JP2005539009A5 - - Google Patents
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- JP2005539009A5 JP2005539009A5 JP2004526000A JP2004526000A JP2005539009A5 JP 2005539009 A5 JP2005539009 A5 JP 2005539009A5 JP 2004526000 A JP2004526000 A JP 2004526000A JP 2004526000 A JP2004526000 A JP 2004526000A JP 2005539009 A5 JP2005539009 A5 JP 2005539009A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- carbon atoms
- xsz
- branched
- linear
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 CC/C1=C\C(\C(*)=N)=C/C=C(\C)/CC1* Chemical compound CC/C1=C\C(\C(*)=N)=C/C=C(\C)/CC1* 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US21011202A | 2002-08-02 | 2002-08-02 | |
| US10/369,563 US7390898B2 (en) | 2002-08-02 | 2003-02-21 | Cytotoxic agents containing novel potent taxanes and their therapeutic use |
| PCT/US2003/019558 WO2004013093A2 (en) | 2002-08-02 | 2003-07-14 | Cytotoxic agents containing novel potent taxanes and their therapeutic use |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010004372A Division JP2010106040A (ja) | 2002-08-02 | 2010-01-12 | 新規の効力のあるタキサンを含む細胞毒性物質、および、それらの治療用途 |
| JP2010004383A Division JP2010111695A (ja) | 2002-08-02 | 2010-01-12 | 新規の効力のあるタキサンを含む細胞毒性物質、および、それらの治療用途 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005539009A JP2005539009A (ja) | 2005-12-22 |
| JP2005539009A5 true JP2005539009A5 (https=) | 2006-02-09 |
Family
ID=31498026
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004526000A Pending JP2005539009A (ja) | 2002-08-02 | 2003-07-14 | 新規の効力のあるタキサンを含む細胞毒性物質、および、それらの治療用途 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US7495114B2 (https=) |
| EP (1) | EP1534674A4 (https=) |
| JP (1) | JP2005539009A (https=) |
| KR (1) | KR20050032110A (https=) |
| CN (1) | CN100522955C (https=) |
| AU (1) | AU2003247587B2 (https=) |
| BR (1) | BR0313197A (https=) |
| CA (1) | CA2494074A1 (https=) |
| IL (1) | IL166624A0 (https=) |
| MX (1) | MXPA05001390A (https=) |
| NO (1) | NO20051108L (https=) |
| WO (1) | WO2004013093A2 (https=) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1392359B2 (en) | 2001-05-11 | 2013-03-13 | Ludwig Institute for Cancer Research Ltd. | Specific binding proteins and uses thereof |
| US20100056762A1 (en) | 2001-05-11 | 2010-03-04 | Old Lloyd J | Specific binding proteins and uses thereof |
| AU2004311630A1 (en) * | 2003-12-02 | 2005-07-21 | Cytimmune Sciences, Inc. | Methods and compositions for the production of monoclonal antibodies |
| EP1715971A4 (en) * | 2004-01-28 | 2010-10-13 | Cytimmune Sciences Inc | FUNCTIONALIZED COLLOIDAL METAL COMPOSITIONS AND METHODS |
| BRPI0511754A (pt) * | 2004-06-03 | 2008-01-02 | Smithkline Beechman Cork Ltd | uso de um composto ou sais ou solvatos do mesmo |
| EP1688415A1 (en) * | 2004-12-07 | 2006-08-09 | Aventis Pharma S.A. | Cytotoxic agents comprising new C-2 modified taxanes |
| EP1669358A1 (en) * | 2004-12-07 | 2006-06-14 | Aventis Pharma S.A. | Cytotoxic agents comprising new taxanes |
| AU2006247471A1 (en) * | 2005-05-12 | 2006-11-23 | Tapestry Pharmaceuticals, Inc. | Molecular constructs suitable for targeted conjugates |
| ES2673822T3 (es) | 2006-07-18 | 2018-06-25 | Sanofi | Anticuerpo antagonista contra EphA2 para el tratamiento de cáncer |
| US9090693B2 (en) * | 2007-01-25 | 2015-07-28 | Dana-Farber Cancer Institute | Use of anti-EGFR antibodies in treatment of EGFR mutant mediated disease |
| ES2542152T3 (es) * | 2007-03-15 | 2015-07-31 | Ludwig Institute For Cancer Research Ltd. | Método de tratamiento que emplea anticuerpos de EGFR e inhibidores de Src y formulaciones relacionadas |
