BR0311627A - Conjugados covalentes entre endoperóxidos artemisinino-relacionados e proteìnas portadoras de ferro e métodos de utilização - Google Patents

Conjugados covalentes entre endoperóxidos artemisinino-relacionados e proteìnas portadoras de ferro e métodos de utilização

Info

Publication number
BR0311627A
BR0311627A BR0311627-1A BR0311627A BR0311627A BR 0311627 A BR0311627 A BR 0311627A BR 0311627 A BR0311627 A BR 0311627A BR 0311627 A BR0311627 A BR 0311627A
Authority
BR
Brazil
Prior art keywords
iron
covalent conjugates
methods
artemisinin
carrying proteins
Prior art date
Application number
BR0311627-1A
Other languages
English (en)
Inventor
Henry C Lai
Tomikazu Sasaki
Narendra P Singh
Original Assignee
Univ Washington
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Washington filed Critical Univ Washington
Priority claimed from PCT/US2003/017881 external-priority patent/WO2003103592A2/en
Publication of BR0311627A publication Critical patent/BR0311627A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A61K31/295—Iron group metal compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/40—Transferrins, e.g. lactoferrins, ovotransferrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)

Abstract

"CONJUGADOS COVALENTES ENTRE ENDOPERóXIDOS ARTEMISININO-RELACIONADOS E PROTEìNAS PORTADORAS DE FERRO E MéTODOS DE UTILIZAçãO". A invenção proporciona conjugados covalentes entre endoperóxidos artemisinino-relacionados e proteínas portadoras de ferro. Em algumas modalidades, os conjugados covalentes compreendem artelinato e holotransferrina. Em um outro aspecto, a invenção proporciona métodos para administrar os conjugados covalentes da invenção para tratar câncer e infecções por patógenos que se ligam a proteínas portadoras de ferro.
BR0311627-1A 2002-06-06 2003-06-06 Conjugados covalentes entre endoperóxidos artemisinino-relacionados e proteìnas portadoras de ferro e métodos de utilização BR0311627A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US38692802P 2002-06-06 2002-06-06
PCT/US2003/017881 WO2003103592A2 (en) 2002-06-06 2003-06-06 Covalent conjugates between artemisinin-related endoperoxides and iron-carrying proteins and methods of use

Publications (1)

Publication Number Publication Date
BR0311627A true BR0311627A (pt) 2005-08-30

Family

ID=29736235

Family Applications (2)

Application Number Title Priority Date Filing Date
BR0312685-4A BR0312685A (pt) 2002-06-06 2003-06-06 Métodos de utilização de compostos do tipo artemisinina para prevenir ou retardar o aparecimento de cancêr
BR0311627-1A BR0311627A (pt) 2002-06-06 2003-06-06 Conjugados covalentes entre endoperóxidos artemisinino-relacionados e proteìnas portadoras de ferro e métodos de utilização

Family Applications Before (1)

Application Number Title Priority Date Filing Date
BR0312685-4A BR0312685A (pt) 2002-06-06 2003-06-06 Métodos de utilização de compostos do tipo artemisinina para prevenir ou retardar o aparecimento de cancêr

Country Status (11)

Country Link
US (2) US20040058981A1 (pt)
EP (2) EP1531851B1 (pt)
JP (2) JP2005529938A (pt)
CN (3) CN101843904A (pt)
AU (2) AU2003243418B2 (pt)
BR (2) BR0312685A (pt)
CA (2) CA2488347A1 (pt)
NZ (2) NZ537113A (pt)
RU (2) RU2004139090A (pt)
WO (1) WO2003103588A2 (pt)
ZA (1) ZA200500023B (pt)

