JP2011504721A5 - - Google Patents
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- Publication number
- JP2011504721A5 JP2011504721A5 JP2010509679A JP2010509679A JP2011504721A5 JP 2011504721 A5 JP2011504721 A5 JP 2011504721A5 JP 2010509679 A JP2010509679 A JP 2010509679A JP 2010509679 A JP2010509679 A JP 2010509679A JP 2011504721 A5 JP2011504721 A5 JP 2011504721A5
- Authority
- JP
- Japan
- Prior art keywords
- polyclonal
- cells
- protein
- cell line
- expression
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000004027 cell Anatomy 0.000 claims 59
- 238000000034 method Methods 0.000 claims 28
- 102000004169 proteins and genes Human genes 0.000 claims 27
- 108090000623 proteins and genes Proteins 0.000 claims 27
- 239000013604 expression vector Substances 0.000 claims 14
- 150000007523 nucleic acids Chemical class 0.000 claims 5
- 239000003550 marker Substances 0.000 claims 4
- 229920001184 polypeptide Polymers 0.000 claims 4
- 102000004196 processed proteins & peptides Human genes 0.000 claims 4
- 108090000765 processed proteins & peptides Proteins 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 3
- 238000001890 transfection Methods 0.000 claims 3
- 241000699802 Cricetulus griseus Species 0.000 claims 2
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 2
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 2
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 2
- 108091023040 Transcription factor Proteins 0.000 claims 2
- 102000040945 Transcription factor Human genes 0.000 claims 2
- 210000000349 chromosome Anatomy 0.000 claims 2
- 210000003527 eukaryotic cell Anatomy 0.000 claims 2
- 210000002950 fibroblast Anatomy 0.000 claims 2
- 210000005260 human cell Anatomy 0.000 claims 2
- 210000004962 mammalian cell Anatomy 0.000 claims 2
- 201000000050 myeloid neoplasm Diseases 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 238000010367 cloning Methods 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 238000001943 fluorescence-activated cell sorting Methods 0.000 claims 1
- 230000010354 integration Effects 0.000 claims 1
- 210000000287 oocyte Anatomy 0.000 claims 1
- 210000001672 ovary Anatomy 0.000 claims 1
- 239000013598 vector Substances 0.000 claims 1
- 230000035899 viability Effects 0.000 claims 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200700764 | 2007-05-25 | ||
| DKPA200700764 | 2007-05-25 | ||
| US92470807P | 2007-05-29 | 2007-05-29 | |
| US60/924,708 | 2007-05-29 | ||
| DKPA200701292 | 2007-09-07 | ||
| DKPA200701292 | 2007-09-07 | ||
| US96000207P | 2007-09-11 | 2007-09-11 | |
| US60/960,002 | 2007-09-11 | ||
| PCT/DK2008/050116 WO2008145133A2 (en) | 2007-05-25 | 2008-05-21 | Method for manufacturing a recombinant polyclonal protein |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014191912A Division JP2015037411A (ja) | 2007-05-25 | 2014-09-19 | 組み換えポリクローナルタンパク質を製造する方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011504721A JP2011504721A (ja) | 2011-02-17 |
| JP2011504721A5 true JP2011504721A5 (https=) | 2011-07-07 |
| JP5941616B2 JP5941616B2 (ja) | 2016-06-29 |
Family
ID=39739965
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010509679A Expired - Fee Related JP5941616B2 (ja) | 2007-05-25 | 2008-05-21 | 組み換えポリクローナルタンパク質を製造する方法 |
| JP2014191912A Pending JP2015037411A (ja) | 2007-05-25 | 2014-09-19 | 組み換えポリクローナルタンパク質を製造する方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014191912A Pending JP2015037411A (ja) | 2007-05-25 | 2014-09-19 | 組み換えポリクローナルタンパク質を製造する方法 |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US7910332B2 (https=) |
| EP (1) | EP2152872B1 (https=) |
| JP (2) | JP5941616B2 (https=) |
| KR (1) | KR101555658B1 (https=) |
| CN (1) | CN101688204B (https=) |
| AT (1) | ATE481483T1 (https=) |
| AU (1) | AU2008255383B2 (https=) |
| BR (1) | BRPI0812091A2 (https=) |
| CA (1) | CA2683800C (https=) |
| CY (1) | CY1110939T1 (https=) |
| DE (1) | DE602008002593D1 (https=) |
| DK (1) | DK2152872T3 (https=) |
| HR (1) | HRP20100640T1 (https=) |
