JP2005537278A5 - - Google Patents

Info

Publication number
JP2005537278A5
JP2005537278A5 JP2004522571A JP2004522571A JP2005537278A5 JP 2005537278 A5 JP2005537278 A5 JP 2005537278A5 JP 2004522571 A JP2004522571 A JP 2004522571A JP 2004522571 A JP2004522571 A JP 2004522571A JP 2005537278 A5 JP2005537278 A5 JP 2005537278A5
Authority
JP
Japan
Prior art keywords
complex
guest molecule
formula
compound
complex according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2004522571A
Other languages
English (en)
Japanese (ja)
Other versions
JP2005537278A (ja
Filing date
Publication date
Priority claimed from US10/200,364 external-priority patent/US6858593B2/en
Application filed filed Critical
Publication of JP2005537278A publication Critical patent/JP2005537278A/ja
Publication of JP2005537278A5 publication Critical patent/JP2005537278A5/ja
Pending legal-status Critical Current

Links

JP2004522571A 2002-07-22 2003-07-21 抗炎症性または抗アレルギー性アンドロスタン複合体 Pending JP2005537278A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/200,364 US6858593B2 (en) 2000-08-05 2002-07-22 Anti-inflammatory androstane derivative compositions
PCT/EP2003/008388 WO2004009613A1 (en) 2002-07-22 2003-07-21 Anti-inflammatory or anti-allergic androstane complexes

Publications (2)

Publication Number Publication Date
JP2005537278A JP2005537278A (ja) 2005-12-08
JP2005537278A5 true JP2005537278A5 (enExample) 2006-09-07

Family

ID=30769534

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2004522571A Pending JP2005537278A (ja) 2002-07-22 2003-07-21 抗炎症性または抗アレルギー性アンドロスタン複合体

Country Status (11)

Country Link
US (1) US6858593B2 (enExample)
EP (1) EP1539796B1 (enExample)
JP (1) JP2005537278A (enExample)
AT (1) ATE353908T1 (enExample)
AU (1) AU2003253354A1 (enExample)
DE (1) DE60311831T2 (enExample)
DK (1) DK1539796T3 (enExample)
ES (1) ES2280802T3 (enExample)
PT (1) PT1539796E (enExample)
SI (1) SI1539796T1 (enExample)
WO (1) WO2004009613A1 (enExample)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020133032A1 (en) * 2000-02-25 2002-09-19 Jufang Barkalow Method for the preparation of fluticasone and related 17beta-carbothioic esters using a novel carbothioic acid synthesis and novel purification methods
US6759398B2 (en) * 2000-08-05 2004-07-06 Smithkline Beecham Corporation Anti-inflammatory androstane derivative
GB0019172D0 (en) 2000-08-05 2000-09-27 Glaxo Group Ltd Novel compounds
PT1305329E (pt) * 2000-08-05 2007-12-24 Glaxo Group Ltd Éster s-fluorometílico do ácido 6.alfa.,9.alfa.-difluoro- 17.alfa.-(2-furanilcarboxil)oxi-11.beta.-hidroxi-16.alfa.-metil- 3-oxo-androsta-1,4-dieno-17-carbotióico como um agente antiinflamatório
US6858596B2 (en) 2000-08-05 2005-02-22 Smithkline Beecham Corporation Formulation containing anti-inflammatory androstane derivative
US6777399B2 (en) * 2000-08-05 2004-08-17 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
UA77656C2 (en) 2001-04-07 2007-01-15 Glaxo Group Ltd S-fluoromethyl ester of 6-alpha, 9-alpha-difluoro-17-alpha-[(2-furanylcarbonyl)oxy]-11-beta-hydroxy-16- alpha-methyl-3-oxoandrosta-1,4-dien-17-beta-carbothioacid as anti-inflammatory agent
MY137522A (en) * 2001-04-30 2009-02-27 Glaxo Group Ltd Novel anti-inflammatory androstane derivatives.
ES2307751T3 (es) * 2001-06-12 2008-12-01 Glaxo Group Limited Nuevos esteres heterociclicos centi-inflamatorios 17 alfa de derivados 17 beta de carbotioato de androstano.
GB0125259D0 (en) * 2001-10-20 2001-12-12 Glaxo Group Ltd Novel compounds
WO2003066655A1 (en) * 2002-02-04 2003-08-14 Glaxo Group Limited Amorphous fluticasone 2-furoate, pharmaceutical compositions thereof and its conversion to the crystalline unsolvated form
US20050175545A1 (en) * 2002-02-04 2005-08-11 Keith Biggadike Formulation for inhalation comprising a glucocorticoid and a beta 2-adrenoreceptor agonist
GB0202635D0 (en) * 2002-02-05 2002-03-20 Glaxo Wellcome Mfg Pte Ltd Formulation containing novel anti-inflammatory androstane derivative
GB2389530B (en) * 2002-06-14 2007-01-10 Cipla Ltd Pharmaceutical compositions
GB0507165D0 (en) * 2005-04-08 2005-05-18 Glaxo Group Ltd Novel crystalline pharmaceutical product
GB0615108D0 (en) * 2006-07-28 2006-09-06 Glaxo Group Ltd Novel formulations
WO2010016931A2 (en) * 2008-08-07 2010-02-11 Plus Chemicals Sa Polymorphs of fluticasone furoate and process for preparation thereof
US20100240629A1 (en) * 2009-03-19 2010-09-23 Adrienne Kovacsne-Mezei Polymorphs of fluticasone furoate and processes for preparation thereof
US9290698B2 (en) 2010-07-15 2016-03-22 Battelle Memorial Institute Biobased polyols for potential use as flame retardants in polyurethane and polyester applications