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US8394365B2 (en) 2003-09-17 2013-03-12 Nektar Therapeutics Multi-arm polymer prodrugs
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US20050096369A1 (en) * 2003-11-04 2005-05-05 Hoang Ba X. Compositions and methods for treating cellular proliferation disorders
CN1882328A (zh) * 2003-11-19 2006-12-20 维克塔有限公司 使用含内过氧化物桥的化合物治疗幽门螺杆菌相关疾病的方法和组合物
CN1311832C (zh) * 2005-01-12 2007-04-25 四川科伦药业股份有限公司 溴代二氢青蒿素的医药用途
US20060270863A1 (en) * 2005-05-27 2006-11-30 Amyris Biotechnologies Conversion of amorpha-4,11-diene to artemisinin and artemisinin precursors
CA2626704C (en) * 2005-10-20 2015-12-15 Epipharm Gmbh Treatment and prevention of benign pigmented moles (naevi) using artemisinine and the derivatives thereof
US7462627B2 (en) * 2006-02-09 2008-12-09 Enzon Pharmaceuticals, Inc. Multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin for treatment of breast, colorectal, pancreatic, ovarian and lung cancers
US7671067B2 (en) * 2006-02-09 2010-03-02 Enzon Pharmaceuticals, Inc. Treatment of non-hodgkin's lymphomas with multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamtothecin
US20070231300A1 (en) * 2006-03-28 2007-10-04 Washington, University Of Covalent conjugates between endoperoxides and transferrin and lactoferrin receptor-binding agents
WO2008046109A2 (en) * 2006-10-13 2008-04-17 University Of Washington Conjugates of artemisinin-related endoperoxides and hydrazone derivatives for the treatment of cancer
JP5277417B2 (ja) 2006-11-30 2013-08-28 ネクター セラピューティクス ポリマー複合体を調製する方法
AU2008213576B2 (en) * 2007-02-09 2013-01-17 Enzon Pharmaceuticals, Inc. Treatment of resistant or refractory cancers with multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin
EP2245054B1 (en) * 2008-01-30 2018-11-28 Pieris Pharmaceuticals GmbH Muteins of tear lipocalin having affinity to human c-met receptor tyrosine kinase and methods for obtaining the same
CN101323569B (zh) * 2008-07-24 2011-01-26 上海交通大学 倍半萜青蒿萜酯ae及其提取纯化方法
AU2009282413B2 (en) 2008-08-11 2014-07-17 Nektar Therapeutics Multi-arm polymeric alkanoate conjugates
TW201010732A (en) * 2008-08-29 2010-03-16 Enzon Pharmaceuticals Inc Method of treating RAS associated cancer
MX2011003063A (es) 2008-09-23 2011-04-21 Nektar Therapeutics Composiciones y metodos para lograr concentraciones terapeuticas de farmaco sostenidas en un individuo.
US20100098654A1 (en) * 2008-10-21 2010-04-22 Fabio Pastorino Treatment of neuroblastoma with multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin
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GB2469791B (en) * 2009-04-23 2011-12-14 Londonpharma Ltd Transmucosal formulation of compounds providing dihydroartemesinin for use in the treatment of neoplastic disease
JP5624735B2 (ja) 2009-07-22 2014-11-12 国立大学法人岡山大学 フィルター
CN102399142B (zh) * 2010-09-14 2014-09-24 华北制药集团新药研究开发有限责任公司 一类倍半萜酯化合物及其制备方法和用途
WO2012088422A1 (en) 2010-12-22 2012-06-28 Nektar Therapeutics Multi-arm polymeric prodrug conjugates of taxane-based compounds
WO2012088445A1 (en) 2010-12-22 2012-06-28 Nektar Therapeutics Multi-arm polymeric prodrug conjugates of cabazitaxel-based compounds
CN102727522B (zh) * 2011-04-08 2013-09-25 石雁羽 由溴代双氢青蒿素和Fe2+剂组成的复方双释胶囊制剂
CN103845360A (zh) * 2012-11-29 2014-06-11 昆明制药集团股份有限公司 含蒿甲醚的药物组合物、制剂及其用途
CN103405779B (zh) * 2013-07-18 2015-09-30 江苏省血吸虫病防治研究所 一种预防血吸虫感染长效青蒿琥酯药物及其制备方法
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Also Published As

Publication number Publication date
EP1553935A4 (en) 2010-07-07
JP2005535606A (ja) 2005-11-24
RU2004139096A (ru) 2005-06-10
NZ537114A (en) 2007-02-23
US20080119542A1 (en) 2008-05-22
CN1668323A (zh) 2005-09-14
EP1531851A2 (en) 2005-05-25
WO2003103588A2 (en) 2003-12-18
US20040058981A1 (en) 2004-03-25
CN1313145C (zh) 2007-05-02
BR0312685A (pt) 2005-09-06
EP1531851B1 (en) 2011-12-14
AU2003243418A1 (en) 2003-12-22
ZA200500023B (en) 2005-10-20
AU2003251405A1 (en) 2003-12-22
CA2488360A1 (en) 2003-12-18
JP2005529938A (ja) 2005-10-06
CN1668293A (zh) 2005-09-14
RU2004139090A (ru) 2005-06-10
JP4440768B2 (ja) 2010-03-24
NZ537113A (en) 2007-01-26
EP1553935A2 (en) 2005-07-20
CN101843904A (zh) 2010-09-29
EP1531851A4 (en) 2007-12-12
WO2003103588A3 (en) 2004-04-15
RU2325156C2 (ru) 2008-05-27
AU2003243418B2 (en) 2009-02-19
CA2488347A1 (en) 2003-12-18

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Legal Events

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B15I Others concerning applications: loss of priority

Free format text: PERDADA PRIORIDADE REIVINDICADA (US 60/386.928 DE 06/06/02), POR NAO ESTAR EM CONFORMIDADE COM O PREVISTO NOS PARAGRAFOS 6 E 7 DO ARTIGO 16 DA LPI.

B150 Others concerning applications: publication cancelled [chapter 15.30 patent gazette]

Free format text: PUBLICADA NA RPI NO 2014, DE 11/08/2009, POR TER SIDO INDEVIDA.

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 11A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2260 DE 29/04/2014.