RU2325156C2 - Ковалентные конъюгаты между родственными артемизинину эндопероксидами и железосодержащими белками и способы применения - Google Patents

Ковалентные конъюгаты между родственными артемизинину эндопероксидами и железосодержащими белками и способы применения Download PDF

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Publication number
RU2325156C2
RU2325156C2 RU2004139096/15A RU2004139096A RU2325156C2 RU 2325156 C2 RU2325156 C2 RU 2325156C2 RU 2004139096/15 A RU2004139096/15 A RU 2004139096/15A RU 2004139096 A RU2004139096 A RU 2004139096A RU 2325156 C2 RU2325156 C2 RU 2325156C2
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Russia
Prior art keywords
iron
artemisinin
endoperoxide
protein
bearing
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RU2004139096/15A
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English (en)
Russian (ru)
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RU2004139096A (ru
Inventor
Генри К. ЛАЙ (US)
Генри К. ЛАЙ
Томиказу САСАКИ (US)
Томиказу САСАКИ
Нарендра П. СИНГХ (US)
Нарендра П. СИНГХ
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Юниверсити Оф Вашингтон
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A61K31/295—Iron group metal compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/40—Transferrins, e.g. lactoferrins, ovotransferrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Communicable Diseases (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
RU2004139096/15A 2002-06-06 2003-06-06 Ковалентные конъюгаты между родственными артемизинину эндопероксидами и железосодержащими белками и способы применения RU2325156C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US38692802P 2002-06-06 2002-06-06
US60/386,928 2002-06-06

Publications (2)

Publication Number Publication Date
RU2004139096A RU2004139096A (ru) 2005-06-10
RU2325156C2 true RU2325156C2 (ru) 2008-05-27

Family

ID=29736235

Family Applications (2)

Application Number Title Priority Date Filing Date
RU2004139090/14A RU2004139090A (ru) 2002-06-06 2003-06-06 Способы применения соединений, подобных артемизинину, для профилактики или задержки возникновения злокачественных опухолей
RU2004139096/15A RU2325156C2 (ru) 2002-06-06 2003-06-06 Ковалентные конъюгаты между родственными артемизинину эндопероксидами и железосодержащими белками и способы применения

Family Applications Before (1)

Application Number Title Priority Date Filing Date
RU2004139090/14A RU2004139090A (ru) 2002-06-06 2003-06-06 Способы применения соединений, подобных артемизинину, для профилактики или задержки возникновения злокачественных опухолей

Country Status (11)

Country Link
US (2) US20040058981A1 (enExample)
EP (2) EP1531851B1 (enExample)
JP (2) JP2005529938A (enExample)
CN (3) CN1313145C (enExample)
AU (2) AU2003251405A1 (enExample)
BR (2) BR0312685A (enExample)
CA (2) CA2488347A1 (enExample)
NZ (2) NZ537114A (enExample)
RU (2) RU2004139090A (enExample)
WO (1) WO2003103588A2 (enExample)
ZA (1) ZA200500023B (enExample)

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US20050096369A1 (en) * 2003-11-04 2005-05-05 Hoang Ba X. Compositions and methods for treating cellular proliferation disorders
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US20060270863A1 (en) * 2005-05-27 2006-11-30 Amyris Biotechnologies Conversion of amorpha-4,11-diene to artemisinin and artemisinin precursors
AU2006303809B2 (en) * 2005-10-20 2012-11-15 Epipharm Ag Treatment and prevention of benign pigmented moles (naevi) using artemisinine and the derivatives thereof
US7671067B2 (en) * 2006-02-09 2010-03-02 Enzon Pharmaceuticals, Inc. Treatment of non-hodgkin's lymphomas with multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamtothecin
US7462627B2 (en) * 2006-02-09 2008-12-09 Enzon Pharmaceuticals, Inc. Multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin for treatment of breast, colorectal, pancreatic, ovarian and lung cancers
WO2007112451A2 (en) * 2006-03-28 2007-10-04 University Of Washington Covalent conjugates between endoperoxides and transferrin and lactoferrin receptor-binding agents
WO2008046109A2 (en) * 2006-10-13 2008-04-17 University Of Washington Conjugates of artemisinin-related endoperoxides and hydrazone derivatives for the treatment of cancer
US8354549B2 (en) * 2006-11-30 2013-01-15 Nektar Therapeutics Method for preparing a polymer conjugate
RU2009133793A (ru) * 2007-02-09 2011-03-20 Энзон Фармасьютикалз, Инк. (Us) Лечение резистентных или невосприимчивых форм рака конъюгатами 7-этил-10-гидроксикампотецина с множеством ответвлений цепи
RU2515063C9 (ru) * 2008-01-30 2014-08-10 Пиерис АГ Мутеины липокалина слезной жидкости, обладающие аффинностью к с-мет рецепторной тирозинкиназе человека, и способы их получения
CN101323569B (zh) * 2008-07-24 2011-01-26 上海交通大学 倍半萜青蒿萜酯ae及其提取纯化方法
KR101671537B1 (ko) 2008-08-11 2016-11-01 넥타르 테라퓨틱스 다분지형 중합체 알카노에이트 컨쥬게이트
US20100056555A1 (en) * 2008-08-29 2010-03-04 Enzon Pharmaceuticals, Inc. Method of treating ras associated cancer
HRP20192120T1 (hr) 2008-09-23 2020-02-21 Nektar Therapeutics Postupak metronomskog doziranja kamptotecinskih prolijekova (e.g.peg-irinotekan)
CA2738807A1 (en) * 2008-10-21 2010-04-29 Enzon Pharmaceuticals, Inc. Treatment of neuroblastoma with multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin
SI2424523T1 (sl) * 2009-04-23 2012-11-30 Londonpharma Ltd Podjezična aerosolna formulacija ki vsebuje dihidroartemezinin
GB2469791B (en) * 2009-04-23 2011-12-14 Londonpharma Ltd Transmucosal formulation of compounds providing dihydroartemesinin for use in the treatment of neoplastic disease
JP5624735B2 (ja) 2009-07-22 2014-11-12 国立大学法人岡山大学 フィルター
CN102399142B (zh) * 2010-09-14 2014-09-24 华北制药集团新药研究开发有限责任公司 一类倍半萜酯化合物及其制备方法和用途
WO2012088445A1 (en) 2010-12-22 2012-06-28 Nektar Therapeutics Multi-arm polymeric prodrug conjugates of cabazitaxel-based compounds
WO2012088422A1 (en) 2010-12-22 2012-06-28 Nektar Therapeutics Multi-arm polymeric prodrug conjugates of taxane-based compounds
CN102727522B (zh) * 2011-04-08 2013-09-25 石雁羽 由溴代双氢青蒿素和Fe2+剂组成的复方双释胶囊制剂
CN103845360A (zh) * 2012-11-29 2014-06-11 昆明制药集团股份有限公司 含蒿甲醚的药物组合物、制剂及其用途
CN103405779B (zh) * 2013-07-18 2015-09-30 江苏省血吸虫病防治研究所 一种预防血吸虫感染长效青蒿琥酯药物及其制备方法
GB201800736D0 (en) 2018-01-17 2018-02-28 St Georges Hospital Medical School Combination therapy for treatment of leukemia
CN109908137B (zh) * 2019-03-11 2022-02-18 江苏省人民医院（南京医科大学第一附属医院） 青蒿素在杀伤乳腺癌干细胞的药物中的应用
CN114983999A (zh) * 2022-06-09 2022-09-02 四川大学 一种青蒿素及其衍生物的新用途、验证方法

