GB2392157B - Nucleic acid-based compounds and methods of use thereof - Google Patents

Nucleic acid-based compounds and methods of use thereof

Info

Publication number
GB2392157B
GB2392157B GB0327057A GB0327057A GB2392157B GB 2392157 B GB2392157 B GB 2392157B GB 0327057 A GB0327057 A GB 0327057A GB 0327057 A GB0327057 A GB 0327057A GB 2392157 B GB2392157 B GB 2392157B
Authority
GB
United Kingdom
Prior art keywords
methods
nucleic acid
based compounds
compounds
nucleic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
GB0327057A
Other languages
English (en)
Other versions
GB0327057D0 (en
GB2392157A (en
Inventor
Radhakrishnan P Iyer
Yi Jin
Arlene Roland
Wenqiang Zhou
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biowest Therapeutics Inc
Original Assignee
Micrologix Biotech Inc
Migenix Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Micrologix Biotech Inc, Migenix Inc filed Critical Micrologix Biotech Inc
Publication of GB0327057D0 publication Critical patent/GB0327057D0/en
Publication of GB2392157A publication Critical patent/GB2392157A/en
Application granted granted Critical
Publication of GB2392157B publication Critical patent/GB2392157B/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C07H19/207—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids the phosphoric or polyphosphoric acids being esterified by a further hydroxylic compound, e.g. flavine adenine dinucleotide or nicotinamide-adenine dinucleotide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
GB0327057A 2001-05-16 2002-05-15 Nucleic acid-based compounds and methods of use thereof Expired - Fee Related GB2392157B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US29147101P 2001-05-16 2001-05-16
PCT/US2002/015383 WO2002092006A2 (en) 2001-05-16 2002-05-15 Nucleic acid-based compounds and methods of use thereof

Publications (3)

Publication Number Publication Date
GB0327057D0 GB0327057D0 (en) 2003-12-24
GB2392157A GB2392157A (en) 2004-02-25
GB2392157B true GB2392157B (en) 2005-12-21

Family

ID=23120429

Family Applications (1)

Application Number Title Priority Date Filing Date
GB0327057A Expired - Fee Related GB2392157B (en) 2001-05-16 2002-05-15 Nucleic acid-based compounds and methods of use thereof

Country Status (7)

Country Link
US (3) US6881831B2 (https=)
JP (5) JP2005525991A (https=)
KR (2) KR100991975B1 (https=)
CN (2) CN101113160A (https=)
AU (1) AU2002316118A1 (https=)
GB (1) GB2392157B (https=)
WO (1) WO2002092006A2 (https=)

