JP2005538741A5 - - Google Patents
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- JP2005538741A5 JP2005538741A5 JP2005505529A JP2005505529A JP2005538741A5 JP 2005538741 A5 JP2005538741 A5 JP 2005538741A5 JP 2005505529 A JP2005505529 A JP 2005505529A JP 2005505529 A JP2005505529 A JP 2005505529A JP 2005538741 A5 JP2005538741 A5 JP 2005538741A5
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- Prior art keywords
- electrodes
- cell
- measuring
- porous membrane
- impedance
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000012528 membrane Substances 0.000 claims description 53
- 238000005259 measurement Methods 0.000 claims description 30
- 238000000034 method Methods 0.000 claims description 16
- 239000007788 liquid Substances 0.000 claims description 14
- 230000004709 cell invasion Effects 0.000 claims description 13
- 238000000576 coating method Methods 0.000 claims description 12
- 239000000758 substrate Substances 0.000 claims description 12
- 206010027476 Metastases Diseases 0.000 claims description 11
- 230000009545 invasion Effects 0.000 claims description 11
- 230000009401 metastasis Effects 0.000 claims description 11
- 239000011148 porous material Substances 0.000 claims description 10
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 claims description 9
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 claims description 9
- 239000011248 coating agent Substances 0.000 claims description 9
- 210000002744 extracellular matrix Anatomy 0.000 claims description 9
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- 230000010261 cell growth Effects 0.000 claims description 3
- 239000004033 plastic Substances 0.000 claims description 3
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- 238000004458 analytical method Methods 0.000 claims description 2
- 201000011510 cancer Diseases 0.000 claims description 2
- 238000012544 monitoring process Methods 0.000 claims 16
- 230000012292 cell migration Effects 0.000 claims 13
- 238000012806 monitoring device Methods 0.000 claims 8
- 210000002919 epithelial cell Anatomy 0.000 claims 4
- 230000001276 controlling effect Effects 0.000 claims 2
- 239000011521 glass Substances 0.000 claims 2
- 229910052710 silicon Inorganic materials 0.000 claims 2
- 239000010703 silicon Substances 0.000 claims 2
- QNRATNLHPGXHMA-XZHTYLCXSA-N (r)-(6-ethoxyquinolin-4-yl)-[(2s,4s,5r)-5-ethyl-1-azabicyclo[2.2.2]octan-2-yl]methanol;hydrochloride Chemical compound Cl.C([C@H]([C@H](C1)CC)C2)CN1[C@@H]2[C@H](O)C1=CC=NC2=CC=C(OCC)C=C21 QNRATNLHPGXHMA-XZHTYLCXSA-N 0.000 claims 1
- 239000004698 Polyethylene Substances 0.000 claims 1
- 239000004642 Polyimide Substances 0.000 claims 1
- 239000004793 Polystyrene Substances 0.000 claims 1
- 229920001807 Urea-formaldehyde Polymers 0.000 claims 1
- GZCGUPFRVQAUEE-SLPGGIOYSA-N aldehydo-D-glucose Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O GZCGUPFRVQAUEE-SLPGGIOYSA-N 0.000 claims 1
- 238000004113 cell culture Methods 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 230000001788 irregular Effects 0.000 claims 1
- 210000004962 mammalian cell Anatomy 0.000 claims 1
- 210000002569 neuron Anatomy 0.000 claims 1
- 239000012466 permeate Substances 0.000 claims 1
- 229920000515 polycarbonate Polymers 0.000 claims 1
- 239000004417 polycarbonate Substances 0.000 claims 1
- 229920000728 polyester Polymers 0.000 claims 1
- -1 polyethylene Polymers 0.000 claims 1
- 229920000573 polyethylene Polymers 0.000 claims 1
- 229920001721 polyimide Polymers 0.000 claims 1
- 229920002223 polystyrene Polymers 0.000 claims 1
- 229920000915 polyvinyl chloride Polymers 0.000 claims 1
- 239000004800 polyvinyl chloride Substances 0.000 claims 1
- 238000010223 real-time analysis Methods 0.000 claims 1
- 230000001105 regulatory effect Effects 0.000 claims 1
- 230000002441 reversible effect Effects 0.000 claims 1
- 230000003068 static effect Effects 0.000 claims 1
