JP2005539009A5 - - Google Patents

Download PDF

Info

Publication number
JP2005539009A5
JP2005539009A5 JP2004526000A JP2004526000A JP2005539009A5 JP 2005539009 A5 JP2005539009 A5 JP 2005539009A5 JP 2004526000 A JP2004526000 A JP 2004526000A JP 2004526000 A JP2004526000 A JP 2004526000A JP 2005539009 A5 JP2005539009 A5 JP 2005539009A5
Authority
JP
Japan
Prior art keywords
group
carbon atoms
xsz
branched
linear
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2004526000A
Other languages
English (en)
Japanese (ja)
Other versions
JP2005539009A (ja
Filing date
Publication date
Priority claimed from US10/369,563 external-priority patent/US7390898B2/en
Application filed filed Critical
Priority claimed from PCT/US2003/019558 external-priority patent/WO2004013093A2/en
Publication of JP2005539009A publication Critical patent/JP2005539009A/ja
Publication of JP2005539009A5 publication Critical patent/JP2005539009A5/ja
Pending legal-status Critical Current

Links

JP2004526000A 2002-08-02 2003-07-14 新規の効力のあるタキサンを含む細胞毒性物質、および、それらの治療用途 Pending JP2005539009A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US21011202A 2002-08-02 2002-08-02
US10/369,563 US7390898B2 (en) 2002-08-02 2003-02-21 Cytotoxic agents containing novel potent taxanes and their therapeutic use
PCT/US2003/019558 WO2004013093A2 (en) 2002-08-02 2003-07-14 Cytotoxic agents containing novel potent taxanes and their therapeutic use

Related Child Applications (2)

Application Number Title Priority Date Filing Date
JP2010004372A Division JP2010106040A (ja) 2002-08-02 2010-01-12 新規の効力のあるタキサンを含む細胞毒性物質、および、それらの治療用途
JP2010004383A Division JP2010111695A (ja) 2002-08-02 2010-01-12 新規の効力のあるタキサンを含む細胞毒性物質、および、それらの治療用途

Publications (2)

Publication Number Publication Date
JP2005539009A JP2005539009A (ja) 2005-12-22
JP2005539009A5 true JP2005539009A5 (https=) 2006-02-09

Family

ID=31498026

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2004526000A Pending JP2005539009A (ja) 2002-08-02 2003-07-14 新規の効力のあるタキサンを含む細胞毒性物質、および、それらの治療用途

Country Status (12)

