JP2006509015A5 - - Google Patents
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- Publication number
- JP2006509015A5 JP2006509015A5 JP2004557589A JP2004557589A JP2006509015A5 JP 2006509015 A5 JP2006509015 A5 JP 2006509015A5 JP 2004557589 A JP2004557589 A JP 2004557589A JP 2004557589 A JP2004557589 A JP 2004557589A JP 2006509015 A5 JP2006509015 A5 JP 2006509015A5
- Authority
- JP
- Japan
- Prior art keywords
- groups
- alkyl
- optionally substituted
- halo
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- 0 CC(CC1)CCC1(CN1Cc(cc2)ccc2C(NCC(C(O)=O)O)=O)CN(c2ccc(*)cc2)C1=O Chemical compound CC(CC1)CCC1(CN1Cc(cc2)ccc2C(NCC(C(O)=O)O)=O)CN(c2ccc(*)cc2)C1=O 0.000 description 37
- AFXVJUFSVHBGFA-UHFFFAOYSA-N CC(C(CNC(c1ccc(CN(C2(CN3c(cc4)ccc4OC(F)(F)F)CCN(Cc4ccccc4)CC2)C3=O)cc1)=O)=O)=O Chemical compound CC(C(CNC(c1ccc(CN(C2(CN3c(cc4)ccc4OC(F)(F)F)CCN(Cc4ccccc4)CC2)C3=O)cc1)=O)=O)=O AFXVJUFSVHBGFA-UHFFFAOYSA-N 0.000 description 1
- VEZFHBRVVUVDEY-UHFFFAOYSA-N CC(C)(C)C(CC1)CCC1(CCN1c(cc2)ccc2OC(F)(F)F)N(Cc(cc2)ccc2C(NCC(C(O)=O)O)=O)C1=O Chemical compound CC(C)(C)C(CC1)CCC1(CCN1c(cc2)ccc2OC(F)(F)F)N(Cc(cc2)ccc2C(NCC(C(O)=O)O)=O)C1=O VEZFHBRVVUVDEY-UHFFFAOYSA-N 0.000 description 1
- XXNUNAVTFOXUGX-UHFFFAOYSA-N CC(C)(C)C(CC1)CCC1(CCN1c(cc2)ccc2OC(F)(F)F)N(Cc(cc2)ccc2C(NCC(C(OC)=O)O)=O)C1=O Chemical compound CC(C)(C)C(CC1)CCC1(CCN1c(cc2)ccc2OC(F)(F)F)N(Cc(cc2)ccc2C(NCC(C(OC)=O)O)=O)C1=O XXNUNAVTFOXUGX-UHFFFAOYSA-N 0.000 description 1
- SAOQLSXJSDSLDQ-UHFFFAOYSA-N CC(C)(C)C(CC1)CCC1(CN1C(CI)c(cc2)ccc2Br)N(Cc(cc2)ccc2C(NCCC(O)=O)=O)C1=O Chemical compound CC(C)(C)C(CC1)CCC1(CN1C(CI)c(cc2)ccc2Br)N(Cc(cc2)ccc2C(NCCC(O)=O)=O)C1=O SAOQLSXJSDSLDQ-UHFFFAOYSA-N 0.000 description 1
- CFKYQBKCUXSYSF-UHFFFAOYSA-N CC(C)(C)C(CC1)CCC1(CN1c(cc2)ccc2Cl)N(Cc(cc2)ccc2C(NCC(C(O)=O)O)=O)C1=O Chemical compound CC(C)(C)C(CC1)CCC1(CN1c(cc2)ccc2Cl)N(Cc(cc2)ccc2C(NCC(C(O)=O)O)=O)C1=O CFKYQBKCUXSYSF-UHFFFAOYSA-N 0.000 description 1
- WSOWRQHROVAZER-UHFFFAOYSA-N CC(C)(C)C(CC1)CCC1(CN1c(cc2)ccc2F)N(Cc(cc2)ccc2C(NCC(C(O)=O)O)=O)C1=O Chemical compound CC(C)(C)C(CC1)CCC1(CN1c(cc2)ccc2F)N(Cc(cc2)ccc2C(NCC(C(O)=O)O)=O)C1=O WSOWRQHROVAZER-UHFFFAOYSA-N 0.000 description 1
- ZJGCRKSGKMYEPI-UHFFFAOYSA-N CC(C)(C)C(CC1)CCC1(CN1c(cc2)ccc2S(C)C(O)=O)N(Cc(cc2)ccc2C(NCCC(O)=O)=O)C1=O Chemical compound CC(C)(C)C(CC1)CCC1(CN1c(cc2)ccc2S(C)C(O)=O)N(Cc(cc2)ccc2C(NCCC(O)=O)=O)C1=O ZJGCRKSGKMYEPI-UHFFFAOYSA-N 0.000 description 1
