JP2007526238A5 - - Google Patents
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- Publication number
- JP2007526238A5 JP2007526238A5 JP2006532814A JP2006532814A JP2007526238A5 JP 2007526238 A5 JP2007526238 A5 JP 2007526238A5 JP 2006532814 A JP2006532814 A JP 2006532814A JP 2006532814 A JP2006532814 A JP 2006532814A JP 2007526238 A5 JP2007526238 A5 JP 2007526238A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- folic acid
- immunogen
- drug
- use according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 claims 8
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 235000019152 folic acid Nutrition 0.000 claims 4
- 239000011724 folic acid Substances 0.000 claims 4
- 229960000304 folic acid Drugs 0.000 claims 4
- 230000002163 immunogen Effects 0.000 claims 4
- 239000003446 ligand Substances 0.000 claims 4
- 206010025135 lupus erythematosus Diseases 0.000 claims 4
- 229940079593 drug Drugs 0.000 claims 3
- 239000003795 chemical substances by application Substances 0.000 claims 2
- -1 dinitrophenyl Chemical group 0.000 claims 2
- MHMNJMPURVTYEJ-UHFFFAOYSA-N fluorescein-5-isothiocyanate Chemical compound O1C(=O)C2=CC(N=C=S)=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 MHMNJMPURVTYEJ-UHFFFAOYSA-N 0.000 claims 2
- 102000006815 folate receptor Human genes 0.000 claims 2
- 108020005243 folate receptor Proteins 0.000 claims 2
- 210000002540 macrophage Anatomy 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US46833003P | 2003-05-06 | 2003-05-06 | |
| PCT/US2004/014097 WO2004100983A2 (en) | 2003-05-06 | 2004-05-06 | Treatment of lupus targeting the macrophages or the folate receptor |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007526238A JP2007526238A (ja) | 2007-09-13 |
| JP2007526238A5 true JP2007526238A5 (enExample) | 2009-01-08 |
Family
ID=33452201
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006532814A Pending JP2007526238A (ja) | 2003-05-06 | 2004-05-06 | マクロファージまたは葉酸受容体を標的とする狼瘡治療法 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US20060204565A1 (enExample) |
| EP (1) | EP1622646B1 (enExample) |
| JP (1) | JP2007526238A (enExample) |
| CA (1) | CA2524441C (enExample) |
| WO (1) | WO2004100983A2 (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2316349C2 (ru) | 2001-05-02 | 2008-02-10 | Пердью Рисерч Фаундейшн | Лечение и диагностика заболеваний, опосредованных макрофагами |
| US8043602B2 (en) | 2002-02-07 | 2011-10-25 | Endocyte, Inc. | Folate targeted enhanced tumor and folate receptor positive tissue optical imaging technology |
| US8043603B2 (en) * | 2002-02-07 | 2011-10-25 | Endocyte, Inc. | Folate targeted enhanced tumor and folate receptor positive tissue optical imaging technology |
| WO2003092742A1 (en) * | 2002-05-06 | 2003-11-13 | Endocyte, Inc. | Vitamin-targeted imaging agents |
| DE602004017452D1 (de) | 2003-05-30 | 2008-12-11 | Purdue Research Foundation | Diagnoseverfahren für atherosklerose |
| CN101098854B (zh) | 2004-07-23 | 2012-12-05 | 恩多塞特公司 | 二价连接体及其轭合物 |
| JP2008525485A (ja) * | 2004-12-23 | 2008-07-17 | パーデュー・リサーチ・ファウンデーション | ポジトロン放射断層画像法 |
| WO2007006041A2 (en) | 2005-07-05 | 2007-01-11 | Purdue Research Foundation | Imaging and therapeutic method using monocytes |
| US8795633B2 (en) | 2005-09-23 | 2014-08-05 | Purdue Research Foundation | Multiphoton in vivo flow cytometry method and device |
| CA2651866C (en) * | 2006-05-11 | 2014-10-28 | Universiteit Gent | Sialoadhesin-related compositions and methods |
| WO2008127298A2 (en) * | 2006-10-24 | 2008-10-23 | Subroto Chatterjee | Staphylococcal enterotoxin b peptide compositions and methods of use |
| EP2087337A4 (en) | 2006-11-03 | 2010-09-08 | Purdue Research Foundation | METHOD AND DEVICE FOR EX-VIVO FLOW CYTOMETRY |
