JP2005533026A5 - - Google Patents
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- JP2005533026A5 JP2005533026A5 JP2004505358A JP2004505358A JP2005533026A5 JP 2005533026 A5 JP2005533026 A5 JP 2005533026A5 JP 2004505358 A JP2004505358 A JP 2004505358A JP 2004505358 A JP2004505358 A JP 2004505358A JP 2005533026 A5 JP2005533026 A5 JP 2005533026A5
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- 125000004432 carbon atom Chemical group C* 0.000 claims 32
- 125000000217 alkyl group Chemical group 0.000 claims 25
- 210000004027 cell Anatomy 0.000 claims 23
- 239000011230 binding agent Substances 0.000 claims 19
- 125000005647 linker group Chemical group 0.000 claims 19
- 229940127089 cytotoxic agent Drugs 0.000 claims 16
- 239000002254 cytotoxic agent Substances 0.000 claims 16
- 231100000599 cytotoxic agent Toxicity 0.000 claims 16
- 229940123237 Taxane Drugs 0.000 claims 15
- 239000002202 Polyethylene glycol Substances 0.000 claims 14
- 229920001223 polyethylene glycol Polymers 0.000 claims 14
- 230000001225 therapeutic effect Effects 0.000 claims 14
- 150000001875 compounds Chemical class 0.000 claims 13
- DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 claims 13
- 125000003118 aryl group Chemical group 0.000 claims 11
- 125000000623 heterocyclic group Chemical group 0.000 claims 9
- 125000003107 substituted aryl group Chemical group 0.000 claims 8
- -1 cyclic ester Chemical class 0.000 claims 5
- 239000003098 androgen Substances 0.000 claims 4
- 125000006575 electron-withdrawing group Chemical group 0.000 claims 4
- 239000000262 estrogen Substances 0.000 claims 4
- 229940011871 estrogen Drugs 0.000 claims 4
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 claims 4
- 239000012634 fragment Substances 0.000 claims 4
- BWGNESOTFCXPMA-UHFFFAOYSA-N Dihydrogen disulfide Chemical compound SS BWGNESOTFCXPMA-UHFFFAOYSA-N 0.000 claims 3
- 108090000371 Esterases Proteins 0.000 claims 3
- 108091005804 Peptidases Proteins 0.000 claims 3
- 102000035195 Peptidases Human genes 0.000 claims 3
- 239000002253 acid Substances 0.000 claims 3
- 235000019833 protease Nutrition 0.000 claims 3
- 125000001424 substituent group Chemical group 0.000 claims 3
- 150000003573 thiols Chemical class 0.000 claims 3
- 108010071942 Colony-Stimulating Factors Proteins 0.000 claims 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 2
- 102000009024 Epidermal Growth Factor Human genes 0.000 claims 2
- 101800003838 Epidermal growth factor Proteins 0.000 claims 2
- 102000018233 Fibroblast Growth Factor Human genes 0.000 claims 2
- 108050007372 Fibroblast Growth Factor Proteins 0.000 claims 2
- 102100039620 Granulocyte-macrophage colony-stimulating factor Human genes 0.000 claims 2
- 101000599951 Homo sapiens Insulin-like growth factor I Proteins 0.000 claims 2
- 101001076292 Homo sapiens Insulin-like growth factor II Proteins 0.000 claims 2
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 2
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 2
- 102100037852 Insulin-like growth factor I Human genes 0.000 claims 2
- 102100025947 Insulin-like growth factor II Human genes 0.000 claims 2
- 102000014150 Interferons Human genes 0.000 claims 2
- 108010050904 Interferons Proteins 0.000 claims 2
- 239000000637 Melanocyte-Stimulating Hormone Substances 0.000 claims 2
- 108010007013 Melanocyte-Stimulating Hormones Proteins 0.000 claims 2
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 claims 2
- 108010038512 Platelet-Derived Growth Factor Proteins 0.000 claims 2
- 102000010780 Platelet-Derived Growth Factor Human genes 0.000 claims 2
- 108010029180 Sialic Acid Binding Ig-like Lectin 3 Proteins 0.000 claims 2
- 102000001555 Sialic Acid Binding Ig-like Lectin 3 Human genes 0.000 claims 2
- 102000005157 Somatostatin Human genes 0.000 claims 2
- 108010056088 Somatostatin Proteins 0.000 claims 2
- 108010061174 Thyrotropin Proteins 0.000 claims 2
- 102000011923 Thyrotropin Human genes 0.000 claims 2
- 102000004338 Transferrin Human genes 0.000 claims 2
- 108090000901 Transferrin Proteins 0.000 claims 2
- 108010009583 Transforming Growth Factors Proteins 0.000 claims 2
- 102000009618 Transforming Growth Factors Human genes 0.000 claims 2
- 108010073929 Vascular Endothelial Growth Factor A Proteins 0.000 claims 2
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims 2
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 125000006165 cyclic alkyl group Chemical group 0.000 claims 2
- 229940116977 epidermal growth factor Drugs 0.000 claims 2
- 229940126864 fibroblast growth factor Drugs 0.000 claims 2
- 229960000304 folic acid Drugs 0.000 claims 2
- 235000019152 folic acid Nutrition 0.000 claims 2
- 239000011724 folic acid Substances 0.000 claims 2
- 239000003102 growth factor Substances 0.000 claims 2
- 239000005556 hormone Substances 0.000 claims 2