| CN108424454B (zh) | 2007-08-14 | 2022-05-31 | 路德维格癌症研究所有限公司 | 靶向egf受体的单克隆抗体175及其衍生物和用途 |
| US20110014118A1 (en) * | 2007-09-21 | 2011-01-20 | Lawrence Tamarkin | Nanotherapeutic colloidal metal compositions and methods |
| US20090104114A1 (en) * | 2007-09-21 | 2009-04-23 | Cytimmune Sciences, Inc. | Nanotherapeutic Colloidal Metal Compositions and Methods |
| EP2217063B1 (en) * | 2007-11-08 | 2014-12-17 | Virginia Tech Intellectual Properties, Inc. | Thiolated paclitaxels for reaction with gold nanoparticles as drug delivery agents |
| CN102365021B (zh) | 2009-02-05 | 2015-07-15 | 伊缪诺金公司 | 新型苯并二氮杂*衍生物 |
| US20110076232A1 (en) * | 2009-09-29 | 2011-03-31 | Ludwig Institute For Cancer Research | Specific binding proteins and uses thereof |
| ES2702400T3 (es) * | 2010-02-03 | 2019-02-28 | Oncbiomune Inc | Composiciones que contienen un taxano o un taxoide y una proteína |
| TW201129384A (en) | 2010-02-10 | 2011-09-01 | Immunogen Inc | CD20 antibodies and uses thereof |
| JP6049642B2 (ja) | 2011-02-15 | 2016-12-21 | イミュノジェン・インコーポレーテッド | 複合体の調製方法 |
| CN103648532A (zh) | 2011-06-21 | 2014-03-19 | 伊缪诺金公司 | 具有肽连接子的新型美登木素生物碱衍生物及其偶联物 |
| WO2014089177A2 (en) | 2012-12-04 | 2014-06-12 | Massachusetts Institute Of Technology | Compounds, conjugates and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines |
| US10208125B2 (en) | 2013-07-15 | 2019-02-19 | University of Pittsburgh—of the Commonwealth System of Higher Education | Anti-mucin 1 binding agents and uses thereof |
| CN105121419B (zh) * | 2013-12-24 | 2016-08-03 | 于跃 | Cabazitaxel类抗多药耐药紫杉烷类抗肿瘤化合物及其制备方法 |
| US9943606B2 (en) | 2014-01-15 | 2018-04-17 | Rutgers, The State University Of New Jersey | Dendritic polypeptide-based nanocarriers for the delivery of therapeutic agents |
| EP3189057A1 (en) | 2014-09-03 | 2017-07-12 | ImmunoGen, Inc. | Cytotoxic benzodiazepine derivatives |
| ES2815353T3 (es) | 2014-09-03 | 2021-03-29 | Immunogen Inc | Derivados de benzodiazepina citotóxicos |
| WO2016090157A1 (en) | 2014-12-04 | 2016-06-09 | Celgene Corporation | Biomolecule conjugates |
| EP3769787A1 (en) | 2015-06-29 | 2021-01-27 | ImmunoGen, Inc. | Conjugates of cysteine engineered antibodies |
| SG10202106529XA (en) | 2015-07-21 | 2021-07-29 | Immunogen Inc | Methods of preparing cytotoxic benzodiazepine derivatives |
| PT3380525T (pt) | 2015-11-25 | 2024-02-05 | Immunogen Inc | Formulações farmacêuticas e métodos que as utilizam |
| US10918627B2 (en) | 2016-05-11 | 2021-02-16 | Massachusetts Institute Of Technology | Convergent and enantioselective total synthesis of Communesin analogs |
| TWI845890B (zh) | 2016-11-23 | 2024-06-21 | 美商伊繆諾金公司 | 苯二氮平衍生物之選擇性磺化 |
| EP3554544A4 (en) | 2016-12-16 | 2020-07-29 | Bluefin Biomedicine, Inc. | ANTI-PROTEIN 1 ANTIBODY CONTAINING AN ANTI-CUB DOMAIN (CDCP1), ANTIBODY-DRUG CONJUGATES AND THEIR METHODS OF USE |
| KR20250171447A (ko) | 2017-02-28 | 2025-12-08 | 이뮤노젠 아이엔씨 | 자기희생적 펩티드 링커 및 이들의 접합체를 갖는 메이탄시노이드 유도체 |
| WO2018195243A1 (en) | 2017-04-20 | 2018-10-25 | Immunogen, Inc. | Cytotoxic benzodiazepine derivatives and conjugates thereof |
| WO2018209239A1 (en) | 2017-05-11 | 2018-11-15 | Massachusetts Institute Of Technology | Potent agelastatin derivatives as modulators for cancer invasion and metastasis |
| US10640508B2 (en) | 2017-10-13 | 2020-05-05 | Massachusetts Institute Of Technology | Diazene directed modular synthesis of compounds with quaternary carbon centers |
| TW202413360A (zh) | 2017-12-28 | 2024-04-01 | 美商伊繆諾金公司 | 苯二氮平衍生物 |
| AU2020241896A1 (en) | 2019-03-20 | 2021-09-23 | The Regents Of The University Of California | Claudin-6 antibodies and drug conjugates |