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CN101113160A (zh) * 2001-05-16 2008-01-30 米珍尼克斯公司 基于核酸的化合物及其使用方法
DE60208400T2 (de) * 2001-10-03 2006-07-06 Bioniche Life Sciences Inc., Belleville Therapeutisch verwendbare triethylenglykol-cholesteryl-oligonukleotide
US20090280567A1 (en) * 2004-02-06 2009-11-12 Dharmacon, Inc. Stabilized sirnas as transfection controls and silencing reagents
EP2123759B1 (en) * 2004-02-06 2014-01-15 Thermo Fisher Scientific Biosciences Inc. Stabilized RNAS as transfection controls and silencing reagents
KR101147147B1 (ko) 2004-04-01 2012-05-25 머크 샤프 앤드 돔 코포레이션 Ｒｎａ 간섭의 오프 타겟 효과 감소를 위한 변형된폴리뉴클레오타이드
US20060166234A1 (en) * 2004-11-22 2006-07-27 Barbara Robertson Apparatus and system having dry control gene silencing compositions
US7923207B2 (en) 2004-11-22 2011-04-12 Dharmacon, Inc. Apparatus and system having dry gene silencing pools
US7935811B2 (en) * 2004-11-22 2011-05-03 Dharmacon, Inc. Apparatus and system having dry gene silencing compositions
US20060223777A1 (en) * 2005-03-29 2006-10-05 Dharmacon, Inc. Highly functional short hairpin RNA
US8076303B2 (en) 2005-12-13 2011-12-13 Spring Bank Pharmaceuticals, Inc. Nucleotide and oligonucleotide prodrugs
WO2008036841A2 (en) * 2006-09-22 2008-03-27 Dharmacon, Inc. Tripartite oligonucleotide complexes and methods for gene silencing by rna interference
US8188060B2 (en) 2008-02-11 2012-05-29 Dharmacon, Inc. Duplex oligonucleotides with enhanced functionality in gene regulation
GB2471806B (en) * 2008-04-03 2012-12-19 Spring Bank Pharmaceuticals Inc Compositions and methods for treating viral infections
KR101926419B1 (ko) 2010-08-30 2018-12-10 스프링 뱅크 파마슈티칼스, 인크. 치료제로서 올리고뉴클레오타이드 유사체의 설계
BR112013005872A2 (pt) 2010-09-22 2019-09-24 Alios Biopharma Inc compostos, composição farmacêutica e respectivos usos
EP2794630A4 (en) 2011-12-22 2015-04-01 Alios Biopharma Inc SUBSTITUTED PHOSPHORTHIOAT NUCLEOTIDE ANALOGUE
WO2013142124A1 (en) 2012-03-21 2013-09-26 Vertex Pharmaceuticals Incorporated Solid forms of a thiophosphoramidate nucleotide prodrug
US9012427B2 (en) 2012-03-22 2015-04-21 Alios Biopharma, Inc. Pharmaceutical combinations comprising a thionucleotide analog
AU2014250762A1 (en) 2013-04-12 2015-10-29 Achillion Pharmaceuticals, Inc. Highly active nucleoside derivative for the treatment of HCV
JP7170535B2 (ja) 2015-10-20 2022-11-14 ソレント・セラピューティクス・インコーポレイテッド 細胞内送達化合物
EP3752511A4 (en) 2018-01-10 2021-12-29 Nucorion Pharmaceuticals, Inc. Phosphor(n)amidatacetal and phosph(on)atalcetal compounds
CN111918870B (zh) * 2018-05-18 2022-07-08 正大天晴药业集团股份有限公司 氘代的低聚核苷酸及前体药物
CN113164506B (zh) * 2018-12-06 2023-12-08 正大天晴药业集团股份有限公司 二核苷酸化合物及其前体药物
CN111484541B (zh) * 2019-01-25 2023-06-02 博瑞生物医药（苏州）股份有限公司 双核苷酸前体药物及其制备方法
CN114206896B (zh) 2019-07-17 2024-12-17 纽科利制药公司 环状脱氧核糖核苷酸化合物
US12552820B2 (en) 2020-04-21 2026-02-17 Ligand Pharmaceuticals Incorporated Benzyloxy phosph(on)ate compounds

Citations (8)

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WO1990012578A1 (en) * 1989-04-21 1990-11-01 Cornell Research Foundation, Inc. Method of inhibiting induction of latent or chronic viral infections
US5212295A (en) * 1990-01-11 1993-05-18 Isis Pharmaceuticals Monomers for preparation of oligonucleotides having chiral phosphorus linkages
US5218103A (en) * 1988-05-26 1993-06-08 University Patents, Inc. Nucleoside thiophosphoramidites
WO1996039154A1 (en) * 1995-06-06 1996-12-12 Isis Pharmaceuticals, Inc. Oligonucleotides having phosphorothioate linkages of high chiral purity
WO1996039502A1 (en) * 1995-06-06 1996-12-12 Hybridon Inc. Oligonucleotides specific for hepatitis b virus
WO2001040515A1 (en) * 1999-11-12 2001-06-07 Isis Pharmaceuticals, Inc. Gapped oligomers having site specific chiral phosphorothioate internucleoside linkages
WO2002043771A2 (en) * 2000-12-01 2002-06-06 Cell Works Inc. Conjugates of glycosylated/galactosylated peptide
WO2002081494A1 (en) * 2001-03-26 2002-10-17 Sirna Therapeutics, Inc. Oligonucleotide mediated inhibition of hepatitis b virus and hepatitis c virus replication

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US5149798A (en) 1989-04-06 1992-09-22 Worcester Foundation For Experimental Biology Process for synthesizing oligonucleotides and their analogs adaptable to large scale syntheses
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US5614504A (en) * 1990-08-01 1997-03-25 The University Of South Florida Method of making inosine monophosphate derivatives and immunopotentiating uses thereof
US5212293A (en) * 1990-08-06 1993-05-18 American Cyanamid Company Process for the preparation of deoxynucleosides
DE4111730A1 (de) 1991-04-10 1992-10-15 Knoll Ag Neue cytarabin-derivate, ihre herstellung und verwendung
GB2257704B (en) * 1991-07-18 1995-03-01 Erba Carlo Spa Cyclic oligonucleotides phosphorothioates
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WO1994000473A2 (en) 1992-06-30 1994-01-06 Res Corp Technologies Inc Pentavalent synthesis of oligonucleotides containing stereospecific alkylphosphonates and arylphosphonates
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AU6449394A (en) 1993-03-30 1994-10-24 Sterling Winthrop Inc. Acyclic nucleoside analogs and oligonucleotide sequences containing them
US5843912A (en) * 1994-07-06 1998-12-01 Universy Of Maryland Ring-expanded nucleosides and nucleotides
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Patent Citations (8)

