JP2004506740A5 - - Google Patents
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- Publication number
- JP2004506740A5 JP2004506740A5 JP2002521477A JP2002521477A JP2004506740A5 JP 2004506740 A5 JP2004506740 A5 JP 2004506740A5 JP 2002521477 A JP2002521477 A JP 2002521477A JP 2002521477 A JP2002521477 A JP 2002521477A JP 2004506740 A5 JP2004506740 A5 JP 2004506740A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- formula
- compound according
- infectious diseases
- hexopyranosyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 17
- 208000035473 Communicable disease Diseases 0.000 claims 5
- 238000000034 method Methods 0.000 claims 4
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims 3
- 125000003118 aryl group Chemical group 0.000 claims 3
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 125000000623 heterocyclic group Chemical group 0.000 claims 3
- 229910052739 hydrogen Inorganic materials 0.000 claims 3
- 239000001257 hydrogen Substances 0.000 claims 3
- 125000000446 sulfanediyl group Chemical group *S* 0.000 claims 3
- 239000002253 acid Substances 0.000 claims 2
- 125000000848 adenin-9-yl group Chemical group [H]N([H])C1=C2N=C([H])N(*)C2=NC([H])=N1 0.000 claims 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 2
- 150000002148 esters Chemical class 0.000 claims 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
- 150000002431 hydrogen Chemical class 0.000 claims 2
- 238000001727 in vivo Methods 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- KTSNTUOKEHVPGX-UHFFFAOYSA-N 1-oxacyclotetradeca-7,9-diene-2,5,11,13-tetrone Chemical compound O=C1CCC(=O)OCC(=O)CC(=O)C=CC=CC1 KTSNTUOKEHVPGX-UHFFFAOYSA-N 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- IDCBOTIENDVCBQ-UHFFFAOYSA-N TEPP Chemical compound CCOP(=O)(OCC)OP(=O)(OCC)OCC IDCBOTIENDVCBQ-UHFFFAOYSA-N 0.000 claims 1
- KPCZJLGGXRGYIE-UHFFFAOYSA-N [C]1=CC=CN=C1 Chemical group [C]1=CC=CN=C1 KPCZJLGGXRGYIE-UHFFFAOYSA-N 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 230000000850 deacetylating effect Effects 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 239000003120 macrolide antibiotic agent Substances 0.000 claims 1
- 210000000056 organ Anatomy 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- -1 pyridinyl-1H-pyrazol-1-yl Chemical group 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP00117971 | 2000-08-22 | ||
| PCT/EP2001/009560 WO2002016380A1 (en) | 2000-08-22 | 2001-08-20 | New macrolides with antibacterial activity |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004506740A JP2004506740A (ja) | 2004-03-04 |
| JP2004506740A5 true JP2004506740A5 (https=) | 2005-03-17 |
| JP4162992B2 JP4162992B2 (ja) | 2008-10-08 |
Family
ID=8169600
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002521477A Expired - Fee Related JP4162992B2 (ja) | 2000-08-22 | 2001-08-20 | 抗菌活性を有する新規マクロライド |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US6740642B2 (https=) |
| EP (1) | EP1313751B1 (https=) |
| JP (1) | JP4162992B2 (https=) |
| KR (1) | KR100502031B1 (https=) |
| CN (1) | CN1234718C (https=) |
| AT (1) | ATE408614T1 (https=) |
| AU (1) | AU2001282105A1 (https=) |
| BR (1) | BR0113472A (https=) |
| CA (1) | CA2419296C (https=) |
| DE (1) | DE60135859D1 (https=) |
| ES (1) | ES2313975T3 (https=) |
| MX (1) | MXPA03001607A (https=) |
| WO (1) | WO2002016380A1 (https=) |
| ZA (1) | ZA200301047B (https=) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1492874A (zh) * | 2000-12-21 | 2004-04-28 | 大环内酯 | |
| FR2826274B1 (fr) * | 2001-06-21 | 2003-09-26 | Aventis Pharma Sa | Formulation pharmaceutique au gout masque et son procede de preparation |
| WO2003024986A1 (en) * | 2001-09-17 | 2003-03-27 | Ortho-Mcneil Pharmaceutical, Inc. | 6-o-carbamate-11,12-lacto-ketolide antimicrobials |
| US6995143B2 (en) * | 2002-02-28 | 2006-02-07 | Basilea Pharmaceutica Ag | Macrolides with antibacterial activity |
| US6727229B2 (en) | 2002-08-19 | 2004-04-27 | Enanta Pharmaceuticals, Inc. | 11,12-substituted lactone ketolide derivatives having antibacterial activity |
