CA2488347A1 - Methods of using artemisinin-like compounds to prevent or delay the appearance of cancer - Google Patents
Methods of using artemisinin-like compounds to prevent or delay the appearance of cancer Download PDFInfo
- Publication number
- CA2488347A1 CA2488347A1 CA002488347A CA2488347A CA2488347A1 CA 2488347 A1 CA2488347 A1 CA 2488347A1 CA 002488347 A CA002488347 A CA 002488347A CA 2488347 A CA2488347 A CA 2488347A CA 2488347 A1 CA2488347 A1 CA 2488347A1
- Authority
- CA
- Canada
- Prior art keywords
- free radical
- iron
- cancer
- artemisinin
- generating agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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Landscapes
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- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
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| WO2006128126A1 (en) * | 2005-05-27 | 2006-11-30 | Amyris Biotechnologies, Inc. | Conversion of amorpha-4,11- diene to artemisinin and artemisinin precursors |
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| CN103393672A (zh) | 2003-02-12 | 2013-11-20 | 乔治敦大学 | 青蒿素在治疗致癌病毒诱导的肿瘤和治疗病毒感染中的应用 |
| US8394365B2 (en) * | 2003-09-17 | 2013-03-12 | Nektar Therapeutics | Multi-arm polymer prodrugs |
| KR20120073370A (ko) * | 2003-09-17 | 2012-07-04 | 넥타르 테라퓨틱스 | 다분지형 고분자 전구약물 |
| CN1255106C (zh) * | 2003-09-26 | 2006-05-10 | 李国桥 | 复方青蒿素 |
| US20050096369A1 (en) * | 2003-11-04 | 2005-05-05 | Hoang Ba X. | Compositions and methods for treating cellular proliferation disorders |
| CA2546210A1 (en) * | 2003-11-19 | 2005-06-02 | Vecta Ltd. | Methods and compositions for the treatment of helicobacter pylori-associated diseases using endoperoxide bridge-containing compounds |
| CN1311832C (zh) * | 2005-01-12 | 2007-04-25 | 四川科伦药业股份有限公司 | 溴代二氢青蒿素的医药用途 |
| NZ568049A (en) * | 2005-10-20 | 2011-10-28 | Epipharm Gmbh | Treatment and prevention of benign pigmented moles (nevi) using artemisinine and the derivatives thereof |
| US7462627B2 (en) * | 2006-02-09 | 2008-12-09 | Enzon Pharmaceuticals, Inc. | Multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin for treatment of breast, colorectal, pancreatic, ovarian and lung cancers |
| US7671067B2 (en) * | 2006-02-09 | 2010-03-02 | Enzon Pharmaceuticals, Inc. | Treatment of non-hodgkin's lymphomas with multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamtothecin |
| US20070231300A1 (en) * | 2006-03-28 | 2007-10-04 | Washington, University Of | Covalent conjugates between endoperoxides and transferrin and lactoferrin receptor-binding agents |
| WO2008046109A2 (en) * | 2006-10-13 | 2008-04-17 | University Of Washington | Conjugates of artemisinin-related endoperoxides and hydrazone derivatives for the treatment of cancer |
| MX2009005780A (es) * | 2006-11-30 | 2009-06-10 | Nektar Therapeutics Al Corp | Metodo para preparar un conjugado de polimeros. |
| KR20090108082A (ko) * | 2007-02-09 | 2009-10-14 | 엔존 파마슈티컬즈, 인코포레이티드 | 7-에틸-10-하이드록시캄토테신 다분지형 고분자 접합체를 이용한 내성 또는 불응성 암의 치료방법 |
| SG172737A1 (en) * | 2008-01-30 | 2011-07-28 | Pieris Ag | Muteins of tear lipocalin having affinity to human c-met receptor tyrosine kinaseand methods for obtaining the same |
| CN101323569B (zh) * | 2008-07-24 | 2011-01-26 | 上海交通大学 | 倍半萜青蒿萜酯ae及其提取纯化方法 |
| CN102159250B (zh) | 2008-08-11 | 2014-08-06 | 尼克塔治疗公司 | 多臂的聚合烷酸酯偶联物 |
| TW201010732A (en) * | 2008-08-29 | 2010-03-16 | Enzon Pharmaceuticals Inc | Method of treating RAS associated cancer |
