JP2006515520A5 - - Google Patents
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- JP2006515520A5 JP2006515520A5 JP2006500508A JP2006500508A JP2006515520A5 JP 2006515520 A5 JP2006515520 A5 JP 2006515520A5 JP 2006500508 A JP2006500508 A JP 2006500508A JP 2006500508 A JP2006500508 A JP 2006500508A JP 2006515520 A5 JP2006515520 A5 JP 2006515520A5
- Authority
- JP
- Japan
- Prior art keywords
- cell
- nucleic acid
- collection
- library
- polyclonal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 210000004027 cell Anatomy 0.000 claims 74
- 238000000034 method Methods 0.000 claims 59
- 150000007523 nucleic acids Chemical group 0.000 claims 35
- 108090000623 proteins and genes Proteins 0.000 claims 31
- 102000004169 proteins and genes Human genes 0.000 claims 23
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 16
- 239000013598 vector Substances 0.000 claims 16
- 238000004519 manufacturing process Methods 0.000 claims 10
- 108091008874 T cell receptors Proteins 0.000 claims 9
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims 9
- 239000000427 antigen Substances 0.000 claims 7
- 108091007433 antigens Proteins 0.000 claims 7
- 102000036639 antigens Human genes 0.000 claims 7
- 108091026890 Coding region Proteins 0.000 claims 6
- 238000012216 screening Methods 0.000 claims 6
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 5
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 5
- 102000018120 Recombinases Human genes 0.000 claims 5
- 108010091086 Recombinases Proteins 0.000 claims 5
- 239000012634 fragment Substances 0.000 claims 5
- 108020004707 nucleic acids Proteins 0.000 claims 5
- 102000039446 nucleic acids Human genes 0.000 claims 5
- 210000004962 mammalian cell Anatomy 0.000 claims 4
- 108090000765 processed proteins & peptides Proteins 0.000 claims 3
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 2
- 241000699802 Cricetulus griseus Species 0.000 claims 2
- 108020004414 DNA Proteins 0.000 claims 2
- 238000002965 ELISA Methods 0.000 claims 2
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 2
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims 2
- 241000700605 Viruses Species 0.000 claims 2
- 102000006707 alpha-beta T-Cell Antigen Receptors Human genes 0.000 claims 2
- 108010087408 alpha-beta T-Cell Antigen Receptors Proteins 0.000 claims 2
- 238000003556 assay Methods 0.000 claims 2
- 230000001580 bacterial effect Effects 0.000 claims 2
- 238000004113 cell culture Methods 0.000 claims 2
- 238000012258 culturing Methods 0.000 claims 2
- 238000003114 enzyme-linked immunosorbent spot assay Methods 0.000 claims 2
- 210000002950 fibroblast Anatomy 0.000 claims 2
- 102000011778 gamma-delta T-Cell Antigen Receptors Human genes 0.000 claims 2
- 108010062214 gamma-delta T-Cell Antigen Receptors Proteins 0.000 claims 2
- 230000010354 integration Effects 0.000 claims 2
- 238000002955 isolation Methods 0.000 claims 2
- 201000000050 myeloid neoplasm Diseases 0.000 claims 2
- 210000001672 ovary Anatomy 0.000 claims 2
- 238000002823 phage display Methods 0.000 claims 2
