CN1311832C - 溴代二氢青蒿素的医药用途 - Google Patents
溴代二氢青蒿素的医药用途 Download PDFInfo
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- CN1311832C CN1311832C CNB2005100201529A CN200510020152A CN1311832C CN 1311832 C CN1311832 C CN 1311832C CN B2005100201529 A CNB2005100201529 A CN B2005100201529A CN 200510020152 A CN200510020152 A CN 200510020152A CN 1311832 C CN1311832 C CN 1311832C
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- dihydroartemisinine
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Abstract
Description
组别 | 转铁蛋白(nM) | 硫酸亚铁(mg) | Br-DHA(nM) |
空白 | ---------- | ---------- | ----------- |
转铁蛋白 | 880nM | 0.25 | |
Br-DHA | 880nM880nM880nM | 0.250.010.002 | 1000408 |
组别 | 样本数 | 药物剂量 | 细胞生存率(%) | ||
转铁蛋白nM | 硫酸亚铁mg/L | BrDHAnM | |||
空白对照 | 4 | ----- | ----- | ----- | 100.0±9.1 |
转铁蛋白 | 4 | 880 | 0.25 | ----- | 44.7±5.6 |
BrDHA | 4 | 880 | 0.25 | 1000 | 23.3±5.3 |
4 | 880 | 0.05 | 200 | 32.7±14.1 | |
4 | 880 | 0.01 | 40 | 31.1±10.6 | |
4 | 880 | 0.002 | 8 | 41.6±3.6 |
组别 | 样本数 | 药物剂量 | 细胞生存率(%) | ||
转铁蛋白nM | 硫酸亚铁mg/L | BrDHAnM | |||
空白对照 | 4 | ----- | ----- | ----- | 100.0±14.9 |
转铁蛋白 | 4 | 880 | 0.25 | ----- | 59.0±9.8 |
BrDHA | 4 | 880 | 0.25 | 1000 | 17.4±7.5 |
4 | 880 | 0.05 | 100 | 39.0±5.2 | |
4 | 880 | 0.0025 | 10 | 58.2±5.2 | |
4 | 880 | 0.00025 | 1 | 59.0±13.0 |
送样单位 | 四川大陆药业 | 送样时间 | 2004.10.28 |
样品名称、编号 | 样品数 | 2 | |
测试仪器 | 氧瓶燃烧法 | 温度 | 湿度 |
分析测试要求 | Br含量测定 | ||
分析测试结果 | Br%BrDHA 22.5422.90 |
Claims (4)
Priority Applications (1)
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CNB2005100201529A CN1311832C (zh) | 2005-01-12 | 2005-01-12 | 溴代二氢青蒿素的医药用途 |
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CNB2005100201529A CN1311832C (zh) | 2005-01-12 | 2005-01-12 | 溴代二氢青蒿素的医药用途 |
Publications (2)
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CN1679587A CN1679587A (zh) | 2005-10-12 |
CN1311832C true CN1311832C (zh) | 2007-04-25 |
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CNB2005100201529A Active CN1311832C (zh) | 2005-01-12 | 2005-01-12 | 溴代二氢青蒿素的医药用途 |
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Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
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CN102727522B (zh) * | 2011-04-08 | 2013-09-25 | 石雁羽 | 由溴代双氢青蒿素和Fe2+剂组成的复方双释胶囊制剂 |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5246930A (en) * | 1990-05-07 | 1993-09-21 | Hoechst Aktiengesellschaft | 9-substituted compounds of 3α, 11α-epoxy-3,4,5,5aα,6,7,8,8a,9,11,11a-undecahydro-3β,6.alpha.,9-trimethylfurano[3,4-j][1,2]benzodioxepin, processes for their preparation and their use as antiprotozoal and antiviral agents |
CN1077455A (zh) * | 1993-03-25 | 1993-10-20 | 中国科学院上海有机化学研究所 | 4位取代青蒿素类似物 |
WO2003035651A2 (fr) * | 2001-10-26 | 2003-05-01 | Centre National De La Recherche Scientifique | Derives de l'artemisinine, et leurs utilisations dans le traitement du paludisme |
US20040058981A1 (en) * | 2002-06-06 | 2004-03-25 | University Of Washington | Methods of using artemisinin-like compounds to prevent or delay the appearance of cancer |
