DK1542968T3 - Fremgangsmåde til fremstilling af mellemforbindelser - Google Patents
Fremgangsmåde til fremstilling af mellemforbindelserInfo
- Publication number
- DK1542968T3 DK1542968T3 DK03755559T DK03755559T DK1542968T3 DK 1542968 T3 DK1542968 T3 DK 1542968T3 DK 03755559 T DK03755559 T DK 03755559T DK 03755559 T DK03755559 T DK 03755559T DK 1542968 T3 DK1542968 T3 DK 1542968T3
- Authority
- DK
- Denmark
- Prior art keywords
- preparation
- intermediate compounds
- intermediates
- lactarn
- directed
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title 1
- 239000000543 intermediate Substances 0.000 abstract 3
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- KDGKTJGPFXIBEB-UHFFFAOYSA-N n-hydroxyformamide Chemical class ONC=O KDGKTJGPFXIBEB-UHFFFAOYSA-N 0.000 abstract 1
- 239000000081 peptide deformylase inhibitor Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
- C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D277/06—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Press Drives And Press Lines (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41192002P | 2002-09-19 | 2002-09-19 | |
| US48024203P | 2003-06-20 | 2003-06-20 | |
| PCT/EP2003/010416 WO2004026824A1 (en) | 2002-09-19 | 2003-09-18 | Process for preparing intermediates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1542968T3 true DK1542968T3 (da) | 2009-04-20 |
Family
ID=32033579
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK03755559T DK1542968T3 (da) | 2002-09-19 | 2003-09-18 | Fremgangsmåde til fremstilling af mellemforbindelser |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US7589216B2 (enExample) |
| EP (1) | EP1542968B1 (enExample) |
| JP (1) | JP2006503053A (enExample) |
| KR (1) | KR20050057429A (enExample) |
| CN (1) | CN100439334C (enExample) |
| AT (1) | ATE417826T1 (enExample) |
| AU (1) | AU2003273404B2 (enExample) |
| BR (1) | BR0314592A (enExample) |
| CA (1) | CA2499426A1 (enExample) |
| DE (1) | DE60325390D1 (enExample) |
| DK (1) | DK1542968T3 (enExample) |
| EC (1) | ECSP055692A (enExample) |
| ES (1) | ES2321504T3 (enExample) |
| MX (1) | MXPA05003089A (enExample) |
| NO (1) | NO20051867L (enExample) |
| NZ (1) | NZ538833A (enExample) |
| PL (1) | PL374961A1 (enExample) |
| PT (1) | PT1542968E (enExample) |
| RU (1) | RU2374227C2 (enExample) |
| WO (1) | WO2004026824A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1406893T3 (da) | 2001-06-15 | 2007-08-06 | Vicuron Pharm Inc | Bicykliske pyrrolidinforbindelser |
| WO2004026824A1 (en) | 2002-09-19 | 2004-04-01 | Novartis Ag | Process for preparing intermediates |
| PL379008A1 (pl) | 2003-02-21 | 2006-06-26 | Novartis Ag | Chemiczny sposób wytwarzania związków pośrednich do otrzymywania związków N-formylohydroksyloaminowych |
| GT200600196A (es) * | 2005-05-23 | 2007-01-15 | Compuestos n-formil de hidroxilamina | |
| CN101434570B (zh) * | 2007-11-16 | 2011-02-02 | 上海医药工业研究院 | 吡咯烷衍生物及其制备方法和应用 |
| US11174288B2 (en) | 2016-12-06 | 2021-11-16 | Northeastern University | Heparin-binding cationic peptide self-assembling peptide amphiphiles useful against drug-resistant bacteria |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU384814A1 (ru) * | 1970-12-25 | 1973-05-29 | Всесоюзный научно исследовательский институт тетических , натуральных душистых веществ | СПОСОБ ПОЛУЧЕНИЯ р-МЕТИЛЗАМЕЩЕННЫХ со-ОКСИКАРБОНОВЫХ КИСЛОТ |
| US4123465A (en) * | 1975-10-16 | 1978-10-31 | Hoffmann-La Roche Inc. | Chiral tertiary phosphines |
| JPS5377010A (en) * | 1976-12-16 | 1978-07-08 | Mitsui Toatsu Chem Inc | Preparation of hydroxypivalic acid |
| JPS6030666B2 (ja) * | 1980-08-20 | 1985-07-17 | 鐘淵化学工業株式会社 | 光学活性メルカプトカルボン酸の製造法 |
| JPS5953839B2 (ja) * | 1980-10-06 | 1984-12-27 | 鐘淵化学工業株式会社 | （−）−α−ヒドロキシメチル酪酸の製造方法 |
| JPH01149751A (ja) * | 1987-12-08 | 1989-06-12 | Agency Of Ind Science & Technol | ２−ｎ−ヘキシル−３−ヒドロキシ−ｎ−デカン酸及びそのエステル |
| AU633260B2 (en) * | 1988-08-09 | 1993-01-28 | Genencor International, Inc. | Chiral hydroxycarboxylic acids from prochiral diols |
