ECSP055692A - Proceso para preparar intermediarios - Google Patents

Proceso para preparar intermediarios

Info

Publication number
ECSP055692A
ECSP055692A EC2005005692A ECSP055692A ECSP055692A EC SP055692 A ECSP055692 A EC SP055692A EC 2005005692 A EC2005005692 A EC 2005005692A EC SP055692 A ECSP055692 A EC SP055692A EC SP055692 A ECSP055692 A EC SP055692A
Authority
EC
Ecuador
Prior art keywords
prepare
intermediaries
intermediates
lactarn
directed
Prior art date
Application number
EC2005005692A
Other languages
English (en)
Inventor
Prasad Koteswara Kapa
Eric M Loeser
Xinglong Jiang
Joel Slade
Mahavir Prashad
George Tien-San Lee
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of ECSP055692A publication Critical patent/ECSP055692A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D277/06—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Press Drives And Press Lines (AREA)

Abstract

La presente invención se dirige a un proceso para preparar intermediarios que son útiles para preparar ciertos compuestos antibacterianos de hidroxilamina N-formilo, los cuales son inhibidores de deformilasa de péptido. El proceso hace uso de un intermediario a ß-lactam. También se reclaman ciertos intermediarios ópticamente puros.
EC2005005692A 2002-09-19 2005-03-18 Proceso para preparar intermediarios ECSP055692A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41192002P 2002-09-19 2002-09-19
US48024203P 2003-06-20 2003-06-20

Publications (1)

Publication Number Publication Date
ECSP055692A true ECSP055692A (es) 2005-07-06

Family

ID=32033579

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2005005692A ECSP055692A (es) 2002-09-19 2005-03-18 Proceso para preparar intermediarios

Country Status (21)

Country Link
US (1) US7589216B2 (es)
EP (1) EP1542968B1 (es)
JP (1) JP2006503053A (es)
KR (1) KR20050057429A (es)
CN (1) CN100439334C (es)
AT (1) ATE417826T1 (es)
AU (1) AU2003273404B2 (es)
BR (1) BR0314592A (es)
CA (1) CA2499426A1 (es)
DE (1) DE60325390D1 (es)
DK (1) DK1542968T3 (es)
EC (1) ECSP055692A (es)
ES (1) ES2321504T3 (es)
HK (1) HK1079513A1 (es)
MX (1) MXPA05003089A (es)
NO (1) NO20051867D0 (es)
NZ (1) NZ538833A (es)
PL (1) PL374961A1 (es)
PT (1) PT1542968E (es)
RU (1) RU2374227C2 (es)
WO (1) WO2004026824A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60219630T2 (de) 2001-06-15 2007-12-27 Vicuron Pharmaceuticals, Inc., Fremont Bicyclische pyrrolidinverbindungen
MXPA05003089A (es) 2002-09-19 2005-05-27 Novartis Ag Proceso para preparar intermediarios.
CN1759097A (zh) 2003-02-21 2006-04-12 诺瓦提斯公司 制备用以获得n－甲酰基羟胺的中间体的化学方法
GT200600196A (es) * 2005-05-23 2007-01-15 Compuestos n-formil de hidroxilamina
CN101434570B (zh) * 2007-11-16 2011-02-02 上海医药工业研究院 吡咯烷衍生物及其制备方法和应用
US11174288B2 (en) 2016-12-06 2021-11-16 Northeastern University Heparin-binding cationic peptide self-assembling peptide amphiphiles useful against drug-resistant bacteria

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4123465A (en) * 1975-10-16 1978-10-31 Hoffmann-La Roche Inc. Chiral tertiary phosphines
JPS5377010A (en) * 1976-12-16 1978-07-08 Mitsui Toatsu Chem Inc Preparation of hydroxypivalic acid
JPS6030666B2 (ja) * 1980-08-20 1985-07-17 鐘淵化学工業株式会社 光学活性メルカプトカルボン酸の製造法
JPS5953839B2 (ja) * 1980-10-06 1984-12-27 鐘淵化学工業株式会社 （−）−α−ヒドロキシメチル酪酸の製造方法
JPH01149751A (ja) * 1987-12-08 1989-06-12 Agency Of Ind Science & Technol ２−ｎ−ヘキシル−３−ヒドロキシ−ｎ−デカン酸及びそのエステル
AU633260B2 (en) 1988-08-09 1993-01-28 Genencor International, Inc. Chiral hydroxycarboxylic acids from prochiral diols
JPH0592948A (ja) * 1991-02-06 1993-04-16 Yoshitomi Pharmaceut Ind Ltd プロピオン酸アミド誘導体およびその医薬用途
CN1298299A (zh) * 1998-02-07 2001-06-06 英国生物技术药物有限公司 抗菌剂
US6977141B2 (en) * 1998-02-10 2005-12-20 Vicuron Pharmaceuticals Inc. Direct adsorption scintillation assay for measuring enzyme activity and assaying biochemical processes
AR032920A1 (es) * 2001-03-01 2003-12-03 Smithkline Beecham Corp Compuestos inhibidores de las peptido-deformilasas y medios para tratar infecciones bacterianas utilizando dichos inhibidores
AR036053A1 (es) 2001-06-15 2004-08-04 Versicor Inc Compuestos de n-formil-hidroxilamina, un proceso para su preparacion y composiciones farmaceuticas
DE60219630T2 (de) * 2001-06-15 2007-12-27 Vicuron Pharmaceuticals, Inc., Fremont Bicyclische pyrrolidinverbindungen
JP2006052138A (ja) * 2002-08-23 2006-02-23 Dainippon Sumitomo Pharma Co Ltd プロリン誘導体
MXPA05003089A (es) 2002-09-19 2005-05-27 Novartis Ag Proceso para preparar intermediarios.
CN1759097A (zh) 2003-02-21 2006-04-12 诺瓦提斯公司 制备用以获得n－甲酰基羟胺的中间体的化学方法
TW200427458A (en) 2003-04-02 2004-12-16 Novartis Ag Crystalline N-formyl hydroxylamine compounds
JP2009513485A (ja) 2003-06-26 2009-04-02 ノバルティス アクチエンゲゼルシャフト ある種の抗菌性ｎ−ホルミルヒドロキシルアミン化合物の製造に有用な中間体の製造法