Family Cites Families (97)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR580494A (fr) 1923-07-10 1924-11-07 Const Metalliques Schiltigheim Procédé d'établissement des buses d'aération ou autres tuyaux
US3067197A (en) * 1961-04-26 1962-12-04 Pfizer & Co C 11-oxygenated 6alpha-fluoro-16-methylene-delta-pregnenes and derivatives
US3639434A (en) * 1967-02-02 1972-02-01 Boots Pure Drug Co Ltd 17-acyloxysteroids and their manufacture
GB1384372A (en) 1971-01-20 1975-02-19 Glaxo Lab Ltd Dereivatives of 17alpha-hydroxyandrost-4-ene-17beta-carboxylic acids
US3828080A (en) * 1972-01-20 1974-08-06 Glaxo Lab Ltd Androstane-17beta-carboxylic acids and processes for the preparation thereof
US3989686A (en) * 1972-06-15 1976-11-02 Glaxo Laboratories Limited Anaesthetic steroids of the androstane series and process for preparing same
GB1438940A (en) * 1972-07-19 1976-06-09 Glaxo Lab Ltd 17beta-haloalkoxycarbonyl-17alpha-oxysteroids
DE2338693A1 (de) 1973-07-31 1975-02-13 Schmude Kg H Verfahren zur herstellung von geschaeumten kunststoff-formteilen, die mit einer homogenen aussenhaut versehen sind
US4093721A (en) * 1974-08-30 1978-06-06 Glaxo Laboratories Limited Pharmaceutical compositions of 6α,9α-difluoro-androst-4-ene-17β-carboxylates and derivatives thereof
GB1517278A (en) 1974-08-30 1978-07-12 Glaxo Lab Ltd Alkyl and haloalkyl androsta-1,4,15-triene and-4,15-diene-17beta-carboxylates
DE2538569A1 (de) 1975-08-29 1977-03-03 Siemens Ag Verfahren zur metallisierung von duroplasten
CH628355A5 (de) * 1976-02-24 1982-02-26 Ciba Geigy Ag Verfahren zur herstellung neuer androstadien-17beta-carbonsaeuren und ihrer ester und salze.
US4261984A (en) * 1978-04-05 1981-04-14 Syntex (U.S.A.) Inc. 17β-thiocarboxylic acid esters of 3-oxo-4-halo-16β-methylandrost-4-enes
US4263289A (en) * 1978-04-05 1981-04-21 Syntex (U.S.A.) Inc. Thio etianic acid derivatives
US4187301A (en) * 1978-04-05 1980-02-05 Syntex (U.S.A.) Inc. 17 Beta-thiocarboxylic acid esters of 6 alpha, 6 beta-difluoro-3-oxoandrost-4-enes
US4188385A (en) * 1978-04-05 1980-02-12 Syntex (U.S.A.) Inc. Thioetianic acid derivatives
US4198403A (en) * 1978-04-05 1980-04-15 Syntex (U.S.A.) Inc. 17 Beta-thiocarboxylic acid esters of 4-halo-3-oxoandrost-4-enes
DE2817988A1 (de) * 1978-04-25 1979-11-08 Hoechst Ag Corticoid 17-alkylcarbonate und verfahren zu deren herstellung
US4310466A (en) * 1979-08-31 1982-01-12 Syntex (U.S.A.) Inc. Thio etianic acid derivatives
US4267173A (en) * 1979-11-05 1981-05-12 Schering Corporation Use of 6β-fluoro-7α-halogenocorticoids as topical anti-inflammatories and pharmaceutical formulations useful therefor
CA1201114A (en) 1980-02-15 1986-02-25 Gordon H. Phillipps Androstane carbothioates
US4996335A (en) * 1980-07-10 1991-02-26 Nicholas S. Bodor Soft steroids having anti-inflammatory activity
SE449106B (sv) 1980-07-10 1987-04-06 Otsuka Pharma Co Ltd Steroid med anti-inflammatorisk verkan samt komposition innehallande denna