- 210000004881 tumor cell Anatomy 0.000 claims 1
- 210000004379 membrane Anatomy 0.000 description 22
- 238000004587 chromatography analysis Methods 0.000 description 6
- 102000004169 proteins and genes Human genes 0.000 description 6
- 108090000623 proteins and genes Proteins 0.000 description 6
- 239000010410 layer Substances 0.000 description 5
- 102000016359 Fibronectins Human genes 0.000 description 4
- 108010067306 Fibronectins Proteins 0.000 description 4
- 210000000265 leukocyte Anatomy 0.000 description 4
- 206010028980 Neoplasm Diseases 0.000 description 3
- 239000013553 cell monolayer Substances 0.000 description 3
- 239000000084 colloidal system Substances 0.000 description 3
- 230000008878 coupling Effects 0.000 description 3
- 238000010168 coupling process Methods 0.000 description 3
- 238000005859 coupling reaction Methods 0.000 description 3
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- 238000000691 measurement method Methods 0.000 description 3
- 208000009331 Experimental Sarcoma Diseases 0.000 description 2
- 101710145505 Fiber protein Proteins 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 230000012010 growth Effects 0.000 description 2
- 238000011081 inoculation Methods 0.000 description 2
- 108010082117 matrigel Proteins 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 241000251730 Chondrichthyes Species 0.000 description 1
- 238000002965 ELISA Methods 0.000 description 1
- 101000925662 Enterobacteria phage PRD1 Endolysin Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 108050007372 Fibroblast Growth Factor Proteins 0.000 description 1
- 102000018233 Fibroblast Growth Factor Human genes 0.000 description 1
- 229920002683 Glycosaminoglycan Polymers 0.000 description 1
- 108060003393 Granulin Proteins 0.000 description 1
- MSFSPUZXLOGKHJ-UHFFFAOYSA-N Muraminsaeure Natural products OC(=O)C(C)OC1C(N)C(O)OC(CO)C1O MSFSPUZXLOGKHJ-UHFFFAOYSA-N 0.000 description 1
- 241001529936 Murinae Species 0.000 description 1
- 108010013639 Peptidoglycan Proteins 0.000 description 1
- 108010039918 Polylysine Proteins 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- 108010009583 Transforming Growth Factors Proteins 0.000 description 1
- 102000009618 Transforming Growth Factors Human genes 0.000 description 1
- PZAGQUOSOTUKEC-UHFFFAOYSA-N acetic acid;sulfuric acid Chemical compound CC(O)=O.OS(O)(=O)=O PZAGQUOSOTUKEC-UHFFFAOYSA-N 0.000 description 1
- 239000000560 biocompatible material Substances 0.000 description 1
- 230000009089 cytolysis Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000005284 excitation Effects 0.000 description 1
- 229940126864 fibroblast growth factor Drugs 0.000 description 1
- 210000000630 fibrocyte Anatomy 0.000 description 1
- 229920000669 heparin Polymers 0.000 description 1
- 229960002897 heparin Drugs 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 230000033001 locomotion Effects 0.000 description 1
- 238000004377 microelectronic Methods 0.000 description 1
- 229920000656 polylysine Polymers 0.000 description 1
- 108010055896 polyornithine Proteins 0.000 description 1
- 229920002714 polyornithine Polymers 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 239000012056 semi-solid material Substances 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 230000005945 translocation Effects 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60/379,749 | 2002-05-14 | ||
| US39774902P | 2002-07-20 | 2002-07-20 | |
| US43540002P | 2002-12-20 | 2002-12-20 | |
| US60/435,400 | 2002-12-20 | ||
| US46957203P | 2003-05-09 | 2003-05-09 | |
| US60/469,572 | 2003-05-09 | ||
| PCT/US2003/022537 WO2004010102A2 (en) | 2002-07-20 | 2003-07-18 | Impedance based apparatuses and methods for analyzing cells and particles |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005538741A JP2005538741A (ja) | 2005-12-22 |