| IL (1) | IL201395A (https=) |
| MX (1) | MX2009012526A (https=) |
| NZ (1) | NZ581316A (https=) |
| PL (1) | PL2152872T3 (https=) |
| PT (1) | PT2152872E (https=) |
| SI (1) | SI2152872T1 (https=) |
| TW (1) | TW200902548A (https=) |
| WO (1) | WO2008145133A2 (https=) |
| ZA (1) | ZA200908021B (https=) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI1583830T1 (sl) | 2003-01-07 | 2006-12-31 | Symphogen As | Postopek za pripravo rekombinantnih poliklonskih proteinov |
| DK2121920T3 (da) * | 2007-03-01 | 2011-11-21 | Symphogen As | Fremgangsmåde til kloning af sammenhørende antistoffer |
| MX2009012526A (es) * | 2007-05-25 | 2009-12-09 | Symphogen As | Metodo para fabricar una proteina policlonal recombinante. |
| CA2695309A1 (en) * | 2007-09-07 | 2009-03-12 | Symphogen A/S | Methods for recombinant manufacturing of anti-rsv antibodies |
| US20100311610A1 (en) * | 2008-02-01 | 2010-12-09 | Chromocell Corporation | CELL LINES AND METHODS FOR MAKING AND USING THEM (As Amended) |
| EP2098536A1 (en) | 2008-03-05 | 2009-09-09 | 4-Antibody AG | Isolation and identification of antigen- or ligand-specific binding proteins |
| NZ588651A (en) * | 2008-04-23 | 2012-04-27 | Symphogen As | Methods for manufacturing a polyclonal protein |
| CA2726289A1 (en) * | 2008-05-28 | 2009-12-23 | Bayer Healthcare Llc | Methods and compositions for production of recombinant protein in hbx-expressing mammalian cells |
| CN102137928A (zh) * | 2008-08-29 | 2011-07-27 | 西福根有限公司 | 克隆禽源抗体的方法 |
| WO2010089387A1 (en) | 2009-02-09 | 2010-08-12 | Morphosys Ag | Production of oligoclonal mixtures of immunoglobulins in single cells |
| MX347981B (es) | 2010-11-01 | 2017-05-22 | Symphogen As | Composicion de anticuerpos pan-her. |
| WO2012068317A2 (en) | 2010-11-16 | 2012-05-24 | Excelimmune, Inc. | Methods for producing recombinant proteins |
| CN102558353A (zh) * | 2011-12-09 | 2012-07-11 | 上海应用技术学院 | 一种大肠杆菌NrfA基因表达蛋白多克隆抗体及其制备方法 |
| GB2502127A (en) | 2012-05-17 | 2013-11-20 | Kymab Ltd | Multivalent antibodies and in vivo methods for their production |
| WO2013164689A2 (en) | 2012-05-02 | 2013-11-07 | Lantto, Johan | Humanized pan-her antibody compositions |
| US9790269B2 (en) | 2013-02-08 | 2017-10-17 | Misfolding Diagnostics, Inc. | Transthyretin antibodies and uses thereof |
| ES2748295T3 (es) | 2014-09-16 | 2020-03-16 | Symphogen As | Anticuerpos anti-MET y composiciones |
| US12404552B2 (en) * | 2015-07-17 | 2025-09-02 | Allele Biotechnology & Pharmaceuticals, Inc. | Methods of selecting antibodies and antibody fragments |
| KR20180096793A (ko) * | 2016-01-14 | 2018-08-29 | 안톤 바우어 | 생산 세포주를 제조하는 방법 |
| WO2018073393A2 (en) | 2016-10-19 | 2018-04-26 | Cellectis | Tal-effector nuclease (talen) -modified allogenic cells suitable for therapy |
| UA129904C2 (uk) | 2017-04-05 | 2025-09-10 | Ле Лаборатуар Сервьє | Комбінація антитіла до tim-3 й антитіла до pd-1 для лікування раку |
| EP3810649A1 (en) * | 2018-06-22 | 2021-04-28 | Genmab A/S | Method for producing a controlled mixture of two or more different antibodies |
| WO2020084034A1 (en) | 2018-10-26 | 2020-04-30 | F. Hoffmann-La Roche Ag | Multispecific antibody screening method using recombinase mediated cassette exchange |
| CA3118692A1 (en) | 2018-11-06 | 2020-05-14 | Alsatech, Inc. | Cell-based gene therapy for neurodegenerative diseases |
| CN109988751A (zh) * | 2019-01-15 | 2019-07-09 | 济宁学院 | 一种用于制备抗egfr全人源化单克隆抗体的细胞株构建方法 |
| CN113728003A (zh) | 2019-04-30 | 2021-11-30 | 吉加根公司 | 重组多克隆蛋白及其使用方法 |
| EP4034637A1 (en) * | 2019-09-27 | 2022-08-03 | GlaxoSmithKline Intellectual Property Development Limited | Method of predicting production stability of clonal cell lines |
| WO2021253002A1 (en) | 2020-06-12 | 2021-12-16 | Gigagen, Inc. | Recombinant polyclonal proteins targeting covid-19 and methods of use thereof |
| EP4713360A1 (en) | 2023-05-19 | 2026-03-25 | Les Laboratoires Servier | Anti-met antibodies, antibody-drug conjugates, compositions and uses thereof |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0530216A4 (en) | 1990-04-19 | 1993-06-30 | Medimmune, Inc. | Administration of monoclonal antibodies against respiratory viruses |