US4710495A (en) * 1980-07-10 1987-12-01 Otsuka Pharmaceutical Co., Ltd. Soft steroids having anti-inflammatory activity
ATE8790T1 (de) 1981-02-02 1984-08-15 Schering Corporation Aromatische heterocyclische steroidester, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen, die sie enthalten.
ZW6584A1 (en) * 1983-04-18 1985-04-17 Glaxo Group Ltd Phenethanolamine derivatives
US4607028A (en) * 1983-08-18 1986-08-19 Ciba-Geigy Corporation Novel carboxylic acid esters
CH664405A5 (de) 1983-09-01 1988-02-29 Plana Eng Ag Verfahren zur stabilisierung einer bodenschicht.
EP0179583A1 (en) 1984-10-04 1986-04-30 Merck & Co. Inc. A system for enhancing the water dissolution rate and solubility of poorly soluble drugs
US4861765A (en) * 1985-06-26 1989-08-29 Jouveinal 21-alkyl-, cycloalkyl- or aryl-substituted thio steroids and pharmaceutical compositions containing them
ZA872389B (en) 1987-04-02 1987-11-25 Advanced Polymer Systems Inc Composition and method for delivering a steroid active ingredient
US4994439A (en) * 1989-01-19 1991-02-19 California Biotechnology Inc. Transmembrane formulations for drug administration
IL95590A (en) 1989-09-08 1996-06-18 Glaxo Group Ltd Medicinal preparations containing Salmetrol and Pluticasone Propionate
DE3931041C2 (de) 1989-09-16 2000-04-06 Boehringer Ingelheim Kg Ester von Thienylcarbonsäuren mit Aminoalkoholen, ihre Quaternierungsprodukte, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
JP3087763B2 (ja) 1990-11-30 2000-09-11 三井化学株式会社 新規な複素環式化合物およびそれを含有する医薬組成物
GB9103764D0 (en) 1991-02-22 1991-04-10 Glaxo Group Ltd Compositions
US5250293A (en) * 1991-04-22 1993-10-05 Gleich Gerald J Method for the treatment of hypersensitivity diseases by administration of anionic polymers
TW247878B (enExample) 1991-07-02 1995-05-21 Takeda Pharm Industry Co Ltd
US6127353A (en) 1991-09-06 2000-10-03 Schering Corporation Mometasone furoate monohydrate, process for making same and pharmaceutical compositions
US5658549A (en) 1991-12-12 1997-08-19 Glaxo Group Limited Aerosol formulations containing propellant 134a and fluticasone propionate
AU679511B2 (en) 1993-03-17 1997-07-03 Minnesota Mining And Manufacturing Company Aerosol formulation containing an ester-, amide-, or mercaptoester-derived dispersing aid
DE4328819A1 (de) 1993-08-27 1995-03-02 Hoechst Ag Corticosteroid-17-alkylcarbonat-21/0/-Carbonsäure- und Kohlensäureester, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel
DE4333920A1 (de) 1993-10-05 1995-04-13 Hoechst Ag Corticoid-17,21-dicarbonsäureester sowie Corticosteroid-17-carbonsäureester-21-kohlensäureester, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel
US5420120A (en) * 1993-12-17 1995-05-30 Alcon Laboratories, Inc. Anti-inflammatory glucocorticoid compounds for topical ophthalmic use
US5837699A (en) 1994-01-27 1998-11-17 Schering Corporation Use of mometasone furoate for treating upper airway passage diseases
