CN100439334C - 制备中间体的方法 - Google Patents

制备中间体的方法 Download PDF

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Publication number
CN100439334C
CN100439334C CNB038224712A CN03822471A CN100439334C CN 100439334 C CN100439334 C CN 100439334C CN B038224712 A CNB038224712 A CN B038224712A CN 03822471 A CN03822471 A CN 03822471A CN 100439334 C CN100439334 C CN 100439334C
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China
Prior art keywords
hydrogen
alkyl
compound
formula
hours
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Expired - Fee Related
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CNB038224712A
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English (en)
Chinese (zh)
Other versions
CN1684945A (zh
Inventor
P·K·卡帕
姜兴龙
E·M·勒泽尔
J·斯莱德
M·普拉沙德
G·T-S·李
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Novartis AG
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Novartis AG
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Publication of CN1684945A publication Critical patent/CN1684945A/zh
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Publication of CN100439334C publication Critical patent/CN100439334C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D277/06—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Press Drives And Press Lines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
CNB038224712A 2002-09-19 2003-09-18 制备中间体的方法 Expired - Fee Related CN100439334C (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US41192002P 2002-09-19 2002-09-19
US60/411,920 2002-09-19
US48024203P 2003-06-20 2003-06-20
US60/480,242 2003-06-20

Publications (2)

Publication Number Publication Date
CN1684945A CN1684945A (zh) 2005-10-19
CN100439334C true CN100439334C (zh) 2008-12-03

Family

ID=32033579

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB038224712A Expired - Fee Related CN100439334C (zh) 2002-09-19 2003-09-18 制备中间体的方法

Country Status (20)

Country Link
US (1) US7589216B2 (enExample)
EP (1) EP1542968B1 (enExample)
JP (1) JP2006503053A (enExample)
KR (1) KR20050057429A (enExample)
CN (1) CN100439334C (enExample)
AT (1) ATE417826T1 (enExample)
AU (1) AU2003273404B2 (enExample)
BR (1) BR0314592A (enExample)
CA (1) CA2499426A1 (enExample)
DE (1) DE60325390D1 (enExample)
DK (1) DK1542968T3 (enExample)
EC (1) ECSP055692A (enExample)
ES (1) ES2321504T3 (enExample)
MX (1) MXPA05003089A (enExample)
NO (1) NO20051867L (enExample)
NZ (1) NZ538833A (enExample)
PL (1) PL374961A1 (enExample)
PT (1) PT1542968E (enExample)
RU (1) RU2374227C2 (enExample)
WO (1) WO2004026824A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1512991A (zh) 2001-06-15 2004-07-14 ά����ҩ�﹫˾ 吡咯烷双环化合物
EP1542968B1 (en) 2002-09-19 2008-12-17 Novartis AG Process for preparing intermediates
JP2006519786A (ja) 2003-02-21 2006-08-31 ノバルティス アクチエンゲゼルシャフト Ｎ−ホルミルヒドロキシルアミン化合物を得るための中間体作成に関する化学的方法
GT200600196A (es) * 2005-05-23 2007-01-15 Compuestos n-formil de hidroxilamina
CN101434570B (zh) * 2007-11-16 2011-02-02 上海医药工业研究院 吡咯烷衍生物及其制备方法和应用
US11174288B2 (en) 2016-12-06 2021-11-16 Northeastern University Heparin-binding cationic peptide self-assembling peptide amphiphiles useful against drug-resistant bacteria

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4115417A (en) * 1975-10-16 1978-09-19 Hoffmann-La Roche Inc. Asymmetric hydrogenation catalyzed by rhodium complexes of chiral tertiary phosphines
US4384139A (en) * 1980-08-20 1983-05-17 Kanegafuchi Chemical Industry Company, Limited Process for preparation of an optically active β-mercaptoalkanoic acid
EP0354529A2 (en) * 1988-08-09 1990-02-14 Genencor International, Inc. Chiral hydroxycarboxylic acids from prochiral diols
WO1999039704A1 (en) * 1998-02-07 1999-08-12 British Biotech Pharmaceuticals Limited Antibacterial agents
WO2002070541A2 (en) * 2001-03-01 2002-09-12 Smith Kline Beecham Corporation Peptide deformylase inhibitors