Country Link
US (2) US7495114B2 (https=)
EP (1) EP1534674A4 (https=)
JP (1) JP2005539009A (https=)
KR (1) KR20050032110A (https=)
CN (1) CN100522955C (https=)
AU (1) AU2003247587B2 (https=)
BR (1) BR0313197A (https=)
CA (1) CA2494074A1 (https=)
IL (1) IL166624A0 (https=)
MX (1) MXPA05001390A (https=)
NO (1) NO20051108L (https=)
WO (1) WO2004013093A2 (https=)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1392359B2 (en) 2001-05-11 2013-03-13 Ludwig Institute for Cancer Research Ltd. Specific binding proteins and uses thereof
US20100056762A1 (en) 2001-05-11 2010-03-04 Old Lloyd J Specific binding proteins and uses thereof
AU2004311630A1 (en) * 2003-12-02 2005-07-21 Cytimmune Sciences, Inc. Methods and compositions for the production of monoclonal antibodies
EP1715971A4 (en) * 2004-01-28 2010-10-13 Cytimmune Sciences Inc FUNCTIONALIZED COLLOIDAL METAL COMPOSITIONS AND METHODS
BRPI0511754A (pt) * 2004-06-03 2008-01-02 Smithkline Beechman Cork Ltd uso de um composto ou sais ou solvatos do mesmo
EP1688415A1 (en) * 2004-12-07 2006-08-09 Aventis Pharma S.A. Cytotoxic agents comprising new C-2 modified taxanes
EP1669358A1 (en) * 2004-12-07 2006-06-14 Aventis Pharma S.A. Cytotoxic agents comprising new taxanes
AU2006247471A1 (en) * 2005-05-12 2006-11-23 Tapestry Pharmaceuticals, Inc. Molecular constructs suitable for targeted conjugates
ES2673822T3 (es) 2006-07-18 2018-06-25 Sanofi Anticuerpo antagonista contra EphA2 para el tratamiento de cáncer
US9090693B2 (en) * 2007-01-25 2015-07-28 Dana-Farber Cancer Institute Use of anti-EGFR antibodies in treatment of EGFR mutant mediated disease
ES2542152T3 (es) * 2007-03-15 2015-07-31 Ludwig Institute For Cancer Research Ltd. Método de tratamiento que emplea anticuerpos de EGFR e inhibidores de Src y formulaciones relacionadas
CN108424454B (zh) 2007-08-14 2022-05-31 路德维格癌症研究所有限公司 靶向egf受体的单克隆抗体175及其衍生物和用途
US20110014118A1 (en) * 2007-09-21 2011-01-20 Lawrence Tamarkin Nanotherapeutic colloidal metal compositions and methods
US20090104114A1 (en) * 2007-09-21 2009-04-23 Cytimmune Sciences, Inc. Nanotherapeutic Colloidal Metal Compositions and Methods
EP2217063B1 (en) * 2007-11-08 2014-12-17 Virginia Tech Intellectual Properties, Inc. Thiolated paclitaxels for reaction with gold nanoparticles as drug delivery agents
CN102365021B (zh) 2009-02-05 2015-07-15 伊缪诺金公司 新型苯并二氮杂*衍生物
US20110076232A1 (en) * 2009-09-29 2011-03-31 Ludwig Institute For Cancer Research Specific binding proteins and uses thereof
ES2702400T3 (es) * 2010-02-03 2019-02-28 Oncbiomune Inc Composiciones que contienen un taxano o un taxoide y una proteína
TW201129384A (en) 2010-02-10 2011-09-01 Immunogen Inc CD20 antibodies and uses thereof
JP6049642B2 (ja) 2011-02-15 2016-12-21 イミュノジェン・インコーポレーテッド 複合体の調製方法
CN103648532A (zh) 2011-06-21 2014-03-19 伊缪诺金公司 具有肽连接子的新型美登木素生物碱衍生物及其偶联物
WO2014089177A2 (en) 2012-12-04 2014-06-12 Massachusetts Institute Of Technology Compounds, conjugates and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines
US10208125B2 (en) 2013-07-15 2019-02-19 University of Pittsburgh—of the Commonwealth System of Higher Education Anti-mucin 1 binding agents and uses thereof
CN105121419B (zh) * 2013-12-24 2016-08-03 于跃 Cabazitaxel类抗多药耐药紫杉烷类抗肿瘤化合物及其制备方法
US9943606B2 (en) 2014-01-15 2018-04-17 Rutgers, The State University Of New Jersey Dendritic polypeptide-based nanocarriers for the delivery of therapeutic agents
EP3189057A1 (en) 2014-09-03 2017-07-12 ImmunoGen, Inc. Cytotoxic benzodiazepine derivatives
ES2815353T3 (es) 2014-09-03 2021-03-29 Immunogen Inc Derivados de benzodiazepina citotóxicos
WO2016090157A1 (en) 2014-12-04 2016-06-09 Celgene Corporation Biomolecule conjugates
EP3769787A1 (en) 2015-06-29 2021-01-27 ImmunoGen, Inc. Conjugates of cysteine engineered antibodies
SG10202106529XA (en) 2015-07-21 2021-07-29 Immunogen Inc Methods of preparing cytotoxic benzodiazepine derivatives
PT3380525T (pt) 2015-11-25 2024-02-05 Immunogen Inc Formulações farmacêuticas e métodos que as utilizam
US10918627B2 (en) 2016-05-11 2021-02-16 Massachusetts Institute Of Technology Convergent and enantioselective total synthesis of Communesin analogs
TWI845890B (zh) 2016-11-23 2024-06-21 美商伊繆諾金公司 苯二氮平衍生物之選擇性磺化
EP3554544A4 (en) 2016-12-16 2020-07-29 Bluefin Biomedicine, Inc. ANTI-PROTEIN 1 ANTIBODY CONTAINING AN ANTI-CUB DOMAIN (CDCP1), ANTIBODY-DRUG CONJUGATES AND THEIR METHODS OF USE
KR20250171447A (ko) 2017-02-28 2025-12-08 이뮤노젠 아이엔씨 자기희생적 펩티드 링커 및 이들의 접합체를 갖는 메이탄시노이드 유도체
WO2018195243A1 (en) 2017-04-20 2018-10-25 Immunogen, Inc. Cytotoxic benzodiazepine derivatives and conjugates thereof
WO2018209239A1 (en) 2017-05-11 2018-11-15 Massachusetts Institute Of Technology Potent agelastatin derivatives as modulators for cancer invasion and metastasis
US10640508B2 (en) 2017-10-13 2020-05-05 Massachusetts Institute Of Technology Diazene directed modular synthesis of compounds with quaternary carbon centers
TW202413360A (zh) 2017-12-28 2024-04-01 美商伊繆諾金公司 苯二氮平衍生物
AU2020241896A1 (en) 2019-03-20 2021-09-23 The Regents Of The University Of California Claudin-6 antibodies and drug conjugates
JP7682797B2 (ja) 2019-03-20 2025-05-26 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア クローディン6二重特異性抗体
EP3947395A1 (en) 2019-03-29 2022-02-09 ImmunoGen, Inc. Cytotoxic bis-benzodiazepine derivatives and conjugates thereof with cell-binding agents for inhibiting abnormal cell growth or for treating proliferative diseases
JP7561141B2 (ja) 2019-04-26 2024-10-03 イミュノジェン・インコーポレーテッド カンプトテシン誘導体
US11535634B2 (en) 2019-06-05 2022-12-27 Massachusetts Institute Of Technology Compounds, conjugates, and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines and uses thereof
MX2022010457A (es) 2020-02-25 2022-11-16 Mediboston Ltd Derivados de camptotecina y conjugados de esta.
EP4178624A2 (en) 2020-07-07 2023-05-17 Bionecure Therapeutics, Inc. Maytansinoids as adc payloads and their use for the treatment of cancer
WO2022182415A1 (en) 2021-02-24 2022-09-01 Massachusetts Institute Of Technology Himastatin derivatives, and processes of preparation thereof, and uses thereof
US12521444B2 (en) 2021-02-25 2026-01-13 Fortvita Biologics Limited Anti-HER2 antibody-drug conjugates and uses thereof
JP2025524986A (ja) 2022-07-27 2025-08-01 メディボストン リミテッド オーリスタチン誘導体およびそのコンジュゲート

