EA200400536A1 - Макролиды - Google Patents

Макролиды

Info

Publication number
EA200400536A1
EA200400536A1 EA200400536A EA200400536A EA200400536A1 EA 200400536 A1 EA200400536 A1 EA 200400536A1 EA 200400536 A EA200400536 A EA 200400536A EA 200400536 A EA200400536 A EA 200400536A EA 200400536 A1 EA200400536 A1 EA 200400536A1
Authority
EA
Eurasian Patent Office
Prior art keywords
macrolides
solvates
systemic
animal
prevention
Prior art date
Application number
EA200400536A
Other languages
English (en)
Other versions
EA007433B1 (ru
Inventor
Сулейман Алиходзик
Даниэле Андреотти
Андреа Бердик
Илария Бьентинези
Стефано Бьонди
Мануэла Чирако
Фредерика Дамиани
Марко Дьерек
Мильенко Думик
Весна Эракович
Антун Хутинек
Горьяна Лазаревски
Серджио Лочиуро
Натаса Марсик
Зорика Марусик-Истук
Стьепан Мутак
Альфредо Пайо
Дразен Павловик
Анна Квалья
Вольфганг Шёнфельд
Владо Стимак
Джессика Тибаско
Original Assignee
Глаксо Груп Лимитед
ПЛИВА-ИСТРАЗИВАЦКИ ИНСТИТУТ д.о.о.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Глаксо Груп Лимитед, ПЛИВА-ИСТРАЗИВАЦКИ ИНСТИТУТ д.о.о. filed Critical Глаксо Груп Лимитед
Publication of EA200400536A1 publication Critical patent/EA200400536A1/ru
Publication of EA007433B1 publication Critical patent/EA007433B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

Настоящее изобретение относится к 14- или 15-членным макролидам, замещенным в 4" положении формулы (I)(I)и их фармацевтически приемлемым солям и сольватам, к способам их получения и к их применению в терапии или профилактике системных или местных бактериальных инфекций организма человека или животного.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200400536A 2001-11-14 2002-11-13 Макролиды EA007433B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0127349.9A GB0127349D0 (en) 2001-11-14 2001-11-14 Macrolides
PCT/GB2002/005101 WO2003042228A1 (en) 2001-11-14 2002-11-13 Macrolides

Publications (2)

Publication Number Publication Date
EA200400536A1 true EA200400536A1 (ru) 2004-12-30
EA007433B1 EA007433B1 (ru) 2006-10-27

Family

ID=9925777

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200400536A EA007433B1 (ru) 2001-11-14 2002-11-13 Макролиды

Country Status (20)

Country Link
US (1) US7202221B2 (ru)
EP (1) EP1453846B1 (ru)
JP (1) JP2005515978A (ru)
CN (1) CN1307194C (ru)
AR (1) AR037371A1 (ru)
AT (1) ATE362479T1 (ru)
BR (1) BR0214132A (ru)
CA (1) CA2466975A1 (ru)
DE (1) DE60220180T2 (ru)
EA (1) EA007433B1 (ru)
ES (1) ES2287332T3 (ru)
GB (1) GB0127349D0 (ru)
HR (1) HRP20040433A2 (ru)
HU (1) HUP0402225A3 (ru)
IL (1) IL161710A0 (ru)
PL (1) PL371472A1 (ru)
RS (1) RS41904A (ru)
UA (1) UA77210C2 (ru)
WO (1) WO2003042228A1 (ru)
ZA (1) ZA200403684B (ru)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6995143B2 (en) * 2002-02-28 2006-02-07 Basilea Pharmaceutica Ag Macrolides with antibacterial activity
US7910558B2 (en) 2002-05-13 2011-03-22 Enanta Pharmaceuticals, Inc. Bridged macrocyclic compounds and processes for the preparation thereof
US6764998B1 (en) 2003-06-18 2004-07-20 Enanta Pharmaceuticals, Inc. 6,11-4C-bicyclic 9a-azalide derivatives
US7022679B2 (en) 2002-05-13 2006-04-04 Enanta Pharmaceuticals, Inc. Processes for the preparation of 6-11 bicyclic erythromycin derivatives
US7135573B2 (en) 2002-05-13 2006-11-14 Enanta Pharmaceuticals, Inc. Processes for the preparation of O-(6-Pyrazol-1-yl-pyridin-3-ylmethyl)-hydroxylamine
ATE417613T1 (de) * 2002-05-14 2009-01-15 Univ California Substituierte chinoloncarbonsäuren, ihre derivate,wirkungsort und anwendungen
AR043050A1 (es) 2002-09-26 2005-07-13 Rib X Pharmaceuticals Inc Compuestos heterociclicos bifuncionales y metodos para preparar y usar los mismos
GB0225384D0 (en) * 2002-10-31 2002-12-11 Glaxo Group Ltd Novel compounds
US6645941B1 (en) 2003-03-26 2003-11-11 Enanta Pharmaceuticals, Inc. 6,11-3C-bicyclic 9a-azalide derivatives
GB0310979D0 (en) * 2003-05-13 2003-06-18 Glaxo Group Ltd Novel compounds
PL1628989T3 (pl) * 2003-05-13 2007-05-31 Glaxo Group Ltd Nowe związki o 14- i 15- członowym pierścieniu
GB0310980D0 (en) * 2003-05-13 2003-06-18 Glaxo Group Ltd Novel compounds
GB0310986D0 (en) * 2003-05-13 2003-06-18 Glaxo Group Ltd Novel compounds
GB0310984D0 (en) * 2003-05-13 2003-06-18 Glaxo Group Ltd Novel compounds
US7276487B2 (en) 2003-09-23 2007-10-02 Enanta Pharmaceuticals, Inc. 9a, 11-3C-bicyclic 9a-azalide derivatives
US7265094B2 (en) 2004-01-09 2007-09-04 Enanta Pharmaceuticals, Inc. 9N-substituted 6-11 bicyclic erythromycin derivatives
US8202843B2 (en) 2004-02-27 2012-06-19 Rib-X Pharmaceuticals, Inc. Macrocyclic compounds and methods of making and using the same
AU2005240849B2 (en) * 2004-05-06 2008-10-23 Glaxosmithkline Istrazivacki Centar Zagreb D.O.O. Ester linked macrolides useful for the treatment of microbial infections
US20080249033A1 (en) * 2004-05-06 2008-10-09 Sulejman Alihodzic Carbamate Linked Macrolides Useful For The Treatment Of Microbial Infections
WO2006047167A2 (en) * 2004-10-21 2006-05-04 Janssen Pharmaceutica, N.V. 9 alkyl and 9 alkylidenyl 6-0 alkyl-11, 12 carbamate ketolide antimicrobials
GB0424951D0 (en) * 2004-11-11 2004-12-15 Glaxo Group Ltd Novel compounds
GB0424961D0 (en) * 2004-11-11 2004-12-15 Glaxo Group Ltd Novel compounds
GB0424959D0 (en) * 2004-11-11 2004-12-15 Glaxo Group Ltd Novel compounds
GB0424958D0 (en) * 2004-11-11 2004-12-15 Glaxo Group Ltd Novel compounds
ES2428874T3 (es) 2006-08-09 2013-11-12 Basilea Pharmaceutica Ag Nuevos macrólidos útiles contra las enfermedades inflamatorias y alérgicas
EP2056844A4 (en) 2006-08-24 2010-11-24 Wockhardt Research Center NEW MACROLIDS AND KETOLIDS WITH ANTIMICROBIAL EFFECT
US8410065B2 (en) 2008-02-08 2013-04-02 Basilea Pharmaceutica Ag Macrolides and their use
KR101566053B1 (ko) 2009-05-27 2015-11-04 욱크하르트 리미티드 항균 활성을 갖는 케톨라이드
EP3216798A3 (en) 2010-12-09 2017-10-25 Wockhardt Limited Ketolide compounds
CN103380141A (zh) * 2011-01-31 2013-10-30 明治制果药业株式会社 新大环内酯衍生物
US9206214B2 (en) 2011-03-01 2015-12-08 Wockhardt Ltd. Process for preparation of ketolide intermediates