- LJUHOCLOILBHQI-UHFFFAOYSA-N CC(C)(C)C(CC1)CCC1(CN1c(ccc(F)c2)c2F)N(Cc(cc2)ccc2C(NCCC(O)=O)=O)C1=O Chemical compound CC(C)(C)C(CC1)CCC1(CN1c(ccc(F)c2)c2F)N(Cc(cc2)ccc2C(NCCC(O)=O)=O)C1=O LJUHOCLOILBHQI-UHFFFAOYSA-N 0.000 description 1
- UBZKWBYUYMXLFH-UHFFFAOYSA-N CC(C)(C)C(CC1)CCC1(CN1c(cccc2)c2Cl)N(Cc(cc2)ccc2C(NCC(C(O)=O)O)=O)C1=O Chemical compound CC(C)(C)C(CC1)CCC1(CN1c(cccc2)c2Cl)N(Cc(cc2)ccc2C(NCC(C(O)=O)O)=O)C1=O UBZKWBYUYMXLFH-UHFFFAOYSA-N 0.000 description 1
- HASGNSGSQSLVJJ-UHFFFAOYSA-N CC(C)(C)C(CC1)CCC1(CN1c2cc(Cl)cc(Cl)c2)N(CC2C=CC(C(NCC(C(O)=O)O)=O)=CC2)C1=O Chemical compound CC(C)(C)C(CC1)CCC1(CN1c2cc(Cl)cc(Cl)c2)N(CC2C=CC(C(NCC(C(O)=O)O)=O)=CC2)C1=O HASGNSGSQSLVJJ-UHFFFAOYSA-N 0.000 description 1
- AFLDSFRTXXHWIX-UHFFFAOYSA-N CC(C)(C)C(CC1)CCC1(CN1c2cccc(Cl)c2)N(Cc(cc2)ccc2C(NCC(C(O)=O)O)=O)C1=O Chemical compound CC(C)(C)C(CC1)CCC1(CN1c2cccc(Cl)c2)N(Cc(cc2)ccc2C(NCC(C(O)=O)O)=O)C1=O AFLDSFRTXXHWIX-UHFFFAOYSA-N 0.000 description 1
- VKWGTVXXZWQDDH-UHFFFAOYSA-N CC(C)(C1)C1(CC1)CCC1(CN1c2cc(C(F)(F)F)cc(C(F)(F)F)c2)N(Cc(cc2)ccc2C(NCCC(O)=O)=O)C1=O Chemical compound CC(C)(C1)C1(CC1)CCC1(CN1c2cc(C(F)(F)F)cc(C(F)(F)F)c2)N(Cc(cc2)ccc2C(NCCC(O)=O)=O)C1=O VKWGTVXXZWQDDH-UHFFFAOYSA-N 0.000 description 1
- ZOKNATNTTBBZQZ-UHFFFAOYSA-N CC(C)C(CC1)CCC1(CCC1c2ccc(C(C3C)OC3=O)cc2)N(Cc(cc2)ccc2C(Nc2nnn[nH]2)=O)C1=O Chemical compound CC(C)C(CC1)CCC1(CCC1c2ccc(C(C3C)OC3=O)cc2)N(Cc(cc2)ccc2C(Nc2nnn[nH]2)=O)C1=O ZOKNATNTTBBZQZ-UHFFFAOYSA-N 0.000 description 1
- DZHWUPOXGAAJPF-UHFFFAOYSA-N CC(C)C(CC1)CCC1(CN1c2cccc(OC(F)(F)F)c2)N(Cc(cc2)ccc2C(NCCC(O)=O)=O)C1O Chemical compound CC(C)C(CC1)CCC1(CN1c2cccc(OC(F)(F)F)c2)N(Cc(cc2)ccc2C(NCCC(O)=O)=O)C1O DZHWUPOXGAAJPF-UHFFFAOYSA-N 0.000 description 1
- MNOJIEJTKWCCEG-UHFFFAOYSA-N CC(C)C(CCC(CC1)(CCC1C(C)(C(C)C)C=C)N1Cc(cc2)ccc2C(NC2=NCNC2C)=O)C1=O Chemical compound CC(C)C(CCC(CC1)(CCC1C(C)(C(C)C)C=C)N1Cc(cc2)ccc2C(NC2=NCNC2C)=O)C1=O MNOJIEJTKWCCEG-UHFFFAOYSA-N 0.000 description 1
- QWDDJEUDPPBDNL-UHFFFAOYSA-N CC(C)C(CCC1)CC1C(CN1c(cc2F)ccc2F)N(Cc(cc2)ccc2C(NCCC(O)=O)=O)C1=O Chemical compound CC(C)C(CCC1)CC1C(CN1c(cc2F)ccc2F)N(Cc(cc2)ccc2C(NCCC(O)=O)=O)C1=O QWDDJEUDPPBDNL-UHFFFAOYSA-N 0.000 description 1
- LCEUJJGHQCVSDF-UHFFFAOYSA-N CC(C)N(CC(CC1)(CCC1C(C)(C)C)N1Cc(cc2)ccc2C(NCCC(O)=O)=O)C1=O Chemical compound CC(C)N(CC(CC1)(CCC1C(C)(C)C)N1Cc(cc2)ccc2C(NCCC(O)=O)=O)C1=O LCEUJJGHQCVSDF-UHFFFAOYSA-N 0.000 description 1
