JP2005525991A - 核酸ベースの化合物およびその使用方法 - Google Patents
核酸ベースの化合物およびその使用方法 Download PDFInfo
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- JP2005525991A JP2005525991A JP2002588925A JP2002588925A JP2005525991A JP 2005525991 A JP2005525991 A JP 2005525991A JP 2002588925 A JP2002588925 A JP 2002588925A JP 2002588925 A JP2002588925 A JP 2002588925A JP 2005525991 A JP2005525991 A JP 2005525991A
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Classifications
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- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/713—Double-stranded nucleic acids or oligonucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
- C07H19/207—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids the phosphoric or polyphosphoric acids being esterified by a further hydroxylic compound, e.g. flavine adenine dinucleotide or nicotinamide-adenine dinucleotide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Pharmacology & Pharmacy (AREA)
- Genetics & Genomics (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
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| US29147101P | 2001-05-16 | 2001-05-16 | |
| PCT/US2002/015383 WO2002092006A2 (en) | 2001-05-16 | 2002-05-15 | Nucleic acid-based compounds and methods of use thereof |
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| JP2013124544A Division JP2013177453A (ja) | 2001-05-16 | 2013-06-13 | 核酸ベースの化合物およびその使用方法 |
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| JP2013124544A Pending JP2013177453A (ja) | 2001-05-16 | 2013-06-13 | 核酸ベースの化合物およびその使用方法 |
| JP2015024999A Withdrawn JP2015091891A (ja) | 2001-05-16 | 2015-02-12 | 核酸ベースの化合物およびその使用方法 |
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| JP (5) | JP2005525991A (https=) |
| KR (2) | KR20040074594A (https=) |
| CN (2) | CN101113160A (https=) |
| AU (1) | AU2002316118A1 (https=) |
| GB (1) | GB2392157B (https=) |
| WO (1) | WO2002092006A2 (https=) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2014500230A (ja) * | 2010-08-30 | 2014-01-09 | スプリング バンク ファーマシューティカルズ，インコーポレイテッド | 治療薬としてオリゴヌクレオチド類縁体の設計 |
| JP2021511305A (ja) * | 2018-01-10 | 2021-05-06 | ヌクオリオン ファーマシューティカルズ インコーポレイテッド | ホスホロ（ン）アミダートアセタールおよびホスファ（ホナ）ートアルセタール化合物 |
| US12110311B2 (en) | 2019-07-17 | 2024-10-08 | Nucorion Pharmaceuticals, Inc. | Cyclic deoxyribonucleotide compounds |
| US12552820B2 (en) | 2020-04-21 | 2026-02-17 | Ligand Pharmaceuticals Incorporated | Benzyloxy phosph(on)ate compounds |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002092006A2 (en) * | 2001-05-16 | 2002-11-21 | Micrologix Biotech, Inc. | Nucleic acid-based compounds and methods of use thereof |
| DE60208400T2 (de) * | 2001-10-03 | 2006-07-06 | Bioniche Life Sciences Inc., Belleville | Therapeutisch verwendbare triethylenglykol-cholesteryl-oligonukleotide |
| US20090280567A1 (en) * | 2004-02-06 | 2009-11-12 | Dharmacon, Inc. | Stabilized sirnas as transfection controls and silencing reagents |
| WO2005078094A2 (en) * | 2004-02-06 | 2005-08-25 | Dharmacon, Inc. | Stabilized rnas as transfection controls and silencing reagents |
| KR101147147B1 (ko) * | 2004-04-01 | 2012-05-25 | 머크 샤프 앤드 돔 코포레이션 | Ｒｎａ 간섭의 오프 타겟 효과 감소를 위한 변형된폴리뉴클레오타이드 |
| US7923207B2 (en) | 2004-11-22 | 2011-04-12 | Dharmacon, Inc. | Apparatus and system having dry gene silencing pools |
| US20060166234A1 (en) * | 2004-11-22 | 2006-07-27 | Barbara Robertson | Apparatus and system having dry control gene silencing compositions |
| US7935811B2 (en) * | 2004-11-22 | 2011-05-03 | Dharmacon, Inc. | Apparatus and system having dry gene silencing compositions |
| US20060223777A1 (en) * | 2005-03-29 | 2006-10-05 | Dharmacon, Inc. | Highly functional short hairpin RNA |
| US8076303B2 (en) | 2005-12-13 | 2011-12-13 | Spring Bank Pharmaceuticals, Inc. | Nucleotide and oligonucleotide prodrugs |
| AU2007299705B2 (en) * | 2006-09-22 | 2012-09-06 | Dharmacon, Inc. | Duplex oligonucleotide complexes and methods for gene silencing by RNA interference |
| US8188060B2 (en) | 2008-02-11 | 2012-05-29 | Dharmacon, Inc. | Duplex oligonucleotides with enhanced functionality in gene regulation |