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE120454T1 (de) 1988-06-14 1995-04-15 Cetus Oncology Corp Kupplungsmittel und sterisch gehinderte, mit disulfid gebundene konjugate daraus.
US5208020A (en) 1989-10-25 1993-05-04 Immunogen Inc. Cytotoxic agents comprising maytansinoids and their therapeutic use
US5399726A (en) 1993-01-29 1995-03-21 Florida State University Process for the preparation of baccatin III analogs bearing new C2 and C4 functional groups
US5728725A (en) 1991-09-23 1998-03-17 Florida State University C2 taxane derivaties and pharmaceutical compositions containing them
US6028205A (en) 1991-09-23 2000-02-22 Florida State University C2 tricyclic taxanes
ES2149768T3 (es) 1992-03-25 2000-11-16 Immunogen Inc Conjugados de agentes enlazantes de celulas derivados de cc-1065.
US5356928A (en) * 1992-11-06 1994-10-18 Hauser Chemical Research, Inc. Cytotoxic agents
US5646176A (en) * 1992-12-24 1997-07-08 Bristol-Myers Squibb Company Phosphonooxymethyl ethers of taxane derivatives
IL108443A0 (en) * 1993-01-29 1994-04-12 Univ Florida State C7 taxane derivatives and pharmaceutical compositions containing them
US6339164B1 (en) 1993-01-29 2002-01-15 Florida State University C2 substituted phenyl taxane derivatives and pharmaceutical compositions containing them
US5703247A (en) * 1993-03-11 1997-12-30 Virginia Tech Intellectual Properties, Inc. 2-Debenzoyl-2-acyl taxol derivatives and methods for making same
US5475011A (en) 1993-03-26 1995-12-12 The Research Foundation Of State University Of New York Anti-tumor compounds, pharmaceutical compositions, methods for preparation thereof and for treatment
US6214345B1 (en) 1993-05-14 2001-04-10 Bristol-Myers Squibb Co. Lysosomal enzyme-cleavable antitumor drug conjugates
CA2129288C (en) * 1993-08-17 2000-05-16 Jerzy Golik Phosphonooxymethyl esters of taxane derivatives
US5824701A (en) 1993-10-20 1998-10-20 Enzon, Inc. Taxane-based prodrugs
WO1996011683A1 (en) * 1994-10-14 1996-04-25 Hauser Chemical Research, Inc. New cytotoxic agents
WO1996023779A1 (en) * 1995-02-02 1996-08-08 Daiichi Pharmaceutical Co., Ltd. Ether derivative
CN1211919A (zh) * 1995-09-13 1999-03-24 佛罗里达州立大学 放射增敏性紫杉烷及其药物制剂
WO1997044026A1 (en) 1996-05-22 1997-11-27 Neuromedica, Inc. Compositions comprising conjugates of cis-docosahexaenoic acid and taxotere
JP2001505194A (ja) 1996-11-05 2001-04-17 ブリストル―マイヤーズ・スクイブ・カンパニー 分枝ペプチド・リンカー
US5811452A (en) 1997-01-08 1998-09-22 The Research Foundation Of State University Of New York Taxoid reversal agents for drug-resistance in cancer chemotherapy and pharmaceutical compositions thereof
IL132941A0 (en) 1997-05-21 2001-03-19 Univ Leland Stanford Junior Composition and method for enhancing transport across biological membranes
WO1999018113A1 (fr) * 1997-10-08 1999-04-15 Bio Research Corporation Of Yokohama Derives taxoides et leur procede de production
US6545125B1 (en) 1997-11-18 2003-04-08 Chugai Seiyaku Kabushiki Kaisha Compounds with antitumor activity
US6958212B1 (en) 1999-02-01 2005-10-25 Eidgenossische Technische Hochschule Zurich Conjugate addition reactions for the controlled delivery of pharmaceutically active compounds
AU768027B2 (en) * 1999-02-24 2003-11-27 Uab Research Foundation, The Taxane derivatives for targeted therapy of cancer
ES2276708T3 (es) * 1999-11-24 2007-07-01 Immunogen, Inc. Agentes citotoxicos que comprenden taxanos y su uso terapeutico.
US6175023B1 (en) 2000-01-31 2001-01-16 Jian Liu Synthesis of water soluble 9-dihydro-paclitaxel derivatives from 9-dihydro-13-acetylbaccatin III
IL145637A0 (en) * 2000-02-02 2002-06-30 Univ Florida State Res Found C7 carbonate substituted taxanes as antitumor agents
AU778991B2 (en) * 2000-02-02 2004-12-23 Florida State University Research Foundation, Inc. C7 carbamoyloxy substituted taxanes as antitumor agents
AU776765B2 (en) * 2000-02-02 2004-09-23 Florida State University Research Foundation, Inc. C7 heterosubstituted acetate taxanes as antitumor agents
KR20010111580A (ko) * 2000-02-02 2001-12-19 플로리다 스테이트 유니버시티 리서치 파운데이션, 인크 개선된 용해도를 갖는 탁산 제형물
CZ20013523A3 (cs) * 2000-02-02 2002-03-13 Florida State University Research Foundation, Inc. Taxany s C10 heterosubstituovaným acetátem jako protinádorové látky
US6596757B1 (en) * 2002-05-14 2003-07-22 Immunogen Inc. Cytotoxic agents comprising polyethylene glycol-containing taxanes and their therapeutic use

