JP2008502584A5 - - Google Patents
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- Publication number
- JP2008502584A5 JP2008502584A5 JP2006534360A JP2006534360A JP2008502584A5 JP 2008502584 A5 JP2008502584 A5 JP 2008502584A5 JP 2006534360 A JP2006534360 A JP 2006534360A JP 2006534360 A JP2006534360 A JP 2006534360A JP 2008502584 A5 JP2008502584 A5 JP 2008502584A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- agent
- monoclonal antibody
- nucleolin
- chemotherapeutic agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 11
- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 claims 6
- 239000002246 antineoplastic agent Substances 0.000 claims 6
- 229940127089 cytotoxic agent Drugs 0.000 claims 6
- 102100021010 Nucleolin Human genes 0.000 claims 5
- 239000003795 chemical substances by application Substances 0.000 claims 5
- 108010044762 nucleolin Proteins 0.000 claims 5
- 206010028980 Neoplasm Diseases 0.000 claims 4
- 201000011510 cancer Diseases 0.000 claims 4
- 231100000196 chemotoxic Toxicity 0.000 claims 4
- 230000002604 chemotoxic effect Effects 0.000 claims 4
- KLWPJMFMVPTNCC-UHFFFAOYSA-N Camptothecin Natural products CCC1(O)C(=O)OCC2=C1C=C3C4Nc5ccccc5C=C4CN3C2=O KLWPJMFMVPTNCC-UHFFFAOYSA-N 0.000 claims 3
- CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical group ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 claims 3
- GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 claims 3
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 claims 3
- 241000124008 Mammalia Species 0.000 claims 3
- 229930192392 Mitomycin Natural products 0.000 claims 3
- NWIBSHFKIJFRCO-WUDYKRTCSA-N Mytomycin Chemical compound C1N2C(C(C(C)=C(N)C3=O)=O)=C3[C@@H](COC(N)=O)[C@@]2(OC)[C@@H]2[C@H]1N2 NWIBSHFKIJFRCO-WUDYKRTCSA-N 0.000 claims 3
- VSJKWCGYPAHWDS-FQEVSTJZSA-N camptothecin Chemical compound C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-FQEVSTJZSA-N 0.000 claims 3
- 229940127093 camptothecin Drugs 0.000 claims 3
- 229960004562 carboplatin Drugs 0.000 claims 3
- 190000008236 carboplatin Chemical compound 0.000 claims 3
- DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 claims 3
- 229960004316 cisplatin Drugs 0.000 claims 3
- 229960004397 cyclophosphamide Drugs 0.000 claims 3
- UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 claims 3
- 229960003957 dexamethasone Drugs 0.000 claims 3
- VSJKWCGYPAHWDS-UHFFFAOYSA-N dl-camptothecin Natural products C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)C5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-UHFFFAOYSA-N 0.000 claims 3
- 229960004679 doxorubicin Drugs 0.000 claims 3
- 239000003937 drug carrier Substances 0.000 claims 3
- VJJPUSNTGOMMGY-MRVIYFEKSA-N etoposide Chemical compound COC1=C(O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H]4O[C@H](C)OC[C@H]4O3)O)[C@@H]3[C@@H]2C(OC3)=O)=C1 VJJPUSNTGOMMGY-MRVIYFEKSA-N 0.000 claims 3
- 229960005420 etoposide Drugs 0.000 claims 3
- 229960002949 fluorouracil Drugs 0.000 claims 3
- 229960000485 methotrexate Drugs 0.000 claims 3
- 229960004857 mitomycin Drugs 0.000 claims 3
- DWAFYCQODLXJNR-BNTLRKBRSA-L oxaliplatin Chemical compound O1C(=O)C(=O)O[Pt]11N[C@@H]2CCCC[C@H]2N1 DWAFYCQODLXJNR-BNTLRKBRSA-L 0.000 claims 3
- 229960001756 oxaliplatin Drugs 0.000 claims 3
- XOFYZVNMUHMLCC-ZPOLXVRWSA-N prednisone Chemical compound O=C1C=C[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 XOFYZVNMUHMLCC-ZPOLXVRWSA-N 0.000 claims 3
- 229960004618 prednisone Drugs 0.000 claims 3
- 238000001959 radiotherapy Methods 0.000 claims 3
- FQZYTYWMLGAPFJ-OQKDUQJOSA-N tamoxifen citrate Chemical compound [H+].[H+].[H+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.C=1C=CC=CC=1C(/CC)=C(C=1C=CC(OCCN(C)C)=CC=1)/C1=CC=CC=C1 FQZYTYWMLGAPFJ-OQKDUQJOSA-N 0.000 claims 3
- 229960003454 tamoxifen citrate Drugs 0.000 claims 3
- OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 claims 3
- 229960004528 vincristine Drugs 0.000 claims 3
- OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 claims 3
- 229960004276 zoledronic acid Drugs 0.000 claims 3
- XRASPMIURGNCCH-UHFFFAOYSA-N zoledronic acid Chemical compound OP(=O)(O)C(P(O)(O)=O)(O)CN1C=CN=C1 XRASPMIURGNCCH-UHFFFAOYSA-N 0.000 claims 3
- 239000000126 substance Substances 0.000 claims 2
- 231100000167 toxic agent Toxicity 0.000 claims 2
- 239000003440 toxic substance Substances 0.000 claims 2
- 230000002163 immunogen Effects 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/683,480 US7357928B2 (en) | 2002-04-08 | 2003-10-09 | Method for the diagnosis and prognosis of malignant diseases |
