Ｓｉｇｌｅｃ−１５を標的とした抗体 |
| RU2010147652A (ru) * | 2008-04-23 | 2012-05-27 | Симфоген А/С (Dk) | Способы производства поликлонального белка |
| RU2011111725A (ru) * | 2008-08-29 | 2012-10-10 | Симфоген А/С (Dk) | Способ клонирования антител птиц |
| US8663640B2 (en) | 2008-08-29 | 2014-03-04 | Symphogen A/S | Methods using recombinant anti-epidermal growth factor receptor antibody compositions |
| RU2539790C2 (ru) | 2009-04-09 | 2015-01-27 | Дайити Санкио Компани, Лимитед | АНТИТЕЛО ПРОТИВ Siglec-15 |
| JP2013508300A (ja) | 2009-10-15 | 2013-03-07 | アヴァクシア バイオロジクス，インコーポレーテッド | 消化管において局所的活性を有する抗体治療薬 |
| NZ610153A (en) | 2010-10-29 | 2014-07-25 | Daiichi Sankyo Co Ltd | Novel anti-dr5 antibody |
| JP6033783B2 (ja) | 2010-11-01 | 2016-11-30 | シムフォゲン・アクティーゼルスカブＳｙｍｐｈｏｇｅｎ Ａ／Ｓ | Ｐａｎ−ｈｅｒ抗体組成物 |
| DK2640743T3 (en) | 2010-11-16 | 2017-01-23 | Excelimmune Inc | PROCEDURES FOR THE PREPARATION OF RECOMBINANT PROTEINS |
| SMT201800269T1 (it) | 2011-04-25 | 2018-07-17 | Daiichi Sankyo Co Ltd | Anticorpo anti-b7-h3 |
| EP2794878B1 (en) | 2011-12-22 | 2020-03-18 | F.Hoffmann-La Roche Ag | Expression vector organization, novel production cell generation methods and their use for the recombinant production of polypeptides |
| GB2502127A (en) | 2012-05-17 | 2013-11-20 | Kymab Ltd | Multivalent antibodies and in vivo methods for their production |
| EP2832855A4 (en) | 2012-03-30 | 2016-02-24 | Daiichi Sankyo Co Ltd | NOVEL ANTI-SIGLEC-15 ANTIBODY |
| MX2014011828A (es) | 2012-03-30 | 2014-12-10 | Daiichi Sankyo Co Ltd | Anticuerpo anti-siglec-15 con region determinante de complementariedad modificada. |
| EP2837685B1 (en) | 2012-04-09 | 2020-09-09 | Daiichi Sankyo Company, Limited | Anti-fgfr2 antibody |
| SI2838917T1 (sl) | 2012-04-20 | 2019-11-29 | Merus Nv | Postopki in sredstva za produkcijo heterodimernih IG-podobnih molekul |
| MX356749B (es) | 2012-04-27 | 2018-06-12 | Daiichi Sankyo Co Ltd | Anticuerpo anti-homologo 4 de roundabout (robo4). |
| EP2844675B1 (en) | 2012-05-02 | 2019-01-02 | Symphogen A/S | Humanized pan-her antibody compositions |
| JP2015163047A (ja) * | 2012-06-20 | 2015-09-10 | 国立大学法人 東京大学 | タンパク質の迅速改良法 |
| BR112015000167B1 (pt) | 2012-07-06 | 2021-11-23 | Genmab B.V. | Proteína dimérica, proteína, composição, kit de partes e seus usos, bem como método para aumentar a oligomerização em solução de uma proteína dimérica compreendendo um primeiro e segundo polipeptídeo, cada um compreendendo pelo menos as regiões ch2 e ch3 de uma cadeia pesada de igg1 humana e proteína dimérica variante |
| EP3470431A1 (en) | 2012-09-27 | 2019-04-17 | Merus N.V. | Bispecific igg antibodies as t cell engagers |
| EP2953970A4 (en) | 2013-02-08 | 2016-06-29 | Misfolding Diagnostics Inc | TRANSTYRETIN ANTIBODIES AND USES THEREOF |
| KR20160062009A (ko) | 2013-09-30 | 2016-06-01 | 다이이찌 산쿄 가부시키가이샤 | 항―ｌｐｓ ０１１ 항체 |
| KR20220019839A (ko) | 2013-10-08 | 2022-02-17 | 다이이찌 산쿄 가부시키가이샤 | 항 fgfr2 항체와 타제의 조합 |
| WO2015093925A1 (es) * | 2013-12-19 | 2015-06-25 | CASTRO ALDRETE, Jorge Isaac | Método de producción de anticuerpos específicos |