Similar Documents

Publication Publication Date Title
JP2005539009A5 (https=)
JP2005533026A5 (https=)
JP2007502814A5 (https=)
JP2007511504A5 (https=)
JP2012508235A5 (https=)
JP2010504286A5 (https=)
JP2015501292A5 (https=)
RU2005127626A (ru) Способ получения производных топирамата-антиконвульсантов
AR056327A1 (es) Compuestos de nucleosidos para el tratamiento de infecciones virales
JP2010510215A5 (https=)
KR102876696B1 (ko) 화합물 라이브러리
JP2021528421A5 (https=)
JP2008539299A5 (https=)
JP6811949B2 (ja) 光硬化性組成物
KR101129088B1 (ko) N-[6-(시스-2,6-디메틸모르폴린-4-일)피리딘-3-일]-2-메틸-4'-(트리플루오로메톡시)[1,1'-비페닐]-3-카르복스아미드의 염
Wang et al. Michael additions of dihydropyrimidines and 2-amino-1, 3, 4-thiadiazoles to α, β-ethylenic compounds: using polyethylene glycols as a green reaction media
Balwe et al. Diversity-oriented one-pot synthesis of furan based densely substituted biheteroaryls via isocyanide insertion
RU2006107579A (ru) 6-[(замещенный)фенил]триазолопиримидины в качестве противораковых препаратов
RU2007101509A (ru) Способ получения антагонистов рецепторов гормона, высвобождающего гонадотропин
JP2006518765A5 (https=)
JP2005526102A5 (https=)
JP2015512399A5 (https=)
RU2002112329A (ru) Новые фторалкилзамещенные циклотрисилоксаны, их использование для получения новых полимеров и новые полимеры
RU96104547A (ru) Замещенные бензотиенилпиперазины, их применение, способы их получения, фармацевтическая композиция
JP2006515854A5 (https=)