| JPH0592948A (ja) * | 1991-02-06 | 1993-04-16 | Yoshitomi Pharmaceut Ind Ltd | プロピオン酸アミド誘導体およびその医薬用途 |
| PL194240B1 (pl) | 1998-02-07 | 2007-05-31 | British Biotech Pharm | Zastosowanie pochodnych N-formylohydroksyloaminy i amidowa pochodna N-formylohydroksyloaminy |
| US6977141B2 (en) * | 1998-02-10 | 2005-12-20 | Vicuron Pharmaceuticals Inc. | Direct adsorption scintillation assay for measuring enzyme activity and assaying biochemical processes |
| UY27192A1 (es) * | 2001-03-01 | 2002-09-30 | Smithkline Beecham Corp | Inhibidores de peptido-deformilasa |
| AR036053A1 (es) * | 2001-06-15 | 2004-08-04 | Versicor Inc | Compuestos de n-formil-hidroxilamina, un proceso para su preparacion y composiciones farmaceuticas |
| DK1406893T3 (da) * | 2001-06-15 | 2007-08-06 | Vicuron Pharm Inc | Bicykliske pyrrolidinforbindelser |
| JP2006052138A (ja) * | 2002-08-23 | 2006-02-23 | Dainippon Sumitomo Pharma Co Ltd | プロリン誘導体 |
| WO2004026824A1 (en) | 2002-09-19 | 2004-04-01 | Novartis Ag | Process for preparing intermediates |
| PL379008A1 (pl) | 2003-02-21 | 2006-06-26 | Novartis Ag | Chemiczny sposób wytwarzania związków pośrednich do otrzymywania związków N-formylohydroksyloaminowych |
| TW200427458A (en) | 2003-04-02 | 2004-12-16 | Novartis Ag | Crystalline N-formyl hydroxylamine compounds |
| WO2005000835A1 (en) | 2003-06-26 | 2005-01-06 | Novartis Ag | Process for preparing intermediates useful to prepare certain antibacterial n-formyl hydroxylamines |
-
2003
- 2003-09-18 WO PCT/EP2003/010416 patent/WO2004026824A1/en not_active Ceased
- 2003-09-18 AU AU2003273404A patent/AU2003273404B2/en not_active Ceased
- 2003-09-18 CN CNB038224712A patent/CN100439334C/zh not_active Expired - Fee Related
- 2003-09-18 RU RU2005111600/04A patent/RU2374227C2/ru not_active IP Right Cessation
- 2003-09-18 EP EP03755559A patent/EP1542968B1/en not_active Expired - Lifetime
- 2003-09-18 ES ES03755559T patent/ES2321504T3/es not_active Expired - Lifetime
- 2003-09-18 KR KR1020057004645A patent/KR20050057429A/ko not_active Ceased
- 2003-09-18 MX MXPA05003089A patent/MXPA05003089A/es active IP Right Grant
- 2003-09-18 JP JP2004537129A patent/JP2006503053A/ja active Pending
- 2003-09-18 AT AT03755559T patent/ATE417826T1/de not_active IP Right Cessation
- 2003-09-18 PT PT03755559T patent/PT1542968E/pt unknown
- 2003-09-18 US US10/527,628 patent/US7589216B2/en not_active Expired - Fee Related
- 2003-09-18 CA CA002499426A patent/CA2499426A1/en not_active Abandoned
- 2003-09-18 BR BR0314592-1A patent/BR0314592A/pt not_active IP Right Cessation
- 2003-09-18 PL PL03374961A patent/PL374961A1/xx not_active Application Discontinuation
- 2003-09-18 DE DE60325390T patent/DE60325390D1/de not_active Expired - Lifetime
- 2003-09-18 NZ NZ538833A patent/NZ538833A/en not_active IP Right Cessation
- 2003-09-18 DK DK03755559T patent/DK1542968T3/da active
-
2005
- 2005-03-18 EC EC2005005692A patent/ECSP055692A/es unknown
- 2005-04-18 NO NO20051867A patent/NO20051867L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| NO20051867D0 (no) | 2005-04-18 |
| HK1079513A1 (en) | 2006-04-07 |
| MXPA05003089A (es) | 2005-05-27 |
| CN100439334C (zh) | 2008-12-03 |
| ATE417826T1 (de) | 2009-01-15 |
| DE60325390D1 (de) | 2009-01-29 |
| RU2005111600A (ru) | 2006-10-27 |
| US7589216B2 (en) | 2009-09-15 |
| PL374961A1 (en) | 2005-11-14 |
| EP1542968A1 (en) | 2005-06-22 |
| ECSP055692A (es) | 2005-07-06 |
| AU2003273404B2 (en) | 2008-05-22 |
| US20050261504A1 (en) | 2005-11-24 |
| PT1542968E (pt) | 2009-03-25 |
| CN1684945A (zh) | 2005-10-19 |
| AU2003273404A1 (en) | 2004-04-08 |
| KR20050057429A (ko) | 2005-06-16 |
| RU2374227C2 (ru) | 2009-11-27 |
| BR0314592A (pt) | 2005-08-09 |
| CA2499426A1 (en) | 2004-04-01 |
| NZ538833A (en) | 2008-05-30 |
| NO20051867L (no) | 2005-04-18 |
| JP2006503053A (ja) | 2006-01-26 |
| ES2321504T3 (es) | 2009-06-08 |
| WO2004026824A1 (en) | 2004-04-01 |
| EP1542968B1 (en) | 2008-12-17 |
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