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US5110909A (en) * 1988-04-20 1992-05-05 Institut Merieux Macromolecular conjugates of hemoglobin, a procedure for their preparation and their uses
US5578637A (en) * 1995-05-03 1996-11-26 University Of Washington Methods of inhibition or killing cancer cells using an endoperoxide
US5681811A (en) * 1993-05-10 1997-10-28 Protein Delivery, Inc. Conjugation-stabilized therapeutic agent compositions, delivery and diagnostic formulations comprising same, and method of making and using the same
RU2098407C1 (ru) * 1989-09-27 1997-12-10 Рон-Пуленк Рорер С.А. Способ получения пероксиацетальлактонового соединения (варианты) и лактон
US6214864B1 (en) * 1999-02-12 2001-04-10 Council Of Scientific And Industrial Research Formulation of dihydroartemisinin for the control of wide spectrum of malaria

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Patent Citations (5)

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Publication number Priority date Publication date Assignee Title
US5110909A (en) * 1988-04-20 1992-05-05 Institut Merieux Macromolecular conjugates of hemoglobin, a procedure for their preparation and their uses
RU2098407C1 (ru) * 1989-09-27 1997-12-10 Рон-Пуленк Рорер С.А. Способ получения пероксиацетальлактонового соединения (варианты) и лактон
US5681811A (en) * 1993-05-10 1997-10-28 Protein Delivery, Inc. Conjugation-stabilized therapeutic agent compositions, delivery and diagnostic formulations comprising same, and method of making and using the same
US5578637A (en) * 1995-05-03 1996-11-26 University Of Washington Methods of inhibition or killing cancer cells using an endoperoxide
US6214864B1 (en) * 1999-02-12 2001-04-10 Council Of Scientific And Industrial Research Formulation of dihydroartemisinin for the control of wide spectrum of malaria

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Also Published As

Publication number Publication date
EP1553935A2 (en) 2005-07-20
WO2003103588A3 (en) 2004-04-15
JP2005535606A (ja) 2005-11-24
ZA200500023B (en) 2005-10-20
EP1553935A4 (en) 2010-07-07
US20040058981A1 (en) 2004-03-25
CN1313145C (zh) 2007-05-02
EP1531851A2 (en) 2005-05-25
CA2488347A1 (en) 2003-12-18
CN1668323A (zh) 2005-09-14
NZ537114A (en) 2007-02-23
BR0311627A (pt) 2005-08-30
JP2005529938A (ja) 2005-10-06
AU2003243418B2 (en) 2009-02-19
JP4440768B2 (ja) 2010-03-24
WO2003103588A2 (en) 2003-12-18
AU2003251405A1 (en) 2003-12-22
AU2003243418A1 (en) 2003-12-22
EP1531851B1 (en) 2011-12-14
BR0312685A (pt) 2005-09-06
RU2004139090A (ru) 2005-06-10
CN101843904A (zh) 2010-09-29
CN1668293A (zh) 2005-09-14
RU2004139096A (ru) 2005-06-10
US20080119542A1 (en) 2008-05-22
NZ537113A (en) 2007-01-26
EP1531851A4 (en) 2007-12-12
CA2488360A1 (en) 2003-12-18

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