BR0312685A - Métodos de utilização de compostos do tipo artemisinina para prevenir ou retardar o aparecimento de cancêr - Google Patents
Métodos de utilização de compostos do tipo artemisinina para prevenir ou retardar o aparecimento de cancêrInfo
- Publication number
- BR0312685A BR0312685A BR0312685-4A BR0312685A BR0312685A BR 0312685 A BR0312685 A BR 0312685A BR 0312685 A BR0312685 A BR 0312685A BR 0312685 A BR0312685 A BR 0312685A
- Authority
- BR
- Brazil
- Prior art keywords
- compounds
- artemisinin
- cancer
- methods
- onset
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 3
- 201000011510 cancer Diseases 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 title abstract 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 abstract 2
- BLUAFEHZUWYNDE-NNWCWBAJSA-N artemisinin Chemical class C([C@](OO1)(C)O2)C[C@H]3[C@H](C)CC[C@@H]4[C@@]31[C@@H]2OC(=O)[C@@H]4C BLUAFEHZUWYNDE-NNWCWBAJSA-N 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 150000003254 radicals Chemical class 0.000 abstract 2
- UYVWNPAMKCDKRB-UHFFFAOYSA-N 1,2,4,5-tetraoxane Chemical class C1OOCOO1 UYVWNPAMKCDKRB-UHFFFAOYSA-N 0.000 abstract 1
- 150000004903 1,2,4-trioxanes Chemical class 0.000 abstract 1
- 229960004191 artemisinin Drugs 0.000 abstract 1
- 229930101531 artemisinin Natural products 0.000 abstract 1
- 230000003834 intracellular effect Effects 0.000 abstract 1
- 229910052742 iron Inorganic materials 0.000 abstract 1
- 159000000014 iron salts Chemical class 0.000 abstract 1
- 229930004725 sesquiterpene Natural products 0.000 abstract 1
- -1 sesquiterpene compounds Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
- A61K31/295—Iron group metal compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/40—Transferrins, e.g. lactoferrins, ovotransferrins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Communicable Diseases (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38692802P | 2002-06-06 | 2002-06-06 | |
| PCT/US2003/017791 WO2003103588A2 (en) | 2002-06-06 | 2003-06-06 | Methods of using artemisinin-like compounds to prevent or delay the appearance of cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0312685A true BR0312685A (pt) | 2005-09-06 |
Family
ID=29736235
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0312685-4A BR0312685A (pt) | 2002-06-06 | 2003-06-06 | Métodos de utilização de compostos do tipo artemisinina para prevenir ou retardar o aparecimento de cancêr |
| BR0311627-1A BR0311627A (pt) | 2002-06-06 | 2003-06-06 | Conjugados covalentes entre endoperóxidos artemisinino-relacionados e proteìnas portadoras de ferro e métodos de utilização |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0311627-1A BR0311627A (pt) | 2002-06-06 | 2003-06-06 | Conjugados covalentes entre endoperóxidos artemisinino-relacionados e proteìnas portadoras de ferro e métodos de utilização |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US20040058981A1 (enExample) |
| EP (2) | EP1531851B1 (enExample) |
| JP (2) | JP2005529938A (enExample) |
| CN (3) | CN1313145C (enExample) |
| AU (2) | AU2003251405A1 (enExample) |
| BR (2) | BR0312685A (enExample) |
| CA (2) | CA2488347A1 (enExample) |
| NZ (2) | NZ537114A (enExample) |
| RU (2) | RU2004139090A (enExample) |
