NO20051867L - Fremgangsmate for fremstilling av intermediater - Google Patents

Fremgangsmate for fremstilling av intermediater

Info

Publication number
NO20051867L
NO20051867L NO20051867A NO20051867A NO20051867L NO 20051867 L NO20051867 L NO 20051867L NO 20051867 A NO20051867 A NO 20051867A NO 20051867 A NO20051867 A NO 20051867A NO 20051867 L NO20051867 L NO 20051867L
Authority
NO
Norway
Prior art keywords
preparing intermediates
intermediates
preparing
lactarn
directed
Prior art date
Application number
NO20051867A
Other languages
English (en)
Other versions
NO20051867D0 (no
Inventor
Prasad Koteswara Kapa
Mahavir Prashad
George Tien-San Lee
Eric M Loeser
Xinglong Jiang
Joel Slade
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of NO20051867D0 publication Critical patent/NO20051867D0/no
Publication of NO20051867L publication Critical patent/NO20051867L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D277/06—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Press Drives And Press Lines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Foreliggende oppfinnelse er rettet mot en fremgangsmåte for fremstilling av intermediater som er anvendelige for fremstilling av visse antibakterielle iV-formyl-hydroksylaminforbndelser som er peptiddeformylaseinhibitorer. Fremgangsmåten gjør anvendelse av a P-laktamintermediat. Visse optiske rene intermediater er også beskrevet.
NO20051867A 2002-09-19 2005-04-18 Fremgangsmate for fremstilling av intermediater NO20051867L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US41192002P 2002-09-19 2002-09-19
US48024203P 2003-06-20 2003-06-20
PCT/EP2003/010416 WO2004026824A1 (en) 2002-09-19 2003-09-18 Process for preparing intermediates

Publications (2)

Publication Number Publication Date
NO20051867D0 NO20051867D0 (no) 2005-04-18
NO20051867L true NO20051867L (no) 2005-04-18

Family

ID=32033579

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20051867A NO20051867L (no) 2002-09-19 2005-04-18 Fremgangsmate for fremstilling av intermediater

Country Status (21)

Country Link
US (1) US7589216B2 (no)
EP (1) EP1542968B1 (no)
JP (1) JP2006503053A (no)
KR (1) KR20050057429A (no)
CN (1) CN100439334C (no)
AT (1) ATE417826T1 (no)
AU (1) AU2003273404B2 (no)
BR (1) BR0314592A (no)
CA (1) CA2499426A1 (no)
DE (1) DE60325390D1 (no)
DK (1) DK1542968T3 (no)
EC (1) ECSP055692A (no)
ES (1) ES2321504T3 (no)
HK (1) HK1079513A1 (no)
MX (1) MXPA05003089A (no)
NO (1) NO20051867L (no)
NZ (1) NZ538833A (no)
PL (1) PL374961A1 (no)
PT (1) PT1542968E (no)
RU (1) RU2374227C2 (no)
WO (1) WO2004026824A1 (no)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60219630T2 (de) 2001-06-15 2007-12-27 Vicuron Pharmaceuticals, Inc., Fremont Bicyclische pyrrolidinverbindungen
WO2004026824A1 (en) 2002-09-19 2004-04-01 Novartis Ag Process for preparing intermediates
AU2004216178B2 (en) 2003-02-21 2008-07-03 Novartis Ag Chemical process for the preparation of intermediates to obtain N-formyl hydroxylamine compounds
GT200600196A (es) * 2005-05-23 2007-01-15 Compuestos n-formil de hidroxilamina
CN101434570B (zh) * 2007-11-16 2011-02-02 上海医药工业研究院 吡咯烷衍生物及其制备方法和应用
US11174288B2 (en) 2016-12-06 2021-11-16 Northeastern University Heparin-binding cationic peptide self-assembling peptide amphiphiles useful against drug-resistant bacteria

