JP2008539299A5 - - Google Patents
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- Publication number
- JP2008539299A5 JP2008539299A5 JP2008508806A JP2008508806A JP2008539299A5 JP 2008539299 A5 JP2008539299 A5 JP 2008539299A5 JP 2008508806 A JP2008508806 A JP 2008508806A JP 2008508806 A JP2008508806 A JP 2008508806A JP 2008539299 A5 JP2008539299 A5 JP 2008539299A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- optionally substituted
- hydrocarbyl
- independently
- carbamoyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- -1 poly (amino ester Chemical class 0.000 claims 41
- 125000001183 hydrocarbyl group Chemical group 0.000 claims 19
- 229910052739 hydrogen Inorganic materials 0.000 claims 16
- 125000002947 alkylene group Chemical group 0.000 claims 15
- 125000003118 aryl group Chemical group 0.000 claims 14
- YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical compound [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 claims 12
- YZCKVEUIGOORGS-NJFSPNSNSA-N Tritium Chemical compound [3H] YZCKVEUIGOORGS-NJFSPNSNSA-N 0.000 claims 12
- 229910052805 deuterium Inorganic materials 0.000 claims 12
- 150000002431 hydrogen Chemical class 0.000 claims 12
- 239000001257 hydrogen Substances 0.000 claims 12
- 229910052722 tritium Inorganic materials 0.000 claims 12
- 125000000217 alkyl group Chemical group 0.000 claims 10
- 125000001072 heteroaryl group Chemical group 0.000 claims 10
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 9
- 229910052799 carbon Inorganic materials 0.000 claims 8
- 125000001181 organosilyl group Chemical group [SiH3]* 0.000 claims 8
- 125000004450 alkenylene group Chemical group 0.000 claims 6
- 125000004419 alkynylene group Chemical group 0.000 claims 6
- 125000000732 arylene group Chemical group 0.000 claims 6
- 239000011203 carbon fibre reinforced carbon Substances 0.000 claims 6
- 125000000753 cycloalkyl group Chemical group 0.000 claims 6
- 125000002993 cycloalkylene group Chemical group 0.000 claims 6
- 125000000623 heterocyclic group Chemical group 0.000 claims 6
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 6
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 6
- 239000002184 metal Substances 0.000 claims 6
- 238000000034 method Methods 0.000 claims 6
- 239000000178 monomer Substances 0.000 claims 6
- 125000000467 secondary amino group Chemical group [H]N([*:1])[*:2] 0.000 claims 6
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 5
- 125000003282 alkyl amino group Chemical group 0.000 claims 5
- 125000003435 aroyl group Chemical group 0.000 claims 5
- 125000001769 aryl amino group Chemical group 0.000 claims 5
- 125000004104 aryloxy group Chemical group 0.000 claims 5
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 5
- 150000001875 compounds Chemical class 0.000 claims 5
- 125000004663 dialkyl amino group Chemical group 0.000 claims 5
- 125000004986 diarylamino group Chemical group 0.000 claims 5
- 125000002837 carbocyclic group Chemical group 0.000 claims 4
- 125000004122 cyclic group Chemical group 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 125000003342 alkenyl group Chemical group 0.000 claims 3
- 125000003545 alkoxy group Chemical group 0.000 claims 3
- 125000004947 alkyl aryl amino group Chemical group 0.000 claims 3
