JP4440768B2 - アルテミシニン関連エンドペルオキシダーゼと鉄保有タンパク質と間の共有結合コンジュゲート、および使用方法 - Google Patents

アルテミシニン関連エンドペルオキシダーゼと鉄保有タンパク質と間の共有結合コンジュゲート、および使用方法 Download PDF

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Publication number
JP4440768B2
JP4440768B2 JP2004510713A JP2004510713A JP4440768B2 JP 4440768 B2 JP4440768 B2 JP 4440768B2 JP 2004510713 A JP2004510713 A JP 2004510713A JP 2004510713 A JP2004510713 A JP 2004510713A JP 4440768 B2 JP4440768 B2 JP 4440768B2
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Prior art keywords
iron
protein
artemisinin
endoperoxide
compound
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Expired - Fee Related
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JP2004510713A
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Japanese (ja)
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JP2005535606A (ja
JP2005535606A5 (enExample
Inventor
ヘンリー シー． ライ，
トミカズ ササキ
ナレンドラ ピー． シン，
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ユニヴァーシティ オブ ワシントン
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Priority claimed from PCT/US2003/017881 external-priority patent/WO2003103592A2/en
Publication of JP2005535606A publication Critical patent/JP2005535606A/ja
Publication of JP2005535606A5 publication Critical patent/JP2005535606A5/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A61K31/295—Iron group metal compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/40—Transferrins, e.g. lactoferrins, ovotransferrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Communicable Diseases (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biochemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
JP2004510713A 2002-06-06 2003-06-06 アルテミシニン関連エンドペルオキシダーゼと鉄保有タンパク質と間の共有結合コンジュゲート、および使用方法 Expired - Fee Related JP4440768B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US38692802P 2002-06-06 2002-06-06
PCT/US2003/017881 WO2003103592A2 (en) 2002-06-06 2003-06-06 Covalent conjugates between artemisinin-related endoperoxides and iron-carrying proteins and methods of use

Publications (3)

Publication Number Publication Date
JP2005535606A JP2005535606A (ja) 2005-11-24
JP2005535606A5 JP2005535606A5 (enExample) 2006-06-29
JP4440768B2 true JP4440768B2 (ja) 2010-03-24

Family

ID=29736235

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2004510713A Expired - Fee Related JP4440768B2 (ja) 2002-06-06 2003-06-06 アルテミシニン関連エンドペルオキシダーゼと鉄保有タンパク質と間の共有結合コンジュゲート、および使用方法
JP2004510709A Pending JP2005529938A (ja) 2002-06-06 2003-06-06 癌の発症を予防または遅延するためのアルテミシニン様化合物を使用する方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2004510709A Pending JP2005529938A (ja) 2002-06-06 2003-06-06 癌の発症を予防または遅延するためのアルテミシニン様化合物を使用する方法

Country Status (11)

Country Link
US (2) US20040058981A1 (enExample)
EP (2) EP1531851B1 (enExample)
JP (2) JP4440768B2 (enExample)
CN (3) CN101843904A (enExample)
AU (2) AU2003243418B2 (enExample)
BR (2) BR0312685A (enExample)
CA (2) CA2488360A1 (enExample)
NZ (2) NZ537114A (enExample)
RU (2) RU2325156C2 (enExample)
WO (1) WO2003103588A2 (enExample)
ZA (1) ZA200500023B (enExample)