| JP7682797B2 (ja) | 2019-03-20 | 2025-05-26 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | クローディン6二重特異性抗体 |
| EP3947395A1 (en) | 2019-03-29 | 2022-02-09 | ImmunoGen, Inc. | Cytotoxic bis-benzodiazepine derivatives and conjugates thereof with cell-binding agents for inhibiting abnormal cell growth or for treating proliferative diseases |
| JP7561141B2 (ja) | 2019-04-26 | 2024-10-03 | イミュノジェン・インコーポレーテッド | カンプトテシン誘導体 |
| US11535634B2 (en) | 2019-06-05 | 2022-12-27 | Massachusetts Institute Of Technology | Compounds, conjugates, and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines and uses thereof |
| MX2022010457A (es) | 2020-02-25 | 2022-11-16 | Mediboston Ltd | Derivados de camptotecina y conjugados de esta. |
| EP4178624A2 (en) | 2020-07-07 | 2023-05-17 | Bionecure Therapeutics, Inc. | Maytansinoids as adc payloads and their use for the treatment of cancer |
| WO2022182415A1 (en) | 2021-02-24 | 2022-09-01 | Massachusetts Institute Of Technology | Himastatin derivatives, and processes of preparation thereof, and uses thereof |
| US12521444B2 (en) | 2021-02-25 | 2026-01-13 | Fortvita Biologics Limited | Anti-HER2 antibody-drug conjugates and uses thereof |
| JP2025524986A (ja) | 2022-07-27 | 2025-08-01 | メディボストン リミテッド | オーリスタチン誘導体およびそのコンジュゲート |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE120454T1 (de) | 1988-06-14 | 1995-04-15 | Cetus Oncology Corp | Kupplungsmittel und sterisch gehinderte, mit disulfid gebundene konjugate daraus. |
| US5208020A (en) | 1989-10-25 | 1993-05-04 | Immunogen Inc. | Cytotoxic agents comprising maytansinoids and their therapeutic use |
| US5399726A (en) | 1993-01-29 | 1995-03-21 | Florida State University | Process for the preparation of baccatin III analogs bearing new C2 and C4 functional groups |
| US5728725A (en) | 1991-09-23 | 1998-03-17 | Florida State University | C2 taxane derivaties and pharmaceutical compositions containing them |
| US6028205A (en) | 1991-09-23 | 2000-02-22 | Florida State University | C2 tricyclic taxanes |
| ES2149768T3 (es) | 1992-03-25 | 2000-11-16 | Immunogen Inc | Conjugados de agentes enlazantes de celulas derivados de cc-1065. |
| US5356928A (en) * | 1992-11-06 | 1994-10-18 | Hauser Chemical Research, Inc. | Cytotoxic agents |
| US5646176A (en) * | 1992-12-24 | 1997-07-08 | Bristol-Myers Squibb Company | Phosphonooxymethyl ethers of taxane derivatives |
| IL108443A0 (en) * | 1993-01-29 | 1994-04-12 | Univ Florida State | C7 taxane derivatives and pharmaceutical compositions containing them |
| US6339164B1 (en) | 1993-01-29 | 2002-01-15 | Florida State University | C2 substituted phenyl taxane derivatives and pharmaceutical compositions containing them |
| US5703247A (en) * | 1993-03-11 | 1997-12-30 | Virginia Tech Intellectual Properties, Inc. | 2-Debenzoyl-2-acyl taxol derivatives and methods for making same |
| US5475011A (en) | 1993-03-26 | 1995-12-12 | The Research Foundation Of State University Of New York | Anti-tumor compounds, pharmaceutical compositions, methods for preparation thereof and for treatment |
| US6214345B1 (en) | 1993-05-14 | 2001-04-10 | Bristol-Myers Squibb Co. | Lysosomal enzyme-cleavable antitumor drug conjugates |
| CA2129288C (en) * | 1993-08-17 | 2000-05-16 | Jerzy Golik | Phosphonooxymethyl esters of taxane derivatives |
| US5824701A (en) | 1993-10-20 | 1998-10-20 | Enzon, Inc. | Taxane-based prodrugs |
| WO1996011683A1 (en) * | 1994-10-14 | 1996-04-25 | Hauser Chemical Research, Inc. | New cytotoxic agents |