- 238000002702 ribosome display Methods 0.000 claims 2
- 238000001890 transfection Methods 0.000 claims 2
- 101710098119 Chaperonin GroEL 2 Proteins 0.000 claims 1
- 239000012228 culture supernatant Substances 0.000 claims 1
- 108020004999 messenger RNA Proteins 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US43840303P | 2003-01-07 | 2003-01-07 | |
| DKPA200300008 | 2003-01-07 | ||
| US47601803P | 2003-06-05 | 2003-06-05 | |
| PCT/DK2004/000001 WO2004061104A2 (en) | 2003-01-07 | 2004-01-07 | Method for manufacturing recombinant polyclonal proteins |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010155716A Division JP2010268806A (ja) | 2003-01-07 | 2010-07-08 | 組換え型ポリクローナルタンパク質の製造方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006515520A JP2006515520A (ja) | 2006-06-01 |
| JP2006515520A5 true JP2006515520A5 (https=) | 2007-01-11 |
| JP4589914B2 JP4589914B2 (ja) | 2010-12-01 |
Family
ID=32718469
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006500508A Expired - Fee Related JP4589914B2 (ja) | 2003-01-07 | 2004-01-07 | 組換え型ポリクローナルタンパク質の製造方法 |
| JP2010155716A Pending JP2010268806A (ja) | 2003-01-07 | 2010-07-08 | 組換え型ポリクローナルタンパク質の製造方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010155716A Pending JP2010268806A (ja) | 2003-01-07 | 2010-07-08 | 組換え型ポリクローナルタンパク質の製造方法 |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US9163232B2 (https=) |
| EP (2) | EP1762617A1 (https=) |
| JP (2) | JP4589914B2 (https=) |
| KR (1) | KR101024443B1 (https=) |
| AT (1) | ATE338816T1 (https=) |
| AU (1) | AU2004203727C1 (https=) |
| BR (1) | BRPI0406678A (https=) |
| CA (1) | CA2512647C (https=) |
| DE (1) | DE602004002275T2 (https=) |
| DK (1) | DK1583830T3 (https=) |
| EA (1) | EA013225B1 (https=) |
| ES (1) | ES2273202T3 (https=) |
| IL (1) | IL169101A (https=) |
| MX (1) | MXPA05006724A (https=) |
| NZ (1) | NZ541458A (https=) |
| PT (1) | PT1583830E (https=) |
| SI (1) | SI1583830T1 (https=) |
| WO (1) | WO2004061104A2 (https=) |
Families Citing this family (81)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| USRE47770E1 (en) | 2002-07-18 | 2019-12-17 | Merus N.V. | Recombinant production of mixtures of antibodies |
| DK2314629T4 (da) | 2002-07-18 | 2023-02-06 | Merus Nv | Rekombinant produktion af blandinger af antistoffer |
| SI1583830T1 (sl) | 2003-01-07 | 2006-12-31 | Symphogen As | Postopek za pripravo rekombinantnih poliklonskih proteinov |
| TWI333977B (en) | 2003-09-18 | 2010-12-01 | Symphogen As | Method for linking sequences of interest |
| US8288109B2 (en) * | 2004-07-20 | 2012-10-16 | Symphogen A/S | Procedure for structural characterization of a recombinant polyclonal protein or a polyclonal cell line |
| EA014182B1 (ru) * | 2004-07-20 | 2010-10-29 | Симфоген А/С | КОМПОЗИЦИЯ ПОЛИКЛОНАЛЬНЫХ АНТИ-RhD АНТИТЕЛ, СПОСОБ ЕЁ ПОЛУЧЕНИЯ И ПРИМЕНЕНИЕ КОМПОЗИЦИИ |
| AU2006261909B2 (en) * | 2005-06-24 | 2011-08-11 | Enteris Biopharma, Inc. | Cell lines for expressing enzyme useful in the preparation of amidated products |
