CN101113160A - 基于核酸的化合物及其使用方法 - Google Patents
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- CN101113160A CN101113160A CNA2007101437468A CN200710143746A CN101113160A CN 101113160 A CN101113160 A CN 101113160A CN A2007101437468 A CNA2007101437468 A CN A2007101437468A CN 200710143746 A CN200710143746 A CN 200710143746A CN 101113160 A CN101113160 A CN 101113160A
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- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 description 1
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- 125000004433 nitrogen atom Chemical group N* 0.000 description 1
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- 125000005561 phenanthryl group Chemical group 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
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- 125000005936 piperidyl group Chemical group 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
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- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 description 1
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- PJANXHGTPQOBST-UHFFFAOYSA-N stilbene Chemical compound C=1C=CC=CC=1C=CC1=CC=CC=C1 PJANXHGTPQOBST-UHFFFAOYSA-N 0.000 description 1
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- 238000012360 testing method Methods 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
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- 125000001544 thienyl group Chemical group 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/713—Double-stranded nucleic acids or oligonucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
- C07H19/207—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids the phosphoric or polyphosphoric acids being esterified by a further hydroxylic compound, e.g. flavine adenine dinucleotide or nicotinamide-adenine dinucleotide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Biotechnology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Genetics & Genomics (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29147101P | 2001-05-16 | 2001-05-16 | |
| US60/291,471 | 2001-05-16 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB028108434A Division CN100400045C (zh) | 2001-05-16 | 2002-05-15 | 基于核酸的化合物及其使用方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101113160A true CN101113160A (zh) | 2008-01-30 |
Family
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| Application Number | Title | Priority Date | Filing Date |
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| CNA2007101437468A Pending CN101113160A (zh) | 2001-05-16 | 2002-05-15 | 基于核酸的化合物及其使用方法 |
| CNB028108434A Expired - Fee Related CN100400045C (zh) | 2001-05-16 | 2002-05-15 | 基于核酸的化合物及其使用方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB028108434A Expired - Fee Related CN100400045C (zh) | 2001-05-16 | 2002-05-15 | 基于核酸的化合物及其使用方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US6881831B2 (https=) |
| JP (5) | JP2005525991A (https=) |
| KR (2) | KR100991975B1 (https=) |
| CN (2) | CN101113160A (https=) |
| AU (1) | AU2002316118A1 (https=) |
| GB (1) | GB2392157B (https=) |
| WO (1) | WO2002092006A2 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111484541A (zh) * | 2019-01-25 | 2020-08-04 | 博瑞生物医药（苏州）股份有限公司 | 双核苷酸前体药物及其制备方法 |
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| CN101113160A (zh) * | 2001-05-16 | 2008-01-30 | 米珍尼克斯公司 | 基于核酸的化合物及其使用方法 |
| DE60208400T2 (de) * | 2001-10-03 | 2006-07-06 | Bioniche Life Sciences Inc., Belleville | Therapeutisch verwendbare triethylenglykol-cholesteryl-oligonukleotide |
| US20090280567A1 (en) * | 2004-02-06 | 2009-11-12 | Dharmacon, Inc. | Stabilized sirnas as transfection controls and silencing reagents |
| EP2123759B1 (en) * | 2004-02-06 | 2014-01-15 | Thermo Fisher Scientific Biosciences Inc. | Stabilized RNAS as transfection controls and silencing reagents |
| KR101147147B1 (ko) | 2004-04-01 | 2012-05-25 | 머크 샤프 앤드 돔 코포레이션 | Ｒｎａ 간섭의 오프 타겟 효과 감소를 위한 변형된폴리뉴클레오타이드 |