| WO (1) | WO2003103588A2 (enExample) |
| ZA (1) | ZA200500023B (enExample) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004071506A1 (en) | 2003-02-12 | 2004-08-26 | Georgetown University | Use of artemisinin for treating tumors induced by oncogenic viruses and for treating viral infections |
| SI1675622T1 (sl) * | 2003-09-17 | 2017-09-29 | Nektar Therapeutics | Večkraka polimerna predzdravila |
| US8394365B2 (en) | 2003-09-17 | 2013-03-12 | Nektar Therapeutics | Multi-arm polymer prodrugs |
| CN1255106C (zh) * | 2003-09-26 | 2006-05-10 | 李国桥 | 复方青蒿素 |
| US20050096369A1 (en) * | 2003-11-04 | 2005-05-05 | Hoang Ba X. | Compositions and methods for treating cellular proliferation disorders |
| JP2007511600A (ja) * | 2003-11-19 | 2007-05-10 | ベクタ・リミテッド | エンドペルオキシド架橋含有化合物を使用するヘリコバクター・ピロリ関連疾患の治療のための方法および組成物 |
| CN1311832C (zh) * | 2005-01-12 | 2007-04-25 | 四川科伦药业股份有限公司 | 溴代二氢青蒿素的医药用途 |
| US20060270863A1 (en) * | 2005-05-27 | 2006-11-30 | Amyris Biotechnologies | Conversion of amorpha-4,11-diene to artemisinin and artemisinin precursors |
| AU2006303809B2 (en) * | 2005-10-20 | 2012-11-15 | Epipharm Ag | Treatment and prevention of benign pigmented moles (naevi) using artemisinine and the derivatives thereof |
| US7671067B2 (en) * | 2006-02-09 | 2010-03-02 | Enzon Pharmaceuticals, Inc. | Treatment of non-hodgkin's lymphomas with multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamtothecin |
| US7462627B2 (en) * | 2006-02-09 | 2008-12-09 | Enzon Pharmaceuticals, Inc. | Multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin for treatment of breast, colorectal, pancreatic, ovarian and lung cancers |
| WO2007112451A2 (en) * | 2006-03-28 | 2007-10-04 | University Of Washington | Covalent conjugates between endoperoxides and transferrin and lactoferrin receptor-binding agents |
| WO2008046109A2 (en) * | 2006-10-13 | 2008-04-17 | University Of Washington | Conjugates of artemisinin-related endoperoxides and hydrazone derivatives for the treatment of cancer |
| US8354549B2 (en) * | 2006-11-30 | 2013-01-15 | Nektar Therapeutics | Method for preparing a polymer conjugate |
| RU2009133793A (ru) * | 2007-02-09 | 2011-03-20 | Энзон Фармасьютикалз, Инк. (Us) | Лечение резистентных или невосприимчивых форм рака конъюгатами 7-этил-10-гидроксикампотецина с множеством ответвлений цепи |
| RU2515063C9 (ru) * | 2008-01-30 | 2014-08-10 | Пиерис АГ | Мутеины липокалина слезной жидкости, обладающие аффинностью к с-мет рецепторной тирозинкиназе человека, и способы их получения |
| CN101323569B (zh) * | 2008-07-24 | 2011-01-26 | 上海交通大学 | 倍半萜青蒿萜酯ae及其提取纯化方法 |
| KR101671537B1 (ko) | 2008-08-11 | 2016-11-01 | 넥타르 테라퓨틱스 | 다분지형 중합체 알카노에이트 컨쥬게이트 |
| US20100056555A1 (en) * | 2008-08-29 | 2010-03-04 | Enzon Pharmaceuticals, Inc. | Method of treating ras associated cancer |
| HRP20192120T1 (hr) | 2008-09-23 | 2020-02-21 | Nektar Therapeutics | Postupak metronomskog doziranja kamptotecinskih prolijekova (e.g.peg-irinotekan) |
| CA2738807A1 (en) * | 2008-10-21 | 2010-04-29 | Enzon Pharmaceuticals, Inc. | Treatment of neuroblastoma with multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin |
| SI2424523T1 (sl) * | 2009-04-23 | 2012-11-30 | Londonpharma Ltd | Podjezična aerosolna formulacija ki vsebuje dihidroartemezinin |