IL109656A (en) 1994-05-15 1998-02-22 Chemagis Ltd Process for the manufacture of androstane - 17 - carbothioates and androstane - 17 - carbothioates prepared thereby
GB9410222D0 (en) 1994-05-21 1994-07-06 Glaxo Wellcome Australia Ltd Medicaments
GB9419536D0 (en) * 1994-09-28 1994-11-16 Glaxo Inc Medicaments
SA95160463B1 (ar) 1994-12-22 2005-10-04 استرا أكتيبولاج مساحيق للاستنشاق
DE19528145A1 (de) 1995-08-01 1997-02-06 Boehringer Ingelheim Kg Neue Arzneimittel und ihre Verwendung
GB9521696D0 (en) 1995-10-23 1996-01-03 Bayer Ag Combination of LTD4 receptor antagonists with glucocorticosteriods
US5707984A (en) * 1995-12-08 1998-01-13 G. D. Searle & Co. Steroid nitrite/nitrate ester derivatives useful as anti-inflammatory drugs
NZ324373A (en) 1995-12-29 1999-10-28 Glaxo Group Ltd Lactone derivatives of 17-beta-carboxy, carbonyl-thio and amide androstane derivatives
US5981517A (en) * 1996-05-09 1999-11-09 Soft Drugs, Inc. Androstene derivatives
EP0954318A1 (en) 1996-06-04 1999-11-10 The Procter & Gamble Company A nasal spray containing an intranasal steroid and an antihistamine
GB9622173D0 (en) 1996-10-24 1996-12-18 Glaxo Group Ltd Particulate Products
US5919776A (en) * 1996-12-20 1999-07-06 Merck & Co., Inc. Substituted aminoquinolines as modulators of chemokine receptor activity
US6126919A (en) 1997-02-07 2000-10-03 3M Innovative Properties Company Biocompatible compounds for pharmaceutical drug delivery systems
DK1493439T3 (da) 1997-04-02 2012-01-30 Brigham & Womens Hospital Middel til fastlæggelse af en persons risikoprofil for aterosklerotisk sygdom
AU8439998A (en) 1997-06-30 1999-01-25 Glaxo Group Limited Compounds
SE9704186D0 (sv) 1997-11-14 1997-11-14 Astra Ab New composition of matter
SE9704833D0 (sv) 1997-12-22 1997-12-22 Astra Ab New formulation
US5972920A (en) * 1998-02-12 1999-10-26 Dermalogix Partners, Inc. Formulation containing a carrier, active ingredient, and surfactant for treating skin disorders
US6136294C1 (en) 1998-09-22 2002-09-24 Aeropharm Technology Inc Amino acid stabilized medical aerosol formulation
US6261539B1 (en) 1998-12-10 2001-07-17 Akwete Adjei Medicinal aerosol formulation
GB9828721D0 (en) 1998-12-24 1999-02-17 Glaxo Group Ltd Novel apparatus and process
WO2000057401A1 (en) 1999-03-24 2000-09-28 Glenayre Electronics, Inc. Computation and quantization of voiced excitation pulse shapes in linear predictive coding of speech
US6395300B1 (en) * 1999-05-27 2002-05-28 Acusphere, Inc. Porous drug matrices and methods of manufacture thereof
ES2165768B1 (es) 1999-07-14 2003-04-01 Almirall Prodesfarma Sa Nuevos derivados de quinuclidina y composiciones farmaceuticas que los contienen.
AU782386C (en) 1999-08-31 2006-08-10 Brigham And Women's Hospital Systemic inflammatory markers as diagnostic tools in the prevention of atherosclerotic diseases
EP1212619B1 (en) 1999-09-14 2007-05-23 Xenoport, Inc. Substrates and screening methods for transport proteins
US6596261B1 (en) 2000-01-25 2003-07-22 Aeropharm Technology Incorporated Method of administering a medicinal aerosol formulation
