JP2006509751A5 - - Google Patents
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- JP2006509751A5 JP2006509751A5 JP2004554308A JP2004554308A JP2006509751A5 JP 2006509751 A5 JP2006509751 A5 JP 2006509751A5 JP 2004554308 A JP2004554308 A JP 2004554308A JP 2004554308 A JP2004554308 A JP 2004554308A JP 2006509751 A5 JP2006509751 A5 JP 2006509751A5
- Authority
- JP
- Japan
- Prior art keywords
- component
- composition
- composition according
- incontinence
- ethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 239000000203 mixture Substances 0.000 claims 17
- 206010069632 Bladder dysfunction Diseases 0.000 claims 5
- 206010046543 Urinary incontinence Diseases 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- ZEUITGRIYCTCEM-KRWDZBQOSA-N (S)-duloxetine Chemical compound C1([C@@H](OC=2C3=CC=CC=C3C=CC=2)CCNC)=CC=CS1 ZEUITGRIYCTCEM-KRWDZBQOSA-N 0.000 claims 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 3
- 229960002866 duloxetine Drugs 0.000 claims 3
- -1 fluparoxane Chemical compound 0.000 claims 3
- 206010020853 Hypertonic bladder Diseases 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 2
- 206010053236 Mixed incontinence Diseases 0.000 claims 2
- 208000009722 Overactive Urinary Bladder Diseases 0.000 claims 2
- 206010066218 Stress Urinary Incontinence Diseases 0.000 claims 2
- 208000000921 Urge Urinary Incontinence Diseases 0.000 claims 2
- 208000015114 central nervous system disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 208000020629 overactive bladder Diseases 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 claims 2
- 208000022170 stress incontinence Diseases 0.000 claims 2
- 206010046494 urge incontinence Diseases 0.000 claims 2
- GJJFMKBJSRMPLA-HIFRSBDPSA-N (1R,2S)-2-(aminomethyl)-N,N-diethyl-1-phenyl-1-cyclopropanecarboxamide Chemical compound C=1C=CC=CC=1[C@@]1(C(=O)N(CC)CC)C[C@@H]1CN GJJFMKBJSRMPLA-HIFRSBDPSA-N 0.000 claims 1
- YWPHCCPCQOJSGZ-LLVKDONJSA-N (2r)-2-[(2-ethoxyphenoxy)methyl]morpholine Chemical compound CCOC1=CC=CC=C1OC[C@@H]1OCCNC1 YWPHCCPCQOJSGZ-LLVKDONJSA-N 0.000 claims 1
- VMMYRRFPMAGXNP-BTYIYWSLSA-N 2-[4-[2-[[(1r,2s)-1-hydroxy-1-(4-hydroxyphenyl)propan-2-yl]amino]ethyl]-2,5-dimethylphenoxy]acetic acid Chemical compound N([C@@H](C)[C@H](O)C=1C=CC(O)=CC=1)CCC1=CC(C)=C(OCC(O)=O)C=C1C VMMYRRFPMAGXNP-BTYIYWSLSA-N 0.000 claims 1
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims 1
- 208000012902 Nervous system disease Diseases 0.000 claims 1
- 239000000048 adrenergic agonist Substances 0.000 claims 1
- 229940126157 adrenergic receptor agonist Drugs 0.000 claims 1
- 229960002430 atomoxetine Drugs 0.000 claims 1
- VHGCDTVCOLNTBX-QGZVFWFLSA-N atomoxetine Chemical compound O([C@H](CCNC)C=1C=CC=CC=1)C1=CC=CC=C1C VHGCDTVCOLNTBX-QGZVFWFLSA-N 0.000 claims 1
- 102000016959 beta-3 Adrenergic Receptors Human genes 0.000 claims 1