| GB2469791B (en) * | 2009-04-23 | 2011-12-14 | Londonpharma Ltd | Transmucosal formulation of compounds providing dihydroartemesinin for use in the treatment of neoplastic disease |
| JP5624735B2 (ja) | 2009-07-22 | 2014-11-12 | 国立大学法人岡山大学 | フィルター |
| CN102399142B (zh) * | 2010-09-14 | 2014-09-24 | 华北制药集团新药研究开发有限责任公司 | 一类倍半萜酯化合物及其制备方法和用途 |
| WO2012088445A1 (en) | 2010-12-22 | 2012-06-28 | Nektar Therapeutics | Multi-arm polymeric prodrug conjugates of cabazitaxel-based compounds |
| WO2012088422A1 (en) | 2010-12-22 | 2012-06-28 | Nektar Therapeutics | Multi-arm polymeric prodrug conjugates of taxane-based compounds |
| CN102727522B (zh) * | 2011-04-08 | 2013-09-25 | 石雁羽 | 由溴代双氢青蒿素和Fe2+剂组成的复方双释胶囊制剂 |
| CN103845360A (zh) * | 2012-11-29 | 2014-06-11 | 昆明制药集团股份有限公司 | 含蒿甲醚的药物组合物、制剂及其用途 |
| CN103405779B (zh) * | 2013-07-18 | 2015-09-30 | 江苏省血吸虫病防治研究所 | 一种预防血吸虫感染长效青蒿琥酯药物及其制备方法 |
| GB201800736D0 (en) | 2018-01-17 | 2018-02-28 | St Georges Hospital Medical School | Combination therapy for treatment of leukemia |
| CN109908137B (zh) * | 2019-03-11 | 2022-02-18 | 江苏省人民医院（南京医科大学第一附属医院） | 青蒿素在杀伤乳腺癌干细胞的药物中的应用 |
| CN114983999A (zh) * | 2022-06-09 | 2022-09-02 | 四川大学 | 一种青蒿素及其衍生物的新用途、验证方法 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4916204A (en) * | 1987-07-31 | 1990-04-10 | Massachusetts Institute Of Technology | Pure polyanhydride from dicarboxylic acid and coupling agent |
| FR2630329B1 (fr) * | 1988-04-20 | 1991-07-05 | Merieux Inst | Conjugues macromoleculaires d'hemoglobine, leur procede de preparation et leurs applications |
| RU2098407C1 (ru) * | 1989-09-27 | 1997-12-10 | Рон-Пуленк Рорер С.А. | Способ получения пероксиацетальлактонового соединения (варианты) и лактон |
| US5681811A (en) * | 1993-05-10 | 1997-10-28 | Protein Delivery, Inc. | Conjugation-stabilized therapeutic agent compositions, delivery and diagnostic formulations comprising same, and method of making and using the same |
| US5472684A (en) * | 1993-06-02 | 1995-12-05 | Colgate Palmolive Company | Oral compositions for plaque and gingivitis |
| US5578637A (en) * | 1995-05-03 | 1996-11-26 | University Of Washington | Methods of inhibition or killing cancer cells using an endoperoxide |
| US5677468A (en) * | 1995-06-29 | 1997-10-14 | Hauser, Inc. | Artemisinin dimer compounds having anticancer activity |
| US5869310A (en) * | 1996-06-03 | 1999-02-09 | Promega Corporation | Isolated agarase enzyme from flavobacterium sp. strain NR19, cloned genes therefor, and expression thereof in transformed host cells |
| US6160004A (en) * | 1997-12-30 | 2000-12-12 | Hauser, Inc. | C-10 carbon-substituted artemisinin-like trioxane compounds having antimalarial, antiproliferative and antitumor activities |
| CN1084333C (zh) * | 1998-06-17 | 2002-05-08 | 中国科学院上海药物研究所 | 新的青蒿素化合物,其制备方法以及含有它们的药物组合物 |
| US6127405A (en) * | 1998-07-10 | 2000-10-03 | Council Of Scientific And Industrial Research | Method for the use of alpha arteether as an anti-bacterial and anti-fungal agent |
| US6297272B1 (en) * | 1999-01-12 | 2001-10-02 | Hauser, Inc. | Artemisinin analogs having antimalarial antiproliferative and antitumor activities and chemoselective methods of making the same |
| IN191696B (enExample) * | 1999-02-12 | 2003-12-20 | Council Scient Ind Res | |