| US7850965B2 (en) | 2005-12-05 | 2010-12-14 | Symphogen A/S | Anti-orthopoxvirus recombinant polyclonal antibody |
| WO2007101441A1 (en) * | 2006-03-06 | 2007-09-13 | Symphogen A/S | Recombinant polyclonal antibody for treatment of respiratory syncytial virus infections |
| US7504106B2 (en) | 2006-03-14 | 2009-03-17 | Boris Skurkovich | Method and composition for treatment of renal failure with antibodies and their equivalents as partial or complete replacement for dialysis |
| FR2910490B1 (fr) * | 2006-12-20 | 2012-10-26 | Lab Francais Du Fractionnement | Lignee cellulaire a forte activite transcriptionnelle pour la production de proteines, notamment therapeutiques |
| US10155038B2 (en) | 2007-02-02 | 2018-12-18 | Yale University | Cells prepared by transient transfection and methods of use thereof |
| US9249423B2 (en) | 2007-02-02 | 2016-02-02 | Yale University | Method of de-differentiating and re-differentiating somatic cells using RNA |
| WO2008097926A2 (en) * | 2007-02-02 | 2008-08-14 | Yale University | Transient transfection with rna |
| TW200846362A (en) * | 2007-02-09 | 2008-12-01 | Symphogen As | A polyclonal antibody product |
| BRPI0808551B1 (pt) | 2007-03-01 | 2022-04-05 | Symphogen A/S | Composições de anticorpo para o receptor do fator de crescimento antiepidérmico recombinante, molécula de ligação bi-específica e composição farmacêutica que os compreende |
| DK2121920T3 (da) | 2007-03-01 | 2011-11-21 | Symphogen As | Fremgangsmåde til kloning af sammenhørende antistoffer |
| JP2010534057A (ja) | 2007-03-06 | 2010-11-04 | シムフォゲン・アクティーゼルスカブ | 呼吸器合胞体ウイルス感染症を治療するための組換え抗体 |
| MX2009012526A (es) * | 2007-05-25 | 2009-12-09 | Symphogen As | Metodo para fabricar una proteina policlonal recombinante. |
| BRPI0816094A2 (pt) | 2007-08-30 | 2015-03-03 | Daiichi Sankyo Co Ltd | Anticorpo, polipeptídeo, hibridoma, composição farmacêutica, método para inibir o desenvolvimento de tumor em um mamífero, polinucleotídeo, célula hospedeira, e, método para produzir um anticorpo. |
| EP2725035A1 (en) | 2007-10-02 | 2014-04-30 | Avaxia Biologics, Inc. | Antibody therapy for use in the digestive tract |
| BRPI0818437B8 (pt) | 2007-10-11 | 2021-05-25 | Daiichi Sankyo Co Ltd | anticorpo ou fragmento funcional do anticorpo, composição farmacêutica, uso de pelo menos um dos anticorpos ou fragmentos funcionais dos anticorpos, e, hibridoma |
| NZ588651A (en) * | 2008-04-23 | 2012-04-27 | Symphogen As | Methods for manufacturing a polyclonal protein |
| CN102137928A (zh) * | 2008-08-29 | 2011-07-27 | 西福根有限公司 | 克隆禽源抗体的方法 |
| WO2010022736A2 (en) | 2008-08-29 | 2010-03-04 | Symphogen A/S | Recombinant anti-epidermal growth factor receptor antibody compositions |
| MX343049B (es) | 2009-04-09 | 2016-10-21 | Daiichi Sankyo Co Ltd | Anticuerpo anti-lectina similar a inmunoglobulina de union a acido sialico-15. |
| PL2488202T3 (pl) | 2009-10-15 | 2015-12-31 | Avaxia Biologics Inc | Przeciwciała terapeutyczne o aktywności miejscowej w przewodzie pokarmowym |
| PH12013500845A1 (en) | 2010-10-29 | 2013-06-24 | Daiichi Sankyo Co Ltd | Novel anti-dr5 antibody |