| PCT/US2004/033174 WO2005035579A1 (en) | 2003-10-09 | 2004-10-08 | A method for the treatment of maligant diseases by inhibiting nucleolin |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008502584A JP2008502584A (ja) | 2008-01-31 |
| JP2008502584A5 true JP2008502584A5 (enExample) | 2009-07-23 |
Family
ID=34435395
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006534360A Pending JP2008502584A (ja) | 2003-10-09 | 2004-10-08 | ヌクレオリンを抑制することによる悪性疾患の治療方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (4) | US7357928B2 (enExample) |
| EP (1) | EP1687337B1 (enExample) |
| JP (1) | JP2008502584A (enExample) |
| AU (1) | AU2004279837B2 (enExample) |
| CA (1) | CA2546730C (enExample) |
| ES (1) | ES2473598T3 (enExample) |
| WO (1) | WO2005035579A1 (enExample) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7960540B2 (en) * | 1999-04-08 | 2011-06-14 | Advanced Cancer Therapeutics, Llc | Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin |
| US20080318889A1 (en) * | 1999-04-08 | 2008-12-25 | Antisoma Research Limited | Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin |
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| US20080318890A1 (en) * | 1999-04-08 | 2008-12-25 | Antisoma Research Limited | Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin |
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| JP6301258B2 (ja) * | 2011-11-03 | 2018-03-28 | トライパス イメージング インコーポレイテッド | 免疫染色試料を調製するための方法および構成物 |
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| CN106405084A (zh) * | 2015-07-31 | 2017-02-15 | 复旦大学附属华山医院 | 核仁素在制备肠癌诊断试剂和治疗药物中的应用 |
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| JP7157981B2 (ja) * | 2016-03-07 | 2022-10-21 | チャールストンファーマ， エルエルシー | 抗ヌクレオリン抗体 |
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| WO2021050779A2 (en) | 2019-09-10 | 2021-03-18 | University Of Louisville Research Foundation, Inc. | Anti-nucleolin agent-peg-conjugated nanoparticles |
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| AU2003228431A1 (en) * | 2002-04-05 | 2003-10-27 | The Burnham Institute | Hmgn2 peptides and related melecules that selectively home to tumor blood vessels and tumor cells |
| US7541150B2 (en) | 2002-04-08 | 2009-06-02 | University Of Louisville Research Foundation, Inc | Method for the diagnosis and prognosis of malignant diseases |
| US7357928B2 (en) | 2002-04-08 | 2008-04-15 | University Of Louisville Research Foundation, Inc. | Method for the diagnosis and prognosis of malignant diseases |
| CA2489520A1 (en) * | 2002-06-26 | 2004-01-08 | University Of Louisville Research Foundation, Inc. | A method for the detection of apoptosis |
| TW200504210A (en) * | 2003-07-30 | 2005-02-01 | Chin-Tarng Lin | A nucleolin antisense inhibiting growth of cancer cell |
| US20050187176A1 (en) * | 2003-10-10 | 2005-08-25 | Bates Paula J. | Method for inhibiting NF-kappa B signaling and use to treat or prevent human diseases |
| CN1862258B (zh) * | 2005-05-12 | 2012-05-30 | 清华大学 | 核仁素辅助的癌症诊断与治疗方法 |
| WO2007016466A2 (en) | 2005-07-29 | 2007-02-08 | Sloan-Kettering Institute For Cancer Research | Single wall nanotube constructs and uses therefor |
| US20090226914A1 (en) * | 2007-12-31 | 2009-09-10 | Bates Paula J | Methods and products to target, capture and characterize stem cells |
| JP2013508399A (ja) | 2009-10-21 | 2013-03-07 | ヘルス リサーチ インコーポレイテッド | 腫瘍イメージングの増強用のｐａａナノ粒子 |
| US20110111002A1 (en) | 2009-11-12 | 2011-05-12 | Calin Viorel Pop | Transport and delivery of glutathione into human cells using gold nanoparticles |
| CN102770529B (zh) | 2009-11-17 | 2018-06-05 | Musc研究发展基金会 | 针对人核仁素的人单克隆抗体 |
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-
2003
- 2003-10-09 US US10/683,480 patent/US7357928B2/en not_active Expired - Fee Related
-
2004
- 2004-10-08 JP JP2006534360A patent/JP2008502584A/ja active Pending
- 2004-10-08 WO PCT/US2004/033174 patent/WO2005035579A1/en not_active Ceased
- 2004-10-08 AU AU2004279837A patent/AU2004279837B2/en not_active Ceased
- 2004-10-08 EP EP04785392.4A patent/EP1687337B1/en not_active Expired - Lifetime
- 2004-10-08 CA CA2546730A patent/CA2546730C/en not_active Expired - Fee Related
- 2004-10-08 ES ES04785392.4T patent/ES2473598T3/es not_active Expired - Lifetime
-
2008
- 2008-03-04 US US12/041,969 patent/US8029784B2/en not_active Expired - Fee Related
-
2011
- 2011-05-26 US US13/116,319 patent/US8586717B2/en not_active Expired - Fee Related
-
2013
- 2013-10-21 US US14/059,211 patent/US20140220013A1/en not_active Abandoned
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