| IL301147A (en) | 2014-02-28 | 2023-05-01 | Merus Nv | An antibody that binds to ErbB-2 and ErbB-3 |
| EP3786186A1 (en) | 2014-02-28 | 2021-03-03 | Merus N.V. | Antibodies that bind egfr and erbb3 |
| US10450376B2 (en) | 2014-09-16 | 2019-10-22 | Symphogen A/S | Anti-MET antibodies and compositions |
| AU2016243124A1 (en) | 2015-03-27 | 2017-11-02 | University Of Southern California | CAR T-cell therapy directed to LHR for the treatment of solid tumors |
| JP7010473B2 (ja) | 2015-06-04 | 2022-02-10 | ユニバーシティ オブ サザン カリフォルニア | Ｌｙｍ－１およびｌｙｍ－２標的化ｃａｒ細胞免疫療法 |
| SI3115376T1 (sl) | 2015-07-10 | 2018-12-31 | Merus N.V. | Humana protitelesa, ki vežejo CD3 |
| CA2999037A1 (en) | 2015-09-23 | 2017-03-30 | Cytoimmune Therapeutics, LLC | Flt3 directed car cells for immunotherapy |
| TWI909341B (zh) | 2015-09-24 | 2025-12-21 | 日商第一三共股份有限公司 | 抗garp抗體及其製造方法及用途 |
| CA3002957A1 (en) | 2015-10-23 | 2017-04-27 | Koninklijke Nederlandse Akademie Van Wetenschappen | Binding molecules that inhibit cancer growth |
| AU2017269115B2 (en) | 2016-05-26 | 2024-06-20 | Qilu Puget Sound Biotherapeutics Corporation | Mixtures of antibodies |
| MX2019007347A (es) | 2016-12-22 | 2019-12-05 | Daiichi Sankyo Co Ltd | Anticuerpo anti-cd3 y moleculas que comprenden el anticuerpo. |
| TW201837174A (zh) | 2017-02-07 | 2018-10-16 | 日商第一三共股份有限公司 | 抗ｇｐｒｃ５ｄ抗體及包含該抗體之分子 |
| TWI782000B (zh) | 2017-03-30 | 2022-11-01 | 日商第一三共股份有限公司 | 抗ｇｐｒ２０抗體、其製造方法及其應用 |
| AU2018246873B2 (en) | 2017-03-31 | 2021-05-06 | Merus B.V. | ErbB-2 and ErbB3 binding bispecific antibodies for use in the treatment f cells that have an NRG1 fusion gene |
| EA201992350A1 (ru) | 2017-04-05 | 2020-03-23 | Симфоген А/С | Комбинированные лекарственные средства, нацеленные на pd-1, tim-3 и lag-3 |
| WO2018212656A1 (en) | 2017-05-17 | 2018-11-22 | Merus N.V. | Combination of an erbb-2/erbb-3 bispecific antibody with endocrine therapy for breast cancer |
| JP7181535B2 (ja) | 2017-06-30 | 2022-12-01 | 国立大学法人北海道大学 | 成長障害を生じない小児骨粗鬆症治療薬 |
| CA3071234A1 (en) | 2017-07-27 | 2019-01-31 | Daiichi Sankyo Company, Limited | Anti-cd147 antibody |
| CN118580366A (zh) | 2017-08-09 | 2024-09-03 | 美勒斯公司 | 结合EGFR和cMET的抗体 |
| EP3693012A4 (en) | 2017-10-05 | 2021-07-21 | Daiichi Sankyo Company, Limited | CYTOTOXIC T-CELL DEPLOYMENT COMPOSITION |
| US11795579B2 (en) | 2017-12-11 | 2023-10-24 | Abalone Bio, Inc. | Yeast display of proteins in the periplasmic space |
| CA3093205A1 (en) | 2018-03-05 | 2019-09-12 | Saitama Medical University | Pharmaceutical composition for treating or preventing heterotopic ossification |
| CA3099900A1 (en) | 2018-05-31 | 2019-12-05 | Daiichi Sankyo Company, Limited | Anti-human tlr7 antibody |
| CN112513074A (zh) * | 2018-06-22 | 2021-03-16 | 健玛保 | 生产两种或更多种不同抗体的受控混合物的方法 |
| KR20250079073A (ko) | 2018-07-10 | 2025-06-04 | 고쿠리츠다이가쿠호진 고베다이가쿠 | 항 SIRPα 항체 |
| TWI846717B (zh) | 2018-07-27 | 2024-07-01 | 日商第一三共股份有限公司 | 辨識抗體-藥物結合物之藥物部位的蛋白質 |
| EP3870604B1 (en) | 2018-10-26 | 2022-11-23 | F. Hoffmann-La Roche AG | Multispecific antibody screening method using recombinase mediated cassette exchange |