| MX347981B (es) | 2010-11-01 | 2017-05-22 | Symphogen As | Composicion de anticuerpos pan-her. |
| WO2012068317A2 (en) | 2010-11-16 | 2012-05-24 | Excelimmune, Inc. | Methods for producing recombinant proteins |
| WO2012147713A1 (ja) | 2011-04-25 | 2012-11-01 | 第一三共株式会社 | 抗ｂ７－ｈ３抗体 |
| ES2791758T3 (es) | 2011-12-22 | 2020-11-05 | Hoffmann La Roche | Organización de vectores de expresión, procedimientos de generación de células de producción novedosos y su uso para la producción recombinante de polipéptidos |
| GB2502127A (en) | 2012-05-17 | 2013-11-20 | Kymab Ltd | Multivalent antibodies and in vivo methods for their production |
| BR112014024267A8 (pt) | 2012-03-30 | 2017-07-25 | Daiichi Sankyo Co Ltd | anticorpo ou um fragmento de ligação de antígeno do anticorpo, composição farmacêutica, usos de pelo menos um dos anticorpos ou fragmentos de ligação de antígeno e de uma composição, polinucleotídeo, vetor, e, célula hospedeira transformada |
| MX2014011828A (es) | 2012-03-30 | 2014-12-10 | Daiichi Sankyo Co Ltd | Anticuerpo anti-siglec-15 con region determinante de complementariedad modificada. |
| AU2013247645B2 (en) | 2012-04-09 | 2019-02-14 | Daiichi Sankyo Company, Limited | Anti-FGFR2 antibody |
| US9248181B2 (en) | 2012-04-20 | 2016-02-02 | Merus B.V. | Methods and means for the production of Ig-like molecules |
| WO2013160879A1 (en) | 2012-04-27 | 2013-10-31 | Daiichi Sankyo Company, Limited | Anti-robo4-antibody |
| WO2013164689A2 (en) | 2012-05-02 | 2013-11-07 | Lantto, Johan | Humanized pan-her antibody compositions |
| JP2015163047A (ja) * | 2012-06-20 | 2015-09-10 | 国立大学法人 東京大学 | タンパク質の迅速改良法 |
| CN104736174B (zh) | 2012-07-06 | 2019-06-14 | 根马布私人有限公司 | 具有三重突变的二聚体蛋白质 |
| HUE042040T2 (hu) | 2012-09-27 | 2019-06-28 | Merus Nv | Bispecifikus IGG antitestek mint T-sejt kapcsolók |
| US9790269B2 (en) | 2013-02-08 | 2017-10-17 | Misfolding Diagnostics, Inc. | Transthyretin antibodies and uses thereof |
| CA2925897A1 (en) | 2013-09-30 | 2015-04-02 | Daiichi Sankyo Company, Limited | Anti-lps o11 antibody |
| TWI664977B (zh) | 2013-10-08 | 2019-07-11 | 第一三共股份有限公司 | 抗ｆｇｆｒ２抗體及其與其他藥劑之組合 |
| WO2015093925A1 (es) * | 2013-12-19 | 2015-06-25 | CASTRO ALDRETE, Jorge Isaac | Método de producción de anticuerpos específicos |
| WO2015130173A1 (en) | 2014-02-28 | 2015-09-03 | Merus B.V. | Antibody that binds erbb-2 and erbb-3 |
| JP6771385B2 (ja) | 2014-02-28 | 2020-10-21 | メルス ナムローゼ フェンノートシャップ | 二重特異性抗体および医薬組成物 |
| ES2748295T3 (es) | 2014-09-16 | 2020-03-16 | Symphogen As | Anticuerpos anti-MET y composiciones |
| WO2016160618A2 (en) | 2015-03-27 | 2016-10-06 | University Of Southern California | Car t-cell therapy directed to lhr for the treatment of solid tumors |
| WO2016197064A1 (en) | 2015-06-04 | 2016-12-08 | Epstein Alan L | Lym-1 and lym-2 targeted car cell immunotherapy |
| US9914777B2 (en) | 2015-07-10 | 2018-03-13 | Merus N.V. | Human CD3 binding antibody |
| EP3569244A1 (en) | 2015-09-23 | 2019-11-20 | CytoImmune Therapeutics, LLC | Flt3 directed car cells for immunotherapy |