| WO1996023779A1 (en) * | 1995-02-02 | 1996-08-08 | Daiichi Pharmaceutical Co., Ltd. | Ether derivative |
| CN1211919A (zh) * | 1995-09-13 | 1999-03-24 | 佛罗里达州立大学 | 放射增敏性紫杉烷及其药物制剂 |
| WO1997044026A1 (en) | 1996-05-22 | 1997-11-27 | Neuromedica, Inc. | Compositions comprising conjugates of cis-docosahexaenoic acid and taxotere |
| JP2001505194A (ja) | 1996-11-05 | 2001-04-17 | ブリストル―マイヤーズ・スクイブ・カンパニー | 分枝ペプチド・リンカー |
| US5811452A (en) | 1997-01-08 | 1998-09-22 | The Research Foundation Of State University Of New York | Taxoid reversal agents for drug-resistance in cancer chemotherapy and pharmaceutical compositions thereof |
| IL132941A0 (en) | 1997-05-21 | 2001-03-19 | Univ Leland Stanford Junior | Composition and method for enhancing transport across biological membranes |
| WO1999018113A1 (fr) * | 1997-10-08 | 1999-04-15 | Bio Research Corporation Of Yokohama | Derives taxoides et leur procede de production |
| US6545125B1 (en) | 1997-11-18 | 2003-04-08 | Chugai Seiyaku Kabushiki Kaisha | Compounds with antitumor activity |
| US6958212B1 (en) | 1999-02-01 | 2005-10-25 | Eidgenossische Technische Hochschule Zurich | Conjugate addition reactions for the controlled delivery of pharmaceutically active compounds |
| AU768027B2 (en) * | 1999-02-24 | 2003-11-27 | Uab Research Foundation, The | Taxane derivatives for targeted therapy of cancer |
| ES2276708T3 (es) * | 1999-11-24 | 2007-07-01 | Immunogen, Inc. | Agentes citotoxicos que comprenden taxanos y su uso terapeutico. |
| US6175023B1 (en) | 2000-01-31 | 2001-01-16 | Jian Liu | Synthesis of water soluble 9-dihydro-paclitaxel derivatives from 9-dihydro-13-acetylbaccatin III |
| IL145637A0 (en) * | 2000-02-02 | 2002-06-30 | Univ Florida State Res Found | C7 carbonate substituted taxanes as antitumor agents |
| AU778991B2 (en) * | 2000-02-02 | 2004-12-23 | Florida State University Research Foundation, Inc. | C7 carbamoyloxy substituted taxanes as antitumor agents |
| AU776765B2 (en) * | 2000-02-02 | 2004-09-23 | Florida State University Research Foundation, Inc. | C7 heterosubstituted acetate taxanes as antitumor agents |
| KR20010111580A (ko) * | 2000-02-02 | 2001-12-19 | 플로리다 스테이트 유니버시티 리서치 파운데이션, 인크 | 개선된 용해도를 갖는 탁산 제형물 |
| CZ20013523A3 (cs) * | 2000-02-02 | 2002-03-13 | Florida State University Research Foundation, Inc. | Taxany s C10 heterosubstituovaným acetátem jako protinádorové látky |
| US6596757B1 (en) * | 2002-05-14 | 2003-07-22 | Immunogen Inc. | Cytotoxic agents comprising polyethylene glycol-containing taxanes and their therapeutic use |
-
2003
- 2003-07-14 CN CNB038232480A patent/CN100522955C/zh not_active Expired - Fee Related
- 2003-07-14 CA CA002494074A patent/CA2494074A1/en not_active Abandoned
- 2003-07-14 WO PCT/US2003/019558 patent/WO2004013093A2/en not_active Ceased
- 2003-07-14 KR KR1020057001946A patent/KR20050032110A/ko not_active Ceased
- 2003-07-14 JP JP2004526000A patent/JP2005539009A/ja active Pending
- 2003-07-14 EP EP03766820A patent/EP1534674A4/en not_active Withdrawn
- 2003-07-14 MX MXPA05001390A patent/MXPA05001390A/es active IP Right Grant
- 2003-07-14 AU AU2003247587A patent/AU2003247587B2/en not_active Ceased
- 2003-07-14 BR BR0313197-1A patent/BR0313197A/pt not_active IP Right Cessation
-
2004
- 2004-08-26 US US10/926,192 patent/US7495114B2/en not_active Expired - Fee Related
- 2004-10-14 US US10/963,711 patent/US7414073B2/en not_active Expired - Fee Related
-
2005
- 2005-02-01 IL IL16662405A patent/IL166624A0/xx unknown
- 2005-03-01 NO NO20051108A patent/NO20051108L/no unknown
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