JP2006503053A - 中間体の製造法 - Google Patents

中間体の製造法 Download PDF

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Publication number
JP2006503053A
JP2006503053A JP2004537129A JP2004537129A JP2006503053A JP 2006503053 A JP2006503053 A JP 2006503053A JP 2004537129 A JP2004537129 A JP 2004537129A JP 2004537129 A JP2004537129 A JP 2004537129A JP 2006503053 A JP2006503053 A JP 2006503053A
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JP
Japan
Prior art keywords
formula
alkyl
hydrogen
compound
hours
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Pending
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JP2004537129A
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English (en)
Japanese (ja)
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JP2006503053A5 (enExample
Inventor
プラサド・コテスワラ・カパ
ジャン・シンロン
エリック・エム・ローサー
ジョエル・スレイド
マハバー・プラシャド
ジョージ・ティエン−サン・リー
Original Assignee
ノバルティス アクチエンゲゼルシャフト
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Application filed by ノバルティス アクチエンゲゼルシャフト filed Critical ノバルティス アクチエンゲゼルシャフト
Publication of JP2006503053A publication Critical patent/JP2006503053A/ja
Publication of JP2006503053A5 publication Critical patent/JP2006503053A5/ja
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D277/06—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Press Drives And Press Lines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
JP2004537129A 2002-09-19 2003-09-18 中間体の製造法 Pending JP2006503053A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US41192002P 2002-09-19 2002-09-19
US48024203P 2003-06-20 2003-06-20
PCT/EP2003/010416 WO2004026824A1 (en) 2002-09-19 2003-09-18 Process for preparing intermediates

Publications (2)

Publication Number Publication Date
JP2006503053A true JP2006503053A (ja) 2006-01-26
JP2006503053A5 JP2006503053A5 (enExample) 2006-11-09

Family

ID=32033579

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2004537129A Pending JP2006503053A (ja) 2002-09-19 2003-09-18 中間体の製造法

Country Status (20)

Country Link
US (1) US7589216B2 (enExample)
EP (1) EP1542968B1 (enExample)
JP (1) JP2006503053A (enExample)
KR (1) KR20050057429A (enExample)
CN (1) CN100439334C (enExample)
AT (1) ATE417826T1 (enExample)
AU (1) AU2003273404B2 (enExample)
BR (1) BR0314592A (enExample)
CA (1) CA2499426A1 (enExample)
DE (1) DE60325390D1 (enExample)
DK (1) DK1542968T3 (enExample)
EC (1) ECSP055692A (enExample)
ES (1) ES2321504T3 (enExample)
MX (1) MXPA05003089A (enExample)
NO (1) NO20051867L (enExample)
NZ (1) NZ538833A (enExample)
PL (1) PL374961A1 (enExample)
PT (1) PT1542968E (enExample)
RU (1) RU2374227C2 (enExample)
WO (1) WO2004026824A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1406893T3 (da) 2001-06-15 2007-08-06 Vicuron Pharm Inc Bicykliske pyrrolidinforbindelser
WO2004026824A1 (en) 2002-09-19 2004-04-01 Novartis Ag Process for preparing intermediates
PL379008A1 (pl) 2003-02-21 2006-06-26 Novartis Ag Chemiczny sposób wytwarzania związków pośrednich do otrzymywania związków N-formylohydroksyloaminowych
GT200600196A (es) * 2005-05-23 2007-01-15 Compuestos n-formil de hidroxilamina
CN101434570B (zh) * 2007-11-16 2011-02-02 上海医药工业研究院 吡咯烷衍生物及其制备方法和应用
US11174288B2 (en) 2016-12-06 2021-11-16 Northeastern University Heparin-binding cationic peptide self-assembling peptide amphiphiles useful against drug-resistant bacteria

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5377010A (en) * 1976-12-16 1978-07-08 Mitsui Toatsu Chem Inc Preparation of hydroxypivalic acid
JPS5765190A (en) * 1980-10-06 1982-04-20 Kanegafuchi Chem Ind Co Ltd Preparation of (-)-alpha-hydroxymethylbutyric acid
JPH01149751A (ja) * 1987-12-08 1989-06-12 Agency Of Ind Science & Technol ２−ｎ−ヘキシル−３−ヒドロキシ−ｎ−デカン酸及びそのエステル
JPH0276591A (ja) * 1988-08-09 1990-03-15 Eastman Kodak Co プロキラルジオールからキラルヒドロキシカルボン酸の製造方法
JPH0592948A (ja) * 1991-02-06 1993-04-16 Yoshitomi Pharmaceut Ind Ltd プロピオン酸アミド誘導体およびその医薬用途
JP2006052138A (ja) * 2002-08-23 2006-02-23 Dainippon Sumitomo Pharma Co Ltd プロリン誘導体