WO2004071506A1 (en) * | 2003-02-12 | 2004-08-26 | Georgetown University | Use of artemisinin for treating tumors induced by oncogenic viruses and for treating viral infections |
US20040229938A1 (en) * | 2002-10-15 | 2004-11-18 | Elsohly Mahmoud A. | Dihydroartemisinin and dihydroartemisitene dimers as anti-cancer and anti-infective agents |
-
2005
- 2005-01-12 CN CNB2005100201529A patent/CN1311832C/zh active Active
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5246930A (en) * | 1990-05-07 | 1993-09-21 | Hoechst Aktiengesellschaft | 9-substituted compounds of 3α, 11α-epoxy-3,4,5,5aα,6,7,8,8a,9,11,11a-undecahydro-3β,6.alpha.,9-trimethylfurano[3,4-j][1,2]benzodioxepin, processes for their preparation and their use as antiprotozoal and antiviral agents |
CN1077455A (zh) * | 1993-03-25 | 1993-10-20 | 中国科学院上海有机化学研究所 | 4位取代青蒿素类似物 |
WO2003035651A2 (fr) * | 2001-10-26 | 2003-05-01 | Centre National De La Recherche Scientifique | Derives de l'artemisinine, et leurs utilisations dans le traitement du paludisme |
US20040058981A1 (en) * | 2002-06-06 | 2004-03-25 | University Of Washington | Methods of using artemisinin-like compounds to prevent or delay the appearance of cancer |
US20040229938A1 (en) * | 2002-10-15 | 2004-11-18 | Elsohly Mahmoud A. | Dihydroartemisinin and dihydroartemisitene dimers as anti-cancer and anti-infective agents |
WO2004071506A1 (en) * | 2003-02-12 | 2004-08-26 | Georgetown University | Use of artemisinin for treating tumors induced by oncogenic viruses and for treating viral infections |
Non-Patent Citations (6)
Title |
---|
Medicinal Chemistry Letters,Vol.4 No.5 1994 * |
Synthesis of a novel ring contracted artemisinin derivative B. Venugopalan et al,Bioorganic & Medicinal Chemistry Letters,Vol.4 No.5 1994 * |
Synthesis of a novel ring contracted artemisinin derivative B. Venugopalan et al,Bioorganic & Medicinal Chemistry Letters,Vol.4 No.5 1994;青蒿素及其生物的抗肿瘤作用 曹培国等,肿瘤防治杂志,第11卷第6期 2004;青蒿素及其衍生物的研究进展 程永浩等,河北师范大学学报(自然科学版),第23卷第4期 1999 * |
Synthesis of a novel ring contracted artemisinin derivative B. Venugopalan et al,Bioorganic & * |
青蒿素及其生物的抗肿瘤作用 曹培国等,肿瘤防治杂志,第11卷第6期 2004 * |
青蒿素及其衍生物的研究进展 程永浩等,河北师范大学学报(自然科学版),第23卷第4期 1999 * |
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CN1679587A (zh) | 2005-10-12 |
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Owner name: KELUN PHARM IND CO., LTD., SICHUAN Free format text: FORMER OWNER: SICHUAN KANGTE PHARMACEUTICAL CO., LTD. Effective date: 20061117 |
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Assignee: Sichuan Xinyuan Pharmaceutical Co., Ltd. Assignor: Sichuan Kelun Pharmaceutical Co., Ltd. Contract fulfillment period: 2009.8.1 to 2019.7.31 contract change Contract record no.: 2009510000136 Denomination of invention: Medicinal use of bromodihydroarteannuin Granted publication date: 20070425 License type: Exclusive license Record date: 20091030 |
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