JP2005525991A5 - - Google Patents

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Publication number
JP2005525991A5
JP2005525991A5 JP2002588925A JP2002588925A JP2005525991A5 JP 2005525991 A5 JP2005525991 A5 JP 2005525991A5 JP 2002588925 A JP2002588925 A JP 2002588925A JP 2002588925 A JP2002588925 A JP 2002588925A JP 2005525991 A5 JP2005525991 A5 JP 2005525991A5
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JP
Japan
Prior art keywords
bond
compound
pharmaceutically acceptable
virus infection
hepatitis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2002588925A
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English (en)
Japanese (ja)
Other versions
JP2005525991A (ja
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Publication date
Application filed filed Critical
Priority claimed from PCT/US2002/015383 external-priority patent/WO2002092006A2/en
Publication of JP2005525991A publication Critical patent/JP2005525991A/ja
Publication of JP2005525991A5 publication Critical patent/JP2005525991A5/ja
Withdrawn legal-status Critical Current

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JP2002588925A 2001-05-16 2002-05-15 核酸ベースの化合物およびその使用方法 Withdrawn JP2005525991A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US29147101P 2001-05-16 2001-05-16
PCT/US2002/015383 WO2002092006A2 (en) 2001-05-16 2002-05-15 Nucleic acid-based compounds and methods of use thereof

Related Child Applications (2)

Application Number Title Priority Date Filing Date
JP2009178281A Division JP2009242439A (ja) 2001-05-16 2009-07-30 核酸ベースの化合物およびその使用方法
JP2013124544A Division JP2013177453A (ja) 2001-05-16 2013-06-13 核酸ベースの化合物およびその使用方法

Publications (2)

Publication Number Publication Date
JP2005525991A JP2005525991A (ja) 2005-09-02
JP2005525991A5 true JP2005525991A5 (https=) 2006-01-05

Family

ID=23120429

Family Applications (5)

Application Number Title Priority Date Filing Date
JP2002588925A Withdrawn JP2005525991A (ja) 2001-05-16 2002-05-15 核酸ベースの化合物およびその使用方法
JP2009178281A Pending JP2009242439A (ja) 2001-05-16 2009-07-30 核酸ベースの化合物およびその使用方法
JP2013124544A Pending JP2013177453A (ja) 2001-05-16 2013-06-13 核酸ベースの化合物およびその使用方法
JP2015024999A Withdrawn JP2015091891A (ja) 2001-05-16 2015-02-12 核酸ベースの化合物およびその使用方法
JP2017062815A Pending JP2017119712A (ja) 2001-05-16 2017-03-28 核酸ベースの化合物およびその使用方法

Family Applications After (4)

Application Number Title Priority Date Filing Date
JP2009178281A Pending JP2009242439A (ja) 2001-05-16 2009-07-30 核酸ベースの化合物およびその使用方法
JP2013124544A Pending JP2013177453A (ja) 2001-05-16 2013-06-13 核酸ベースの化合物およびその使用方法
JP2015024999A Withdrawn JP2015091891A (ja) 2001-05-16 2015-02-12 核酸ベースの化合物およびその使用方法
JP2017062815A Pending JP2017119712A (ja) 2001-05-16 2017-03-28 核酸ベースの化合物およびその使用方法

Country Status (7)

Country Link
US (3) US6881831B2 (https=)
JP (5) JP2005525991A (https=)
KR (2) KR100991975B1 (https=)
CN (2) CN101113160A (https=)
AU (1) AU2002316118A1 (https=)
GB (1) GB2392157B (https=)
WO (1) WO2002092006A2 (https=)