| US12590386B2 (en) | 2019-04-30 | 2026-03-31 | Gigagen, Inc. | Recombinant polyclonal proteins and methods of use thereof |
| JP7668013B2 (ja) | 2019-07-26 | 2025-04-24 | 学校法人 埼玉医科大学 | Ａｌｋ２／ａｃｖｒ１の細胞外領域を認識する抗体 |
| EP4049675A4 (en) | 2019-10-25 | 2023-11-22 | Daiichi Sankyo Company, Limited | COMBINATION OF ANTI-GARP ANTIBODIES AND IMMUNE REGULATOR |
| JP2023509062A (ja) | 2019-12-31 | 2023-03-06 | アンタゴニス | 黄色ブドウ球菌感染の予防のための組成物および方法 |
| CA3177152A1 (en) | 2020-06-12 | 2021-12-16 | David Scott Johnson | Recombinant polyclonal proteins targeting covid-19 and methods of use thereof |
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| IL324556A (en) | 2023-05-19 | 2026-01-01 | Servier Lab | Anti-met antibodies, antibody-drug conjugates, compositions and uses thereof |
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| ES2332524T3 (es) | 2004-07-20 | 2010-02-08 | Symphogen A/S | Un procedimiento para la caracterizacion de una linea celular policlonal. |
| EP2314619A1 (en) | 2005-12-05 | 2011-04-27 | Symphogen A/S | Anti-orthopoxvirus recombinant polyclonal antibody |
| JP2009528828A (ja) | 2006-03-06 | 2009-08-13 | シムフォゲン・アクティーゼルスカブ | 消化器多核体ウイルス感染症の治療のための組み換えポリクローナル抗体 |
| TW200846362A (en) | 2007-02-09 | 2008-12-01 | Symphogen As | A polyclonal antibody product |
| HRP20100640T1 (hr) | 2007-05-25 | 2010-12-31 | Symphogen A/S | Postupak proizvodnje rekombinantnog poliklonskog proteina |
-
2004
- 2004-01-07 ES ES04700438T patent/ES2273202T3/es not_active Expired - Lifetime
- 2004-01-07 MX MXPA05006724A patent/MXPA05006724A/es active IP Right Grant
- 2004-01-07 CA CA2512647A patent/CA2512647C/en not_active Expired - Fee Related
- 2004-01-07 JP JP2006500508A patent/JP4589914B2/ja not_active Expired - Fee Related
- 2004-01-07 BR BR0406678-2A patent/BRPI0406678A/pt not_active Application Discontinuation
- 2004-01-07 DE DE602004002275T patent/DE602004002275T2/de not_active Expired - Lifetime
- 2004-01-07 EP EP04700438A patent/EP1583830B1/en not_active Expired - Lifetime
- 2004-01-07 EA EA200501101A patent/EA013225B1/ru not_active IP Right Cessation
- 2004-01-07 NZ NZ541458A patent/NZ541458A/en not_active IP Right Cessation
- 2004-01-07 KR KR1020057012745A patent/KR101024443B1/ko not_active Expired - Fee Related
- 2004-01-07 SI SI200430074T patent/SI1583830T1/sl unknown
- 2004-01-07 DK DK04700438T patent/DK1583830T3/da active
- 2004-01-07 EP EP06018504A patent/EP1762617A1/en not_active Withdrawn
- 2004-01-07 WO PCT/DK2004/000001 patent/WO2004061104A2/en not_active Ceased
- 2004-01-07 AT AT04700438T patent/ATE338816T1/de active
- 2004-01-07 AU AU2004203727A patent/AU2004203727C1/en not_active Ceased
- 2004-01-07 PT PT04700438T patent/PT1583830E/pt unknown
-
2005
- 2005-06-09 IL IL169101A patent/IL169101A/en not_active IP Right Cessation
-
2008
- 2008-12-19 US US12/339,490 patent/US9163232B2/en not_active Expired - Fee Related
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2010
- 2010-07-08 JP JP2010155716A patent/JP2010268806A/ja active Pending
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