- VZZJXALBAVRQLJ-UHFFFAOYSA-N CC(CC=C)(C(CC1)CCC1(CN1c2ccccc2)N(Cc(cc2)ccc2C(NCCC(O)=O)=O)C1=O)C=C Chemical compound CC(CC=C)(C(CC1)CCC1(CN1c2ccccc2)N(Cc(cc2)ccc2C(NCCC(O)=O)=O)C1=O)C=C VZZJXALBAVRQLJ-UHFFFAOYSA-N 0.000 description 1
- BEBMPKNEZXAXHT-UHFFFAOYSA-N CC(c(cc1)ccc1Br)N(CC(CC1)(CCC1C(C)(C)C)CC(Cc(cc1)ccc1C(Nc1nnn[nH]1)=O)=C1)C1=O Chemical compound CC(c(cc1)ccc1Br)N(CC(CC1)(CCC1C(C)(C)C)CC(Cc(cc1)ccc1C(Nc1nnn[nH]1)=O)=C1)C1=O BEBMPKNEZXAXHT-UHFFFAOYSA-N 0.000 description 1
- MVJIHYHAKQEZJL-UHFFFAOYSA-N CC(c(cc1)ccc1Br)N(CC(CC1)(CCC1C(C)(C)C)N1Cc(cc2)ccc2C(NCc2nnn[nH]2)=O)C1=O Chemical compound CC(c(cc1)ccc1Br)N(CC(CC1)(CCC1C(C)(C)C)N1Cc(cc2)ccc2C(NCc2nnn[nH]2)=O)C1=O MVJIHYHAKQEZJL-UHFFFAOYSA-N 0.000 description 1
- AMPICRWPLIJTSR-UHFFFAOYSA-N CCC(C)(C)C(CC1)CCC1(CN1Cc2cc(F)ccc2)N(Cc(cc2)ccc2C(NC2=NN=NCC2=C)=O)C1=O Chemical compound CCC(C)(C)C(CC1)CCC1(CN1Cc2cc(F)ccc2)N(Cc(cc2)ccc2C(NC2=NN=NCC2=C)=O)C1=O AMPICRWPLIJTSR-UHFFFAOYSA-N 0.000 description 1
- FVWXVNGQVMGYQL-UHFFFAOYSA-N CCC(C)(C)C(CC1)CCC1(CN1c(cc(cc2)Cl)c2Cl)N(Cc(cc2)ccc2C(NCCC(O)=O)=O)C1=O Chemical compound CCC(C)(C)C(CC1)CCC1(CN1c(cc(cc2)Cl)c2Cl)N(Cc(cc2)ccc2C(NCCC(O)=O)=O)C1=O FVWXVNGQVMGYQL-UHFFFAOYSA-N 0.000 description 1
- NYIOLAWHSMOPIS-UHFFFAOYSA-N O=C(c1ccc(CN(C2(CN3c(cc4)ccc4OC(F)(F)F)CCN(Cc4ccccc4)CC2)C3=O)cc1)Nc1n[n]c[nH]1 Chemical compound O=C(c1ccc(CN(C2(CN3c(cc4)ccc4OC(F)(F)F)CCN(Cc4ccccc4)CC2)C3=O)cc1)Nc1n[n]c[nH]1 NYIOLAWHSMOPIS-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US43079902P | 2002-12-04 | 2002-12-04 | |
| PCT/US2003/038590 WO2004050039A2 (en) | 2002-12-04 | 2003-11-26 | Spirocyclic ureas, compositions containing such compounds and methods of use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006509015A JP2006509015A (ja) | 2006-03-16 |
| JP2006509015A5 true JP2006509015A5 (https=) | 2006-08-03 |
Family
ID=32469534
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004557589A Withdrawn JP2006509015A (ja) | 2002-12-04 | 2003-11-26 | スピロ環尿素、そのような化合物を含有する組成物、及び使用方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20060116366A1 (https=) |
| EP (1) | EP1569915A4 (https=) |
| JP (1) | JP2006509015A (https=) |
| AU (1) | AU2003298889A1 (https=) |
| CA (1) | CA2508581A1 (https=) |
