JP2006524702A5 - - Google Patents
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- Publication number
- JP2006524702A5 JP2006524702A5 JP2006513275A JP2006513275A JP2006524702A5 JP 2006524702 A5 JP2006524702 A5 JP 2006524702A5 JP 2006513275 A JP2006513275 A JP 2006513275A JP 2006513275 A JP2006513275 A JP 2006513275A JP 2006524702 A5 JP2006524702 A5 JP 2006524702A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- alkyl
- hydrogen
- defined above
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229910052739 hydrogen Inorganic materials 0.000 claims 47
- 239000001257 hydrogen Substances 0.000 claims 47
- 150000002431 hydrogen Chemical class 0.000 claims 33
- 125000001072 heteroaryl group Chemical group 0.000 claims 26
- 150000002148 esters Chemical class 0.000 claims 25
- 239000000651 prodrug Substances 0.000 claims 25
- 229940002612 prodrug Drugs 0.000 claims 25
- 150000003839 salts Chemical class 0.000 claims 25
- 150000001875 compounds Chemical class 0.000 claims 23
- 125000000217 alkyl group Chemical group 0.000 claims 15
- 125000003118 aryl group Chemical group 0.000 claims 14
- 229910052736 halogen Inorganic materials 0.000 claims 13
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 12
- -1 wherein Chemical compound 0.000 claims 12
- 150000002367 halogens Chemical class 0.000 claims 11
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 11
- 125000003107 substituted aryl group Chemical group 0.000 claims 10
- 125000001424 substituent group Chemical group 0.000 claims 6
- 125000005843 halogen group Chemical group 0.000 claims 5
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 5
- 125000006710 (C2-C12) alkenyl group Chemical group 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 125000004642 (C1-C12) alkoxy group Chemical group 0.000 claims 3
- 125000001843 C4-C10 alkenyl group Chemical group 0.000 claims 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 3
- 125000005346 substituted cycloalkyl group Chemical group 0.000 claims 3
- 125000006711 (C2-C12) alkynyl group Chemical group 0.000 claims 2
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 2
- 208000035143 Bacterial infection Diseases 0.000 claims 2
- 125000003342 alkenyl group Chemical group 0.000 claims 2
- 125000000304 alkynyl group Chemical group 0.000 claims 2
- 208000022362 bacterial infectious disease Diseases 0.000 claims 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 2
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 125000004400 (C1-C12) alkyl group Chemical group 0.000 claims 1
- 125000006584 (C3-C10) heterocycloalkyl group Chemical group 0.000 claims 1
- YKYIFUROKBDHCY-ONEGZZNKSA-N (e)-4-ethoxy-1,1,1-trifluorobut-3-en-2-one Chemical group CCO\C=C\C(=O)C(F)(F)F YKYIFUROKBDHCY-ONEGZZNKSA-N 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 229910052731 fluorine Inorganic materials 0.000 claims 1
- 239000011737 fluorine Substances 0.000 claims 1
- 125000001153 fluoro group Chemical group F* 0.000 claims 1
- 125000004446 heteroarylalkyl group Chemical group 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 125000000547 substituted alkyl group Chemical group 0.000 claims 1
- 150000007970 thio esters Chemical class 0.000 claims 1
- 150000003573 thiols Chemical class 0.000 claims 1
- 0 C*[C@@](C[C@@](C)O[C@]1O[C@]([C@@](C)C([C@](C)(*)C(O[C@]2([C@@](C)C2)[C@](C)([C@@]([C@@](C)C([C@](C)C2)=O)N3CCCC[n]4c(*)nc(-c5cccnc5)c4C)OC3=O)=O)=O)[C@@]2(C)O*)[C@@]1O Chemical compound C*[C@@](C[C@@](C)O[C@]1O[C@]([C@@](C)C([C@](C)(*)C(O[C@]2([C@@](C)C2)[C@](C)([C@@]([C@@](C)C([C@](C)C2)=O)N3CCCC[n]4c(*)nc(-c5cccnc5)c4C)OC3=O)=O)=O)[C@@]2(C)O*)[C@@]1O 0.000 description 5
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US46529403P | 2003-04-25 | 2003-04-25 | |
| PCT/US2004/012645 WO2004096822A2 (en) | 2003-04-25 | 2004-04-23 | Pyridyl substituted ketolide antibiotics |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006524702A JP2006524702A (ja) | 2006-11-02 |
| JP2006524702A5 true JP2006524702A5 (https=) | 2007-05-24 |
Family
ID=33418219
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006513275A Pending JP2006524702A (ja) | 2003-04-25 | 2004-04-23 | ピリジル置換ケトライド抗体 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US7332476B2 (https=) |
| EP (1) | EP1618119A2 (https=) |