| CA2677792C (en) | 2007-02-07 | 2015-04-14 | Purdue Research Foundation | Positron emission tomography imaging method |
| WO2008101231A2 (en) | 2007-02-16 | 2008-08-21 | Endocyte, Inc. | Methods and compositions for treating and diagnosing kidney disease |
| NZ599239A (en) | 2007-03-14 | 2013-10-25 | Endocyte Inc | Binding ligand linked drug delivery conjugates of tubulysins |
| EP2164525A2 (en) * | 2007-05-25 | 2010-03-24 | Purdue Research Foundation | Method of imaging localized infections |
| US9138484B2 (en) | 2007-06-25 | 2015-09-22 | Endocyte, Inc. | Conjugates containing hydrophilic spacer linkers |
| US9187521B2 (en) | 2007-10-25 | 2015-11-17 | Endocyte, Inc. | Tubulysins and processes for preparing |
| WO2011150392A1 (en) | 2010-05-28 | 2011-12-01 | Purdue Research Foundation | Delivery of therapeutic agents to inflamed tissues using folate-targeted agents |
| WO2013126797A1 (en) | 2012-02-24 | 2013-08-29 | Purdue Research Foundation | Cholecystokinin b receptor targeting for imaging and therapy |
| US9662402B2 (en) | 2012-10-16 | 2017-05-30 | Endocyte, Inc. | Drug delivery conjugates containing unnatural amino acids and methods for using |
| US10420850B2 (en) | 2015-08-14 | 2019-09-24 | Endocyte, Inc. | Method of imaging with a chelating agent |
| CN114377017A (zh) * | 2020-10-21 | 2022-04-22 | 复旦大学 | 叶酸和叶酸修饰在诱导B细胞免疫耐受和靶向mIgM阳性表达的B细胞淋巴瘤中的用途 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4713249A (en) * | 1981-11-12 | 1987-12-15 | Schroeder Ulf | Crystallized carbohydrate matrix for biologically active substances, a process of preparing said matrix, and the use thereof |
| US5266333A (en) * | 1985-03-06 | 1993-11-30 | American Cyanamid Company | Water dispersible and water soluble carbohydrate polymer compositions for parenteral administration of growth hormone |
| US5688488A (en) * | 1989-04-03 | 1997-11-18 | Purdue Research Foundation | Composition and method for tumor imaging |
| US5108921A (en) * | 1989-04-03 | 1992-04-28 | Purdue Research Foundation | Method for enhanced transmembrane transport of exogenous molecules |
| US5417982A (en) * | 1994-02-17 | 1995-05-23 | Modi; Pankaj | Controlled release of drugs or hormones in biodegradable polymer microspheres |
| DE69803392D1 (de) * | 1997-06-20 | 2002-02-28 | Tanox Pharma B V | Anti-cd40l immunotoxine zur behandlung von krankheiten |
| SI20475A (sl) * | 1998-02-17 | 2001-08-31 | Medarex, Inc. | Zdravljenje in diagnosticiranje z makrofagi posredovanih bolezni z uporabo Fc receptorskih ligandov |
| AU5697001A (en) * | 2000-03-31 | 2001-10-15 | Purdue Research Foundation | Method of treatment using ligand-immunogen conjugates |
| RU2316349C2 (ru) * | 2001-05-02 | 2008-02-10 | Пердью Рисерч Фаундейшн | Лечение и диагностика заболеваний, опосредованных макрофагами |
| EP1434603B1 (en) * | 2001-09-28 | 2009-12-16 | Purdue Research Foundation | Method of treatment using ligand-immunogen conjugates |
| WO2003054193A2 (en) * | 2001-12-21 | 2003-07-03 | Applied Research Systems Ars Holding N.V. | Raf/ras binding compounds |
| WO2003092742A1 (en) * | 2002-05-06 | 2003-11-13 | Endocyte, Inc. | Vitamin-targeted imaging agents |
-
2004
- 2004-05-06 US US10/552,569 patent/US20060204565A1/en not_active Abandoned
- 2004-05-06 EP EP04751467A patent/EP1622646B1/en not_active Expired - Lifetime
- 2004-05-06 CA CA2524441A patent/CA2524441C/en not_active Expired - Fee Related
- 2004-05-06 JP JP2006532814A patent/JP2007526238A/ja active Pending
- 2004-05-06 WO PCT/US2004/014097 patent/WO2004100983A2/en not_active Ceased
-
2007
- 2007-11-30 US US11/948,656 patent/US20080119475A1/en not_active Abandoned
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