JP2006111566A - メチオニン配合内服液剤 - Google Patents
メチオニン配合内服液剤 Download PDFInfo
- Publication number
- JP2006111566A JP2006111566A JP2004300219A JP2004300219A JP2006111566A JP 2006111566 A JP2006111566 A JP 2006111566A JP 2004300219 A JP2004300219 A JP 2004300219A JP 2004300219 A JP2004300219 A JP 2004300219A JP 2006111566 A JP2006111566 A JP 2006111566A
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- JP
- Japan
- Prior art keywords
- active oxygen
- methionine
- liquid preparation
- preparation according
- vitamin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000007788 liquid Substances 0.000 title claims abstract description 37
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims abstract description 26
- 229930182817 methionine Natural products 0.000 claims abstract description 26
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims abstract description 19
- 229910052760 oxygen Inorganic materials 0.000 claims abstract description 19
- 239000001301 oxygen Substances 0.000 claims abstract description 19
- 239000003814 drug Substances 0.000 claims abstract description 13
- 229940079593 drug Drugs 0.000 claims abstract description 10
- 239000003086 colorant Substances 0.000 claims abstract description 7
- 239000000284 extract Substances 0.000 claims description 23
- 235000013824 polyphenols Nutrition 0.000 claims description 18
- 150000008442 polyphenolic compounds Chemical class 0.000 claims description 16
- 238000002360 preparation method Methods 0.000 claims description 16
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- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 claims description 13
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- 230000000694 effects Effects 0.000 claims description 9
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- 230000002401 inhibitory effect Effects 0.000 claims description 9
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Images
Landscapes
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Non-Alcoholic Beverages (AREA)
Abstract
本発明は、メチオニンとビタミンB2類を同時配合した際に経時的に発生する不快臭を抑制し、メチオニンとビタミンB2類を同時に配合した内服液剤を提供することにある。
【解決手段】 メチオニン、ビタミンB2類および活性酸素発生抑制成分を含む内服液剤。
【選択図】なし
Description
メチオニン30mg、リン酸リボフラビンナトリウム5mgおよび赤色3号50mgの各成分を配合し、リン酸でpH3.0に調製して全量を精製水で50mLに調節して液剤を得た。
メチオニン30mg、リン酸リボフラビンナトリウム5mgおよびカルミン色素1.8mgを配合し、リン酸でpH3.0に調製して全量を精製水で50mLに調節して液剤を得た
実施例1〜5の液剤、比較例1、2について、不快臭の程度を4人のパネラーによる官能試験により評価した。評価は臭いが、1:非常に弱い、2:比較的弱い、3:やや弱い、4:どちらでもない、5:やや強い、6:比較的強い、7:非常に強い、の7段階で評価し、各パネラーの平均値で評価した結果を図1に示した。
50mLあたりメチオニン30mg、リン酸リボフラビンナトリウム5mg配合し、リン酸でpH3.0に調製したものをコントロールとし、実施例6〜8の処方について匂いの評価を4人のパネラーによる官能試験(ビジュアルアナログスケール法)によって評価した。結果はコントロールを100としたときの臭いの強さで図2に示した。
実施例10〜22で製造した液剤について匂いの評価を3人のパネラーによる官能試験(ビジュアルアナログスケール法)によって評価した。
試験例1により有効性が認められた黄色5号について、その濃度を変更して匂いの評価を5人のパネラーにより、試験例1と同様に匂いの評価を行った。
Claims (9)
- メチオニン、ビタミンB2類、ならびに活性酸素発生抑制成分およびポリグリセリン脂肪酸エステルから選ばれる1種または2種を含む内服液剤。
- 活性酸素発生抑制成分が活性酸素発生抑制効果を有する着色料である請求項1記載の内服液剤。
- 活性酸素発生抑制効果を有する着色料が黄色5号、黄色4号、赤色2号、赤色102号、青色2号、βカロテンから選ばれる一種または二種以上である請求項2記載の内服液剤。
- 活性酸素発生抑制成分が活性酸素発生抑制効果を有する生薬成分である請求項1記載の内服液剤。
- 活性酸素発生抑制効果を有する生薬成分が、エゾウコギ、オウセイ、クコシ、シャクヤク、チンピ、トシシ、ローヤルゼリー、ハゲキテン、センキュウおよびビャクジュツから選ばれる一種または二種以上である請求項4記載の内服液剤。
- 活性酸素発生抑制成分が亜硫酸ナトリウムである請求項1記載の内服液剤。
- 活性酸素発生抑制成分が多価フェノールである請求項1記載の内服液剤。
- 多価フェノールが没食子酸、没食子酸誘導体、緑茶ポリフェノール、緑茶抽出物、酵素処理ルチン、リンゴポリフェノールおよびリンゴ抽出物から選ばれる一種または二種以上である請求項7記載の内服液剤。
- ポリグリセンリン脂肪酸エステルがデカグリセリンモノステアリン酸エステルまたはデカグリセリンモノミリスチン酸エステルである請求項1記載の内服液剤。
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KR20210022882A (ko) * | 2019-08-21 | 2021-03-04 | 주식회사 오스테온 | 알데히드계 악취 및 활성산소 제거용 조성물 |
KR102279633B1 (ko) | 2019-08-21 | 2021-07-21 | 주식회사 오스테온 | 알데히드계 악취 및 활성산소 제거용 조성물 |
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