| US6720308B1 (en) | 2002-11-07 | 2004-04-13 | Enanta Pharmaceuticals, Inc. | Anhydrolide derivatives having antibacterial activity |
| US6765016B1 (en) | 2003-06-05 | 2004-07-20 | Enanta Pharmaceuticals, Inc. | Bicyclic ketolide derivatives |
| US6790835B1 (en) | 2003-06-05 | 2004-09-14 | Enanta Pharmaceuticals, Inc. | Bicyclic macrolide derivatives |
| US6774115B1 (en) | 2003-06-05 | 2004-08-10 | Enanta Pharmaceuticals, Inc. | 6-O-substituted bicyclic ketolides |
| WO2004108745A2 (en) * | 2003-06-05 | 2004-12-16 | Enanta Pharmaceuticals, Inc. | 11-12 bicyclic erythromycin derivatives |
| US20040254126A1 (en) * | 2003-06-05 | 2004-12-16 | Yao-Ling Qiu | 11-12 Bicyclic erythromycin derivatives |
| US6716820B1 (en) | 2003-06-05 | 2004-04-06 | Enanta Pharmaceuticals, Inc. | 6-O-substituted bicyclic macrolides |
| US7291602B2 (en) * | 2004-12-13 | 2007-11-06 | Enanta Pharmaceuticals, Inc. | 11,12-lactone bicyclolides |
| CN101115764B (zh) * | 2005-02-09 | 2012-09-26 | 巴斯利尔药物股份公司 | 大环内酯类化合物 |
| AU2006212626B2 (en) * | 2005-02-09 | 2010-04-29 | Basilea Pharmaceutica Ag | New macrolides |
| US7517859B2 (en) * | 2005-05-04 | 2009-04-14 | Enanta Pharmaceuticals, Inc. | Spirocyclic bicyclolides |
| EP3290427A1 (en) | 2005-08-24 | 2018-03-07 | Melinta Therapeutics, Inc. | Triazole compounds and methods of making and using the same |
| DK2049556T3 (da) * | 2006-08-09 | 2013-08-12 | Basilea Pharmaceutica Ag | Nye makrolider anvendelige mod inflammatoriske og allergiske sygdomme |
| WO2008023248A2 (en) * | 2006-08-24 | 2008-02-28 | Wockhardt Research Centre | Novel macrolides and ketolides having antimicrobial activity |
| WO2009106419A1 (en) * | 2008-02-08 | 2009-09-03 | Basilea Pharmaceutica Ag | New macrolides and their use |
| PL2247294T3 (pl) * | 2008-02-08 | 2014-09-30 | Basilea Pharmaceutica Ag | Makrolidy do leczenia chorób przez hamowanie PDE |
| BRPI1011959A2 (pt) | 2009-05-27 | 2016-04-26 | Wockhardt Research Center | compostos de cetolídeo tendo atividade antimicrobiana. |
| US8796474B1 (en) | 2010-08-23 | 2014-08-05 | Rutgers, The State University Of New Jersey | Macrolide compounds and methods and intermediates useful for their preparation |
| CN102417530A (zh) * | 2010-09-26 | 2012-04-18 | 中国医学科学院药物研究所 | 广谱抗菌素红霉素a大环酮内酯类衍生物的合成方法和用途 |
| WO2012076989A1 (en) | 2010-12-09 | 2012-06-14 | Wockhardt Limited | Ketolide compounds |
| KR101567658B1 (ko) | 2011-03-01 | 2015-11-09 | 욱크하르트 리미티드 | 케톨리드 중간체의 제조 방법 |
| JP6154026B2 (ja) * | 2012-12-31 | 2017-06-28 | バジリア ファルマスーチカ アーゲーＢａｓｉｌｅａ Ｐｈａｒｍａｃｅｕｔｉｃａ ＡＧ | Ｐｄｅ４阻害活性を有する選ばれたマクロライド |
| CN108778255B (zh) * | 2016-01-12 | 2020-11-13 | 沃克哈特有限公司 | 药物组合物 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2719587B1 (fr) | 1994-05-03 | 1996-07-12 | Roussel Uclaf | Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments. |
-
2001
- 2001-08-20 BR BR0113472-8A patent/BR0113472A/pt not_active Application Discontinuation
- 2001-08-20 CN CNB018160891A patent/CN1234718C/zh not_active Expired - Fee Related
- 2001-08-20 KR KR10-2003-7002616A patent/KR100502031B1/ko not_active Expired - Fee Related
- 2001-08-20 CA CA002419296A patent/CA2419296C/en not_active Expired - Fee Related
- 2001-08-20 EP EP01960680A patent/EP1313751B1/en not_active Expired - Lifetime
- 2001-08-20 JP JP2002521477A patent/JP4162992B2/ja not_active Expired - Fee Related
- 2001-08-20 MX MXPA03001607A patent/MXPA03001607A/es active IP Right Grant
- 2001-08-20 AT AT01960680T patent/ATE408614T1/de not_active IP Right Cessation
- 2001-08-20 WO PCT/EP2001/009560 patent/WO2002016380A1/en not_active Ceased
- 2001-08-20 DE DE60135859T patent/DE60135859D1/de not_active Expired - Lifetime
- 2001-08-20 AU AU2001282105A patent/AU2001282105A1/en not_active Abandoned
- 2001-08-20 ES ES01960680T patent/ES2313975T3/es not_active Expired - Lifetime
- 2001-08-20 US US10/362,526 patent/US6740642B2/en not_active Expired - Lifetime
-
2003
- 2003-02-06 ZA ZA200301047A patent/ZA200301047B/en unknown
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