| JP2005538741A5 true JP2005538741A5 (enExample) | 2010-10-07 |
| JP4745056B2 JP4745056B2 (ja) | 2011-08-10 |
Family
ID=30773523
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005505529A Expired - Lifetime JP4745056B2 (ja) | 2002-07-20 | 2003-07-18 | インピーダンスによる細胞と微粒子の測定装置及び方法 |
| JP2005505531A Pending JP2005537498A (ja) | 2002-07-20 | 2003-07-18 | インピーダンスによる測定装置および方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005505531A Pending JP2005537498A (ja) | 2002-07-20 | 2003-07-18 | インピーダンスによる測定装置および方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7459303B2 (enExample) |
| EP (2) | EP1539992B1 (enExample) |
| JP (2) | JP4745056B2 (enExample) |
| CN (2) | CN100577811C (enExample) |
| AT (2) | ATE442587T1 (enExample) |
| AU (2) | AU2003269911A1 (enExample) |
| CA (2) | CA2493108C (enExample) |
| DE (2) | DE60329187D1 (enExample) |
| WO (2) | WO2004010103A2 (enExample) |
Families Citing this family (169)
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| US7732127B2 (en) * | 2002-12-20 | 2010-06-08 | Acea Biosciences, Inc. | Dynamic monitoring of cell adhesion and spreading using the RT-CES system |
| US11346797B2 (en) | 2002-12-20 | 2022-05-31 | Agilent Technologies, Inc. | System and method for monitoring cardiomyocyte beating, viability, morphology and electrophysiological properties |
| US10551371B2 (en) | 2003-11-10 | 2020-02-04 | Acea Biosciences, Inc. | System and method for monitoring cardiomyocyte beating, viability and morphology and for screening for pharmacological agents which may induce cardiotoxicity or modulate cardiomyocyte function |
| US10539523B2 (en) | 2002-12-20 | 2020-01-21 | Acea Biosciences, Inc. | System and method for monitoring cardiomyocyte beating, viability, morphology, and electrophysiological properties |
| US10215748B2 (en) | 2002-12-20 | 2019-02-26 | Acea Biosciences, Inc. | Using impedance-based cell response profiling to identify putative inhibitors for oncogene addicted targets or pathways |
| US9612234B2 (en) | 2008-05-05 | 2017-04-04 | Acea Biosciences, Inc. | Data analysis of impedance-based cardiomyocyte-beating signals as detected on real-time cell analysis (RTCA) cardio instruments |
| EP1692258A4 (en) | 2003-11-12 | 2007-03-21 | Xiao Xu | REAL-TIME ELECTRONIC CELL DETECTION SYSTEMS FOR CELL-BASED TESTS |
| CA2554027C (en) * | 2004-01-29 | 2013-10-08 | Biosilab S.R.L. | Biochip electroporator and its use in multi-site, single-cell electroporation |
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2003
- 2003-07-18 AT AT03751801T patent/ATE442587T1/de not_active IP Right Cessation
- 2003-07-18 AT AT03748948T patent/ATE448482T1/de not_active IP Right Cessation
- 2003-07-18 DE DE60329187T patent/DE60329187D1/de not_active Expired - Lifetime
- 2003-07-18 CA CA2493108A patent/CA2493108C/en not_active Expired - Lifetime
- 2003-07-18 WO PCT/US2003/022557 patent/WO2004010103A2/en not_active Ceased
- 2003-07-18 DE DE60330022T patent/DE60330022D1/de not_active Expired - Lifetime
- 2003-07-18 CN CN03822348A patent/CN100577811C/zh not_active Expired - Lifetime
- 2003-07-18 AU AU2003269911A patent/AU2003269911A1/en not_active Abandoned
- 2003-07-18 CN CNB038224542A patent/CN100487133C/zh not_active Expired - Lifetime
- 2003-07-18 EP EP03748948A patent/EP1539992B1/en not_active Expired - Lifetime
- 2003-07-18 JP JP2005505529A patent/JP4745056B2/ja not_active Expired - Lifetime
- 2003-07-18 JP JP2005505531A patent/JP2005537498A/ja active Pending
- 2003-07-18 WO PCT/US2003/022537 patent/WO2004010102A2/en not_active Ceased
- 2003-07-18 AU AU2003267998A patent/AU2003267998A1/en not_active Abandoned
- 2003-07-18 EP EP03751801A patent/EP1527328B1/en not_active Expired - Lifetime
- 2003-07-18 CA CA2493101A patent/CA2493101C/en not_active Expired - Lifetime
- 2003-11-10 US US10/705,615 patent/US7459303B2/en not_active Expired - Lifetime
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