- 108010014502 beta-3 Adrenergic Receptors Proteins 0.000 claims 1
- 210000003169 central nervous system Anatomy 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- MJRPHRMGEKCADU-JVLSTEMRSA-N lortalamine Chemical compound C12=CC(Cl)=CC=C2O[C@]23CCN(C)C[C@@H]2[C@H]1CC(=O)N3 MJRPHRMGEKCADU-JVLSTEMRSA-N 0.000 claims 1
- 229950004863 lortalamine Drugs 0.000 claims 1
- 229960000600 milnacipran Drugs 0.000 claims 1
- 229960001073 nomifensine Drugs 0.000 claims 1
- XXPANQJNYNUNES-UHFFFAOYSA-N nomifensine Chemical compound C12=CC=CC(N)=C2CN(C)CC1C1=CC=CC=C1 XXPANQJNYNUNES-UHFFFAOYSA-N 0.000 claims 1
- 239000002767 noradrenalin uptake inhibitor Substances 0.000 claims 1
- 229940127221 norepinephrine reuptake inhibitor Drugs 0.000 claims 1
- 238000007911 parenteral administration Methods 0.000 claims 1
- AMJPIGOYWBNJLP-UHFFFAOYSA-N pirandamine Chemical compound C1C2=CC=CC=C2C2=C1C(CCN(C)C)(C)OCC2 AMJPIGOYWBNJLP-UHFFFAOYSA-N 0.000 claims 1
- 229950007239 pirandamine Drugs 0.000 claims 1
- DTPOQEUUHFQKSS-UHFFFAOYSA-N pyrrolo[2,1,5-cd]indolizine Chemical compound C1=CC(N23)=CC=C3C=CC2=C1 DTPOQEUUHFQKSS-UHFFFAOYSA-N 0.000 claims 1
- 229960003770 reboxetine Drugs 0.000 claims 1
- CBQGYUDMJHNJBX-RTBURBONSA-N reboxetine Chemical compound CCOC1=CC=CC=C1O[C@H](C=1C=CC=CC=1)[C@@H]1OCCNC1 CBQGYUDMJHNJBX-RTBURBONSA-N 0.000 claims 1
- 229940076279 serotonin Drugs 0.000 claims 1
- 239000003772 serotonin uptake inhibitor Substances 0.000 claims 1
- LJBBMCNHIUJBDU-UHFFFAOYSA-N talopram Chemical compound O1C(C)(C)C2=CC=CC=C2C1(CCCNC)C1=CC=CC=C1 LJBBMCNHIUJBDU-UHFFFAOYSA-N 0.000 claims 1
- 229950007352 talopram Drugs 0.000 claims 1
- BRPOADLGOFPKKJ-UHFFFAOYSA-N tandamine Chemical compound C12=CC=CC=C2N(CC)C2=C1CCSC2(C)CCN(C)C BRPOADLGOFPKKJ-UHFFFAOYSA-N 0.000 claims 1
- 229950006964 tandamine Drugs 0.000 claims 1
- 230000000699 topical effect Effects 0.000 claims 1
- 229960004688 venlafaxine Drugs 0.000 claims 1
- PNVNVHUZROJLTJ-UHFFFAOYSA-N venlafaxine Chemical compound C1=CC(OC)=CC=C1C(CN(C)C)C1(O)CCCCC1 PNVNVHUZROJLTJ-UHFFFAOYSA-N 0.000 claims 1
- 229960001255 viloxazine Drugs 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP02026546A EP1424079A1 (en) | 2002-11-27 | 2002-11-27 | Combination of a beta-3-receptor agonist and of a reuptake inhibitor of serotonin and/or norepinephrine |
| PCT/EP2003/012225 WO2004047830A2 (de) | 2002-11-27 | 2003-11-03 | Pharmazeutische zusammensetzung aus einem beta-3-adrenozeptor-agonisten und einem serotonin- und/oder norepinephrin-reuptake-inhibitor deren verwendung zur behandlung von blasenfunktionsstörungen |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006509751A JP2006509751A (ja) | 2006-03-23 |
| JP2006509751A5 true JP2006509751A5 (enExample) | 2006-12-21 |
Family
ID=32241298