| DK3354729T5 (da) | 2015-09-24 | 2024-09-30 | Daiichi Sankyo Co Ltd | Anti-garp-antistof |
| SMT202100230T1 (it) | 2015-10-23 | 2021-07-12 | Fundacio Inst De Recerca Biomedica Irb Barcelona | Molecole di legame che inibiscono la crescita tumorale |
| CN109475627B (zh) * | 2016-05-26 | 2023-01-06 | 齐鲁普吉湾生物治疗公司 | 抗体混合物 |
| JP7202185B2 (ja) | 2016-12-22 | 2023-01-11 | 第一三共株式会社 | 抗ｃｄ３抗体及び該抗体を含む分子 |
| SG11201907321TA (en) | 2017-02-07 | 2019-09-27 | Daiichi Sankyo Co Ltd | Anti-gprc5d antibody and molecule comprising the antibody |
| TWI782000B (zh) | 2017-03-30 | 2022-11-01 | 日商第一三共股份有限公司 | 抗ｇｐｒ２０抗體、其製造方法及其應用 |
| IL269656B2 (en) | 2017-03-31 | 2024-06-01 | Merus Nv | Bispecific antibodies that bind ERBB-2 and ERBB3 for use in the treatment of cells with NRG1 fusion gene |
| UA129904C2 (uk) | 2017-04-05 | 2025-09-10 | Ле Лаборатуар Сервьє | Комбінація антитіла до tim-3 й антитіла до pd-1 для лікування раку |
| JP7296891B2 (ja) | 2017-05-17 | 2023-06-23 | メルス ナムローゼ フェンノートシャップ | 乳癌のためのＥｒｂＢ－２／ＥｒｂＢ－３二重特異性抗体と内分泌療法との組み合わせ |
| WO2019004487A1 (ja) | 2017-06-30 | 2019-01-03 | 国立大学法人北海道大学 | 成長障害を生じない小児骨粗鬆症治療薬 |
| US11661451B2 (en) | 2017-07-27 | 2023-05-30 | Daiichi Sankyo Company, Limited | Anti-CD147 antibody |
| SG11202001050PA (en) | 2017-08-09 | 2020-03-30 | Merus Nv | Antibodies that bind egfr and cmet |
| EP3693012A4 (en) | 2017-10-05 | 2021-07-21 | Daiichi Sankyo Company, Limited | CYTOTOXIC T-CELL DEPLOYMENT COMPOSITION |
| IL275239B2 (en) | 2017-12-11 | 2026-03-01 | Abalone Bio Inc | Yeast presentation of proteins in the subplasmic space |
| MX2020008582A (es) | 2018-03-05 | 2020-09-21 | Univ Saitama Medical | Composicion farmaceutica para tratar o prevenir la osificacion heterotopica. |
| BR112020021266A2 (pt) | 2018-05-31 | 2021-01-26 | Daiichi Sankyo Company, Limited | anticorpo anti-tlr7 humano |
| EP3810649A1 (en) * | 2018-06-22 | 2021-04-28 | Genmab A/S | Method for producing a controlled mixture of two or more different antibodies |
| SG11202012338QA (en) | 2018-07-10 | 2021-01-28 | Univ Kobe Nat Univ Corp | ANTI-SIRPa ANTIBODY |
| WO2020022475A1 (ja) | 2018-07-27 | 2020-01-30 | 第一三共株式会社 | 抗体－薬物コンジュゲートの薬物部位を認識する蛋白質 |
| WO2020084034A1 (en) * | 2018-10-26 | 2020-04-30 | F. Hoffmann-La Roche Ag | Multispecific antibody screening method using recombinase mediated cassette exchange |
| CN113728003A (zh) | 2019-04-30 | 2021-11-30 | 吉加根公司 | 重组多克隆蛋白及其使用方法 |
| EP4008350A4 (en) | 2019-07-26 | 2023-06-14 | Saitama Medical University | ANTIBODY RECOGNIZING THE EXTRACELLULAR REGION OF ALK2/ACVR1 |
| US20240190961A1 (en) | 2019-10-25 | 2024-06-13 | Daiichi Sankyo Company, Limited | Combination of anti-garp antibody and immunomodulator |
| EP4084824A1 (en) | 2019-12-31 | 2022-11-09 | Antagonis | Compositions and methods for the prevention of s. aureus infection |
| WO2021253002A1 (en) | 2020-06-12 | 2021-12-16 | Gigagen, Inc. | Recombinant polyclonal proteins targeting covid-19 and methods of use thereof |