| GB9022543D0 (en) * | 1990-10-17 | 1990-11-28 | Wellcome Found | Antibody production |
| US6111166A (en) | 1994-09-19 | 2000-08-29 | Medarex, Incorporated | Transgenic mice expressing human Fcα and β receptors |
| GB9703369D0 (en) | 1997-02-18 | 1997-04-09 | Lindqvist Bjorn H | Process |
| EP1293564A4 (en) * | 2000-06-08 | 2005-08-17 | Mitsubishi Pharma Corp | EXPRESSION VECTOR FOR SCREENING CELLS HIGH EXPRESSION OF RECOMBINANT PROTEINS, TRANSFORMING HIGH EXPRESSION OF A RECOMBINANT PROTEIN AND USE THEREOF |
| US6849259B2 (en) | 2000-06-16 | 2005-02-01 | Symphogen A/S | Polyclonal antibody composition for treating allergy |
| DK2314629T4 (da) * | 2002-07-18 | 2023-02-06 | Merus Nv | Rekombinant produktion af blandinger af antistoffer |
| US20040115814A1 (en) * | 2002-09-30 | 2004-06-17 | Protein Design Labs, Inc. | Efficient generation of stable expression cell lines through the use of scorable homeostatic reporter genes |
| SI1583830T1 (sl) * | 2003-01-07 | 2006-12-31 | Symphogen As | Postopek za pripravo rekombinantnih poliklonskih proteinov |
| US20060275766A1 (en) | 2003-01-07 | 2006-12-07 | Haurum John S | Method for manufacturing recombinant polyclonal proteins |
| CN100383244C (zh) * | 2003-01-07 | 2008-04-23 | 西福根有限公司 | 用于生产重组多克隆蛋白质的方法 |
| TWI333977B (en) * | 2003-09-18 | 2010-12-01 | Symphogen As | Method for linking sequences of interest |
| EA014182B1 (ru) * | 2004-07-20 | 2010-10-29 | Симфоген А/С | КОМПОЗИЦИЯ ПОЛИКЛОНАЛЬНЫХ АНТИ-RhD АНТИТЕЛ, СПОСОБ ЕЁ ПОЛУЧЕНИЯ И ПРИМЕНЕНИЕ КОМПОЗИЦИИ |
| US8288109B2 (en) * | 2004-07-20 | 2012-10-16 | Symphogen A/S | Procedure for structural characterization of a recombinant polyclonal protein or a polyclonal cell line |
| US7850965B2 (en) | 2005-12-05 | 2010-12-14 | Symphogen A/S | Anti-orthopoxvirus recombinant polyclonal antibody |
| WO2007101441A1 (en) | 2006-03-06 | 2007-09-13 | Symphogen A/S | Recombinant polyclonal antibody for treatment of respiratory syncytial virus infections |
| MX2009012526A (es) * | 2007-05-25 | 2009-12-09 | Symphogen As | Metodo para fabricar una proteina policlonal recombinante. |
-
2008
- 2008-05-21 MX MX2009012526A patent/MX2009012526A/es active IP Right Grant
- 2008-05-21 EP EP08748815A patent/EP2152872B1/en not_active Not-in-force
- 2008-05-21 KR KR1020097027038A patent/KR101555658B1/ko not_active Expired - Fee Related
- 2008-05-21 NZ NZ581316A patent/NZ581316A/en not_active IP Right Cessation
- 2008-05-21 DE DE602008002593T patent/DE602008002593D1/de active Active
- 2008-05-21 PL PL08748815T patent/PL2152872T3/pl unknown
- 2008-05-21 JP JP2010509679A patent/JP5941616B2/ja not_active Expired - Fee Related
- 2008-05-21 DK DK08748815.1T patent/DK2152872T3/da active
- 2008-05-21 AU AU2008255383A patent/AU2008255383B2/en not_active Ceased
- 2008-05-21 PT PT08748815T patent/PT2152872E/pt unknown
- 2008-05-21 CN CN2008800174383A patent/CN101688204B/zh not_active Expired - Fee Related
- 2008-05-21 CA CA2683800A patent/CA2683800C/en not_active Expired - Fee Related
- 2008-05-21 AT AT08748815T patent/ATE481483T1/de active
- 2008-05-21 BR BRPI0812091-9A2A patent/BRPI0812091A2/pt not_active Application Discontinuation
- 2008-05-21 WO PCT/DK2008/050116 patent/WO2008145133A2/en not_active Ceased
- 2008-05-21 HR HR20100640T patent/HRP20100640T1/hr unknown
- 2008-05-21 SI SI200830107T patent/SI2152872T1/sl unknown
- 2008-05-23 TW TW097119118A patent/TW200902548A/zh unknown
- 2008-05-23 US US12/153,809 patent/US7910332B2/en not_active Expired - Fee Related
-
2009
- 2009-10-11 IL IL201395A patent/IL201395A/en active IP Right Grant
- 2009-11-13 ZA ZA2009/08021A patent/ZA200908021B/en unknown
-
2010
- 2010-11-24 CY CY20101101058T patent/CY1110939T1/el unknown
-
2014
- 2014-09-19 JP JP2014191912A patent/JP2015037411A/ja active Pending
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