JP2006524702A5 - - Google Patents

Info

Publication number

JP2006524702A5

JP2006524702A5 JP2006513275A JP2006513275A JP2006524702A5 JP 2006524702 A5 JP2006524702 A5 JP 2006524702A5 JP 2006513275 A JP2006513275 A JP 2006513275A JP 2006513275 A JP2006513275 A JP 2006513275A JP 2006524702 A5 JP2006524702 A5 JP 2006524702A5

Authority

JP

Japan

Prior art keywords

substituted

alkyl

hydrogen

defined above

pharmaceutically acceptable

Prior art date

2004-04-23

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

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• 229910052739 hydrogen Inorganic materials 0.000 claims 47
• 239000001257 hydrogen Substances 0.000 claims 47
• 150000002431 hydrogen Chemical class 0.000 claims 33
• 125000001072 heteroaryl group Chemical group 0.000 claims 26
• 150000002148 esters Chemical class 0.000 claims 25
• 239000000651 prodrug Substances 0.000 claims 25
• 229940002612 prodrug Drugs 0.000 claims 25
• 150000003839 salts Chemical class 0.000 claims 25
• 150000001875 compounds Chemical class 0.000 claims 23
• 125000000217 alkyl group Chemical group 0.000 claims 15
• 125000003118 aryl group Chemical group 0.000 claims 14
• 229910052736 halogen Inorganic materials 0.000 claims 13
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 12
• -1 wherein Chemical compound 0.000 claims 12
• 150000002367 halogens Chemical class 0.000 claims 11
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 11
• 125000003107 substituted aryl group Chemical group 0.000 claims 10
• 125000001424 substituent group Chemical group 0.000 claims 6
• 125000005843 halogen group Chemical group 0.000 claims 5
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 5
• 125000006710 (C2-C12) alkenyl group Chemical group 0.000 claims 4
• 239000000203 mixture Substances 0.000 claims 4
• 125000004642 (C1-C12) alkoxy group Chemical group 0.000 claims 3
• 125000001843 C4-C10 alkenyl group Chemical group 0.000 claims 3
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 3
• 125000005346 substituted cycloalkyl group Chemical group 0.000 claims 3
• 125000006711 (C2-C12) alkynyl group Chemical group 0.000 claims 2
• 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 2
• 208000035143 Bacterial infection Diseases 0.000 claims 2
• 125000003342 alkenyl group Chemical group 0.000 claims 2
• 125000000304 alkynyl group Chemical group 0.000 claims 2
• 208000022362 bacterial infectious disease Diseases 0.000 claims 2
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 2
• 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 claims 2
• 239000003937 drug carrier Substances 0.000 claims 2
• 125000000592 heterocycloalkyl group Chemical group 0.000 claims 2
• 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 2
• 239000008194 pharmaceutical composition Substances 0.000 claims 2
• 125000004400 (C1-C12) alkyl group Chemical group 0.000 claims 1
• 125000006584 (C3-C10) heterocycloalkyl group Chemical group 0.000 claims 1
• YKYIFUROKBDHCY-ONEGZZNKSA-N (e)-4-ethoxy-1,1,1-trifluorobut-3-en-2-one Chemical group CCO\C=C\C(=O)C(F)(F)F YKYIFUROKBDHCY-ONEGZZNKSA-N 0.000 claims 1
• 125000004429 atom Chemical group 0.000 claims 1
• 229910052799 carbon Inorganic materials 0.000 claims 1
• 125000004432 carbon atom Chemical group C* 0.000 claims 1
• 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims 1
• 125000000753 cycloalkyl group Chemical group 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 claims 1
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
• 229910052731 fluorine Inorganic materials 0.000 claims 1
• 239000011737 fluorine Substances 0.000 claims 1
• 125000001153 fluoro group Chemical group F* 0.000 claims 1
• 125000004446 heteroarylalkyl group Chemical group 0.000 claims 1
• 125000005842 heteroatom Chemical group 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
• 229910052757 nitrogen Inorganic materials 0.000 claims 1
• 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
• 230000002265 prevention Effects 0.000 claims 1
• 125000000547 substituted alkyl group Chemical group 0.000 claims 1
• 150000007970 thio esters Chemical class 0.000 claims 1
• 150000003573 thiols Chemical class 0.000 claims 1
• 0 C*[C@@](C[C@@](C)O[C@]1O[C@]([C@@](C)C([C@](C)(*)C(O[C@]2([C@@](C)C2)[C@](C)([C@@]([C@@](C)C([C@](C)C2)=O)N3CCCC[n]4c(*)nc(-c5cccnc5)c4C)OC3=O)=O)=O)[C@@]2(C)O*)[C@@]1O Chemical compound C*[C@@](C[C@@](C)O[C@]1O[C@]([C@@](C)C([C@](C)(*)C(O[C@]2([C@@](C)C2)[C@](C)([C@@]([C@@](C)C([C@](C)C2)=O)N3CCCC[n]4c(*)nc(-c5cccnc5)c4C)OC3=O)=O)=O)[C@@]2(C)O*)[C@@]1O 0.000 description 5