| WO2022031834A1 (en) * | 2020-08-05 | 2022-02-10 | Gigagen, Inc. | Recombinant polyclonal proteins targeting zika and methods of use thereof |
| EP4204005A1 (en) | 2020-08-31 | 2023-07-05 | Sab, Llc | Ungulate-derived polyclonal immunoglobulin specific for coronavirus protein and uses thereof |
| EP4713360A1 (en) | 2023-05-19 | 2026-03-25 | Les Laboratoires Servier | Anti-met antibodies, antibody-drug conjugates, compositions and uses thereof |
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| SI1583830T1 (sl) | 2003-01-07 | 2006-12-31 | Symphogen As | Postopek za pripravo rekombinantnih poliklonskih proteinov |
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| US8288109B2 (en) | 2004-07-20 | 2012-10-16 | Symphogen A/S | Procedure for structural characterization of a recombinant polyclonal protein or a polyclonal cell line |
| US7850965B2 (en) | 2005-12-05 | 2010-12-14 | Symphogen A/S | Anti-orthopoxvirus recombinant polyclonal antibody |
| WO2007101441A1 (en) | 2006-03-06 | 2007-09-13 | Symphogen A/S | Recombinant polyclonal antibody for treatment of respiratory syncytial virus infections |
| TW200846362A (en) | 2007-02-09 | 2008-12-01 | Symphogen As | A polyclonal antibody product |
| MX2009012526A (es) | 2007-05-25 | 2009-12-09 | Symphogen As | Metodo para fabricar una proteina policlonal recombinante. |
-
2004
- 2004-01-07 SI SI200430074T patent/SI1583830T1/sl unknown
- 2004-01-07 ES ES04700438T patent/ES2273202T3/es not_active Expired - Lifetime
- 2004-01-07 EP EP06018504A patent/EP1762617A1/en not_active Withdrawn
- 2004-01-07 MX MXPA05006724A patent/MXPA05006724A/es active IP Right Grant
- 2004-01-07 EA EA200501101A patent/EA013225B1/ru not_active IP Right Cessation
- 2004-01-07 PT PT04700438T patent/PT1583830E/pt unknown
- 2004-01-07 KR KR1020057012745A patent/KR101024443B1/ko not_active Expired - Fee Related
- 2004-01-07 CA CA2512647A patent/CA2512647C/en not_active Expired - Fee Related
- 2004-01-07 AT AT04700438T patent/ATE338816T1/de active
- 2004-01-07 WO PCT/DK2004/000001 patent/WO2004061104A2/en not_active Ceased
- 2004-01-07 NZ NZ541458A patent/NZ541458A/en not_active IP Right Cessation
- 2004-01-07 BR BR0406678-2A patent/BRPI0406678A/pt not_active Application Discontinuation
- 2004-01-07 JP JP2006500508A patent/JP4589914B2/ja not_active Expired - Fee Related
- 2004-01-07 EP EP04700438A patent/EP1583830B1/en not_active Expired - Lifetime
- 2004-01-07 AU AU2004203727A patent/AU2004203727C1/en not_active Ceased
- 2004-01-07 DE DE602004002275T patent/DE602004002275T2/de not_active Expired - Lifetime
- 2004-01-07 DK DK04700438T patent/DK1583830T3/da active
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2005
- 2005-06-09 IL IL169101A patent/IL169101A/en not_active IP Right Cessation
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2008
- 2008-12-19 US US12/339,490 patent/US9163232B2/en not_active Expired - Fee Related
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2010
- 2010-07-08 JP JP2010155716A patent/JP2010268806A/ja active Pending
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