- 125000005103 alkyl silyl group Chemical group 0.000 claims 3
- 125000004687 alkyl sulfinyl alkyl group Chemical group 0.000 claims 3
- 125000004414 alkyl thio group Chemical group 0.000 claims 3
- 125000000304 alkynyl group Chemical group 0.000 claims 3
- 125000000747 amidyl group Chemical group [H][N-]* 0.000 claims 3
- 125000004103 aminoalkyl group Chemical group 0.000 claims 3
- 125000003710 aryl alkyl group Chemical group 0.000 claims 3
- 125000005161 aryl oxy carbonyl group Chemical group 0.000 claims 3
- 125000005104 aryl silyl group Chemical group 0.000 claims 3
- 125000005110 aryl thio group Chemical group 0.000 claims 3
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 3
- 125000004181 carboxyalkyl group Chemical group 0.000 claims 3
- 125000004093 cyano group Chemical group *C#N 0.000 claims 3
- 125000004446 heteroarylalkyl group Chemical group 0.000 claims 3
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 3
- 125000005353 silylalkyl group Chemical group 0.000 claims 3
- 125000000446 sulfanediyl group Chemical group *S* 0.000 claims 3
- 125000000475 sulfinyl group Chemical group [*:2]S([*:1])=O 0.000 claims 3
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 claims 3
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 3
- 125000004001 thioalkyl group Chemical group 0.000 claims 3
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 claims 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 2
- 125000003647 acryloyl group Chemical group O=C([*])C([H])=C([H])[H] 0.000 claims 2
- 125000004688 alkyl sulfonyl alkyl group Chemical group 0.000 claims 2
- 125000005278 alkyl sulfonyloxy group Chemical group 0.000 claims 2
- 150000001356 alkyl thiols Chemical class 0.000 claims 2
- 150000001504 aryl thiols Chemical class 0.000 claims 2
- 125000001589 carboacyl group Chemical group 0.000 claims 2
- PFKFTWBEEFSNDU-UHFFFAOYSA-N carbonyldiimidazole Chemical compound C1=CN=CN1C(=O)N1C=CN=C1 PFKFTWBEEFSNDU-UHFFFAOYSA-N 0.000 claims 2
- 150000004985 diamines Chemical class 0.000 claims 2
- 125000004404 heteroalkyl group Chemical group 0.000 claims 2
- 125000004170 methylsulfonyl group Chemical group [H]C([H])([H])S(*)(=O)=O 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 125000005420 sulfonamido group Chemical group S(=O)(=O)(N*)* 0.000 claims 2
- 150000003573 thiols Chemical class 0.000 claims 2
- 125000002088 tosyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])S(*)(=O)=O 0.000 claims 2
- 108020004414 DNA Proteins 0.000 claims 1
- 102000053602 DNA Human genes 0.000 claims 1
- 239000012867 bioactive agent Substances 0.000 claims 1
- 229910021386 carbon form Inorganic materials 0.000 claims 1
- 239000002872 contrast media Substances 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 238000001415 gene therapy Methods 0.000 claims 1
- 238000003384 imaging method Methods 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- PXQLVRUNWNTZOS-UHFFFAOYSA-N sulfanyl Chemical group [SH] PXQLVRUNWNTZOS-UHFFFAOYSA-N 0.000 claims 1
- 229940124530 sulfonamide Drugs 0.000 claims 1
- 150000003456 sulfonamides Chemical class 0.000 claims 1
- 125000004963 sulfonylalkyl group Chemical group 0.000 claims 1