| RS59607B1 (sr) | 2008-09-23 | 2020-01-31 | Nektar Therapeutics | Metod metronomskog doziranja kamptotecinskih prolekova (npr. peg-irinotekan) |
| KR20110075029A (ko) * | 2008-10-21 | 2011-07-05 | 엔즌 파마슈티칼스, 인코포레이티드 | 7-에틸-10-하이드록시캄토테신의 다중-암 고분자 컨쥬게이트로 신경모세포종의 치료 |
| GB2469791B (en) * | 2009-04-23 | 2011-12-14 | Londonpharma Ltd | Transmucosal formulation of compounds providing dihydroartemesinin for use in the treatment of neoplastic disease |
| BRPI1014887A8 (pt) * | 2009-04-23 | 2019-02-12 | Londonpharma Ltd | composição farmacêutica para uso no tratamento de neoplasias e uso de um composto provendo di-hidroartemesinina via dosagem sublingual, transmucosal, bucal ou nasal |
| JP5624735B2 (ja) | 2009-07-22 | 2014-11-12 | 国立大学法人岡山大学 | フィルター |
| CN102399142B (zh) * | 2010-09-14 | 2014-09-24 | 华北制药集团新药研究开发有限责任公司 | 一类倍半萜酯化合物及其制备方法和用途 |
| US20130331443A1 (en) | 2010-12-22 | 2013-12-12 | Nektar Therapeutics | Multi-arm polymeric prodrug conjugates of taxane-based compounds |
| US10894087B2 (en) | 2010-12-22 | 2021-01-19 | Nektar Therapeutics | Multi-arm polymeric prodrug conjugates of cabazitaxel-based compounds |
| CN102727522B (zh) * | 2011-04-08 | 2013-09-25 | 石雁羽 | 由溴代双氢青蒿素和Fe2+剂组成的复方双释胶囊制剂 |
| CN103845360A (zh) * | 2012-11-29 | 2014-06-11 | 昆明制药集团股份有限公司 | 含蒿甲醚的药物组合物、制剂及其用途 |
| CN103405779B (zh) * | 2013-07-18 | 2015-09-30 | 江苏省血吸虫病防治研究所 | 一种预防血吸虫感染长效青蒿琥酯药物及其制备方法 |
| GB201800736D0 (en) | 2018-01-17 | 2018-02-28 | St Georges Hospital Medical School | Combination therapy for treatment of leukemia |
| CN109908137B (zh) * | 2019-03-11 | 2022-02-18 | 江苏省人民医院（南京医科大学第一附属医院） | 青蒿素在杀伤乳腺癌干细胞的药物中的应用 |
| CN114983999A (zh) * | 2022-06-09 | 2022-09-02 | 四川大学 | 一种青蒿素及其衍生物的新用途、验证方法 |
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| US4916204A (en) * | 1987-07-31 | 1990-04-10 | Massachusetts Institute Of Technology | Pure polyanhydride from dicarboxylic acid and coupling agent |
| FR2630329B1 (fr) * | 1988-04-20 | 1991-07-05 | Merieux Inst | Conjugues macromoleculaires d'hemoglobine, leur procede de preparation et leurs applications |
| RU2098407C1 (ru) * | 1989-09-27 | 1997-12-10 | Рон-Пуленк Рорер С.А. | Способ получения пероксиацетальлактонового соединения (варианты) и лактон |
| US5681811A (en) * | 1993-05-10 | 1997-10-28 | Protein Delivery, Inc. | Conjugation-stabilized therapeutic agent compositions, delivery and diagnostic formulations comprising same, and method of making and using the same |
| US5472684A (en) * | 1993-06-02 | 1995-12-05 | Colgate Palmolive Company | Oral compositions for plaque and gingivitis |
| US5578637A (en) * | 1995-05-03 | 1996-11-26 | University Of Washington | Methods of inhibition or killing cancer cells using an endoperoxide |
| US5677468A (en) * | 1995-06-29 | 1997-10-14 | Hauser, Inc. | Artemisinin dimer compounds having anticancer activity |
| US5869310A (en) * | 1996-06-03 | 1999-02-09 | Promega Corporation | Isolated agarase enzyme from flavobacterium sp. strain NR19, cloned genes therefor, and expression thereof in transformed host cells |
| US6160004A (en) * | 1997-12-30 | 2000-12-12 | Hauser, Inc. | C-10 carbon-substituted artemisinin-like trioxane compounds having antimalarial, antiproliferative and antitumor activities |
| CN1084333C (zh) * | 1998-06-17 | 2002-05-08 | 中国科学院上海药物研究所 | 新的青蒿素化合物,其制备方法以及含有它们的药物组合物 |
| US6127405A (en) * | 1998-07-10 | 2000-10-03 | Council Of Scientific And Industrial Research | Method for the use of alpha arteether as an anti-bacterial and anti-fungal agent |
