ATE408614T1 - Neue macrolide mit antibakterieller wirkung - Google Patents

Neue macrolide mit antibakterieller wirkung

Info

Publication number
ATE408614T1
ATE408614T1 AT01960680T AT01960680T ATE408614T1 AT E408614 T1 ATE408614 T1 AT E408614T1 AT 01960680 T AT01960680 T AT 01960680T AT 01960680 T AT01960680 T AT 01960680T AT E408614 T1 ATE408614 T1 AT E408614T1
Authority
AT
Austria
Prior art keywords
antibacterial effect
new macrolides
heterocyclyl
hydrogen
formula
Prior art date
Application number
AT01960680T
Other languages
English (en)
Inventor
Peter Angehrn
Daniel Hunziker
Pierre-Charles Wyss
Original Assignee
Basilea Pharmaceutica Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basilea Pharmaceutica Ag filed Critical Basilea Pharmaceutica Ag
Application granted granted Critical
Publication of ATE408614T1 publication Critical patent/ATE408614T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0031—Rectum, anus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/02—Suppositories; Bougies; Bases therefor; Ovules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
AT01960680T 2000-08-22 2001-08-20 Neue macrolide mit antibakterieller wirkung ATE408614T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP00117971 2000-08-22

Publications (1)

Publication Number Publication Date
ATE408614T1 true ATE408614T1 (de) 2008-10-15

Family

ID=8169600

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01960680T ATE408614T1 (de) 2000-08-22 2001-08-20 Neue macrolide mit antibakterieller wirkung

Country Status (14)

Country Link
US (1) US6740642B2 (de)
EP (1) EP1313751B1 (de)
JP (1) JP4162992B2 (de)
KR (1) KR100502031B1 (de)
CN (1) CN1234718C (de)
AT (1) ATE408614T1 (de)
AU (1) AU2001282105A1 (de)
BR (1) BR0113472A (de)
CA (1) CA2419296C (de)
DE (1) DE60135859D1 (de)
ES (1) ES2313975T3 (de)
MX (1) MXPA03001607A (de)
WO (1) WO2002016380A1 (de)
ZA (1) ZA200301047B (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU1727702A (en) * 2000-12-21 2002-07-01 Glaxo Group Ltd Macrolide antibiotics
FR2826274B1 (fr) * 2001-06-21 2003-09-26 Aventis Pharma Sa Formulation pharmaceutique au gout masque et son procede de preparation
EP1430068A1 (de) * 2001-09-17 2004-06-23 Ortho-Mcneil Pharmaceutical, Inc. Antimikrobielle 6-0-carbamat-11,12-lacto-ketolid-verbindungen
US6995143B2 (en) * 2002-02-28 2006-02-07 Basilea Pharmaceutica Ag Macrolides with antibacterial activity
US6727229B2 (en) 2002-08-19 2004-04-27 Enanta Pharmaceuticals, Inc. 11,12-substituted lactone ketolide derivatives having antibacterial activity
US6720308B1 (en) 2002-11-07 2004-04-13 Enanta Pharmaceuticals, Inc. Anhydrolide derivatives having antibacterial activity
US20040254126A1 (en) * 2003-06-05 2004-12-16 Yao-Ling Qiu 11-12 Bicyclic erythromycin derivatives
WO2004108745A2 (en) * 2003-06-05 2004-12-16 Enanta Pharmaceuticals, Inc. 11-12 bicyclic erythromycin derivatives
US6774115B1 (en) 2003-06-05 2004-08-10 Enanta Pharmaceuticals, Inc. 6-O-substituted bicyclic ketolides
US6716820B1 (en) 2003-06-05 2004-04-06 Enanta Pharmaceuticals, Inc. 6-O-substituted bicyclic macrolides
US6790835B1 (en) 2003-06-05 2004-09-14 Enanta Pharmaceuticals, Inc. Bicyclic macrolide derivatives
US6765016B1 (en) 2003-06-05 2004-07-20 Enanta Pharmaceuticals, Inc. Bicyclic ketolide derivatives
US7291602B2 (en) * 2004-12-13 2007-11-06 Enanta Pharmaceuticals, Inc. 11,12-lactone bicyclolides
EP1846430B1 (de) * 2005-02-09 2009-04-01 Basilea Pharmaceutica AG Neue makrolide
CN101115764B (zh) * 2005-02-09 2012-09-26 巴斯利尔药物股份公司 大环内酯类化合物
US7517859B2 (en) * 2005-05-04 2009-04-14 Enanta Pharmaceuticals, Inc. Spirocyclic bicyclolides
JP5395432B2 (ja) 2005-08-24 2014-01-22 リブ−エックス ファーマシューティカルズ，インコーポレイテッド トリアゾール化合物ならびにこれを作製する方法および使用する方法
DK2049556T3 (da) 2006-08-09 2013-08-12 Basilea Pharmaceutica Ag Nye makrolider anvendelige mod inflammatoriske og allergiske sygdomme
KR20090042971A (ko) * 2006-08-24 2009-05-04 욱크하르트 리서치 센터 항미생물 활성을 갖는 신규한 마크로라이드 및 케토라이드
ES2474697T3 (es) 2008-02-08 2014-07-09 Basilea Pharmaceutica Ag Macr�lidos para tratar enfermedades mediadas por la inhibición de PDE
JP5651019B2 (ja) * 2008-02-08 2015-01-07 バジリア ファルマスーチカ アーゲーＢａｓｉｌｅａ Ｐｈａｒｍａｃｅｕｔｉｃａ ＡＧ 新規マクロライドおよびそれらの使用
US8541420B2 (en) 2009-05-27 2013-09-24 Wockhardt Ltd. Ketolide compounds having antimicrobial activity
US8796474B1 (en) 2010-08-23 2014-08-05 Rutgers, The State University Of New Jersey Macrolide compounds and methods and intermediates useful for their preparation
CN102417530A (zh) * 2010-09-26 2012-04-18 中国医学科学院药物研究所 广谱抗菌素红霉素a大环酮内酯类衍生物的合成方法和用途
DK2673285T3 (en) 2010-12-09 2017-10-16 Wockhardt Ltd Ketolide compounds
US9206214B2 (en) 2011-03-01 2015-12-08 Wockhardt Ltd. Process for preparation of ketolide intermediates
WO2014102315A1 (en) * 2012-12-31 2014-07-03 Basilea Pharmaceutica Ag Selected macrolides with pde4-inhibiting activity
AU2017206672A1 (en) 2016-01-12 2018-08-23 Wockhardt Limited Pharmaceutical compositions

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2719587B1 (fr) * 1994-05-03 1996-07-12 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.

Also Published As

Publication number Publication date
MXPA03001607A (es) 2003-06-04
AU2001282105A1 (en) 2002-03-04
KR20030029839A (ko) 2003-04-16
JP4162992B2 (ja) 2008-10-08
US6740642B2 (en) 2004-05-25
ZA200301047B (en) 2004-05-06
KR100502031B1 (ko) 2005-07-25
CN1234718C (zh) 2006-01-04
BR0113472A (pt) 2003-07-01
WO2002016380A1 (en) 2002-02-28
ES2313975T3 (es) 2009-03-16
DE60135859D1 (de) 2008-10-30
CN1464880A (zh) 2003-12-31
EP1313751B1 (de) 2008-09-17
CA2419296A1 (en) 2002-02-28
US20030199459A1 (en) 2003-10-23
JP2004506740A (ja) 2004-03-04
EP1313751A1 (de) 2003-05-28
CA2419296C (en) 2008-12-09

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Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties
REN Ceased due to non-payment of the annual fee