- 0 CC*(CC)C(*)(*)C(*)C(O*(OCCC(*)C(*)(*)**NC(*)(CC)C(CC)(N*)Br)OC(C(*)C(*)(*)*)=O)=O Chemical compound CC*(CC)C(*)(*)C(*)C(O*(OCCC(*)C(*)(*)**NC(*)(CC)C(CC)(N*)Br)OC(C(*)C(*)(*)*)=O)=O 0.000 description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US67645105P | 2005-04-29 | 2005-04-29 | |
| US60/676,451 | 2005-04-29 | ||
| PCT/SG2006/000109 WO2006118547A1 (en) | 2005-04-29 | 2006-04-28 | Hyperbranched polymers and their applications |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013142369A Division JP2013237853A (ja) | 2005-04-29 | 2013-07-08 | 超分岐ポリマーおよびそれらの適用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008539299A JP2008539299A (ja) | 2008-11-13 |
| JP2008539299A5 true JP2008539299A5 (https=) | 2009-06-18 |
| JP5541861B2 JP5541861B2 (ja) | 2014-07-09 |
Family
ID=37308246
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008508806A Expired - Fee Related JP5541861B2 (ja) | 2005-04-29 | 2006-04-28 | 超分岐ポリマーおよびそれらの適用 |
| JP2013142369A Pending JP2013237853A (ja) | 2005-04-29 | 2013-07-08 | 超分岐ポリマーおよびそれらの適用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013142369A Pending JP2013237853A (ja) | 2005-04-29 | 2013-07-08 | 超分岐ポリマーおよびそれらの適用 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US8476386B2 (https=) |
| EP (1) | EP1874844A4 (https=) |
| JP (2) | JP5541861B2 (https=) |
| KR (1) | KR101504622B1 (https=) |
| WO (1) | WO2006118547A1 (https=) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006118547A1 (en) * | 2005-04-29 | 2006-11-09 | Agency For Science, Technology And Research | Hyperbranched polymers and their applications |
| WO2011065916A1 (en) | 2009-11-24 | 2011-06-03 | Agency For Science, Technology And Research | Crosslinking branched molecule through thiol-disulfide exchange to form hydrogel |
| US8765432B2 (en) | 2009-12-18 | 2014-07-01 | Oligasis, Llc | Targeted drug phosphorylcholine polymer conjugates |
| US9475894B2 (en) * | 2013-06-25 | 2016-10-25 | China Petroleum & Chemical Corporation | Dendritic polymer, dendritic polymer monomer, and hyperbranched copolymer |
| JP6463361B2 (ja) | 2013-09-08 | 2019-01-30 | コディアック サイエンシーズ インコーポレイテッドＫｏｄｉａｋ Ｓｃｉｅｎｃｅｓ Ｉｎｃ． | 第ｖｉｉｉ因子両性イオンポリマーコンジュゲート |
| US9840553B2 (en) | 2014-06-28 | 2017-12-12 | Kodiak Sciences Inc. | Dual PDGF/VEGF antagonists |
| GB201413907D0 (en) * | 2014-08-06 | 2014-09-17 | Nat Univ Ireland | Hyberbranched poly(beta-amino ester) for gene therapy |
| EP3180465B1 (en) * | 2014-09-16 | 2020-04-08 | SRI International | Libraries of non-natural, dihydroisoquinolinone-based polymers for high-throughput drug screening through fiber-optic array scanning technology |
| KR20210013299A (ko) | 2014-10-17 | 2021-02-03 | 코디악 사이언시스 인코포레이티드 | 부티릴콜린에스테라제 양성이온성 중합체 컨쥬게이트 |
| CN105017526B (zh) * | 2015-08-19 | 2017-09-01 | 常熟理工学院 | 一种增韧增强尼龙6的增容剂及其制备方法和用途 |
| TWI572662B (zh) * | 2015-12-30 | 2017-03-01 | 奇美實業股份有限公司 | 熱可塑性樹脂組成物及其所形成的成型品 |
| KR102799807B1 (ko) | 2015-12-30 | 2025-04-24 | 코디악 사이언시스 인코포레이티드 | 항체 및 이의 접합체 |
| CN107723305B (zh) * | 2017-09-19 | 2020-10-16 | 浙江大学 | 一种用于基因转染中可光场调控基因快速释放的方法 |
| MX2020009152A (es) | 2018-03-02 | 2020-11-09 | Kodiak Sciences Inc | Anticuerpos de il-6 y constructos de fusion y conjugados de los mismos. |
| CN110746599B (zh) * | 2019-09-30 | 2021-06-18 | 苏州大学 | 具有高效基因递送能力的UV光响应性超支化聚β-氨基酯及其制备方法与应用 |