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004554308A Pending JP2006509751A (ja) | 2002-11-27 | 2003-11-03 | β−３アドレナリン受容体アゴニストとセロトニン及び／又はノルエピネフリン再取り込み阻害剤とを含む医薬組成物 |
| JP2004554318A Pending JP2006509752A (ja) | 2002-11-27 | 2003-11-05 | β−３アドレナリン受容体アゴニスト及び抗ムスカリン作用薬を含む医薬組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004554318A Pending JP2006509752A (ja) | 2002-11-27 | 2003-11-05 | β−３アドレナリン受容体アゴニスト及び抗ムスカリン作用薬を含む医薬組成物 |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US20090012161A9 (enExample) |
| EP (4) | EP1424079A1 (enExample) |
| JP (2) | JP2006509751A (enExample) |
| KR (1) | KR20050088295A (enExample) |
| CN (1) | CN1717230A (enExample) |
| AT (1) | ATE399005T1 (enExample) |
| AU (2) | AU2003285312A1 (enExample) |
| BR (1) | BR0316535A (enExample) |
| CA (2) | CA2507266A1 (enExample) |
| CO (1) | CO5580754A2 (enExample) |
| DE (1) | DE50310046D1 (enExample) |
| EA (1) | EA009781B1 (enExample) |
| EC (1) | ECSP055814A (enExample) |
| ES (1) | ES2309371T3 (enExample) |
| HR (1) | HRP20050467A2 (enExample) |
| MX (1) | MXPA05005483A (enExample) |
| NO (1) | NO20053088L (enExample) |
| PL (1) | PL376259A1 (enExample) |
| RS (1) | RS20050392A (enExample) |
| UA (1) | UA81931C2 (enExample) |
| WO (2) | WO2004047830A2 (enExample) |
| ZA (1) | ZA200503282B (enExample) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7704527B2 (en) * | 2002-10-25 | 2010-04-27 | Collegium Pharmaceutical, Inc. | Modified release compositions of milnacipran |
| KR20060124603A (ko) * | 2003-11-03 | 2006-12-05 | 베링거 인겔하임 인터내셔날 게엠베하 | 베타-3-아드레날린 수용체 효능제 및 알파 길항제 및/또는5-알파-리덕타제 억제제를 함유하는 약제학적 조성물 |
| DE10356112A1 (de) * | 2003-11-27 | 2005-06-23 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Pharmazeutische Zusammensetzung aus einem Beta-3-Adrenozeptor-Agonisten und einem in den Prostglandinstoffwechsel eingreifendem Wirkstoff |
| EP1804778A1 (de) * | 2004-10-18 | 2007-07-11 | Boehringer Ingelheim International GmbH | Verwendung eines beta-3-agonisten zur behandlung von beschwerden der prostata und des unteren urogenitaltrakts |
| US20090247781A1 (en) * | 2004-10-26 | 2009-10-01 | Kissei Pharmaceutical Co., Ltd. | Synthesis of phenoxyacetic acid derivatives |
| US20090131469A1 (en) * | 2005-02-25 | 2009-05-21 | Astellas Pharma Inc. | Pharmaceutical agent comprising solifenacin |
| US20060165776A1 (en) * | 2005-08-31 | 2006-07-27 | Ramesh Sesha | Antidepressant oral pharmaceutical compositions |
| EP1769792A1 (de) * | 2005-09-30 | 2007-04-04 | Boehringer Ingelheim Pharma GmbH & Co.KG | Verwendung eines beta-3-Adrenozeptor-Agonisten zur Behandlung von Nieren- und Blasenbeschwerden |
| US9440003B2 (en) * | 2005-11-04 | 2016-09-13 | Boston Scientific Scimed, Inc. | Medical devices having particle-containing regions with diamond-like coatings |
| FR2895259B1 (fr) * | 2005-12-22 | 2008-02-22 | Urosphere Sas | Methodes de traitement des incontinences urinaires |