| WO (1) | WO2004050039A2 (https=) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7572922B2 (en) | 2003-01-27 | 2009-08-11 | Merck & Co., Inc. | Substituted pyrazoles, compositions containing such compounds and methods of use |
| DE602005006806D1 (de) | 2004-06-04 | 2008-06-26 | Merck & Co Inc | Pyrazolderivate, zusammensetzungen, die solche verbindungen enthalten, und anwendungsverfahren |
| AU2005272043B2 (en) * | 2004-07-07 | 2010-07-29 | Merck Sharp & Dohme Corp. | Pyrazole amide derivatives, compositions containing such compounds and methods of use |
| US7625938B2 (en) | 2004-07-22 | 2009-12-01 | Merck & Co., Inc. | Substituted pyrazoles, compositions containing such compounds and methods of use |
| US8318760B2 (en) | 2005-03-21 | 2012-11-27 | Merck Sharp & Dohme Corp. | Substituted aryl and heteroaryl derivatives, compositions containing such compounds and methods of use |
| US8211904B2 (en) | 2005-07-18 | 2012-07-03 | Merck, Sharp & Dohme Corp. | Spiropiperidine beta-secretase inhibitors for the treatment of alzheimer's disease |
| JP2009502923A (ja) | 2005-07-26 | 2009-01-29 | メルク エンド カムパニー インコーポレーテッド | 置換ピラゾールを合成するための方法 |
| TW200745031A (en) | 2005-10-13 | 2007-12-16 | Merck & Co Inc | Acyl indoles, compositions containing such compounds and methods of use |
| US7989472B2 (en) | 2006-03-23 | 2011-08-02 | Merck Sharp & Dohme Corp. | Glucagon receptor antagonist compounds, compositions containing such compounds and methods of use |
| WO2007136577A2 (en) | 2006-05-16 | 2007-11-29 | Merck & Co., Inc. | Glucagon receptor antagonist compounds, compositions containing such compounds and methods of use |
| CA2668065A1 (en) | 2006-10-30 | 2008-05-08 | Merck & Co., Inc. | Spiropiperidine beta-secretase inhibitors for the treatment of alzheimer's disease |
| KR20190126460A (ko) | 2007-02-09 | 2019-11-11 | 메타베이시스 테라퓨틱스, 인크. | 글루카곤 수용체의 길항제 |
| CA2770298C (en) | 2008-08-13 | 2017-06-20 | Metabasis Therapeutics, Inc. | Glucagon antagonists |
| WO2011119559A1 (en) * | 2010-03-25 | 2011-09-29 | Schering Corporation | Novel spiro imidazolones as glucagon receptor antagonists, compositions, and methods for their use |
| EP2552209A4 (en) * | 2010-03-26 | 2014-01-22 | Merck Sharp & Dohme | NEW SPIROIMIDAZOLON DERIVATIVES AS GLUCAGON RECEPTOR ANTAGONISTS, COMPOSITIONS AND METHOD FOR THEIR USE |
| JP2014040374A (ja) * | 2010-12-15 | 2014-03-06 | Taisho Pharmaceutical Co Ltd | グリシントランスポーター阻害物質 |