US20020133032A1 (en) 2000-02-25 2002-09-19 Jufang Barkalow Method for the preparation of fluticasone and related 17beta-carbothioic esters using a novel carbothioic acid synthesis and novel purification methods
DE10017791A1 (de) 2000-04-10 2001-10-11 Basf Ag Verfahren und Vorrichtung zur Mikrodosierung kleinster Flüssigkeitsmengen für Biopolymerarrays
GB0009583D0 (en) 2000-04-18 2000-06-07 Glaxo Group Ltd Respiratory formulations
GB0009606D0 (en) 2000-04-18 2000-06-07 Glaxo Group Ltd Therapeutic combinations
GB0009592D0 (en) 2000-04-18 2000-06-07 Glaxo Group Ltd Respiratory combinations
GB0015876D0 (en) 2000-06-28 2000-08-23 Novartis Ag Organic compounds
GB0016040D0 (en) 2000-06-29 2000-08-23 Glaxo Group Ltd Novel process for preparing crystalline particles
GB0017988D0 (en) 2000-07-21 2000-09-13 Glaxo Group Ltd Novel process
WO2002007767A2 (en) 2000-07-26 2002-01-31 Alcon Universal Ltd. Pharmaceutical suspension compositions lacking a polymeric suspending agent
PT1305329E (pt) 2000-08-05 2007-12-24 Glaxo Group Ltd Éster s-fluorometílico do ácido 6.alfa.,9.alfa.-difluoro- 17.alfa.-(2-furanilcarboxil)oxi-11.beta.-hidroxi-16.alfa.-metil- 3-oxo-androsta-1,4-dieno-17-carbotióico como um agente antiinflamatório
GB0020089D0 (en) 2000-08-15 2000-10-04 Smithkline Beecham Biolog Vaccine Composition
CA2423305A1 (en) 2000-09-29 2002-04-04 Glaxo Group Limited Compounds useful in the treatment of inflammatory diseases
US20020132803A1 (en) 2001-01-05 2002-09-19 Mahendra Dedhiya Fluticasone suspension formulation, spray pattern method, and nasal spray apparatus
GB0103630D0 (en) 2001-02-14 2001-03-28 Glaxo Group Ltd Chemical compounds
JP2004526720A (ja) 2001-03-08 2004-09-02 グラクソ グループ リミテッド βアドレナリン受容体のアゴニスト
ATE381537T1 (de) 2001-03-22 2008-01-15 Glaxo Group Ltd Formanilid-derivative als beta2-adrenorezeptor- agonisten
WO2002085296A2 (en) 2001-04-24 2002-10-31 Epigenesis Pharmaceuticals, Inc. Composition, formulations and kit for treatment of respiratory and lung disease with non-glucocorticoid steroids and/or ubiquinone and a bronchodilating agent
MY137522A (en) 2001-04-30 2009-02-27 Glaxo Group Ltd Novel anti-inflammatory androstane derivatives.
ES2307751T3 (es) 2001-06-12 2008-12-01 Glaxo Group Limited Nuevos esteres heterociclicos centi-inflamatorios 17 alfa de derivados 17 beta de carbotioato de androstano.
WO2003013427A2 (en) 2001-08-03 2003-02-20 Smithkline Beecham Corporation A method for preparing fluticasone derivatives
GB0124523D0 (en) 2001-10-12 2001-12-05 Glaxo Group Ltd Pharmaceutical combination
GB0125259D0 (en) 2001-10-20 2001-12-12 Glaxo Group Ltd Novel compounds
CN1613012A (zh) 2001-11-05 2005-05-04 布赖汉姆妇女医院 可溶的cd40l(cd154)作为动脉粥样硬化的疾病的先兆标记
GB0127160D0 (en) 2001-11-12 2002-01-02 Glaxo Group Ltd Novel compounds
WO2003042229A1 (en) 2001-11-12 2003-05-22 Glaxo Group Limited Non-aromatic heterocyclic esters of furan-2-one-esters of 17.beta.-carboxyl or 17.beta.-carbothio glucocorticoids