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU384814A1 (ru) * 1970-12-25 1973-05-29 Всесоюзный научно исследовательский институт тетических , натуральных душистых веществ СПОСОБ ПОЛУЧЕНИЯ р-МЕТИЛЗАМЕЩЕННЫХ со-ОКСИКАРБОНОВЫХ КИСЛОТ
US4123465A (en) * 1975-10-16 1978-10-31 Hoffmann-La Roche Inc. Chiral tertiary phosphines
JPS6030666B2 (ja) * 1980-08-20 1985-07-17 鐘淵化学工業株式会社 光学活性メルカプトカルボン酸の製造法
PL194240B1 (pl) 1998-02-07 2007-05-31 British Biotech Pharm Zastosowanie pochodnych N-formylohydroksyloaminy i amidowa pochodna N-formylohydroksyloaminy
US6977141B2 (en) * 1998-02-10 2005-12-20 Vicuron Pharmaceuticals Inc. Direct adsorption scintillation assay for measuring enzyme activity and assaying biochemical processes
UY27192A1 (es) * 2001-03-01 2002-09-30 Smithkline Beecham Corp Inhibidores de peptido-deformilasa
AR036053A1 (es) * 2001-06-15 2004-08-04 Versicor Inc Compuestos de n-formil-hidroxilamina, un proceso para su preparacion y composiciones farmaceuticas
DK1406893T3 (da) * 2001-06-15 2007-08-06 Vicuron Pharm Inc Bicykliske pyrrolidinforbindelser
WO2004026824A1 (en) 2002-09-19 2004-04-01 Novartis Ag Process for preparing intermediates
PL379008A1 (pl) 2003-02-21 2006-06-26 Novartis Ag Chemiczny sposób wytwarzania związków pośrednich do otrzymywania związków N-formylohydroksyloaminowych
TW200427458A (en) 2003-04-02 2004-12-16 Novartis Ag Crystalline N-formyl hydroxylamine compounds
WO2005000835A1 (en) 2003-06-26 2005-01-06 Novartis Ag Process for preparing intermediates useful to prepare certain antibacterial n-formyl hydroxylamines

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5377010A (en) * 1976-12-16 1978-07-08 Mitsui Toatsu Chem Inc Preparation of hydroxypivalic acid
JPS5765190A (en) * 1980-10-06 1982-04-20 Kanegafuchi Chem Ind Co Ltd Preparation of (-)-alpha-hydroxymethylbutyric acid
JPH01149751A (ja) * 1987-12-08 1989-06-12 Agency Of Ind Science & Technol ２−ｎ−ヘキシル−３−ヒドロキシ−ｎ−デカン酸及びそのエステル
JPH0276591A (ja) * 1988-08-09 1990-03-15 Eastman Kodak Co プロキラルジオールからキラルヒドロキシカルボン酸の製造方法
JPH0592948A (ja) * 1991-02-06 1993-04-16 Yoshitomi Pharmaceut Ind Ltd プロピオン酸アミド誘導体およびその医薬用途
JP2006052138A (ja) * 2002-08-23 2006-02-23 Dainippon Sumitomo Pharma Co Ltd プロリン誘導体

Also Published As

Publication number Publication date
NO20051867D0 (no) 2005-04-18
HK1079513A1 (en) 2006-04-07
DK1542968T3 (da) 2009-04-20
MXPA05003089A (es) 2005-05-27
CN100439334C (zh) 2008-12-03
ATE417826T1 (de) 2009-01-15
DE60325390D1 (de) 2009-01-29
RU2005111600A (ru) 2006-10-27
US7589216B2 (en) 2009-09-15
PL374961A1 (en) 2005-11-14
EP1542968A1 (en) 2005-06-22
ECSP055692A (es) 2005-07-06
AU2003273404B2 (en) 2008-05-22
US20050261504A1 (en) 2005-11-24
PT1542968E (pt) 2009-03-25
CN1684945A (zh) 2005-10-19
AU2003273404A1 (en) 2004-04-08
KR20050057429A (ko) 2005-06-16
RU2374227C2 (ru) 2009-11-27
BR0314592A (pt) 2005-08-09
CA2499426A1 (en) 2004-04-01
NZ538833A (en) 2008-05-30
NO20051867L (no) 2005-04-18
ES2321504T3 (es) 2009-06-08
WO2004026824A1 (en) 2004-04-01
EP1542968B1 (en) 2008-12-17

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