- 229940088597 hormone Drugs 0.000 claims 2
- 229940079322 interferon Drugs 0.000 claims 2
- 229960000553 somatostatin Drugs 0.000 claims 2
- NHXLMOGPVYXJNR-ATOGVRKGSA-N somatostatin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N1)[C@@H](C)O)NC(=O)CNC(=O)[C@H](C)N)C(O)=O)=O)[C@H](O)C)C1=CC=CC=C1 NHXLMOGPVYXJNR-ATOGVRKGSA-N 0.000 claims 2
- 239000012581 transferrin Substances 0.000 claims 2
- VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 claims 2
- 239000011782 vitamin Substances 0.000 claims 2
- 229940088594 vitamin Drugs 0.000 claims 2
- 229930003231 vitamin Natural products 0.000 claims 2
- 235000013343 vitamin Nutrition 0.000 claims 2
- 150000003722 vitamin derivatives Chemical class 0.000 claims 2
- 102100024222 B-lymphocyte antigen CD19 Human genes 0.000 claims 1
- 108010003639 CD56 Antigen Proteins 0.000 claims 1
- 102000004652 CD56 Antigen Human genes 0.000 claims 1
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 claims 1
- 101000980825 Homo sapiens B-lymphocyte antigen CD19 Proteins 0.000 claims 1
- 239000004698 Polyethylene Substances 0.000 claims 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 125000004122 cyclic group Chemical group 0.000 claims 1
- 231100000433 cytotoxic Toxicity 0.000 claims 1
- 230000001472 cytotoxic effect Effects 0.000 claims 1
- 230000003013 cytotoxicity Effects 0.000 claims 1
- 231100000135 cytotoxicity Toxicity 0.000 claims 1
- 125000004915 dibutylamino group Chemical group C(CCC)N(CCCC)* 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 125000004914 dipropylamino group Chemical group C(CC)N(CCC)* 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 150000002170 ethers Chemical class 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 229920000573 polyethylene Polymers 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/144,042 US6596757B1 (en) | 2002-05-14 | 2002-05-14 | Cytotoxic agents comprising polyethylene glycol-containing taxanes and their therapeutic use |
| PCT/US2003/002675 WO2003097625A1 (en) | 2002-05-14 | 2003-02-11 | Cytotoxic agents comprising polyethylene glycol-containing taxanes and their therapeutic use |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010238562A Division JP2011042679A (ja) | 2002-05-14 | 2010-10-25 | ポリエチレングリコール含有タキサンを含む細胞毒性剤およびその治療用途 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005533026A JP2005533026A (ja) | 2005-11-04 |
| JP2005533026A5 true JP2005533026A5 (https=) | 2006-02-09 |
Family
ID=22506806
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004505358A Pending JP2005533026A (ja) | 2002-05-14 | 2003-02-11 | ポリエチレングリコール含有タキサンを含む細胞毒性剤およびその治療用途 |
| JP2010238562A Pending JP2011042679A (ja) | 2002-05-14 | 2010-10-25 | ポリエチレングリコール含有タキサンを含む細胞毒性剤およびその治療用途 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010238562A Pending JP2011042679A (ja) | 2002-05-14 | 2010-10-25 | ポリエチレングリコール含有タキサンを含む細胞毒性剤およびその治療用途 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US6596757B1 (https=) |
| EP (1) | EP1506181A4 (https=) |
| JP (2) | JP2005533026A (https=) |
| AU (1) | AU2003210731C1 (https=) |
| CA (1) | CA2485424C (https=) |
| WO (1) | WO2003097625A1 (https=) |
Families Citing this family (92)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
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| EP1392359B2 (en) | 2001-05-11 | 2013-03-13 | Ludwig Institute for Cancer Research Ltd. | Specific binding proteins and uses thereof |
| WO2003097647A1 (en) * | 2002-05-15 | 2003-11-27 | Endocyte, Inc. | Vitamin-mitomycin conjugates |
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| WO1993024476A1 (en) * | 1992-06-04 | 1993-12-09 | Clover Consolidated, Limited | Water-soluble polymeric carriers for drug delivery |
| US5547981A (en) * | 1993-03-09 | 1996-08-20 | Enzon, Inc. | Taxol-7-carbazates |
| US5824701A (en) * | 1993-10-20 | 1998-10-20 | Enzon, Inc. | Taxane-based prodrugs |
| AU768027B2 (en) * | 1999-02-24 | 2003-11-27 | Uab Research Foundation, The | Taxane derivatives for targeted therapy of cancer |
| ES2276708T3 (es) * | 1999-11-24 | 2007-07-01 | Immunogen, Inc. | Agentes citotoxicos que comprenden taxanos y su uso terapeutico. |
| EP1279405A1 (en) * | 2000-03-30 | 2003-01-29 | Ajinomoto Co., Inc. | Drugs retained in target tissue over long time |
-
2002
- 2002-05-14 US US10/144,042 patent/US6596757B1/en not_active Expired - Fee Related
-
2003
- 2003-02-11 WO PCT/US2003/002675 patent/WO2003097625A1/en not_active Ceased
- 2003-02-11 CA CA2485424A patent/CA2485424C/en not_active Expired - Fee Related
- 2003-02-11 EP EP03752980A patent/EP1506181A4/en not_active Withdrawn
- 2003-02-11 AU AU2003210731A patent/AU2003210731C1/en not_active Ceased
- 2003-02-11 JP JP2004505358A patent/JP2005533026A/ja active Pending
-
2010
- 2010-10-25 JP JP2010238562A patent/JP2011042679A/ja active Pending
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