Similar Documents

Publication Publication Date Title
JP2006502172A5 (enExample)
JP2005537278A5 (enExample)
ES2644615T3 (es) Derivados de heteroarilo C17 del ácido oleanólico y métodos de uso de éstos
ES2320181T3 (es) Composiciones farmaceuticas que tienen un efecto reductor del colesterol.
US10457666B2 (en) Stable crystal form of tipiracil hydrochloride and crystallization method for the same
JP5513660B2 (ja) 結晶の差異評価への表面自由エネルギーの使用、表面自由エネルギーを指標として評価される結晶及び該結晶を含有してなる医薬組成物
JP6670841B2 (ja) フェノール酸trpv1アゴニストのプロドラッグ
CN109422752A (zh) 一类具有抑制并降解布鲁顿酪氨酸蛋白激酶Btk活性的化合物
BR112013015241A2 (pt) enonas tricíclicas de pirazolila e pirimidinila como moduladores de inflamação antioxidantes
TW200900058A (en) N-(heteroaryl)-1-heteroaryl-1H-indole-2-carboxamide derivatives, their preparation and their therapeutic application
CN109422733A (zh) 一类抑制并降解酪氨酸蛋白激酶alk的化合物
CN113490484B (zh) 治疗血液疾病的组合疗法
WO2013042782A1 (ja) 縮合複素環化合物
ES2657551T3 (es) Derivados de biguanida sustituidos en N1-amina cíclica-N5, métodos de preparación de los mismos y composición farmacéutica que comprende los mismos
CN117088875A (zh) 一种高活性Wnt通路抑制剂化合物
TW200914442A (en) Gamma secretase modulators
TW202241880A (zh) 黑皮質素-4受體促效劑
TWI226831B (en) Pharmaceutical composition for ameliorating an undesirable anxiety state in a mammal
US12274694B2 (en) Dizocilpine derivatives as peripheral NMDA receptor antagonists
CN104447770A (zh) 阿塞那平化合物
BR112021001322A2 (pt) 17 beta-heterociclil-digitalis como compostos para o tratamento de insuficiência cardíaca
JPWO2018038255A1 (ja) 環状アミン誘導体の結晶及びその医薬用途
TW202128182A (zh) 用於治療心臟衰竭的具有作為SERCA2a的純或顯著純刺激劑的活性的雄烷衍生物
EP2373316A1 (en) Treatment for glomerulonephritis with 2 - ý 4- ( -7-ethyl-5h-pyrrolo ý 2,3-b¨-pyrazin- 6 -yl) propan-2-ol
US20150051404A1 (en) Pain-relieving compositions and uses therefor