| MX2013006768A (es) | 2010-12-23 | 2013-07-22 | Pfizer | Moduladores de receptor de glucagon. |
| HRP20161177T1 (hr) | 2011-02-08 | 2016-11-04 | Pfizer Inc. | Modulator glukagonskog receptora |
| AU2012288493B2 (en) | 2011-07-22 | 2015-08-06 | Pfizer Inc. | Quinolinyl glucagon receptor modulators |
| US8742111B1 (en) * | 2013-02-21 | 2014-06-03 | The United States Of America As Represented By The Secretary Of The Army | Synthesis of intermediate anilino methyl esters used in the production of synthetic opioid analgesics |
| EP3065736B1 (en) | 2013-11-04 | 2018-11-14 | Merck Sharp & Dohme Corp. | Glucagon receptor antagonist compounds, compositions thereof, and methods of use |
| WO2015191900A1 (en) | 2014-06-12 | 2015-12-17 | Ligand Pharmaceuticals, Inc. | Glucagon antagonists |
| ES2829550T3 (es) * | 2016-07-07 | 2021-06-01 | Bristol Myers Squibb Co | Ureas cíclicas espiro-condensadas como inhibidores de ROCK |
| WO2018015235A1 (en) * | 2016-07-18 | 2018-01-25 | F. Hoffmann-La Roche Ag | Ethynyl derivatives |
| WO2019160940A1 (en) | 2018-02-13 | 2019-08-22 | Ligand Pharmaceuticals Incorporated | Glucagon receptor antagonists |
| WO2021078132A1 (en) * | 2019-10-21 | 2021-04-29 | Sironax Ltd | Inhibitors of mtor-mediated induction of autophagy |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4556670A (en) * | 1982-12-06 | 1985-12-03 | Pfizer Inc. | Spiro-3-hetero-azolones for treatment of diabetic complications |
| FR2677984B1 (fr) * | 1991-06-21 | 1994-02-25 | Elf Sanofi | Derives d'imidazoline n-substitues, leur preparation, les compositions pharmaceutiques en contenant. |
| DE4201709A1 (de) * | 1992-01-23 | 1993-07-29 | Bayer Ag | (alpha)-aryl-(alpha)-hydroxy-ss-imidazolinyl-propionsaeureamide |
| KR19990012061A (ko) * | 1997-07-26 | 1999-02-25 | 성재갑 | 파네실 전이효소 저해제로 유용한 하이덴토인 유도체 |
| US6384061B1 (en) * | 1997-07-26 | 2002-05-07 | Lg Chemical Ltd. | Hydantoin compounds and methods related thereto |
-
2003
- 2003-11-26 WO PCT/US2003/038590 patent/WO2004050039A2/en not_active Ceased
- 2003-11-26 CA CA002508581A patent/CA2508581A1/en not_active Abandoned
- 2003-11-26 JP JP2004557589A patent/JP2006509015A/ja not_active Withdrawn
- 2003-11-26 EP EP03796648A patent/EP1569915A4/en not_active Withdrawn
- 2003-11-26 US US10/537,187 patent/US20060116366A1/en not_active Abandoned
- 2003-11-26 AU AU2003298889A patent/AU2003298889A1/en not_active Abandoned