| JP (1) | JP2006524702A (https=) |
| CA (1) | CA2523134A1 (https=) |
| WO (1) | WO2004096822A2 (https=) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2552682T3 (es) | 2003-03-10 | 2015-12-01 | Merck Sharp & Dohme Corp. | Agentes antibacterianos novedosos |
| US7163924B2 (en) * | 2003-04-25 | 2007-01-16 | Chiron Corporation | Ketolide derivatives |
| JP2008508322A (ja) * | 2004-07-28 | 2008-03-21 | ランバクシー ラボラトリーズ リミテッド | 抗菌剤としてのケトライド誘導体 |
| EP3290427A1 (en) | 2005-08-24 | 2018-03-07 | Melinta Therapeutics, Inc. | Triazole compounds and methods of making and using the same |
| CN105732745A (zh) | 2007-10-25 | 2016-07-06 | 森普拉制药公司 | 大环内酯类抗菌剂的制备方法 |
| AU2009308182B2 (en) | 2008-10-24 | 2016-05-19 | Cempra Pharmaceuticals, Inc. | Biodefenses using triazole-containing macrolides |
| US9937194B1 (en) | 2009-06-12 | 2018-04-10 | Cempra Pharmaceuticals, Inc. | Compounds and methods for treating inflammatory diseases |
| US9480679B2 (en) | 2009-09-10 | 2016-11-01 | Cempra Pharmaceuticals, Inc. | Methods for treating malaria, tuberculosis and MAC diseases |
| CN105198944B (zh) | 2010-05-20 | 2018-06-01 | 森普拉制药公司 | 制备大环内酯和酮内酯及其中间体的方法 |
| EP2613630A4 (en) * | 2010-09-10 | 2014-01-15 | Cempra Pharmaceuticals Inc | HYDROGEN BOND FOR THE PREPARATION OF FLUOROCHETOLIDES FOR THE TREATMENT OF DISEASES |
| EP2658855A2 (en) | 2010-12-31 | 2013-11-06 | Acies Bio d.o.o. | Novel polyketide compounds and methods of making same |
| KR101567658B1 (ko) * | 2011-03-01 | 2015-11-09 | 욱크하르트 리미티드 | 케톨리드 중간체의 제조 방법 |
| MX2014011537A (es) | 2012-03-27 | 2015-02-10 | Cempra Pharmaceuticals Inc | Formulaciones parenterales para la administracion de antibioticos macrolidos. |
| HK1217665A1 (zh) | 2013-03-14 | 2017-01-20 | 森普拉制药公司 | 用於治療呼吸道疾病的方法及其製劑 |
| RU2015138797A (ru) | 2013-03-15 | 2017-04-24 | Семпра Фармасьютикалс, Инк. | Конвергентные способы получения макролидных антибактериальных агентов |
| MX2019002444A (es) * | 2016-08-29 | 2019-09-02 | Univ Texas | Inhibidores de cinasa de cremallera de leucina dual (dlk) para el tratamiento de enfermedades. |
| JP2019533669A (ja) * | 2016-10-04 | 2019-11-21 | バイオファーマティ ソシエテ アノニム | 抗菌活性を有するケトライド |
| JP7128816B2 (ja) | 2016-12-08 | 2022-08-31 | ボード オブ レジェンツ，ザ ユニバーシティ オブ テキサス システム | 疾患の治療のための二重ロイシンジッパー（ｄｌｋ）キナーゼのビシクロ［１．１．１］ペンタン阻害剤 |
| US11560366B2 (en) | 2019-10-21 | 2023-01-24 | Board Of Regents, The University Of Texas System | Bicyclo[1.1.1]pentane inhibitors of dual leucine zipper (DLK) kinase for the treatment of disease |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4857641A (en) | 1987-08-14 | 1989-08-15 | Pfizer Inc. | C.12 modified erythromycin A derivatives |
| US6063561A (en) * | 1991-01-17 | 2000-05-16 | Abbott Laboratories | Polyketide derivatives and recombinant methods for making same |
| FR2718450B1 (fr) * | 1994-04-08 | 1997-01-10 | Roussel Uclaf | Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments. |
| US5750510A (en) * | 1997-04-04 | 1998-05-12 | Abbott Laboratories | 3-descladinose-2,3-anhydroerythromycin derivatives |
| CA2253338C (en) * | 1996-05-07 | 2007-05-08 | Abbott Laboratories | 6-o-substituted erythromycins and method for making them |
| UA51730C2 (uk) * | 1996-09-04 | 2002-12-16 | Ебботт Лабораторіз | 6-o-заміщені кетоліди з антибактеріальною активністю, спосіб їх одержання (варіанти), фармацевтична композиція та спосіб регулювання бактеріальної інфекції у ссавців |
| AU720921B2 (en) | 1996-11-27 | 2000-06-15 | Taisho Pharmaceutical Co., Ltd. | Erythromycin A derivatives |
| US6140479A (en) | 1997-03-24 | 2000-10-31 | Taisho Pharmaceuticals Co., Ltd. | Erythromycin a derivatives |
| WO2003004509A2 (en) * | 2001-07-03 | 2003-01-16 | Chiron Corporation | C12 modified erythromycin macrolides and ketolides having antibacterial activity |
| US7163924B2 (en) * | 2003-04-25 | 2007-01-16 | Chiron Corporation | Ketolide derivatives |
-
2004
- 2004-04-23 US US10/831,749 patent/US7332476B2/en not_active Expired - Fee Related
- 2004-04-23 CA CA002523134A patent/CA2523134A1/en not_active Abandoned
- 2004-04-23 WO PCT/US2004/012645 patent/WO2004096822A2/en not_active Ceased
- 2004-04-23 EP EP04750576A patent/EP1618119A2/en not_active Withdrawn
- 2004-04-23 JP JP2006513275A patent/JP2006524702A/ja active Pending