JP2005535606A5 - - Google Patents

Info

Publication number

JP2005535606A5

JP2005535606A5 JP2004510713A JP2004510713A JP2005535606A5 JP 2005535606 A5 JP2005535606 A5 JP 2005535606A5 JP 2004510713 A JP2004510713 A JP 2004510713A JP 2004510713 A JP2004510713 A JP 2004510713A JP 2005535606 A5 JP2005535606 A5 JP 2005535606A5

Authority

JP

Japan

Prior art keywords

iron

artemisinin

compound

protein

carrying protein

Prior art date

2003-06-06

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 235000018102 proteins Nutrition 0.000 claims 20
• 102000004169 proteins and genes Human genes 0.000 claims 20
• 108090000623 proteins and genes Proteins 0.000 claims 20
• XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical group [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims 16
• 229960004191 artemisinin Drugs 0.000 claims 16
• BLUAFEHZUWYNDE-NNWCWBAJSA-N artemisinin Chemical compound C([C@](OO1)(C)O2)C[C@H]3[C@H](C)CC[C@@H]4[C@@]31[C@@H]2OC(=O)[C@@H]4C BLUAFEHZUWYNDE-NNWCWBAJSA-N 0.000 claims 16
• 229930101531 artemisinin Natural products 0.000 claims 16
• 150000001875 compounds Chemical class 0.000 claims 15
• XNSAINXGIQZQOO-SRVKXCTJSA-N protirelin Chemical compound NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H]1NC(=O)CC1)CC1=CN=CN1 XNSAINXGIQZQOO-SRVKXCTJSA-N 0.000 claims 9
• 229910052742 iron Inorganic materials 0.000 claims 8
• 239000000203 mixture Substances 0.000 claims 8
• 244000052769 pathogen Species 0.000 claims 8
• 230000001717 pathogenic effect Effects 0.000 claims 8
• 108010045676 holotransferrin Proteins 0.000 claims 7
• 229960002521 artenimol Drugs 0.000 claims 6
• BJDCWCLMFKKGEE-ISOSDAIHSA-N artenimol Chemical compound C([C@](OO1)(C)O2)C[C@H]3[C@H](C)CC[C@@H]4[C@@]31[C@@H]2O[C@H](O)[C@@H]4C BJDCWCLMFKKGEE-ISOSDAIHSA-N 0.000 claims 6
• 229930016266 dihydroartemisinin Natural products 0.000 claims 6
• 102000001554 Hemoglobins Human genes 0.000 claims 4
• 108010054147 Hemoglobins Proteins 0.000 claims 4
• 239000003814 drug Substances 0.000 claims 4
• 102000013382 Gelatinases Human genes 0.000 claims 3
• 108010026132 Gelatinases Proteins 0.000 claims 3
• 102000013271 Hemopexin Human genes 0.000 claims 3
• 108010026027 Hemopexin Proteins 0.000 claims 3
• 102000019298 Lipocalin Human genes 0.000 claims 3
• 108050006654 Lipocalin Proteins 0.000 claims 3
• 230000007935 neutral effect Effects 0.000 claims 3
• 239000008194 pharmaceutical composition Substances 0.000 claims 3
• 241000590002 Helicobacter pylori Species 0.000 claims 2
• 101000798114 Homo sapiens Lactotransferrin Proteins 0.000 claims 2
• 101000766306 Homo sapiens Serotransferrin Proteins 0.000 claims 2
• 241000588650 Neisseria meningitidis Species 0.000 claims 2
• 206010028980 Neoplasm Diseases 0.000 claims 2
• 201000011510 cancer Diseases 0.000 claims 2
• 229940037467 helicobacter pylori Drugs 0.000 claims 2
• -1 hololactoferrin Proteins 0.000 claims 2
• 102000050459 human LTF Human genes 0.000 claims 2
• 238000004519 manufacturing process Methods 0.000 claims 2
• 238000007911 parenteral administration Methods 0.000 claims 2
• 102000003839 Human Proteins Human genes 0.000 claims 1
• 108090000144 Human Proteins Proteins 0.000 claims 1
• 102000010445 Lactoferrin Human genes 0.000 claims 1
• 108010063045 Lactoferrin Proteins 0.000 claims 1
• UVNHKOOJXSALHN-KYNHBKCMSA-N artelinate Chemical compound O([C@@H]1[C@H](C)[C@@H]2CC[C@H]([C@@H]3CCC4(C)O[C@H]([C@]23OO4)O1)C)CC1=CC=C(C(O)=O)C=C1 UVNHKOOJXSALHN-KYNHBKCMSA-N 0.000 claims 1
• 125000003118 aryl group Chemical group 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• CSSYQJWUGATIHM-IKGCZBKSSA-N l-phenylalanyl-l-lysyl-l-cysteinyl-l-arginyl-l-arginyl-l-tryptophyl-l-glutaminyl-l-tryptophyl-l-arginyl-l-methionyl-l-lysyl-l-lysyl-l-leucylglycyl-l-alanyl-l-prolyl-l-seryl-l-isoleucyl-l-threonyl-l-cysteinyl-l-valyl-l-arginyl-l-arginyl-l-alanyl-l-phenylal Chemical compound C([C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)C1=CC=CC=C1 CSSYQJWUGATIHM-IKGCZBKSSA-N 0.000 claims 1
• 229940078795 lactoferrin Drugs 0.000 claims 1
• 235000021242 lactoferrin Nutrition 0.000 claims 1
• 238000000034 method Methods 0.000 claims 1