Also Published As

Publication number Publication date
ATE417826T1 (de) 2009-01-15
KR20050057429A (ko) 2005-06-16
BR0314592A (pt) 2005-08-09
JP2006503053A (ja) 2006-01-26
AU2003273404B2 (en) 2008-05-22
RU2005111600A (ru) 2006-10-27
NZ538833A (en) 2008-05-30
CN1684945A (zh) 2005-10-19
US7589216B2 (en) 2009-09-15
DK1542968T3 (da) 2009-04-20
PL374961A1 (en) 2005-11-14
US20050261504A1 (en) 2005-11-24
PT1542968E (pt) 2009-03-25
NO20051867L (no) 2005-04-18
AU2003273404A1 (en) 2004-04-08
HK1079513A1 (en) 2006-04-07
DE60325390D1 (de) 2009-01-29
CA2499426A1 (en) 2004-04-01
ES2321504T3 (es) 2009-06-08
MXPA05003089A (es) 2005-05-27
WO2004026824A1 (en) 2004-04-01
EP1542968A1 (en) 2005-06-22
NO20051867D0 (no) 2005-04-18
EP1542968B1 (en) 2008-12-17
RU2374227C2 (ru) 2009-11-27
CN100439334C (zh) 2008-12-03

Similar Documents

Publication Publication Date Title
ITMI20050801A1 (it) Procedimento per la preparazione di telmisartan
NO20050199L (no) Azadisyklo-oktan og nonanderivater med DDP-IV-inhiberende aktivitet
BRPI0615705A2 (pt) processo para preparar um composto, e, composto
CL2012000033A1 (es) Compuestos n-(3-(4as,7as)-2-amino-4a,5,7,7a-tetrahidro-4h-furo[3,4-d][1,3] tiazin-7a-il)-4- fluorofenilo) -5-fluoropiconilamida, inhibidor de bace; composicion farmaceutica que los comprende, uso del compuesto para el tratamiento de la enfermedad de alzheimer.
CY1109088T1 (el) Μεθοδος για την παρασκευη υποκατεστημενων ενωσεων 3-αρυλο-βουτυλ-αμινης
EA200702346A1 (ru) КРИСТАЛЛИЧЕСКАЯ ФОРМА 1-ХЛОР-4-(β-D-ГЛЮКОПИРАНОЗ-1-ИЛ)-2-[4-((S)-ТЕТРАГИДРОФУРАН-3-ИЛОКСИ)БЕНЗИЛ]БЕНЗОЛА, СПОСОБ ЕЁ ПОЛУЧЕНИЯ И ЕЁ ПРИМЕНЕНИЕ ДЛЯ ПРИГОТОВЛЕНИЯ ЛЕКАРСТВЕННЫХ СРЕДСТВ
DOP2011000301A (es) Derivados de azaadamantano y metodos de uso de los mismos
ECSP066721A (es) Inhibidores novedosos de quimasa
SE0203713D0 (sv) Novel compounds
BRPI0710199A2 (pt) Processo para preparação de inibidores de hiv protease
DK1483265T3 (da) Purinderivater som kinaseinhibitorer
SE0303180D0 (sv) Novel compounds
SE0302232D0 (sv) Novel Compounds
ECSP055692A (es) Proceso para preparar intermediarios
EA200500202A1 (ru) Новый способ синтеза (7-метокси-3,4-дигидро-1-нафталинил)ацетонитрила и его применение при синтезе агомелатина
ECSP10010145A (es) Uso de 3,11b-cis-dihidrotetrabenazina en el tratamiento de la esclerosis múltiple y la mielitis autoinmunitaria
EA200801365A1 (ru) Замещенные 5-фенил-3,6-дигидро-2-оксо-6h-1,3,4-тиадиазины
BRPI0417992A (pt) método para purificar fsh
TNSN05277A1 (en) Novel bioisosteres of actinonin
EA200500204A1 (ru) Новый способ синтеза (7-метокси-1-нафтил)ацетонитрила и его применение при синтезе агомелатина
NO20080661L (no) Nye cystein-protease-inhibitorer og deres terapeutiske anvendelser
RS52260B (en) N- (2-hydroxyethyl) -N-methyl-4- (quinoline-8-yl (1- (thiazol-4-ylmethyl) piperidin-4-ylidene) methyl) benzamide, a process for its production as well as its use for treatment PAIN, TENSION AND DEPRESSION
CO6390054A2 (es) Formas cristalinas de un compuesto 3-carboxipropil-aminotetralina
BRPI0411921A (pt) processo para preparar intermediários úteis para preparar determinadas hidroxilaminas de n-formila antibacterianas
DE602006003204D1 (de) Reinigungsverfahren von Moxonidine