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0126344A2 (en) 1983-05-20 1984-11-28 Abbott Laboratories Tripeptide esters of therapeutic agents
US4742049A (en) * 1986-06-04 1988-05-03 Abbott Laboratories Semisynthetic erythromycin antibiotics
ATE128714T1 (de) 1989-03-28 1995-10-15 Abbott Lab Erythromycinderivate.
CA2064634C (en) * 1991-04-04 1998-08-04 James V. Heck 9-deoxo-8a-aza-8a-homoerythromycin a derivatives modified at the 4"- and8a-positions
WO1997042206A1 (en) 1996-05-07 1997-11-13 Abbott Laboratories 6-o-substituted erythromycin compounds and method for making same
EP0895999A1 (en) 1997-08-06 1999-02-10 Pfizer Products Inc. C-4" substituted macrolide antibiotics
US6262030B1 (en) 1998-11-03 2001-07-17 Pfizer Inc. Erythromycin derivatives
CN1351608A (zh) 1999-05-24 2002-05-29 辉瑞产品公司 13－甲基红霉素衍生物
BR0009101A (pt) 1999-08-24 2002-02-05 Abbott Lab 9a-azalidas com atividade antibacteriana
DE60115851T2 (de) 2000-02-24 2006-08-10 Abbott Laboratories, Abbott Park Anti-infektionsmittel, die gegen gegenüber mehreren arzneimitteln resistente bakterienstämme nützlich sind
US6946446B2 (en) 2000-02-24 2005-09-20 Abbott Laboratories Anti-infective agents useful against multidrug-resistant strains of bacteria
JP2002173498A (ja) 2000-09-27 2002-06-21 Hokuriku Seiyaku Co Ltd エリスロマイシン誘導体
GB0025688D0 (en) * 2000-10-19 2000-12-06 Glaxo Group Ltd Macrolides

Also Published As

Publication number Publication date
EP1453846A1 (en) 2004-09-08
HUP0402225A3 (en) 2006-01-30
EA007433B1 (ru) 2006-10-27
WO2003042228A1 (en) 2003-05-22
ATE362479T1 (de) 2007-06-15
EP1453846B1 (en) 2007-05-16
JP2005515978A (ja) 2005-06-02
IL161710A0 (en) 2004-09-27
US20050080025A1 (en) 2005-04-14
CA2466975A1 (en) 2003-05-22
HRP20040433A2 (en) 2005-04-30
CN1612888A (zh) 2005-05-04
GB0127349D0 (en) 2002-01-02
DE60220180T2 (de) 2008-01-17
CN1307194C (zh) 2007-03-28
HUP0402225A2 (hu) 2005-02-28
DE60220180D1 (de) 2007-06-28
BR0214132A (pt) 2004-09-14
RS41904A (en) 2006-10-27
UA77210C2 (en) 2006-11-15
ZA200403684B (en) 2005-09-13
US7202221B2 (en) 2007-04-10
AR037371A1 (es) 2004-11-03
ES2287332T3 (es) 2007-12-16
PL371472A1 (en) 2005-06-13

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU