WO2003035600A1 - Process for producing benzocycloheptene derivative - Google Patents

Process for producing benzocycloheptene derivative Download PDF

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Publication number
WO2003035600A1
WO2003035600A1 PCT/JP2002/010812 JP0210812W WO03035600A1 WO 2003035600 A1 WO2003035600 A1 WO 2003035600A1 JP 0210812 W JP0210812 W JP 0210812W WO 03035600 A1 WO03035600 A1 WO 03035600A1
Authority
WO
WIPO (PCT)
Prior art keywords
producing
compound
benzocycloheptene
optically active
derivative
Prior art date
Application number
PCT/JP2002/010812
Other languages
French (fr)
Japanese (ja)
Inventor
Norio Hashimoto
Norifumi Itoh
Takumi Okamoto
Shigeru Ieda
Atsushi Kanda
Yukihisa Baba
Nobuyasu Ishibashi
Kazuo Okawa
Original Assignee
Fujisawa Pharmaceutical Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujisawa Pharmaceutical Co., Ltd. filed Critical Fujisawa Pharmaceutical Co., Ltd.
Publication of WO2003035600A1 publication Critical patent/WO2003035600A1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/02—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

A process for producing an optically active benzocycloheptene derivative (X) which comprises reacting a compound (III) with an optically active compound (IV), reducing the resultant reaction product to obtain an optically active benzocycloheptene compound (II) or a salt thereof, and using the compound (II) as an intermediate. (II) (X)
PCT/JP2002/010812 2001-10-19 2002-10-17 Process for producing benzocycloheptene derivative WO2003035600A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2001322438 2001-10-19
JP2001-322438 2001-10-19

Publications (1)

Publication Number Publication Date
WO2003035600A1 true WO2003035600A1 (en) 2003-05-01

Family

ID=19139488

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2002/010812 WO2003035600A1 (en) 2001-10-19 2002-10-17 Process for producing benzocycloheptene derivative

Country Status (1)

Country Link
WO (1) WO2003035600A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004047838A2 (en) * 2002-11-27 2004-06-10 Boehringer Ingelheim International Gmbh Pharmaceutical composition comprising beta-3-adrenoceptor agonists and antimuscarinic agents

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993015041A1 (en) * 1992-02-03 1993-08-05 Fujisawa Pharmaceutical Co., Ltd. Ethanolamine derivatives having sympathomimetic and anti-pollakiuria activities
EP0976720A1 (en) * 1997-03-17 2000-02-02 Fujisawa Pharmaceutical Co., Ltd. Propanolamine derivatives
WO2000068203A1 (en) * 1999-05-07 2000-11-16 Takeda Chemical Industries, Ltd. Cyclic compounds and uses thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993015041A1 (en) * 1992-02-03 1993-08-05 Fujisawa Pharmaceutical Co., Ltd. Ethanolamine derivatives having sympathomimetic and anti-pollakiuria activities
EP0976720A1 (en) * 1997-03-17 2000-02-02 Fujisawa Pharmaceutical Co., Ltd. Propanolamine derivatives
WO2000068203A1 (en) * 1999-05-07 2000-11-16 Takeda Chemical Industries, Ltd. Cyclic compounds and uses thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
HATTORI K. ET AL.: "Asymmetric synthesis of FR165914: a novel beta3-adrenergic agonist with a benzocycloheptene structure", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 5, no. 23, 1995, pages 2821 - 2824, XP004135174 *
PROCTOR G.R. ET AL.: "Bridged-ring nitrogen compounds. Part 4. Synthesis and applications of 8-ethoxycarbonyl-6,7-dihydro-2-methoxybezocyclohepten-5-one; preparation of methanobenzazocines and ethanobenzazepines", J. CHEM. RESEARCH(S), no. 9, 1980, pages 286 - 287, XP002961075 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004047838A2 (en) * 2002-11-27 2004-06-10 Boehringer Ingelheim International Gmbh Pharmaceutical composition comprising beta-3-adrenoceptor agonists and antimuscarinic agents
WO2004047838A3 (en) * 2002-11-27 2004-10-28 Boehringer Ingelheim Int Pharmaceutical composition comprising beta-3-adrenoceptor agonists and antimuscarinic agents

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