| GB2471806B (en) * | 2008-04-03 | 2012-12-19 | Spring Bank Pharmaceuticals Inc | Compositions and methods for treating viral infections |
| NZ607996A (en) | 2010-09-22 | 2014-07-25 | Alios Biopharma Inc | Substituted nucleotide analogs |
| CA2860234A1 (en) * | 2011-12-22 | 2013-06-27 | Alios Biopharma, Inc. | Substituted phosphorothioate nucleotide analogs |
| HK1206362A1 (zh) | 2012-03-21 | 2016-01-08 | Alios Biopharma, Inc. | 硫代氨基磷酸酯核苷酸前藥的固體形式 |
| WO2013142157A1 (en) | 2012-03-22 | 2013-09-26 | Alios Biopharma, Inc. | Pharmaceutical combinations comprising a thionucleotide analog |
| US9447132B2 (en) | 2013-04-12 | 2016-09-20 | Achillion Pharmaceuticals, Inc. | Highly active nucleoside derivative for the treatment of HCV |
| AU2016341208A1 (en) | 2015-10-20 | 2018-05-10 | Sorrento Therapeutics, Inc. | Intracellular delivery compounds |
| WO2019219070A1 (zh) * | 2018-05-18 | 2019-11-21 | 正大天晴药业集团股份有限公司 | 氘代的低聚核苷酸及前体药物 |
| CN113164506B (zh) * | 2018-12-06 | 2023-12-08 | 正大天晴药业集团股份有限公司 | 二核苷酸化合物及其前体药物 |
| CN111484541B (zh) * | 2019-01-25 | 2023-06-02 | 博瑞生物医药（苏州）股份有限公司 | 双核苷酸前体药物及其制备方法 |
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| US5218103A (en) * | 1988-05-26 | 1993-06-08 | University Patents, Inc. | Nucleoside thiophosphoramidites |
| JPH06511492A (ja) * | 1991-10-15 | 1994-12-22 | アイシス・ファーマシューティカルス・インコーポレーテッド | キラルリン結合を有するオリゴヌクレオチド |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2641537A1 (fr) | 1989-01-09 | 1990-07-13 | Centre Nat Rech Scient | Phosphates d'oxysteryle, synthese et utilisation comme agent pharmaceutique |
| US5149798A (en) | 1989-04-06 | 1992-09-22 | Worcester Foundation For Experimental Biology | Process for synthesizing oligonucleotides and their analogs adaptable to large scale syntheses |
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- 2002-05-15 CN CNA2007101437468A patent/CN101113160A/zh active Pending
- 2002-05-15 KR KR10-2003-7014856A patent/KR20040074594A/ko not_active Ceased
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- 2002-05-15 CN CNB028108434A patent/CN100400045C/zh not_active Expired - Fee Related
- 2002-05-15 KR KR1020097009006A patent/KR100991975B1/ko not_active Expired - Fee Related
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2005
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2014500230A (ja) * | 2010-08-30 | 2014-01-09 | スプリング バンク ファーマシューティカルズ，インコーポレイテッド | 治療薬としてオリゴヌクレオチド類縁体の設計 |
| JP2016164148A (ja) * | 2010-08-30 | 2016-09-08 | スプリング バンク ファーマシューティカルズ，インコーポレイテッド | 治療薬としてオリゴヌクレオチド類縁体の設計 |
| JP2021511305A (ja) * | 2018-01-10 | 2021-05-06 | ヌクオリオン ファーマシューティカルズ インコーポレイテッド | ホスホロ（ン）アミダートアセタールおよびホスファ（ホナ）ートアルセタール化合物 |
| JP7181938B2 (ja) | 2018-01-10 | 2022-12-01 | ヌクオリオン ファーマシューティカルズ インコーポレイテッド | ホスホロ（ン）アミダートアセタールおよびホスファ（ホナ）ートアルセタール化合物 |
| US12110308B2 (en) | 2018-01-10 | 2024-10-08 | Nucorion Pharmaceuticals, Inc. | Phosphor(n)amidatacetal and phosph(on)atalcetal compounds |
| US12110311B2 (en) | 2019-07-17 | 2024-10-08 | Nucorion Pharmaceuticals, Inc. | Cyclic deoxyribonucleotide compounds |
| US12552820B2 (en) | 2020-04-21 | 2026-02-17 | Ligand Pharmaceuticals Incorporated | Benzyloxy phosph(on)ate compounds |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2009242439A (ja) | 2009-10-22 |
| CN100400045C (zh) | 2008-07-09 |
| WO2002092006A3 (en) | 2004-08-19 |
| US20030109471A1 (en) | 2003-06-12 |
| GB0327057D0 (en) | 2003-12-24 |
| GB2392157A (en) | 2004-02-25 |
| KR20040074594A (ko) | 2004-08-25 |
| HK1060736A1 (en) | 2004-08-20 |
| WO2002092006A2 (en) | 2002-11-21 |
| US6881831B2 (en) | 2005-04-19 |
| JP2017119712A (ja) | 2017-07-06 |
| US7256179B2 (en) | 2007-08-14 |
| US20070270359A1 (en) | 2007-11-22 |
| JP2013177453A (ja) | 2013-09-09 |
| CN101113160A (zh) | 2008-01-30 |
| AU2002316118A1 (en) | 2002-11-25 |
| GB2392157B (en) | 2005-12-21 |
| HK1077503A1 (zh) | 2006-02-17 |
| US7709449B2 (en) | 2010-05-04 |
| JP2015091891A (ja) | 2015-05-14 |
| KR100991975B1 (ko) | 2010-11-04 |
| KR20090048658A (ko) | 2009-05-14 |
| US20050143337A1 (en) | 2005-06-30 |
| CN1610553A (zh) | 2005-04-27 |
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