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US8394365B2 (en) * 2003-09-17 2013-03-12 Nektar Therapeutics Multi-arm polymer prodrugs
CN1255106C (zh) * 2003-09-26 2006-05-10 李国桥 复方青蒿素
US20050096369A1 (en) * 2003-11-04 2005-05-05 Hoang Ba X. Compositions and methods for treating cellular proliferation disorders
KR20060109915A (ko) * 2003-11-19 2006-10-23 벡타 리미티드 엔도퍼옥사이드 브리지 함유 화합물을 이용하여 헬리코박터파일로리 연관 질병의 치료를 위한 방법 및 조성물
CN1311832C (zh) * 2005-01-12 2007-04-25 四川科伦药业股份有限公司 溴代二氢青蒿素的医药用途
US20060270863A1 (en) * 2005-05-27 2006-11-30 Amyris Biotechnologies Conversion of amorpha-4,11-diene to artemisinin and artemisinin precursors
JP5119155B2 (ja) * 2005-10-20 2013-01-16 エピフアルマ・アクチエンゲゼルシヤフト アルテミシニン及びその誘導体を使用する良性色素性ホクロ（母斑）の処置及び予防
US7671067B2 (en) * 2006-02-09 2010-03-02 Enzon Pharmaceuticals, Inc. Treatment of non-hodgkin's lymphomas with multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamtothecin
US7462627B2 (en) * 2006-02-09 2008-12-09 Enzon Pharmaceuticals, Inc. Multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin for treatment of breast, colorectal, pancreatic, ovarian and lung cancers
US20070231300A1 (en) * 2006-03-28 2007-10-04 Washington, University Of Covalent conjugates between endoperoxides and transferrin and lactoferrin receptor-binding agents
WO2008046109A2 (en) * 2006-10-13 2008-04-17 University Of Washington Conjugates of artemisinin-related endoperoxides and hydrazone derivatives for the treatment of cancer
WO2008066902A2 (en) * 2006-11-30 2008-06-05 Nektar Therapeutics Al, Corporation Method for preparing a polymer conjugate
US7928095B2 (en) * 2007-02-09 2011-04-19 Enzon Pharmaceuticals, Inc. Treatment of resistant or refractory cancers with multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin
SG172737A1 (en) * 2008-01-30 2011-07-28 Pieris Ag Muteins of tear lipocalin having affinity to human c-met receptor tyrosine kinaseand methods for obtaining the same
CN101323569B (zh) * 2008-07-24 2011-01-26 上海交通大学 倍半萜青蒿萜酯ae及其提取纯化方法
KR101671537B1 (ko) * 2008-08-11 2016-11-01 넥타르 테라퓨틱스 다분지형 중합체 알카노에이트 컨쥬게이트
US20100056555A1 (en) * 2008-08-29 2010-03-04 Enzon Pharmaceuticals, Inc. Method of treating ras associated cancer
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CN102215688A (zh) * 2008-10-21 2011-10-12 安龙制药公司 用7-乙基-10-羟基喜树碱的多臂聚合物对神经母细胞瘤的治疗
NZ595469A (en) * 2009-04-23 2013-10-25 Londonpharma Ltd Sublingual spray formulation comprising dihydroartemesinin
GB2469791B (en) * 2009-04-23 2011-12-14 Londonpharma Ltd Transmucosal formulation of compounds providing dihydroartemesinin for use in the treatment of neoplastic disease
JP5624735B2 (ja) 2009-07-22 2014-11-12 国立大学法人岡山大学 フィルター
CN102399142B (zh) * 2010-09-14 2014-09-24 华北制药集团新药研究开发有限责任公司 一类倍半萜酯化合物及其制备方法和用途
US10894087B2 (en) 2010-12-22 2021-01-19 Nektar Therapeutics Multi-arm polymeric prodrug conjugates of cabazitaxel-based compounds
WO2012088422A1 (en) 2010-12-22 2012-06-28 Nektar Therapeutics Multi-arm polymeric prodrug conjugates of taxane-based compounds
CN102727522B (zh) * 2011-04-08 2013-09-25 石雁羽 由溴代双氢青蒿素和Fe2+剂组成的复方双释胶囊制剂
CN103845360A (zh) * 2012-11-29 2014-06-11 昆明制药集团股份有限公司 含蒿甲醚的药物组合物、制剂及其用途
CN103405779B (zh) * 2013-07-18 2015-09-30 江苏省血吸虫病防治研究所 一种预防血吸虫感染长效青蒿琥酯药物及其制备方法
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Also Published As

Publication number Publication date
RU2004139090A (ru) 2005-06-10
ZA200500023B (en) 2005-10-20
RU2004139096A (ru) 2005-06-10
CN101843904A (zh) 2010-09-29
JP2005535606A (ja) 2005-11-24
RU2325156C2 (ru) 2008-05-27
EP1553935A2 (en) 2005-07-20
CA2488347A1 (en) 2003-12-18
NZ537114A (en) 2007-02-23
JP2005529938A (ja) 2005-10-06
EP1531851A2 (en) 2005-05-25
BR0311627A (pt) 2005-08-30
CN1668293A (zh) 2005-09-14
CN1668323A (zh) 2005-09-14
WO2003103588A3 (en) 2004-04-15
AU2003251405A1 (en) 2003-12-22
US20040058981A1 (en) 2004-03-25
CA2488360A1 (en) 2003-12-18
EP1531851B1 (en) 2011-12-14
EP1553935A4 (en) 2010-07-07
AU2003243418A1 (en) 2003-12-22
AU2003243418B2 (en) 2009-02-19
NZ537113A (en) 2007-01-26
US20080119542A1 (en) 2008-05-22
EP1531851A4 (en) 2007-12-12
WO2003103588A2 (en) 2003-12-18
CN1313145C (zh) 2007-05-02
BR0312685A (pt) 2005-09-06

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