| US6297272B1 (en) * | 1999-01-12 | 2001-10-02 | Hauser, Inc. | Artemisinin analogs having antimalarial antiproliferative and antitumor activities and chemoselective methods of making the same |
| IN191696B (enExample) * | 1999-02-12 | 2003-12-20 | Council Scient Ind Res | |
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| JP2002128784A (ja) * | 2000-10-25 | 2002-05-09 | Japan Science & Technology Corp | 細胞侵入型励起一重項酸素発生化合物および該化合物を含む薬剤類 |
| EP1395264A4 (en) * | 2001-05-16 | 2006-03-22 | Faulk Pharmaceuticals Inc | TARGETED RELEASE OF MEDICAMENTS FOR THE TREATMENT OF PARASITIC INFECTIONS |
-
2003
- 2003-06-06 RU RU2004139090/14A patent/RU2004139090A/ru unknown
- 2003-06-06 JP JP2004510709A patent/JP2005529938A/ja active Pending
- 2003-06-06 CN CNA038167972A patent/CN1668293A/zh active Pending
- 2003-06-06 AU AU2003243418A patent/AU2003243418B2/en not_active Ceased
- 2003-06-06 AU AU2003251405A patent/AU2003251405A1/en not_active Abandoned
- 2003-06-06 EP EP03757363A patent/EP1553935A4/en not_active Withdrawn
- 2003-06-06 NZ NZ537114A patent/NZ537114A/en not_active IP Right Cessation
- 2003-06-06 JP JP2004510713A patent/JP4440768B2/ja not_active Expired - Fee Related
- 2003-06-06 NZ NZ537113A patent/NZ537113A/en unknown
- 2003-06-06 CN CNB038167956A patent/CN1313145C/zh not_active Expired - Fee Related
- 2003-06-06 EP EP03757380A patent/EP1531851B1/en not_active Expired - Lifetime
- 2003-06-06 BR BR0311627-1A patent/BR0311627A/pt not_active IP Right Cessation
- 2003-06-06 CA CA002488347A patent/CA2488347A1/en not_active Abandoned
- 2003-06-06 BR BR0312685-4A patent/BR0312685A/pt not_active IP Right Cessation
- 2003-06-06 CA CA002488360A patent/CA2488360A1/en not_active Abandoned
- 2003-06-06 WO PCT/US2003/017791 patent/WO2003103588A2/en not_active Ceased
- 2003-06-06 RU RU2004139096/15A patent/RU2325156C2/ru not_active IP Right Cessation
- 2003-06-06 US US10/457,079 patent/US20040058981A1/en not_active Abandoned
- 2003-06-06 CN CN201010165713A patent/CN101843904A/zh active Pending
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2005
- 2005-01-03 ZA ZA200500023A patent/ZA200500023B/en unknown
-
2007
- 2007-11-30 US US11/948,560 patent/US20080119542A1/en not_active Abandoned
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006128126A1 (en) * | 2005-05-27 | 2006-11-30 | Amyris Biotechnologies, Inc. | Conversion of amorpha-4,11- diene to artemisinin and artemisinin precursors |
Also Published As
| Publication number | Publication date |
|---|---|
| RU2004139090A (ru) | 2005-06-10 |
| BR0311627A (pt) | 2005-08-30 |
| AU2003243418A1 (en) | 2003-12-22 |
| EP1531851A2 (en) | 2005-05-25 |
| WO2003103588A3 (en) | 2004-04-15 |
| RU2325156C2 (ru) | 2008-05-27 |
| EP1553935A2 (en) | 2005-07-20 |
| WO2003103588A2 (en) | 2003-12-18 |
| CN1313145C (zh) | 2007-05-02 |
| JP2005535606A (ja) | 2005-11-24 |
| EP1531851A4 (en) | 2007-12-12 |
| AU2003243418B2 (en) | 2009-02-19 |
| EP1531851B1 (en) | 2011-12-14 |
| NZ537114A (en) | 2007-02-23 |
| CN101843904A (zh) | 2010-09-29 |
| NZ537113A (en) | 2007-01-26 |
| EP1553935A4 (en) | 2010-07-07 |
| BR0312685A (pt) | 2005-09-06 |
| CN1668323A (zh) | 2005-09-14 |
| US20040058981A1 (en) | 2004-03-25 |
| US20080119542A1 (en) | 2008-05-22 |
| ZA200500023B (en) | 2005-10-20 |
| JP4440768B2 (ja) | 2010-03-24 |
| JP2005529938A (ja) | 2005-10-06 |
| CA2488360A1 (en) | 2003-12-18 |
| CN1668293A (zh) | 2005-09-14 |
| RU2004139096A (ru) | 2005-06-10 |
| AU2003251405A1 (en) | 2003-12-22 |
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