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Publication number Priority date Publication date Assignee Title
US5218103A (en) * 1988-05-26 1993-06-08 University Patents, Inc. Nucleoside thiophosphoramidites
WO1990012578A1 (en) * 1989-04-21 1990-11-01 Cornell Research Foundation, Inc. Method of inhibiting induction of latent or chronic viral infections
US5212295A (en) * 1990-01-11 1993-05-18 Isis Pharmaceuticals Monomers for preparation of oligonucleotides having chiral phosphorus linkages
WO1996039154A1 (en) * 1995-06-06 1996-12-12 Isis Pharmaceuticals, Inc. Oligonucleotides having phosphorothioate linkages of high chiral purity
WO1996039502A1 (en) * 1995-06-06 1996-12-12 Hybridon Inc. Oligonucleotides specific for hepatitis b virus
WO2001040515A1 (en) * 1999-11-12 2001-06-07 Isis Pharmaceuticals, Inc. Gapped oligomers having site specific chiral phosphorothioate internucleoside linkages
WO2002043771A2 (en) * 2000-12-01 2002-06-06 Cell Works Inc. Conjugates of glycosylated/galactosylated peptide
WO2002081494A1 (en) * 2001-03-26 2002-10-17 Sirna Therapeutics, Inc. Oligonucleotide mediated inhibition of hepatitis b virus and hepatitis c virus replication

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
Analytica Chimica Acta, 2001, Vol. 435(1), pages 65-74 & Chemical Abstracts, abstr no 135:104404 *
Bioconjugate Chemistry, 1996, Vol. 7(3), pages 369-379, see dinucleotide d5'Tp(S)C3'. *
Bioorganic & Medicinal Chemistry Letters, 1993, Vol. 3(12), pages 2637-2640 & Chemical Abstracts, abstr no 120:324109 *
Bioorganic & Medicinal Chemistry Letters, 2001, Vol. 11(16), pages 2057-2060, see page 2060 (compounds 3'AG-N13 (present example 24) & 3'UA-N18), and tables 1 & 2 *
Chemical Abstracts, abstr no 127:81733 *
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1997, Vol. 36B(11), pages 1000-1004 & Chemical Abstracts, abstr no 128:294993, see preparation of d(GpT) on page 1003 (compound RN 206061-73-6; cf present compound 6). *
Journal of the American Chemical Society, 1989, Vol. 111, pages 2321-2322 *
Nucleosides & Nucleotides, 1997, Vol. 16(7-9), pages 1709-1712 & Chemical Abstracts, abstr no 128:34972, see preparation of d(ApsG) on page 1710 (compound RN 183506-06-1; cf present compound 5). *

Also Published As

Publication number Publication date
HK1077503A1 (zh) 2006-02-17
KR20090048658A (ko) 2009-05-14
US7709449B2 (en) 2010-05-04
CN1610553A (zh) 2005-04-27
JP2015091891A (ja) 2015-05-14
AU2002316118A1 (en) 2002-11-25
CN100400045C (zh) 2008-07-09
US20030109471A1 (en) 2003-06-12
JP2013177453A (ja) 2013-09-09
US7256179B2 (en) 2007-08-14
CN101113160A (zh) 2008-01-30
JP2017119712A (ja) 2017-07-06
WO2002092006A3 (en) 2004-08-19
HK1060736A1 (en) 2004-08-20
JP2009242439A (ja) 2009-10-22
GB0327057D0 (en) 2003-12-24
WO2002092006A2 (en) 2002-11-21
KR100991975B1 (ko) 2010-11-04
US6881831B2 (en) 2005-04-19
US20070270359A1 (en) 2007-11-22
US20050143337A1 (en) 2005-06-30
GB2392157A (en) 2004-02-25
KR20040074594A (ko) 2004-08-25
JP2005525991A (ja) 2005-09-02

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