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4123465A (en) * 1975-10-16 1978-10-31 Hoffmann-La Roche Inc. Chiral tertiary phosphines
JPS5377010A (en) * 1976-12-16 1978-07-08 Mitsui Toatsu Chem Inc Preparation of hydroxypivalic acid
JPS6030666B2 (ja) * 1980-08-20 1985-07-17 鐘淵化学工業株式会社 光学活性メルカプトカルボン酸の製造法
JPS5953839B2 (ja) * 1980-10-06 1984-12-27 鐘淵化学工業株式会社 （−）−α−ヒドロキシメチル酪酸の製造方法
JPH01149751A (ja) * 1987-12-08 1989-06-12 Agency Of Ind Science & Technol ２−ｎ−ヘキシル−３−ヒドロキシ−ｎ−デカン酸及びそのエステル
AU633260B2 (en) * 1988-08-09 1993-01-28 Genencor International, Inc. Chiral hydroxycarboxylic acids from prochiral diols
JPH0592948A (ja) * 1991-02-06 1993-04-16 Yoshitomi Pharmaceut Ind Ltd プロピオン酸アミド誘導体およびその医薬用途
ES2221359T3 (es) 1998-02-07 2004-12-16 Vernalis (Oxford) Ltd Agentes antibacterianos.
US6977141B2 (en) 1998-02-10 2005-12-20 Vicuron Pharmaceuticals Inc. Direct adsorption scintillation assay for measuring enzyme activity and assaying biochemical processes
UY27192A1 (es) * 2001-03-01 2002-09-30 Smithkline Beecham Corp Inhibidores de peptido-deformilasa
AR036053A1 (es) 2001-06-15 2004-08-04 Versicor Inc Compuestos de n-formil-hidroxilamina, un proceso para su preparacion y composiciones farmaceuticas
DE60219630T2 (de) 2001-06-15 2007-12-27 Vicuron Pharmaceuticals, Inc., Fremont Bicyclische pyrrolidinverbindungen
JP2006052138A (ja) * 2002-08-23 2006-02-23 Dainippon Sumitomo Pharma Co Ltd プロリン誘導体
WO2004026824A1 (en) 2002-09-19 2004-04-01 Novartis Ag Process for preparing intermediates
AU2004216178B2 (en) 2003-02-21 2008-07-03 Novartis Ag Chemical process for the preparation of intermediates to obtain N-formyl hydroxylamine compounds
TW200427458A (en) 2003-04-02 2004-12-16 Novartis Ag Crystalline N-formyl hydroxylamine compounds
US20070060753A1 (en) 2003-06-26 2007-03-15 Joel Slade Process for preparing intermediates useful to prepare certain antibacterial n-formyl hydroxylamines

Also Published As

Publication number Publication date
CN1684945A (zh) 2005-10-19
AU2003273404A1 (en) 2004-04-08
RU2005111600A (ru) 2006-10-27
NO20051867D0 (no) 2005-04-18
US7589216B2 (en) 2009-09-15
MXPA05003089A (es) 2005-05-27
JP2006503053A (ja) 2006-01-26
KR20050057429A (ko) 2005-06-16
CA2499426A1 (en) 2004-04-01
PL374961A1 (en) 2005-11-14
BR0314592A (pt) 2005-08-09
ATE417826T1 (de) 2009-01-15
RU2374227C2 (ru) 2009-11-27
AU2003273404B2 (en) 2008-05-22
EP1542968A1 (en) 2005-06-22
US20050261504A1 (en) 2005-11-24
CN100439334C (zh) 2008-12-03
NZ538833A (en) 2008-05-30
ES2321504T3 (es) 2009-06-08
ECSP055692A (es) 2005-07-06
HK1079513A1 (en) 2006-04-07
DE60325390D1 (de) 2009-01-29
DK1542968T3 (da) 2009-04-20
EP1542968B1 (en) 2008-12-17
WO2004026824A1 (en) 2004-04-01
PT1542968E (pt) 2009-03-25

Similar Documents

Publication Publication Date Title
NO20050199L (no) Azadisyklo-oktan og nonanderivater med DDP-IV-inhiberende aktivitet
SE0302232D0 (sv) Novel Compounds
SE0203713D0 (sv) Novel compounds
CY1111225T1 (el) Νεα πεπτιδια ως αναστολεις πρωτεασης νs3-σερινης ιου ηπατiτιδας c
IS7845A (is) Forröðuð þríhringja integrase hindrandi efnasambönd
ATE411030T1 (de) Phosphonatanaloga von hiv- integrasehemmerverbindungen
NO20044221L (no) Nye forbindelser
ITMI20050801A1 (it) Procedimento per la preparazione di telmisartan
ATE490253T1 (de) Synthese von 5-substituierten 7-azaindolen und 7- azaindolinen
NO20062021L (no) Omleirede pentanoler, fremgangsmpte for fremstilling av dette, og deres anvendelse som antiflogistika
DE502005008057D1 (de) Substituierte cyclopenten-verbindungen
NO20051867D0 (no) Fremgangsmate for fremstilling av intermediater
EA201101015A1 (ru) Способ получения бивалирудина
EA200601029A1 (ru) Способ очистки фсг
NO20055657L (no) Nye bioisostaererav aktinonin
SE0103710D0 (sv) Compounds
TNSN06260A1 (en) Process for the preparation of tryptase inhibitors
EA200500204A1 (ru) Новый способ синтеза (7-метокси-1-нафтил)ацетонитрила и его применение при синтезе агомелатина
RS52260B (en) N- (2-hydroxyethyl) -N-methyl-4- (quinoline-8-yl (1- (thiazol-4-ylmethyl) piperidin-4-ylidene) methyl) benzamide, a process for its production as well as its use for treatment PAIN, TENSION AND DEPRESSION
NO20080661L (no) Nye cystein-protease-inhibitorer og deres terapeutiske anvendelser
EA200600898A1 (ru) Новый способ синтеза периндоприла и его фармацевтически приемлемых солей
NO20060603L (no) Fremgangsmate for fremstillingen av fenyltetrazolderivater
ATE411310T1 (de) Reinigungsverfahren von moxonidine
MXPA05014217A (es) Proceso para preparar intermediarios utiles para preparar ciertas n-formil hidroxilaminas antibacterianas.
EA200601086A1 (ru) Новый способ синтеза периндоприла и его фармацевтически приемлемых солей

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application