CN1717230A - 包含β－3－肾上腺素能受体激动剂以及血清素和/或去甲肾上腺素再摄取抑制剂的药物组合物 - Google Patents

包含β－3－肾上腺素能受体激动剂以及血清素和/或去甲肾上腺素再摄取抑制剂的药物组合物 Download PDF

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Publication number
CN1717230A
CN1717230A CNA2003801044257A CN200380104425A CN1717230A CN 1717230 A CN1717230 A CN 1717230A CN A2003801044257 A CNA2003801044257 A CN A2003801044257A CN 200380104425 A CN200380104425 A CN 200380104425A CN 1717230 A CN1717230 A CN 1717230A
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CN
China
Prior art keywords
compositions
urinary incontinence
ethyl
bladder function
component
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA2003801044257A
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English (en)
Chinese (zh)
Inventor
路德维格·梅尔伯格
马丁·米歇尔
马里恩·威恩里奇
厄休拉·埃宾杰
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Boehringer Ingelheim International GmbH
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Boehringer Ingelheim International GmbH
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Publication of CN1717230A publication Critical patent/CN1717230A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
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    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
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    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • A—HUMAN NECESSITIES
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/433—Thidiazoles
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4406—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 3, e.g. zimeldine
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
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  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
CNA2003801044257A 2002-11-27 2003-11-03 包含β－3－肾上腺素能受体激动剂以及血清素和/或去甲肾上腺素再摄取抑制剂的药物组合物 Pending CN1717230A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02026546A EP1424079A1 (en) 2002-11-27 2002-11-27 Combination of a beta-3-receptor agonist and of a reuptake inhibitor of serotonin and/or norepinephrine
EP02026546.8 2002-11-27

Publications (1)

Publication Number Publication Date
CN1717230A true CN1717230A (zh) 2006-01-04

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CNA2003801044257A Pending CN1717230A (zh) 2002-11-27 2003-11-03 包含β－3－肾上腺素能受体激动剂以及血清素和/或去甲肾上腺素再摄取抑制剂的药物组合物

Country Status (22)

Country Link
US (2) US20090012161A9 (enExample)
EP (4) EP1424079A1 (enExample)
JP (2) JP2006509751A (enExample)
KR (1) KR20050088295A (enExample)
CN (1) CN1717230A (enExample)
AT (1) ATE399005T1 (enExample)
AU (2) AU2003285312A1 (enExample)
BR (1) BR0316535A (enExample)
CA (2) CA2507266A1 (enExample)
CO (1) CO5580754A2 (enExample)
DE (1) DE50310046D1 (enExample)
EA (1) EA009781B1 (enExample)
EC (1) ECSP055814A (enExample)
ES (1) ES2309371T3 (enExample)
HR (1) HRP20050467A2 (enExample)
MX (1) MXPA05005483A (enExample)
NO (1) NO20053088L (enExample)
PL (1) PL376259A1 (enExample)
RS (1) RS20050392A (enExample)
UA (1) UA81931C2 (enExample)
WO (2) WO2004047830A2 (enExample)
ZA (1) ZA200503282B (enExample)

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WO2004047838A2 (de) 2004-06-10
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UA81931C2 (uk) 2008-02-25
PL376259A1 (pl) 2005-12-27
AU2003289854A1 (en) 2004-06-18
US20090012161A9 (en) 2009-01-08
WO2004047830A2 (de) 2004-06-10
US20050261328A1 (en) 2005-11-24
EP1424079A1 (en) 2004-06-02
KR20050088295A (ko) 2005-09-05
CA2507266A1 (en) 2004-06-10
WO2004047830A3 (de) 2004-08-19
WO2004047838A3 (de) 2004-10-28
BR0316535A (pt) 2005-10-04
EA009781B1 (ru) 2008-04-28
EP1640000A2 (de) 2006-03-29
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JP2006509752A (ja) 2006-03-23
EP1640000A3 (de) 2007-01-17
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US20050261369A1 (en) 2005-11-24
DE50310046D1 (de) 2008-08-07
CA2507343A1 (en) 2005-07-14
EP1572181B1 (de) 2008-06-25
AU2003285312A1 (en) 2004-06-18
NO20053088L (no) 2005-06-23
CO5580754A2 (es) 2005-11-30
EA200500776A1 (ru) 2005-12-29
RS20050392A (sr) 2007-04-10
ATE399005T1 (de) 2008-07-15
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