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CN101113160A (zh) * 2001-05-16 2008-01-30 米珍尼克斯公司 基于核酸的化合物及其使用方法
DE60208400T2 (de) * 2001-10-03 2006-07-06 Bioniche Life Sciences Inc., Belleville Therapeutisch verwendbare triethylenglykol-cholesteryl-oligonukleotide
US20090280567A1 (en) * 2004-02-06 2009-11-12 Dharmacon, Inc. Stabilized sirnas as transfection controls and silencing reagents
EP2123759B1 (en) * 2004-02-06 2014-01-15 Thermo Fisher Scientific Biosciences Inc. Stabilized RNAS as transfection controls and silencing reagents
KR101147147B1 (ko) 2004-04-01 2012-05-25 머크 샤프 앤드 돔 코포레이션 Ｒｎａ 간섭의 오프 타겟 효과 감소를 위한 변형된폴리뉴클레오타이드
US20060166234A1 (en) * 2004-11-22 2006-07-27 Barbara Robertson Apparatus and system having dry control gene silencing compositions
US7923207B2 (en) 2004-11-22 2011-04-12 Dharmacon, Inc. Apparatus and system having dry gene silencing pools
US7935811B2 (en) * 2004-11-22 2011-05-03 Dharmacon, Inc. Apparatus and system having dry gene silencing compositions
US20060223777A1 (en) * 2005-03-29 2006-10-05 Dharmacon, Inc. Highly functional short hairpin RNA
US8076303B2 (en) 2005-12-13 2011-12-13 Spring Bank Pharmaceuticals, Inc. Nucleotide and oligonucleotide prodrugs
WO2008036841A2 (en) * 2006-09-22 2008-03-27 Dharmacon, Inc. Tripartite oligonucleotide complexes and methods for gene silencing by rna interference
US8188060B2 (en) 2008-02-11 2012-05-29 Dharmacon, Inc. Duplex oligonucleotides with enhanced functionality in gene regulation
GB2471806B (en) * 2008-04-03 2012-12-19 Spring Bank Pharmaceuticals Inc Compositions and methods for treating viral infections
KR101926419B1 (ko) 2010-08-30 2018-12-10 스프링 뱅크 파마슈티칼스, 인크. 치료제로서 올리고뉴클레오타이드 유사체의 설계
BR112013005872A2 (pt) 2010-09-22 2019-09-24 Alios Biopharma Inc compostos, composição farmacêutica e respectivos usos
EP2794630A4 (en) 2011-12-22 2015-04-01 Alios Biopharma Inc SUBSTITUTED PHOSPHORTHIOAT NUCLEOTIDE ANALOGUE
WO2013142124A1 (en) 2012-03-21 2013-09-26 Vertex Pharmaceuticals Incorporated Solid forms of a thiophosphoramidate nucleotide prodrug
US9012427B2 (en) 2012-03-22 2015-04-21 Alios Biopharma, Inc. Pharmaceutical combinations comprising a thionucleotide analog
AU2014250762A1 (en) 2013-04-12 2015-10-29 Achillion Pharmaceuticals, Inc. Highly active nucleoside derivative for the treatment of HCV
JP7170535B2 (ja) 2015-10-20 2022-11-14 ソレント・セラピューティクス・インコーポレイテッド 細胞内送達化合物
EP3752511A4 (en) 2018-01-10 2021-12-29 Nucorion Pharmaceuticals, Inc. Phosphor(n)amidatacetal and phosph(on)atalcetal compounds
CN111918870B (zh) * 2018-05-18 2022-07-08 正大天晴药业集团股份有限公司 氘代的低聚核苷酸及前体药物
CN113164506B (zh) * 2018-12-06 2023-12-08 正大天晴药业集团股份有限公司 二核苷酸化合物及其前体药物
CN111484541B (zh) * 2019-01-25 2023-06-02 博瑞生物医药（苏州）股份有限公司 双核苷酸前体药物及其制备方法
CN114206896B (zh) 2019-07-17 2024-12-17 纽科利制药公司 环状脱氧核糖核苷酸化合物
US12552820B2 (en) 2020-04-21 2026-02-17 Ligand Pharmaceuticals Incorporated Benzyloxy phosph(on)ate compounds

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