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU384814A1 (ru) * 1970-12-25 1973-05-29 Всесоюзный научно исследовательский институт тетических , натуральных душистых веществ СПОСОБ ПОЛУЧЕНИЯ р-МЕТИЛЗАМЕЩЕННЫХ со-ОКСИКАРБОНОВЫХ КИСЛОТ
JPS5377010A (en) * 1976-12-16 1978-07-08 Mitsui Toatsu Chem Inc Preparation of hydroxypivalic acid
JPS5953839B2 (ja) * 1980-10-06 1984-12-27 鐘淵化学工業株式会社 （−）−α−ヒドロキシメチル酪酸の製造方法
JPH01149751A (ja) * 1987-12-08 1989-06-12 Agency Of Ind Science & Technol ２−ｎ−ヘキシル−３−ヒドロキシ−ｎ−デカン酸及びそのエステル
JPH0592948A (ja) * 1991-02-06 1993-04-16 Yoshitomi Pharmaceut Ind Ltd プロピオン酸アミド誘導体およびその医薬用途
US6977141B2 (en) 1998-02-10 2005-12-20 Vicuron Pharmaceuticals Inc. Direct adsorption scintillation assay for measuring enzyme activity and assaying biochemical processes
CN1512991A (zh) 2001-06-15 2004-07-14 ά����ҩ�﹫˾ 吡咯烷双环化合物
AR036053A1 (es) 2001-06-15 2004-08-04 Versicor Inc Compuestos de n-formil-hidroxilamina, un proceso para su preparacion y composiciones farmaceuticas
JP2006052138A (ja) * 2002-08-23 2006-02-23 Dainippon Sumitomo Pharma Co Ltd プロリン誘導体
EP1542968B1 (en) 2002-09-19 2008-12-17 Novartis AG Process for preparing intermediates
JP2006519786A (ja) 2003-02-21 2006-08-31 ノバルティス アクチエンゲゼルシャフト Ｎ−ホルミルヒドロキシルアミン化合物を得るための中間体作成に関する化学的方法
TW200427458A (en) 2003-04-02 2004-12-16 Novartis Ag Crystalline N-formyl hydroxylamine compounds
AU2004251876A1 (en) 2003-06-26 2005-01-06 Novartis Ag Process for preparing intermediates useful to prepare certain antibacterial N-formyl hydroxylamines

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4115417A (en) * 1975-10-16 1978-09-19 Hoffmann-La Roche Inc. Asymmetric hydrogenation catalyzed by rhodium complexes of chiral tertiary phosphines
US4384139A (en) * 1980-08-20 1983-05-17 Kanegafuchi Chemical Industry Company, Limited Process for preparation of an optically active β-mercaptoalkanoic acid
EP0354529A2 (en) * 1988-08-09 1990-02-14 Genencor International, Inc. Chiral hydroxycarboxylic acids from prochiral diols
WO1999039704A1 (en) * 1998-02-07 1999-08-12 British Biotech Pharmaceuticals Limited Antibacterial agents
WO2002070541A2 (en) * 2001-03-01 2002-09-12 Smith Kline Beecham Corporation Peptide deformylase inhibitors

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
A Practical Method for the Conversion of beta-HydroxyCarboxylic Acids into the Corresponding beta-Amino Acids. 1189-1190.SYNLETT,Vol.11. 1998 *
A Practical Method for the Conversion of beta-HydroxyCarboxylic Acids into the Corresponding beta-Amino Acids. YONGHAO JIN ET AL.SYNLETT,Vol.11. 1998 *
alpha an ions of carboxylic acids v simple high yieldpreparation of alpha alkylhydracryl ic acids andalpha alkylacrylic acids. PFEFFER PHILIP E ET AL.JOURNAL OF ORGANI C CHEMISTRY,Vol.37 No.8. 1972 *
Darstellung von Derivaten der 3-Hydroxypropiohydroxamsaureunter Anwendung der Carbodiimid-Methode. DETLEF GEFFKEN ET AL.CHEMISCHE BERICHTE,Vol.106. 1973 *
Design of Selective and Soluble Inhibitors of Tumor NecrosisFactor-alpha Converting Enzyme (TACE). MICHAEL H. RABINOWITZ ET AL.JOURNAL OF MEDICINAL CHEMISTRY,Vol.44. 2001 *
synthesis of 1 3 dioxin 4 ones and their use in synthesis XVIII synthesis of azetidin 2 o nes from 1 3 dioxin 4 ones via 3 hydro. JUN ICHI SAKAKI ET AL.CHEMICAL & PHARM ACEUTICAL BULLETIN,Vol.37 No.11. 1989 *
Synthesis of beta-Lactams from Substituted Hydroxamic Acids. MARVIN J. MILLER ET AL.JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,Vol.102 No.23. 1980 *
Terpenoids. IL. The Prins reaction on the isopropylidene-typedouble bonds. RAMASWAMI SURYAKUMARI ET AL.JOURNAL OF ORGANIC CHEMISTRY,Vol.29 No.8. 1980 *

Also Published As

Publication number Publication date
HK1079513A1 (en) 2006-04-07
NZ538833A (en) 2008-05-30
PL374961A1 (en) 2005-11-14
EP1542968B1 (en) 2008-12-17
AU2003273404B2 (en) 2008-05-22
ATE417826T1 (de) 2009-01-15
ES2321504T3 (es) 2009-06-08
CN1684945A (zh) 2005-10-19
US7589216B2 (en) 2009-09-15
NO20051867D0 (no) 2005-04-18
ECSP055692A (es) 2005-07-06
MXPA05003089A (es) 2005-05-27
RU2005111600A (ru) 2006-10-27
DE60325390D1 (de) 2009-01-29
DK1542968T3 (da) 2009-04-20
JP2006503053A (ja) 2006-01-26
NO20051867L (no) 2005-04-18
BR0314592A (pt) 2005-08-09
US20050261504A1 (en) 2005-11-24
WO2004026824A1 (en) 2004-04-01
EP1542968A1 (en) 2005-06-22
AU2003273404A1 (en) 2004-04-08
CA2499426A1 (en) 2004-04-01
KR20050057429A (ko) 2005-06-16
PT1542968E (pt) 2009-03-25
RU2374227C2 (ru) 2009-11-27

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Granted publication date: 20081203

Termination date: 20100918