| GB9916012D0 (en) * | 1999-07-09 | 1999-09-08 | Ufc Limited | Peroxide-based antimalarial compounds |
| JP2002128784A (ja) * | 2000-10-25 | 2002-05-09 | Japan Science & Technology Corp | 細胞侵入型励起一重項酸素発生化合物および該化合物を含む薬剤類 |
| WO2002091992A2 (en) * | 2001-05-16 | 2002-11-21 | Faulk Pharmaceuticals, Inc. | Targeted delivery of drugs for the treatment of parasitic infections |
-
2003
- 2003-06-06 EP EP03757380A patent/EP1531851B1/en not_active Expired - Lifetime
- 2003-06-06 NZ NZ537114A patent/NZ537114A/en not_active IP Right Cessation
- 2003-06-06 AU AU2003251405A patent/AU2003251405A1/en not_active Abandoned
- 2003-06-06 RU RU2004139090/14A patent/RU2004139090A/ru unknown
- 2003-06-06 BR BR0312685-4A patent/BR0312685A/pt not_active IP Right Cessation
- 2003-06-06 CN CNB038167956A patent/CN1313145C/zh not_active Expired - Fee Related
- 2003-06-06 US US10/457,079 patent/US20040058981A1/en not_active Abandoned
- 2003-06-06 JP JP2004510709A patent/JP2005529938A/ja active Pending
- 2003-06-06 CN CNA038167972A patent/CN1668293A/zh active Pending
- 2003-06-06 JP JP2004510713A patent/JP4440768B2/ja not_active Expired - Fee Related
- 2003-06-06 BR BR0311627-1A patent/BR0311627A/pt not_active IP Right Cessation
- 2003-06-06 CA CA002488347A patent/CA2488347A1/en not_active Abandoned
- 2003-06-06 WO PCT/US2003/017791 patent/WO2003103588A2/en not_active Ceased
- 2003-06-06 EP EP03757363A patent/EP1553935A4/en not_active Withdrawn
- 2003-06-06 NZ NZ537113A patent/NZ537113A/en unknown
- 2003-06-06 RU RU2004139096/15A patent/RU2325156C2/ru not_active IP Right Cessation
- 2003-06-06 AU AU2003243418A patent/AU2003243418B2/en not_active Ceased
- 2003-06-06 CA CA002488360A patent/CA2488360A1/en not_active Abandoned
- 2003-06-06 CN CN201010165713A patent/CN101843904A/zh active Pending
-
2005
- 2005-01-03 ZA ZA200500023A patent/ZA200500023B/en unknown
-
2007
- 2007-11-30 US US11/948,560 patent/US20080119542A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1553935A2 (en) | 2005-07-20 |
| WO2003103588A3 (en) | 2004-04-15 |
| JP2005535606A (ja) | 2005-11-24 |
| ZA200500023B (en) | 2005-10-20 |
| EP1553935A4 (en) | 2010-07-07 |
| US20040058981A1 (en) | 2004-03-25 |
| CN1313145C (zh) | 2007-05-02 |
| EP1531851A2 (en) | 2005-05-25 |
| CA2488347A1 (en) | 2003-12-18 |
| CN1668323A (zh) | 2005-09-14 |
| NZ537114A (en) | 2007-02-23 |
| BR0311627A (pt) | 2005-08-30 |
| JP2005529938A (ja) | 2005-10-06 |
| AU2003243418B2 (en) | 2009-02-19 |
| JP4440768B2 (ja) | 2010-03-24 |
| WO2003103588A2 (en) | 2003-12-18 |
| AU2003251405A1 (en) | 2003-12-22 |
| AU2003243418A1 (en) | 2003-12-22 |
| EP1531851B1 (en) | 2011-12-14 |
| RU2004139090A (ru) | 2005-06-10 |
| CN101843904A (zh) | 2010-09-29 |
| CN1668293A (zh) | 2005-09-14 |
| RU2004139096A (ru) | 2005-06-10 |
| US20080119542A1 (en) | 2008-05-22 |
| NZ537113A (en) | 2007-01-26 |
| EP1531851A4 (en) | 2007-12-12 |
| CA2488360A1 (en) | 2003-12-18 |
| RU2325156C2 (ru) | 2008-05-27 |
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| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
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| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
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