| US20100172988A1 (en) * | 2006-01-10 | 2010-07-08 | Kissei Pharmaceutical Co., Ltd. | Sustained release preparation and method for production thereof |
| US20070292511A1 (en) * | 2006-05-22 | 2007-12-20 | Gershon Kolatkar | Duloxetine hydrochloride delayed release formulations |
| US20090175935A1 (en) * | 2006-08-14 | 2009-07-09 | Torrent Research Ltd. | Pharmaceutical compositions of duloxetine |
| EP1947103A1 (en) | 2007-01-22 | 2008-07-23 | 4Sc Ag | Aryloxypropanolamines, methods of preparation thereof and use of aryloxypropanolamines as medicaments |
| US20080226711A1 (en) * | 2007-03-12 | 2008-09-18 | Torrent Pharmaceuticals Ltd. | Pharmaceutical compositions of duloxetine |
| WO2009066181A2 (en) * | 2007-07-09 | 2009-05-28 | Combino Pharm, S.L. | Oral delayed-release duloxentine hydrochloride pellets |
| PT2216021E (pt) | 2007-11-02 | 2012-11-06 | Astellas Pharma Inc | Composição farmacêutica para tratar uma bexiga hiperactiva |
| TWI478712B (zh) | 2008-09-30 | 2015-04-01 | Astellas Pharma Inc | 釋控性醫藥組成物 |
| ES2376095B1 (es) * | 2008-10-02 | 2013-01-24 | Laboratorios Del Dr. Esteve, S.A. | Pellets entéricos de duloxetina. |
| WO2010053068A1 (ja) * | 2008-11-07 | 2010-05-14 | 大日本住友製薬株式会社 | 新規で有用な下部尿路症状治療剤 |
| EP2316432A1 (de) * | 2009-10-30 | 2011-05-04 | ratiopharm GmbH | Zusammensetzung enthaltend Fesoterodin und Ballaststoffe |
| EP2377525A1 (en) * | 2010-03-26 | 2011-10-19 | Laboratorios del Dr. Esteve S.A. | Duloxetine enteric pellets |
| TR201802207T4 (tr) | 2010-03-29 | 2018-03-21 | Astellas Pharma Inc | Kontrollü Salımlı Farmasötik Bileşim. |
| KR20180008918A (ko) * | 2010-08-03 | 2018-01-24 | 앨씨알엑스, 인크. | 과민성 방광 치료를 위한 베타-3 아드레날린 수용체 작용제 및 무스카린 수용체 길항제의 약학적 배합제 |
| US9907767B2 (en) | 2010-08-03 | 2018-03-06 | Velicept Therapeutics, Inc. | Pharmaceutical compositions and the treatment of overactive bladder |
| US9522129B2 (en) | 2010-08-03 | 2016-12-20 | Velicept Therapeutics, Inc. | Pharmaceutical Combination |
| KR20150020160A (ko) * | 2012-02-09 | 2015-02-25 | 앨씨알엑스, 인크. | 과민성 방광의 치료를 위한 무스카린 수용체 길항제 및 베타―3 아드레날린 수용체 작용제의 조합물 |
| MX379066B (es) * | 2012-09-18 | 2025-03-04 | Taris Biomedical Llc | Sistemas de administracion de farmaco y metodos para el tratamiento de la disfuncion miccional de la vejiga y otros trastornos del tracto urinario inferior. |
| PL224543B1 (pl) | 2013-08-21 | 2017-01-31 | Pabianickie Zakłady Farm Polfa Spółka Akcyjna | Dojelitowa tabletka duloksetyny |
| CN107205964A (zh) | 2014-12-03 | 2017-09-26 | 威力塞帕特治疗股份有限公司 | 使用调节释放索拉贝隆用于下尿路症状的组合物和方法 |
| JP2018536453A (ja) * | 2015-10-15 | 2018-12-13 | デューク ユニバーシティ | 膀胱機能障害を処置するための状態依存的末梢神経調節 |
| WO2017070689A2 (en) | 2015-10-23 | 2017-04-27 | Velicept Therapeutics, Inc. | Solabegron zwitterion and uses thereof |