| US20060166234A1 (en) * | 2004-11-22 | 2006-07-27 | Barbara Robertson | Apparatus and system having dry control gene silencing compositions |
| US7923207B2 (en) | 2004-11-22 | 2011-04-12 | Dharmacon, Inc. | Apparatus and system having dry gene silencing pools |
| US7935811B2 (en) * | 2004-11-22 | 2011-05-03 | Dharmacon, Inc. | Apparatus and system having dry gene silencing compositions |
| US20060223777A1 (en) * | 2005-03-29 | 2006-10-05 | Dharmacon, Inc. | Highly functional short hairpin RNA |
| US8076303B2 (en) | 2005-12-13 | 2011-12-13 | Spring Bank Pharmaceuticals, Inc. | Nucleotide and oligonucleotide prodrugs |
| WO2008036841A2 (en) * | 2006-09-22 | 2008-03-27 | Dharmacon, Inc. | Tripartite oligonucleotide complexes and methods for gene silencing by rna interference |
| US8188060B2 (en) | 2008-02-11 | 2012-05-29 | Dharmacon, Inc. | Duplex oligonucleotides with enhanced functionality in gene regulation |
| GB2471806B (en) * | 2008-04-03 | 2012-12-19 | Spring Bank Pharmaceuticals Inc | Compositions and methods for treating viral infections |
| KR101926419B1 (ko) | 2010-08-30 | 2018-12-10 | 스프링 뱅크 파마슈티칼스, 인크. | 치료제로서 올리고뉴클레오타이드 유사체의 설계 |
| BR112013005872A2 (pt) | 2010-09-22 | 2019-09-24 | Alios Biopharma Inc | compostos, composição farmacêutica e respectivos usos |
| EP2794630A4 (en) | 2011-12-22 | 2015-04-01 | Alios Biopharma Inc | SUBSTITUTED PHOSPHORTHIOAT NUCLEOTIDE ANALOGUE |
| WO2013142124A1 (en) | 2012-03-21 | 2013-09-26 | Vertex Pharmaceuticals Incorporated | Solid forms of a thiophosphoramidate nucleotide prodrug |
| US9012427B2 (en) | 2012-03-22 | 2015-04-21 | Alios Biopharma, Inc. | Pharmaceutical combinations comprising a thionucleotide analog |
| AU2014250762A1 (en) | 2013-04-12 | 2015-10-29 | Achillion Pharmaceuticals, Inc. | Highly active nucleoside derivative for the treatment of HCV |
| JP7170535B2 (ja) | 2015-10-20 | 2022-11-14 | ソレント・セラピューティクス・インコーポレイテッド | 細胞内送達化合物 |
| EP3752511A4 (en) | 2018-01-10 | 2021-12-29 | Nucorion Pharmaceuticals, Inc. | Phosphor(n)amidatacetal and phosph(on)atalcetal compounds |
| CN111918870B (zh) * | 2018-05-18 | 2022-07-08 | 正大天晴药业集团股份有限公司 | 氘代的低聚核苷酸及前体药物 |
| CN113164506B (zh) * | 2018-12-06 | 2023-12-08 | 正大天晴药业集团股份有限公司 | 二核苷酸化合物及其前体药物 |
| CN114206896B (zh) | 2019-07-17 | 2024-12-17 | 纽科利制药公司 | 环状脱氧核糖核苷酸化合物 |
| US12552820B2 (en) | 2020-04-21 | 2026-02-17 | Ligand Pharmaceuticals Incorporated | Benzyloxy phosph(on)ate compounds |
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| US5218103A (en) * | 1988-05-26 | 1993-06-08 | University Patents, Inc. | Nucleoside thiophosphoramidites |
| FR2641537A1 (fr) | 1989-01-09 | 1990-07-13 | Centre Nat Rech Scient | Phosphates d'oxysteryle, synthese et utilisation comme agent pharmaceutique |
| US5149798A (en) | 1989-04-06 | 1992-09-22 | Worcester Foundation For Experimental Biology | Process for synthesizing oligonucleotides and their analogs adaptable to large scale syntheses |
| ZA902912B (en) * | 1989-04-21 | 1991-01-30 | Cornell Res Foundation Inc | Method of inhibiting induction of latent or chronic viral infection |
| US5149796A (en) * | 1989-08-31 | 1992-09-22 | City Of Hope | Chimeric DNA-RNA catalytic sequences |
| US5212295A (en) * | 1990-01-11 | 1993-05-18 | Isis Pharmaceuticals | Monomers for preparation of oligonucleotides having chiral phosphorus linkages |
| US5608046A (en) | 1990-07-27 | 1997-03-04 | Isis Pharmaceuticals, Inc. | Conjugated 4'-desmethyl nucleoside analog compounds |
| US5614504A (en) * | 1990-08-01 | 1997-03-25 | The University Of South Florida | Method of making inosine monophosphate derivatives and immunopotentiating uses thereof |
| US5212293A (en) * | 1990-08-06 | 1993-05-18 | American Cyanamid Company | Process for the preparation of deoxynucleosides |
| DE4111730A1 (de) | 1991-04-10 | 1992-10-15 | Knoll Ag | Neue cytarabin-derivate, ihre herstellung und verwendung |