| CA3157509A1 (en) | 2019-10-10 | 2021-04-15 | Kodiak Sciences Inc. | Methods of treating an eye disorder |
| CN111408346B (zh) * | 2020-04-09 | 2022-05-24 | 中冶华天工程技术有限公司 | 一种磁性锰氧化物负载活性炭吸附催化材料快速制备方法 |
| CN111468071B (zh) * | 2020-04-09 | 2022-09-20 | 中冶华天工程技术有限公司 | 一种可磁分离复合吸附材料快速制备方法 |
| CN111909388A (zh) * | 2020-08-04 | 2020-11-10 | 华容县恒兴建材有限公司 | 一种超支化聚酯丙烯酸酯及其制备方法 |
| CN116640301A (zh) * | 2023-06-28 | 2023-08-25 | 复旦大学附属儿科医院 | 一类功能性高度灵活的支化聚、制备方法及mRNA递送应用 |
| CN119101237A (zh) * | 2024-08-14 | 2024-12-10 | 安徽艾迪特生物科技有限公司 | 支化聚(β-氨基酯)及其制备方法和用途 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5166320A (en) | 1987-04-22 | 1992-11-24 | University Of Connecticut | Carrier system and method for the introduction of genes into mammalian cells |
| US5399346A (en) | 1989-06-14 | 1995-03-21 | The United States Of America As Represented By The Department Of Health And Human Services | Gene therapy |
| JPH0339366A (ja) * | 1989-07-06 | 1991-02-20 | Mitsubishi Petrochem Co Ltd | ハードコート用被覆材組成物 |
| US5871713A (en) * | 1991-12-04 | 1999-02-16 | Guerbet S.A. | Macromolecular polyamine iodine-containing compound, process for its preparation and its use as a contrast agent |
| CA2131620A1 (en) | 1992-03-20 | 1993-09-30 | Louis C. Smith | A dna transporter system and method of use |
| DK0636028T3 (da) | 1992-04-03 | 2004-07-12 | Univ California | Selvorganiserende polynucleotidleveringssystem omfattende et amfipatisk kationisk peptid |
| SG54115A1 (en) | 1993-04-27 | 1998-11-16 | Gerber Scient Products Inc | Thermal printing apparatus with improved power supply |
| EP0708637B1 (en) | 1993-07-14 | 2004-01-28 | The Regents of the University of California | Self-assembling polynucleotide delivery system comprising dendrimer polycations |
| ATE218893T1 (de) | 1993-08-12 | 2002-06-15 | Neurotech Sa | Biokompatible immunoisolatorische kapseln, die genetisch veränderte zellen enthalten |
| US6998115B2 (en) * | 2000-10-10 | 2006-02-14 | Massachusetts Institute Of Technology | Biodegradable poly(β-amino esters) and uses thereof |
| US7427394B2 (en) * | 2000-10-10 | 2008-09-23 | Massachusetts Institute Of Technology | Biodegradable poly(β-amino esters) and uses thereof |
| US20030215395A1 (en) * | 2002-05-14 | 2003-11-20 | Lei Yu | Controllably degradable polymeric biomolecule or drug carrier and method of synthesizing said carrier |
| US7309757B2 (en) * | 2003-06-20 | 2007-12-18 | Agency For Science, Technology And Research | Polymers for the delivery of bioactive agents and methods of their preparation |
| WO2006118547A1 (en) * | 2005-04-29 | 2006-11-09 | Agency For Science, Technology And Research | Hyperbranched polymers and their applications |
-
2006
- 2006-04-28 WO PCT/SG2006/000109 patent/WO2006118547A1/en not_active Ceased
- 2006-04-28 JP JP2008508806A patent/JP5541861B2/ja not_active Expired - Fee Related
- 2006-04-28 EP EP20060733552 patent/EP1874844A4/en not_active Withdrawn
- 2006-04-28 KR KR1020077027817A patent/KR101504622B1/ko not_active Expired - Fee Related
-
2012
- 2012-03-08 US US13/415,801 patent/US8476386B2/en not_active Expired - Fee Related
-
2013
- 2013-07-08 JP JP2013142369A patent/JP2013237853A/ja active Pending
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