| WO2017186598A1 (en) | 2016-04-25 | 2017-11-02 | Synthon B.V. | Modified release tablet composition comprising mirabegron |
| US20190307696A1 (en) | 2016-04-25 | 2019-10-10 | Synthon B.V. | Tablets comprising mirabegron and solifenacin |
| US10478399B2 (en) | 2017-10-12 | 2019-11-19 | Synthon B.V. | Modified release tablet composition comprising mirabegron |
| US12097189B1 (en) | 2024-02-09 | 2024-09-24 | Astellas Pharma Inc. | Pharmaceutical composition for modified release |
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-
2002
- 2002-11-27 EP EP02026546A patent/EP1424079A1/en not_active Withdrawn
-
2003
- 2003-03-11 UA UAA200506227A patent/UA81931C2/uk unknown
- 2003-11-03 CN CNA2003801044257A patent/CN1717230A/zh active Pending
- 2003-11-03 ES ES03778298T patent/ES2309371T3/es not_active Expired - Lifetime
- 2003-11-03 CA CA002507266A patent/CA2507266A1/en not_active Abandoned
- 2003-11-03 MX MXPA05005483A patent/MXPA05005483A/es not_active Application Discontinuation
- 2003-11-03 PL PL03376259A patent/PL376259A1/xx unknown
- 2003-11-03 JP JP2004554308A patent/JP2006509751A/ja active Pending
- 2003-11-03 EP EP03778298A patent/EP1572181B1/de not_active Expired - Lifetime
- 2003-11-03 DE DE50310046T patent/DE50310046D1/de not_active Expired - Fee Related
- 2003-11-03 EA EA200500776A patent/EA009781B1/ru not_active IP Right Cessation
- 2003-11-03 AU AU2003285312A patent/AU2003285312A1/en not_active Abandoned
- 2003-11-03 HR HR20050467A patent/HRP20050467A2/xx not_active Application Discontinuation
- 2003-11-03 AT AT03778298T patent/ATE399005T1/de not_active IP Right Cessation
- 2003-11-03 RS RSP-2005/0392A patent/RS20050392A/sr unknown
- 2003-11-03 WO PCT/EP2003/012225 patent/WO2004047830A2/de not_active Ceased
- 2003-11-03 KR KR1020057009414A patent/KR20050088295A/ko not_active Withdrawn
- 2003-11-03 BR BR0316535-3A patent/BR0316535A/pt not_active IP Right Cessation
- 2003-11-03 EP EP05027827A patent/EP1640000A3/de not_active Withdrawn
- 2003-11-05 EP EP03782183A patent/EP1567149A2/de not_active Withdrawn
- 2003-11-05 CA CA002507343A patent/CA2507343A1/en not_active Abandoned
- 2003-11-05 WO PCT/EP2003/012331 patent/WO2004047838A2/de not_active Ceased
- 2003-11-05 AU AU2003289854A patent/AU2003289854A1/en not_active Abandoned
- 2003-11-05 JP JP2004554318A patent/JP2006509752A/ja active Pending
-
2005
- 2005-04-22 ZA ZA200503282A patent/ZA200503282B/en unknown
- 2005-05-23 EC EC2005005814A patent/ECSP055814A/es unknown
- 2005-05-24 US US11/136,165 patent/US20090012161A9/en not_active Abandoned
- 2005-05-24 US US11/136,148 patent/US20050261328A1/en not_active Abandoned
- 2005-06-23 NO NO20053088A patent/NO20053088L/no not_active Application Discontinuation
- 2005-06-27 CO CO05062906A patent/CO5580754A2/es not_active Application Discontinuation
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