| GB2257704B (en) * | 1991-07-18 | 1995-03-01 | Erba Carlo Spa | Cyclic oligonucleotides phosphorothioates |
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| WO1994000473A2 (en) | 1992-06-30 | 1994-01-06 | Res Corp Technologies Inc | Pentavalent synthesis of oligonucleotides containing stereospecific alkylphosphonates and arylphosphonates |
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| AU6449394A (en) | 1993-03-30 | 1994-10-24 | Sterling Winthrop Inc. | Acyclic nucleoside analogs and oligonucleotide sequences containing them |
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| DE4418690A1 (de) | 1994-05-28 | 1996-01-11 | Boehringer Mannheim Gmbh | Neue Lipidester von Nucleosid-Monophosphaten und deren Verwendung als immunsuppressive Arzneimittel |
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| KR100484124B1 (ko) | 1994-10-17 | 2005-09-08 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 변형된 뉴클레오티드 결합부위를 갖는 dna 서열화용 dna 폴리머라제 |
| AU5871196A (en) | 1995-05-23 | 1996-12-24 | Hybridon, Inc. | Methods and compounds for the synthesis of oligonucleotides and the oligonucleotides thereby produced |
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| WO1998030575A1 (en) | 1997-01-08 | 1998-07-16 | Proligo Llc | Bioconjugation of macromolecules |
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| CN101113160A (zh) * | 2001-05-16 | 2008-01-30 | 米珍尼克斯公司 | 基于核酸的化合物及其使用方法 |
-
2002
- 2002-05-15 CN CNA2007101437468A patent/CN101113160A/zh active Pending
- 2002-05-15 AU AU2002316118A patent/AU2002316118A1/en not_active Abandoned
- 2002-05-15 KR KR1020097009006A patent/KR100991975B1/ko not_active Expired - Fee Related
- 2002-05-15 CN CNB028108434A patent/CN100400045C/zh not_active Expired - Fee Related
- 2002-05-15 JP JP2002588925A patent/JP2005525991A/ja not_active Withdrawn
- 2002-05-15 US US10/146,175 patent/US6881831B2/en not_active Expired - Lifetime
- 2002-05-15 KR KR10-2003-7014856A patent/KR20040074594A/ko not_active Ceased
- 2002-05-15 WO PCT/US2002/015383 patent/WO2002092006A2/en not_active Ceased
- 2002-05-15 GB GB0327057A patent/GB2392157B/en not_active Expired - Fee Related
-
2005
- 2005-02-14 US US11/057,779 patent/US7256179B2/en not_active Expired - Lifetime
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2007
- 2007-07-10 US US11/775,591 patent/US7709449B2/en not_active Expired - Fee Related
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2009
- 2009-07-30 JP JP2009178281A patent/JP2009242439A/ja active Pending
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2013
- 2013-06-13 JP JP2013124544A patent/JP2013177453A/ja active Pending
-
2015
- 2015-02-12 JP JP2015024999A patent/JP2015091891A/ja not_active Withdrawn
-
2017
- 2017-03-28 JP JP2017062815A patent/JP2017119712A/ja active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111484541A (zh) * | 2019-01-25 | 2020-08-04 | 博瑞生物医药（苏州）股份有限公司 | 双核苷酸前体药物及其制备方法 |
| CN111484541B (zh) * | 2019-01-25 | 2023-06-02 | 博瑞生物医药（苏州）股份有限公司 | 双核苷酸前体药物及其制备方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| HK1077503A1 (zh) | 2006-02-17 |
| KR20090048658A (ko) | 2009-05-14 |
| US7709449B2 (en) | 2010-05-04 |
| CN1610553A (zh) | 2005-04-27 |
| JP2015091891A (ja) | 2015-05-14 |
| AU2002316118A1 (en) | 2002-11-25 |
| CN100400045C (zh) | 2008-07-09 |
| US20030109471A1 (en) | 2003-06-12 |
| JP2013177453A (ja) | 2013-09-09 |
| US7256179B2 (en) | 2007-08-14 |
| JP2017119712A (ja) | 2017-07-06 |
| WO2002092006A3 (en) | 2004-08-19 |
| GB2392157B (en) | 2005-12-21 |
| HK1060736A1 (en) | 2004-08-20 |
| JP2009242439A (ja) | 2009-10-22 |
| GB0327057D0 (en) | 2003-12-24 |
| WO2002092006A2 (en) | 2002-11-21 |
| KR100991975B1 (ko) | 2010-11-04 |
| US6881831B2 (en) | 2005-04-19 |
| US20070270359A1 (en) | 2007-11-22 |
| US20050143337A1 (en) | 2005-06-30 |
| GB2392157A (en) | 2004-02-25 |
| KR20040074594A (ko) | 2004-08-25 |
| JP2005525991A (ja) | 2005-09-02 |
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